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Items: 1 to 20 of 95


Translating the human microbiome.

Brown J, de Vos WM, DiStefano PS, Doré J, Huttenhower C, Knight R, Lawley TD, Raes J, Turnbaugh P.

Nat Biotechnol. 2013 Apr;31(4):304-8. doi: 10.1038/nbt.2543. No abstract available.


Pharmacologic inhibition of ghrelin receptor signaling is insulin sparing and promotes insulin sensitivity.

Longo KA, Govek EK, Nolan A, McDonagh T, Charoenthongtrakul S, Giuliana DJ, Morgan K, Hixon J, Zhou C, Kelder B, Kopchick JJ, Saunders JO, Navia MA, Curtis R, DiStefano PS, Geddes BJ.

J Pharmacol Exp Ther. 2011 Oct;339(1):115-24. doi: 10.1124/jpet.111.183764. Epub 2011 Jul 20. Erratum in: J Pharmacol Exp Ther. 2012 Mar;340(3):810.


SIRT1-independent mechanisms of the putative sirtuin enzyme activators SRT1720 and SRT2183.

Huber JL, McBurney MW, Distefano PS, McDonagh T.

Future Med Chem. 2010 Dec;2(12):1751-9. doi: 10.4155/fmc.10.257.


Characterization of the insulin sensitivity of ghrelin receptor KO mice using glycemic clamps.

Qi Y, Longo KA, Giuliana DJ, Gagne S, McDonagh T, Govek E, Nolan A, Zou C, Morgan K, Hixon J, Saunders JO, Distefano PS, Geddes BJ.

BMC Physiol. 2011 Jan 6;11:1. doi: 10.1186/1472-6793-11-1.


The 24-hour respiratory quotient predicts energy intake and changes in body mass.

Longo KA, Charoenthongtrakul S, Giuliana DJ, Govek EK, McDonagh T, Distefano PS, Geddes BJ.

Am J Physiol Regul Integr Comp Physiol. 2010 Mar;298(3):R747-54. doi: 10.1152/ajpregu.00476.2009. Epub 2009 Dec 16.


Daily energy balance in growth hormone receptor/binding protein (GHR -/-) gene-disrupted mice is achieved through an increase in dark-phase energy efficiency.

Longo KA, Berryman DE, Kelder B, Charoenthongtrakul S, Distefano PS, Geddes BJ, Kopchick JJ.

Growth Horm IGF Res. 2010 Feb;20(1):73-9. doi: 10.1016/j.ghir.2009.08.002. Epub 2009 Sep 10.


Enhanced gastrointestinal motility with orally active ghrelin receptor agonists.

Charoenthongtrakul S, Giuliana D, Longo KA, Govek EK, Nolan A, Gagne S, Morgan K, Hixon J, Flynn N, Murphy BJ, Hernández AS, Li J, Tino JA, Gordon DA, DiStefano PS, Geddes BJ.

J Pharmacol Exp Ther. 2009 Jun;329(3):1178-86. doi: 10.1124/jpet.108.150193. Epub 2009 Feb 27.


Improved insulin sensitivity and metabolic flexibility in ghrelin receptor knockout mice.

Longo KA, Charoenthongtrakul S, Giuliana DJ, Govek EK, McDonagh T, Qi Y, DiStefano PS, Geddes BJ.

Regul Pept. 2008 Oct 9;150(1-3):55-61. doi: 10.1016/j.regpep.2008.03.011. Epub 2008 Mar 30.


Insulin resistance, glycemic control and adiposity: key determinants of healthy lifespan.

DiStefano PS, Curtis R, Geddes BJ.

Curr Alzheimer Res. 2007 Apr;4(2):153-7. Review.


Proapoptotic effects of NARC 1 (= PCSK9), the gene encoding a novel serine proteinase.

Bingham B, Shen R, Kotnis S, Lo CF, Ozenberger BA, Ghosh N, Kennedy JD, Jacobsen JS, Grenier JM, DiStefano PS, Chiang LW, Wood A.

Cytometry A. 2006 Nov 1;69(11):1123-31.


Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage.

Solomon JM, Pasupuleti R, Xu L, McDonagh T, Curtis R, DiStefano PS, Huber LJ.

Mol Cell Biol. 2006 Jan;26(1):28-38.


Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.

Napper AD, Hixon J, McDonagh T, Keavey K, Pons JF, Barker J, Yau WT, Amouzegh P, Flegg A, Hamelin E, Thomas RJ, Kates M, Jones S, Navia MA, Saunders JO, DiStefano PS, Curtis R.

J Med Chem. 2005 Dec 15;48(25):8045-54. Erratum in: J Med Chem. 2007 Mar 8;50(5):1086.


Microplate filtration assay for nicotinamide release from NAD using a boronic acid resin.

McDonagh T, Hixon J, DiStefano PS, Curtis R, Napper AD.

Methods. 2005 Aug;36(4):346-50.


Ageing and metabolism: drug discovery opportunities.

Curtis R, Geesaman BJ, DiStefano PS.

Nat Rev Drug Discov. 2005 Jul;4(7):569-80. Review.


Substrate-specific activation of sirtuins by resveratrol.

Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell SD, Napper A, Curtis R, DiStefano PS, Fields S, Bedalov A, Kennedy BK.

J Biol Chem. 2005 Apr 29;280(17):17038-45. Epub 2005 Jan 31.


The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans.

Apfeld J, O'Connor G, McDonagh T, DiStefano PS, Curtis R.

Genes Dev. 2004 Dec 15;18(24):3004-9. Epub 2004 Dec 1. Erratum in: Genes Dev. 2005 Jan 1;19(1):188. Genes Dev. 2005 Feb 1;19(3):411.


Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island.

Viala J, Chaput C, Boneca IG, Cardona A, Girardin SE, Moran AP, Athman R, Mémet S, Huerre MR, Coyle AJ, DiStefano PS, Sansonetti PJ, Labigne A, Bertin J, Philpott DJ, Ferrero RL.

Nat Immunol. 2004 Nov;5(11):1166-74. Epub 2004 Oct 17.


Functional characterization of Narc 1, a novel proteinase related to proteinase K.

Naureckiene S, Ma L, Sreekumar K, Purandare U, Lo CF, Huang Y, Chiang LW, Grenier JM, Ozenberger BA, Jacobsen JS, Kennedy JD, DiStefano PS, Wood A, Bingham B.

Arch Biochem Biophys. 2003 Dec 1;420(1):55-67.


Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2.

Yu FH, Westenbroek RE, Silos-Santiago I, McCormick KA, Lawson D, Ge P, Ferriera H, Lilly J, DiStefano PS, Catterall WA, Scheuer T, Curtis R.

J Neurosci. 2003 Aug 20;23(20):7577-85.

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