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Results: 1 to 20 of 28

1.

The E3 ligase PARC mediates the degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells.

Gama V, Swahari V, Schafer J, Kole AJ, Evans A, Huang Y, Cliffe A, Golitz B, Sciaky N, Pei XH, Xiong Y, Deshmukh M.

Sci Signal. 2014 Jul 15;7(334):ra67. doi: 10.1126/scisignal.2005309.

PMID:
25028717
[PubMed - in process]
2.

Adaptations of energy metabolism during cerebellar neurogenesis are co-opted in medulloblastoma.

Tech K, Deshmukh M, Gershon TR.

Cancer Lett. 2014 Feb 22. pii: S0304-3835(14)00119-0. doi: 10.1016/j.canlet.2014.02.017. [Epub ahead of print]

PMID:
24569090
[PubMed - as supplied by publisher]
3.

Hexokinase-2-mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastoma.

Gershon TR, Crowther AJ, Tikunov A, Garcia I, Annis R, Yuan H, Miller CR, Macdonald J, Olson J, Deshmukh M.

Cancer Metab. 2013 Jan 23;1(1):2. doi: 10.1186/2049-3002-1-2.

PMID:
24280485
[PubMed]
Free PMC Article
4.

Cerebellar granule neuron progenitors are the source of Hk2 in the postnatal cerebellum.

Gershon TR, Crowther AJ, Liu H, Miller CR, Deshmukh M.

Cancer Metab. 2013 Jun 11;1(1):15. doi: 10.1186/2049-3002-1-15. No abstract available.

PMID:
24280296
[PubMed]
5.

Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma.

Crowther AJ, Gama V, Bevilacqua A, Chang SX, Yuan H, Deshmukh M, Gershon TR.

J Neurosci. 2013 Nov 13;33(46):18098-108. doi: 10.1523/JNEUROSCI.2602-13.2013.

PMID:
24227720
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Distinct pathways mediate axon degeneration during apoptosis and axon-specific pruning.

Cusack CL, Swahari V, Hampton Henley W, Michael Ramsey J, Deshmukh M.

Nat Commun. 2013;4:1876. doi: 10.1038/ncomms2910.

PMID:
23695670
[PubMed - indexed for MEDLINE]
7.

Adenosine: essential for life but licensed to kill.

Gama V, Deshmukh M.

Mol Cell. 2013 May 9;50(3):307-8. doi: 10.1016/j.molcel.2013.04.020.

PMID:
23664374
[PubMed]
Free PMC Article
8.

Human embryonic stem cells: living on the edge.

Gama V, Deshmukh M.

Cell Cycle. 2012 Nov 1;11(21):3905-6. doi: 10.4161/cc.22233. Epub 2012 Oct 3. No abstract available.

PMID:
23032268
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Human embryonic stem cells have constitutively active Bax at the Golgi and are primed to undergo rapid apoptosis.

Dumitru R, Gama V, Fagan BM, Bower JJ, Swahari V, Pevny LH, Deshmukh M.

Mol Cell. 2012 Jun 8;46(5):573-83. doi: 10.1016/j.molcel.2012.04.002. Epub 2012 May 3.

PMID:
22560721
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice.

Uribe V, Wong BK, Graham RK, Cusack CL, Skotte NH, Pouladi MA, Xie Y, Feinberg K, Ou Y, Ouyang Y, Deng Y, Franciosi S, Bissada N, Spreeuw A, Zhang W, Ehrnhoefer DE, Vaid K, Miller FD, Deshmukh M, Howland D, Hayden MR.

Hum Mol Genet. 2012 May 1;21(9):1954-67. doi: 10.1093/hmg/dds005. Epub 2012 Jan 18.

PMID:
22262731
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Activation of apoptosis by cytoplasmic microinjection of cytochrome c.

Kole AJ, Knight ER, Deshmukh M.

J Vis Exp. 2011 Jun 29;(52). pii: 2773. doi: 10.3791/2773.

PMID:
21730954
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

miR-29b is activated during neuronal maturation and targets BH3-only genes to restrict apoptosis.

Kole AJ, Swahari V, Hammond SM, Deshmukh M.

Genes Dev. 2011 Jan 15;25(2):125-30. doi: 10.1101/gad.1975411.

PMID:
21245165
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Lack of X-linked inhibitor of apoptosis protein leads to increased apoptosis and tissue loss following neonatal brain injury.

West T, Stump M, Lodygensky G, Neil JJ, Deshmukh M, Holtzman DM.

ASN Neuro. 2009 Apr 14;1(1). pii: e00004. doi: 10.1042/AN20090005.

PMID:
19570023
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Skeletal muscle differentiation evokes endogenous XIAP to restrict the apoptotic pathway.

Smith MI, Huang YY, Deshmukh M.

PLoS One. 2009;4(3):e5097. doi: 10.1371/journal.pone.0005097. Epub 2009 Mar 31.

PMID:
19333375
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c.

Vaughn AE, Deshmukh M.

Nat Cell Biol. 2008 Dec;10(12):1477-83. doi: 10.1038/ncb1807. Epub 2008 Nov 23.

PMID:
19029908
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Differential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissues.

Johnson CE, Huang YY, Parrish AB, Smith MI, Vaughn AE, Zhang Q, Wright KM, Van Dyke T, Wechsler-Reya RJ, Kornbluth S, Deshmukh M.

Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20820-5. Epub 2007 Dec 18.

PMID:
18093951
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Chromatin modification of Apaf-1 restricts the apoptotic pathway in mature neurons.

Wright KM, Smith MI, Farrag L, Deshmukh M.

J Cell Biol. 2007 Dec 3;179(5):825-32.

PMID:
18056406
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC.

Willingham SB, Bergstralh DT, O'Connor W, Morrison AC, Taxman DJ, Duncan JA, Barnoy S, Venkatesan MM, Flavell RA, Deshmukh M, Hoffman HM, Ting JP.

Cell Host Microbe. 2007 Sep 13;2(3):147-59.

PMID:
18005730
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Restricting apoptosis for postmitotic cell survival and its relevance to cancer.

Wright KM, Deshmukh M.

Cell Cycle. 2006 Aug;5(15):1616-20. Epub 2006 Aug 1. Review.

PMID:
16880745
[PubMed - indexed for MEDLINE]
Free Article
20.

Enhanced sensitivity to cytochrome c-induced apoptosis mediated by PHAPI in breast cancer cells.

Schafer ZT, Parrish AB, Wright KM, Margolis SS, Marks JR, Deshmukh M, Kornbluth S.

Cancer Res. 2006 Feb 15;66(4):2210-8.

PMID:
16489023
[PubMed - indexed for MEDLINE]
Free Article

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