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Items: 1 to 20 of 35


The paradox of dicer in cancer.

Swahari V, Nakamura A, Deshmukh M.

Mol Cell Oncol. 2016 Feb 26;3(3):e1155006. doi: 10.1080/23723556.2016.1155006. eCollection 2016 May.


Axon degeneration: context defines distinct pathways.

Geden MJ, Deshmukh M.

Curr Opin Neurobiol. 2016 May 16;39:108-115. doi: 10.1016/j.conb.2016.05.002. [Epub ahead of print] Review.


Bcl-xL Is Essential for the Survival and Function of Differentiated Neurons in the Cortex That Control Complex Behaviors.

Nakamura A, Swahari V, Plestant C, Smith I, McCoy E, Smith S, Moy SS, Anton ES, Deshmukh M.

J Neurosci. 2016 May 18;36(20):5448-61. doi: 10.1523/JNEUROSCI.4247-15.2016.


Essential Function of Dicer in Resolving DNA Damage in the Rapidly Dividing Cells of the Developing and Malignant Cerebellum.

Swahari V, Nakamura A, Baran-Gale J, Garcia I, Crowther AJ, Sons R, Gershon TR, Hammond S, Sethupathy P, Deshmukh M.

Cell Rep. 2016 Jan 12;14(2):216-24. doi: 10.1016/j.celrep.2015.12.037. Epub 2015 Dec 31.


Nonnative SOD1 trimer is toxic to motor neurons in a model of amyotrophic lateral sclerosis.

Proctor EA, Fee L, Tao Y, Redler RL, Fay JM, Zhang Y, Lv Z, Mercer IP, Deshmukh M, Lyubchenko YL, Dokholyan NV.

Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):614-9. doi: 10.1073/pnas.1516725113. Epub 2015 Dec 30.


Neuronal Stress Pathway Mediating a Histone Methyl/Phospho Switch Is Required for Herpes Simplex Virus Reactivation.

Cliffe AR, Arbuckle JH, Vogel JL, Geden MJ, Rothbart SB, Cusack CL, Strahl BD, Kristie TM, Deshmukh M.

Cell Host Microbe. 2015 Dec 9;18(6):649-58. doi: 10.1016/j.chom.2015.11.007.


Life after MOMP.

Gama V, Deshmukh M.

Mol Cell. 2015 Apr 16;58(2):199-201. doi: 10.1016/j.molcel.2015.03.035.


The E3 ligase PARC mediates the degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells.

Gama V, Swahari V, Schafer J, Kole AJ, Evans A, Huang Y, Cliffe A, Golitz B, Sciaky N, Pei XH, Xiong Y, Deshmukh M.

Sci Signal. 2014 Jul 15;7(334):ra67. doi: 10.1126/scisignal.2005309.


Adaptations of energy metabolism during cerebellar neurogenesis are co-opted in medulloblastoma.

Tech K, Deshmukh M, Gershon TR.

Cancer Lett. 2015 Jan 28;356(2 Pt A):268-72. doi: 10.1016/j.canlet.2014.02.017. Epub 2014 Feb 22. Review.


Hexokinase-2-mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastoma.

Gershon TR, Crowther AJ, Tikunov A, Garcia I, Annis R, Yuan H, Miller CR, Macdonald J, Olson J, Deshmukh M.

Cancer Metab. 2013 Jan 23;1(1):2. doi: 10.1186/2049-3002-1-2.


Cerebellar granule neuron progenitors are the source of Hk2 in the postnatal cerebellum.

Gershon TR, Crowther AJ, Liu H, Miller CR, Deshmukh M.

Cancer Metab. 2013 Jun 11;1(1):15. doi: 10.1186/2049-3002-1-15. No abstract available.


Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma.

Crowther AJ, Gama V, Bevilacqua A, Chang SX, Yuan H, Deshmukh M, Gershon TR.

J Neurosci. 2013 Nov 13;33(46):18098-108. doi: 10.1523/JNEUROSCI.2602-13.2013.


Distinct pathways mediate axon degeneration during apoptosis and axon-specific pruning.

Cusack CL, Swahari V, Hampton Henley W, Michael Ramsey J, Deshmukh M.

Nat Commun. 2013;4:1876. doi: 10.1038/ncomms2910.


Adenosine: essential for life but licensed to kill.

Gama V, Deshmukh M.

Mol Cell. 2013 May 9;50(3):307-8. doi: 10.1016/j.molcel.2013.04.020.


Human embryonic stem cells: living on the edge.

Gama V, Deshmukh M.

Cell Cycle. 2012 Nov 1;11(21):3905-6. doi: 10.4161/cc.22233. Epub 2012 Oct 3. No abstract available.


Human embryonic stem cells have constitutively active Bax at the Golgi and are primed to undergo rapid apoptosis.

Dumitru R, Gama V, Fagan BM, Bower JJ, Swahari V, Pevny LH, Deshmukh M.

Mol Cell. 2012 Jun 8;46(5):573-83. doi: 10.1016/j.molcel.2012.04.002. Epub 2012 May 3.


Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice.

Uribe V, Wong BK, Graham RK, Cusack CL, Skotte NH, Pouladi MA, Xie Y, Feinberg K, Ou Y, Ouyang Y, Deng Y, Franciosi S, Bissada N, Spreeuw A, Zhang W, Ehrnhoefer DE, Vaid K, Miller FD, Deshmukh M, Howland D, Hayden MR.

Hum Mol Genet. 2012 May 1;21(9):1954-67. doi: 10.1093/hmg/dds005. Epub 2012 Jan 18.


Activation of apoptosis by cytoplasmic microinjection of cytochrome c.

Kole AJ, Knight ER, Deshmukh M.

J Vis Exp. 2011 Jun 29;(52). pii: 2773. doi: 10.3791/2773.


miR-29b is activated during neuronal maturation and targets BH3-only genes to restrict apoptosis.

Kole AJ, Swahari V, Hammond SM, Deshmukh M.

Genes Dev. 2011 Jan 15;25(2):125-30. doi: 10.1101/gad.1975411.


Lack of X-linked inhibitor of apoptosis protein leads to increased apoptosis and tissue loss following neonatal brain injury.

West T, Stump M, Lodygensky G, Neil JJ, Deshmukh M, Holtzman DM.

ASN Neuro. 2009 Apr 14;1(1). pii: e00004. doi: 10.1042/AN20090005.

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