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Items: 1 to 20 of 136

1.

Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle.

Mosadeghi R, Reichermeier KM, Winkler M, Schreiber A, Reitsma JM, Zhang Y, Stengel F, Cao J, Kim M, Sweredoski MJ, Hess S, Leitner A, Aebersold R, Peter M, Deshaies RJ, Enchev RI.

Elife. 2016 Mar 31;5. pii: e12102. doi: 10.7554/eLife.12102. [Epub ahead of print]

2.

Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon.

Nguyen TV, Lee JE, Sweredoski MJ, Yang SJ, Jeon SJ, Harrison JS, Yim JH, Lee SG, Handa H, Kuhlman B, Jeong JS, Reitsma JM, Park CS, Hess S, Deshaies RJ.

Mol Cell. 2016 Mar 17;61(6):809-20. doi: 10.1016/j.molcel.2016.02.032.

PMID:
26990986
3.

Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway.

Alverez C, Bulfer SL, Chakrasali R, Chimenti MS, Deshaies RJ, Green N, Kelly M, LaPorte MG, Lewis TS, Liang M, Moore WJ, Neitz RJ, Peshkov VA, Walters MA, Zhang F, Arkin MR, Wipf P, Huryn DM.

ACS Med Chem Lett. 2015 Dec 22;7(2):182-7. doi: 10.1021/acsmedchemlett.5b00396. eCollection 2016 Feb 11.

PMID:
26985295
4.

2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition.

Banerjee S, Bartesaghi A, Merk A, Rao P, Bulfer SL, Yan Y, Green N, Mroczkowski B, Neitz RJ, Wipf P, Falconieri V, Deshaies RJ, Milne JL, Huryn D, Arkin M, Subramaniam S.

Science. 2016 Feb 19;351(6275):871-5. doi: 10.1126/science.aad7974. Epub 2016 Jan 28.

PMID:
26822609
5.

Corrigendum: Protein degradation: Prime time for PROTACs.

Deshaies RJ.

Nat Chem Biol. 2015 Nov;11(11):887. doi: 10.1038/nchembio1115-887b. No abstract available.

PMID:
26485081
6.

Protein degradation: Prime time for PROTACs.

Deshaies RJ.

Nat Chem Biol. 2015 Sep;11(9):634-5. doi: 10.1038/nchembio.1887. No abstract available. Erratum in: Nat Chem Biol. 2015 Nov;11(11):887.

PMID:
26284668
7.

Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline.

Pulvino M, Chen L, Oleksyn D, Li J, Compitello G, Rossi R, Spence S, Balakrishnan V, Jordan C, Poligone B, Casulo C, Burack R, Shapiro JL, Bernstein S, Friedberg JW, Deshaies RJ, Land H, Zhao J.

Oncotarget. 2015 Jun 20;6(17):14796-813.

8.

Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline.

Pulvino M, Chen L, Oleksyn D, Li J, Compitello G, Rossi R, Spence S, Balakrishnan V, Jordan C, Poligone B, Casulo C, Burack R, Shapiro JL, Bernstein S, Friedberg JW, Deshaies RJ, Land H, Zhao J.

Oncotarget. 2015 Jun 20:14796-14813. [Epub ahead of print]

9.

Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy.

Deshaies RJ.

BMC Biol. 2014 Nov 11;12:94. doi: 10.1186/s12915-014-0094-0. Review.

10.

Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress.

Fang NN, Chan GT, Zhu M, Comyn SA, Persaud A, Deshaies RJ, Rotin D, Gsponer J, Mayor T.

Nat Cell Biol. 2014 Dec;16(12):1227-37. doi: 10.1038/ncb3054. Epub 2014 Oct 26.

PMID:
25344756
11.

Structural biology: Corralling a protein-degradation regulator.

Deshaies RJ.

Nature. 2014 Aug 14;512(7513):145-6. doi: 10.1038/nature13644. Epub 2014 Jul 16. No abstract available.

PMID:
25043034
12.

Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains.

Chou TF, Bulfer SL, Weihl CC, Li K, Lis LG, Walters MA, Schoenen FJ, Lin HJ, Deshaies RJ, Arkin MR.

J Mol Biol. 2014 Jul 29;426(15):2886-99. doi: 10.1016/j.jmb.2014.05.022. Epub 2014 May 27.

13.

Degradation of the deubiquitinating enzyme USP33 is mediated by p97 and the ubiquitin ligase HERC2.

Chan NC, den Besten W, Sweredoski MJ, Hess S, Deshaies RJ, Chan DC.

J Biol Chem. 2014 Jul 11;289(28):19789-98. doi: 10.1074/jbc.M114.569392. Epub 2014 May 22.

14.

p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition.

Radhakrishnan SK, den Besten W, Deshaies RJ.

Elife. 2014;3:e01856. doi: 10.7554/eLife.01856. Epub 2014 Jan 21.

15.

F-box protein FBXL16 binds PP2A-B55α and regulates differentiation of embryonic stem cells along the FLK1+ lineage.

Honarpour N, Rose CM, Brumbaugh J, Anderson J, Graham RL, Sweredoski MJ, Hess S, Coon JJ, Deshaies RJ.

Mol Cell Proteomics. 2014 Mar;13(3):780-91. doi: 10.1074/mcp.M113.031765. Epub 2014 Jan 5.

16.

Perturbations to the ubiquitin conjugate proteome in yeast δubx mutants identify Ubx2 as a regulator of membrane lipid composition.

Kolawa N, Sweredoski MJ, Graham RL, Oania R, Hess S, Deshaies RJ.

Mol Cell Proteomics. 2013 Oct;12(10):2791-803. doi: 10.1074/mcp.M113.030163. Epub 2013 Jun 22.

17.

Activation of p107 by fibroblast growth factor, which is essential for chondrocyte cell cycle exit, is mediated by the protein phosphatase 2A/B55α holoenzyme.

Kurimchak A, Haines DS, Garriga J, Wu S, De Luca F, Sweredoski MJ, Deshaies RJ, Hess S, Graña X.

Mol Cell Biol. 2013 Aug;33(16):3330-42. doi: 10.1128/MCB.00082-13. Epub 2013 Jun 17.

18.

Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins.

Pierce NW, Lee JE, Liu X, Sweredoski MJ, Graham RL, Larimore EA, Rome M, Zheng N, Clurman BE, Hess S, Shan SO, Deshaies RJ.

Cell. 2013 Mar 28;153(1):206-15. doi: 10.1016/j.cell.2013.02.024. Epub 2013 Feb 28.

19.

Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome.

Verma R, Oania RS, Kolawa NJ, Deshaies RJ.

Elife. 2013 Jan 22;2:e00308. doi: 10.7554/eLife.00308.

20.

Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase.

Chou TF, Li K, Frankowski KJ, Schoenen FJ, Deshaies RJ.

ChemMedChem. 2013 Feb;8(2):297-312. doi: 10.1002/cmdc.201200520. Epub 2013 Jan 11.

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