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Items: 1 to 20 of 27


Discovery of Dual-Stage Malaria Inhibitors with New Targets.

Raphemot R, Lafuente-Monasterio MJ, Gamo-Benito FJ, Clardy J, Derbyshire ER.

Antimicrob Agents Chemother. 2015 Dec 14;60(3):1430-7. doi: 10.1128/AAC.02110-15.


The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.

Herman JD, Pepper LR, Cortese JF, Estiu G, Galinsky K, Zuzarte-Luis V, Derbyshire ER, Ribacke U, Lukens AK, Santos SA, Patel V, Clish CB, Sullivan WJ Jr, Zhou H, Bopp SE, Schimmel P, Lindquist S, Clardy J, Mota MM, Keller TL, Whitman M, Wiest O, Wirth DF, Mazitschek R.

Sci Transl Med. 2015 May 20;7(288):288ra77. doi: 10.1126/scitranslmed.aaa3575.


Chemical interrogation of the malaria kinome.

Derbyshire ER, Zuzarte-Luís V, Magalhães AD, Kato N, Sanschagrin PC, Wang J, Zhou W, Miduturu CV, Mazitschek R, Sliz P, Mota MM, Gray NS, Clardy J.

Chembiochem. 2014 Sep 5;15(13):1920-30. doi: 10.1002/cbic.201400025. Epub 2014 Aug 8.


Dihydroquinazolinone inhibitors of proliferation of blood and liver stage malaria parasites.

Derbyshire ER, Min J, Guiguemde WA, Clark JA, Connelly MC, Magalhães AD, Guy RK, Clardy J.

Antimicrob Agents Chemother. 2014;58(3):1516-22. doi: 10.1128/AAC.02148-13. Epub 2013 Dec 23.


Closing in on a new treatment for sleeping sickness.

Derbyshire ER, Clardy J.

Elife. 2013 Jul 9;2:e01042. doi: 10.7554/eLife.01042. Erratum in: Elife. 2013;2:e01221.


Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide.

Fernhoff NB, Derbyshire ER, Underbakke ES, Marletta MA.

J Biol Chem. 2012 Dec 14;287(51):43053-62. doi: 10.1074/jbc.M112.393892. Epub 2012 Oct 23.


Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp.

Carr G, Derbyshire ER, Caldera E, Currie CR, Clardy J.

J Nat Prod. 2012 Oct 26;75(10):1806-9. doi: 10.1021/np300380t. Epub 2012 Oct 1.


Conformationally distinct five-coordinate heme-NO complexes of soluble guanylate cyclase elucidated by multifrequency electron paramagnetic resonance (EPR).

Gunn A, Derbyshire ER, Marletta MA, Britt RD.

Biochemistry. 2012 Oct 23;51(42):8384-90. doi: 10.1021/bi300831m. Epub 2012 Oct 9.


Liver-stage malaria parasites vulnerable to diverse chemical scaffolds.

Derbyshire ER, Prudêncio M, Mota MM, Clardy J.

Proc Natl Acad Sci U S A. 2012 May 29;109(22):8511-6. doi: 10.1073/pnas.1118370109. Epub 2012 May 14.


Characterization of Plasmodium liver stage inhibition by halofuginone.

Derbyshire ER, Mazitschek R, Clardy J.

ChemMedChem. 2012 May;7(5):844-9. doi: 10.1002/cmdc.201200045. Epub 2012 Mar 21.


Structure and regulation of soluble guanylate cyclase.

Derbyshire ER, Marletta MA.

Annu Rev Biochem. 2012;81:533-59. doi: 10.1146/annurev-biochem-050410-100030. Epub 2012 Feb 9. Review.


Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors.

Dong CK, Urgaonkar S, Cortese JF, Gamo FJ, Garcia-Bustos JF, Lafuente MJ, Patel V, Ross L, Coleman BI, Derbyshire ER, Clish CB, Serrano AE, Cromwell M, Barker RH Jr, Dvorin JD, Duraisingh MT, Wirth DF, Clardy J, Mazitschek R.

Chem Biol. 2011 Dec 23;18(12):1602-10. doi: 10.1016/j.chembiol.2011.09.016.


The next opportunity in anti-malaria drug discovery: the liver stage.

Derbyshire ER, Mota MM, Clardy J.

PLoS Pathog. 2011 Sep;7(9):e1002178. doi: 10.1371/journal.ppat.1002178. Epub 2011 Sep 22. No abstract available.


Probing domain interactions in soluble guanylate cyclase.

Derbyshire ER, Winter MB, Ibrahim M, Deng S, Spiro TG, Marletta MA.

Biochemistry. 2011 May 24;50(20):4281-90. doi: 10.1021/bi200341b. Epub 2011 May 3.


Soluble guanylate cyclase is activated differently by excess NO and by YC-1: resonance Raman spectroscopic evidence.

Ibrahim M, Derbyshire ER, Soldatova AV, Marletta MA, Spiro TG.

Biochemistry. 2010 Jun 15;49(23):4864-71. doi: 10.1021/bi100506j.


Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopy.

Ibrahim M, Derbyshire ER, Marletta MA, Spiro TG.

Biochemistry. 2010 May 11;49(18):3815-23. doi: 10.1021/bi902214j.


Incorporation of tyrosine and glutamine residues into the soluble guanylate cyclase heme distal pocket alters NO and O2 binding.

Derbyshire ER, Deng S, Marletta MA.

J Biol Chem. 2010 Jun 4;285(23):17471-8. doi: 10.1074/jbc.M109.098269. Epub 2010 Mar 15.


A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase.

Fernhoff NB, Derbyshire ER, Marletta MA.

Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21602-7. doi: 10.1073/pnas.0911083106. Epub 2009 Dec 9.


Nucleotide regulation of soluble guanylate cyclase substrate specificity.

Derbyshire ER, Fernhoff NB, Deng S, Marletta MA.

Biochemistry. 2009 Aug 11;48(31):7519-24. doi: 10.1021/bi900696x.


Biochemistry of soluble guanylate cyclase.

Derbyshire ER, Marletta MA.

Handb Exp Pharmacol. 2009;(191):17-31. doi: 10.1007/978-3-540-68964-5_2. Review.

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