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Results: 1 to 20 of 24

1.

Dihydroquinazolinone inhibitors of proliferation of blood and liver stage malaria parasites.

Derbyshire ER, Min J, Guiguemde WA, Clark JA, Connelly MC, Magalhães AD, Guy RK, Clardy J.

Antimicrob Agents Chemother. 2014 Mar;58(3):1516-22. doi: 10.1128/AAC.02148-13. Epub 2013 Dec 23.

PMID:
24366746
[PubMed - in process]
2.

Closing in on a new treatment for sleeping sickness.

Derbyshire ER, Clardy J.

Elife. 2013 Jul 9;2:e01042. doi: 10.7554/eLife.01042. Erratum in: Elife. 2013;2:e01221.

PMID:
23853715
[PubMed]
Free PMC Article
3.

Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide.

Fernhoff NB, Derbyshire ER, Underbakke ES, Marletta MA.

J Biol Chem. 2012 Dec 14;287(51):43053-62. doi: 10.1074/jbc.M112.393892. Epub 2012 Oct 23.

PMID:
23093402
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp.

Carr G, Derbyshire ER, Caldera E, Currie CR, Clardy J.

J Nat Prod. 2012 Oct 26;75(10):1806-9. doi: 10.1021/np300380t. Epub 2012 Oct 1.

PMID:
23025282
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Conformationally distinct five-coordinate heme-NO complexes of soluble guanylate cyclase elucidated by multifrequency electron paramagnetic resonance (EPR).

Gunn A, Derbyshire ER, Marletta MA, Britt RD.

Biochemistry. 2012 Oct 23;51(42):8384-90. doi: 10.1021/bi300831m. Epub 2012 Oct 9.

PMID:
22985445
[PubMed - indexed for MEDLINE]
6.

Liver-stage malaria parasites vulnerable to diverse chemical scaffolds.

Derbyshire ER, Prudêncio M, Mota MM, Clardy J.

Proc Natl Acad Sci U S A. 2012 May 29;109(22):8511-6. doi: 10.1073/pnas.1118370109. Epub 2012 May 14.

PMID:
22586124
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Characterization of Plasmodium liver stage inhibition by halofuginone.

Derbyshire ER, Mazitschek R, Clardy J.

ChemMedChem. 2012 May;7(5):844-9. doi: 10.1002/cmdc.201200045. Epub 2012 Mar 21.

PMID:
22438279
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Structure and regulation of soluble guanylate cyclase.

Derbyshire ER, Marletta MA.

Annu Rev Biochem. 2012;81:533-59. doi: 10.1146/annurev-biochem-050410-100030. Epub 2012 Feb 9. Review.

PMID:
22404633
[PubMed - indexed for MEDLINE]
9.

Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors.

Dong CK, Urgaonkar S, Cortese JF, Gamo FJ, Garcia-Bustos JF, Lafuente MJ, Patel V, Ross L, Coleman BI, Derbyshire ER, Clish CB, Serrano AE, Cromwell M, Barker RH Jr, Dvorin JD, Duraisingh MT, Wirth DF, Clardy J, Mazitschek R.

Chem Biol. 2011 Dec 23;18(12):1602-10. doi: 10.1016/j.chembiol.2011.09.016.

PMID:
22195562
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

The next opportunity in anti-malaria drug discovery: the liver stage.

Derbyshire ER, Mota MM, Clardy J.

PLoS Pathog. 2011 Sep;7(9):e1002178. doi: 10.1371/journal.ppat.1002178. Epub 2011 Sep 22. No abstract available.

PMID:
21966266
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Probing domain interactions in soluble guanylate cyclase.

Derbyshire ER, Winter MB, Ibrahim M, Deng S, Spiro TG, Marletta MA.

Biochemistry. 2011 May 24;50(20):4281-90. doi: 10.1021/bi200341b. Epub 2011 May 3.

PMID:
21491957
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Soluble guanylate cyclase is activated differently by excess NO and by YC-1: resonance Raman spectroscopic evidence.

Ibrahim M, Derbyshire ER, Soldatova AV, Marletta MA, Spiro TG.

Biochemistry. 2010 Jun 15;49(23):4864-71. doi: 10.1021/bi100506j.

PMID:
20459051
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopy.

Ibrahim M, Derbyshire ER, Marletta MA, Spiro TG.

Biochemistry. 2010 May 11;49(18):3815-23. doi: 10.1021/bi902214j.

PMID:
20353168
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Incorporation of tyrosine and glutamine residues into the soluble guanylate cyclase heme distal pocket alters NO and O2 binding.

Derbyshire ER, Deng S, Marletta MA.

J Biol Chem. 2010 Jun 4;285(23):17471-8. doi: 10.1074/jbc.M109.098269. Epub 2010 Mar 15.

PMID:
20231286
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase.

Fernhoff NB, Derbyshire ER, Marletta MA.

Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21602-7. doi: 10.1073/pnas.0911083106. Epub 2009 Dec 9.

PMID:
20007374
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Nucleotide regulation of soluble guanylate cyclase substrate specificity.

Derbyshire ER, Fernhoff NB, Deng S, Marletta MA.

Biochemistry. 2009 Aug 11;48(31):7519-24. doi: 10.1021/bi900696x.

PMID:
19527054
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Biochemistry of soluble guanylate cyclase.

Derbyshire ER, Marletta MA.

Handb Exp Pharmacol. 2009;(191):17-31. doi: 10.1007/978-3-540-68964-5_2. Review.

PMID:
19089323
[PubMed - indexed for MEDLINE]
18.

The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase.

Winger JA, Derbyshire ER, Lamers MH, Marletta MA, Kuriyan J.

BMC Struct Biol. 2008 Oct 7;8:42. doi: 10.1186/1472-6807-8-42.

PMID:
18842118
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Characterization of two different five-coordinate soluble guanylate cyclase ferrous-nitrosyl complexes.

Derbyshire ER, Gunn A, Ibrahim M, Spiro TG, Britt RD, Marletta MA.

Biochemistry. 2008 Mar 25;47(12):3892-9. doi: 10.1021/bi7022943. Epub 2008 Feb 27.

PMID:
18302323
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Butyl isocyanide as a probe of the activation mechanism of soluble guanylate cyclase. Investigating the role of non-heme nitric oxide.

Derbyshire ER, Marletta MA.

J Biol Chem. 2007 Dec 7;282(49):35741-8. Epub 2007 Oct 4.

PMID:
17916555
[PubMed - indexed for MEDLINE]
Free Article

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