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Lysosomal pH-inducible supramolecular dissociation of polyrotaxanes possessing acid-labile N-triphenylmethyl end groups and their therapeutic potential for Niemann-Pick type C disease.
Tamura A, Nishida K, Yui N. Tamura A, et al. Sci Technol Adv Mater. 2016 Jul 26;17(1):361-374. doi: 10.1080/14686996.2016.1200948. eCollection 2016. Sci Technol Adv Mater. 2016. PMID: 27877888 Free PMC article.
Niemann-Pick type C (NPC) disease is characterized by the accumulation of cholesterol in lysosomes. ...The effect of the number of HEE groups of the HEE-PRXs, which was modified to impart water solubility to the PRXs, on cellular internalization efficiency, lysosoma …
Niemann-Pick type C (NPC) disease is characterized by the accumulation of cholesterol in lysosomes. ...The effect of the number of HE …
CSF glial markers are elevated in a subset of patients with genetic frontotemporal dementia.
Woollacott IOC, Swift IJ, Sogorb-Esteve A, Heller C, Knowles K, Bouzigues A, Russell LL, Peakman G, Greaves CV, Convery R, Heslegrave A, Rowe JB, Borroni B, Galimberti D, Tiraboschi P, Masellis M, Tartaglia MC, Finger E, van Swieten JC, Seelaar H, Jiskoot L, Sorbi S, Butler CR, Graff C, Gerhard A, Laforce R, Sanchez-Valle R, de Mendonça A, Moreno F, Synofzik M, Vandenberghe R, Ducharme S, Ber IL, Levin J, Otto M, Pasquier F, Santana I, Zetterberg H, Rohrer JD; Genetic FTD Initiative, GENFI. Woollacott IOC, et al. Ann Clin Transl Neurol. 2022 Nov;9(11):1764-1777. doi: 10.1002/acn3.51672. Epub 2022 Oct 17. Ann Clin Transl Neurol. 2022. PMID: 36245297 Free PMC article.
Radiochemical synthesis and preclinical evaluation of 68Ga-labeled NODAGA-hydroxypropyl-beta-cyclodextrin (68Ga-NODAGA-HPBCD).
Hajdu I, Angyal J, Szikra D, Kertész I, Malanga M, Fenyvesi É, Szente L, Vecsernyés M, Bácskay I, Váradi J, Fehér P, Ujhelyi Z, Vasvári G, Rusznyák Á, Trencsényi G, Fenyvesi F. Hajdu I, et al. Eur J Pharm Sci. 2019 Feb 1;128:202-208. doi: 10.1016/j.ejps.2018.12.001. Epub 2018 Dec 4. Eur J Pharm Sci. 2019. PMID: 30521943
A new renaissance started in the research and application of cyclodextrins a few years ago. 2-Hydroxypropyl-beta-cyclodextrin (HPBCD) is used in the formulation of drugs and recently orphan designation was granted for the treatment of Niemann-Pick disease, type C. HPBCD is …
A new renaissance started in the research and application of cyclodextrins a few years ago. 2-Hydroxypropyl-beta-cyclodextrin (HPBCD) is use …
Oligo(ethylene glycol)-modified β-cyclodextrin-based polyrotaxanes for simultaneously modulating solubility and cellular internalization efficiency.
Tamura A, Ohashi M, Yui N. Tamura A, et al. J Biomater Sci Polym Ed. 2017 Jul-Aug;28(10-12):1124-1139. doi: 10.1080/09205063.2017.1304173. Epub 2017 Mar 16. J Biomater Sci Polym Ed. 2017. PMID: 28299982
We developed stimuli-labile polyrotaxanes (PRXs) composed of beta-cyclodextrin (beta-CD), Pluronic as an axle polymer, and acid-cleavable N-triphenylmethyl groups as bulky stopper molecules, and found that the PRXs are potent therapeutics for Niemann-Pick type C disease, b …
We developed stimuli-labile polyrotaxanes (PRXs) composed of beta-cyclodextrin (beta-CD), Pluronic as an axle polymer, and acid-cleavable N- …
Knowledge and Awareness Regarding Avulsion and Its Immediate Treatment in School Teachers in Bangalore City (South).
Prathyusha P, Harshini T, Haripriya B, Pramod IJ, Swathi K, Samyuktha CL. Prathyusha P, et al. J Int Oral Health. 2015 Aug;7(8):93-7. J Int Oral Health. 2015. PMID: 26464548 Free PMC article.
BACKGROUND: Dental traumas are most common in children in school environment. ...RESULTS: Results showed that 97.5%of teachers received no orientation regarding this, 33.3% of them felt they cannot identify the tooth, 52% opined they would not pick up the tooth, 62. …
BACKGROUND: Dental traumas are most common in children in school environment. ...RESULTS: Results showed that 97.5%of teachers receiv …
Knowledge regarding emergency management of avulsed teeth among elementary school teachers in Jaboatão dos Guararapes, Pernambuco, Brazil.
de Lima Ludgero A, de Santana Santos T, Fernandes AV, de Melo DG, Peixoto AC, da Costa Araújo FA, Dourado AT, Gomes A. de Lima Ludgero A, et al. Indian J Dent Res. 2012 Sep-Oct;23(5):585-90. doi: 10.4103/0970-9290.107331. Indian J Dent Res. 2012. PMID: 23422601 Free article.
If an avulsed tooth had fallen to the ground, 84.3% of the teachers said they would pick it up, and 67.8% of them stated that they would clean it with water or some other liquid. A total of 33.1% said that they would take the student with the tooth in hand to a d
If an avulsed tooth had fallen to the ground, 84.3% of the teachers said they would pick it up, and 67.8% of them stated that they wo …
Are flowable resin-based composites a reliable material for metal orthodontic bracket bonding?
Pick B, Rosa V, Azeredo TR, Cruz Filho EA, Miranda WG Jr. Pick B, et al. J Contemp Dent Pract. 2010 Jul 1;11(4):E017-24. J Contemp Dent Pract. 2010. PMID: 20953560
Enamel surfaces were etched with 37 percent phosphoric acid for 30 seconds and stainless steel orthodontic brackets were bonded using either flowable resin-based composites (3M Flow, FL; Tetric Flow, TF; and Wave, WA) or orthodontic bonding systems (Transbond XT, TX; Concise Orth …
Enamel surfaces were etched with 37 percent phosphoric acid for 30 seconds and stainless steel orthodontic brackets were bonded using either …