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Results: 1 to 20 of 46

1.

Stochastic modeling indicates that aging and somatic evolution in the hematopoetic system are driven by non-cell-autonomous processes.

Rozhok AI, Salstrom JL, DeGregori J.

Aging (Albany NY). 2014 Dec;6(12):1033-48.

PMID:
25564763
[PubMed - in process]
Free PMC Article
2.

Tyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations.

Alvarez-Calderon F, Gregory MA, Pham-Danis C, DeRyckere D, Stevens BM, Zaberezhnyy V, Hill AA, Gemta L, Kumar A, Kumar V, Wempe MF, Pollyea DA, Jordan CT, Serkova NJ, Graham DK, DeGregori J.

Clin Cancer Res. 2014 Dec 29. pii: clincanres.2146.2014. [Epub ahead of print]

PMID:
25547679
[PubMed - as supplied by publisher]
3.

Personalized one-two punches for lung cancer.

Scarborough HA, Bunn PA Jr, DeGregori J.

Cell Res. 2014 Dec 30. doi: 10.1038/cr.2014.168. [Epub ahead of print]

PMID:
25547118
[PubMed - as supplied by publisher]
4.

Contrasting Roles for C/EBPα and Notch in Irradiation-Induced Multipotent Hematopoietic Progenitor Cell Defects.

Fleenor CJ, Rozhok AI, Zaberezhnyy V, Mathew D, Kim J, Tan AC, Bernstein ID, DeGregori J.

Stem Cells. 2014 Dec 27. doi: 10.1002/stem.1936. [Epub ahead of print]

PMID:
25546133
[PubMed - as supplied by publisher]
5.

Inhibition of calcineurin combined with dasatinib has direct and indirect anti-leukemia effects against BCR-ABL1(+) leukemia.

Gardner LA, Klawitter J, Gregory MA, Zaberezhnyy V, Baturin D, Pollyea DA, Takebe N, Christians U, Gore L, DeGregori J, Porter CC.

Am J Hematol. 2014 Sep;89(9):896-903. doi: 10.1002/ajh.23776. Epub 2014 Jun 19.

PMID:
24891015
[PubMed - indexed for MEDLINE]
6.

Patterns of somatically acquired amplifications and deletions in apparently normal tissues of ovarian cancer patients.

Aghili L, Foo J, DeGregori J, De S.

Cell Rep. 2014 May 22;7(4):1310-9. doi: 10.1016/j.celrep.2014.03.071. Epub 2014 May 1.

PMID:
24794429
[PubMed - in process]
Free Article
7.

Cancer evolution is associated with pervasive positive selection on globally expressed genes.

Ostrow SL, Barshir R, DeGregori J, Yeger-Lotem E, Hershberg R.

PLoS Genet. 2014 Mar 6;10(3):e1004239. doi: 10.1371/journal.pgen.1004239. eCollection 2014 Mar.

PMID:
24603726
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Simultaneous activation of Kras and inactivation of p53 induces soft tissue sarcoma and bladder urothelial hyperplasia.

Yang X, La Rosa FG, Genova EE, Huber K, Schaack J, Degregori J, Serkova NJ, Li Y, Su LJ, Kessler E, Flaig TW.

PLoS One. 2013 Sep 18;8(9):e74809. doi: 10.1371/journal.pone.0074809. eCollection 2013.

PMID:
24058630
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Rational combination of a MEK inhibitor, selumetinib, and the Wnt/calcium pathway modulator, cyclosporin A, in preclinical models of colorectal cancer.

Spreafico A, Tentler JJ, Pitts TM, Tan AC, Gregory MA, Arcaroli JJ, Klauck PJ, McManus MC, Hansen RJ, Kim J, Micel LN, Selby HM, Newton TP, McPhillips KL, Gustafson DL, Degregori JV, Messersmith WA, Winn RA, Eckhardt SG.

Clin Cancer Res. 2013 Aug 1;19(15):4149-62. doi: 10.1158/1078-0432.CCR-12-3140. Epub 2013 Jun 11.

PMID:
23757356
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

A receptor tyrosine kinase network composed of fibroblast growth factor receptors, epidermal growth factor receptor, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, and hepatocyte growth factor receptor drives growth and survival of head and neck squamous carcinoma cell lines.

Singleton KR, Kim J, Hinz TK, Marek LA, Casás-Selves M, Hatheway C, Tan AC, DeGregori J, Heasley LE.

Mol Pharmacol. 2013 Apr;83(4):882-93. doi: 10.1124/mol.112.084111. Epub 2013 Jan 31.

PMID:
23371912
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Targeting developmental pathways in children with cancer: what price success?

Gore L, DeGregori J, Porter CC.

Lancet Oncol. 2013 Feb;14(2):e70-8. doi: 10.1016/S1470-2045(12)70530-2. Review.

PMID:
23369685
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Tankyrase and the canonical Wnt pathway protect lung cancer cells from EGFR inhibition.

Casás-Selves M, Kim J, Zhang Z, Helfrich BA, Gao D, Porter CC, Scarborough HA, Bunn PA Jr, Chan DC, Tan AC, DeGregori J.

Cancer Res. 2012 Aug 15;72(16):4154-64. doi: 10.1158/0008-5472.CAN-11-2848. Epub 2012 Jun 27.

PMID:
22738915
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53.

Sullivan KD, Padilla-Just N, Henry RE, Porter CC, Kim J, Tentler JJ, Eckhardt SG, Tan AC, DeGregori J, Espinosa JM.

Nat Chem Biol. 2012 Jul;8(7):646-54. doi: 10.1038/nchembio.965. Epub 2012 Jun 3.

PMID:
22660439
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Extracellular cyclophilin-A stimulates ERK1/2 phosphorylation in a cell-dependent manner but broadly stimulates nuclear factor kappa B.

Bahmed K, Henry C, Holliday M, Redzic J, Ciobanu M, Zhang F, Weekes C, Sclafani R, Degregori J, Eisenmesser E.

Cancer Cell Int. 2012 Jul 4;12(1):19. doi: 10.1186/1475-2867-12-19.

PMID:
22631225
[PubMed]
Free PMC Article
15.

How cancer shapes evolution, and how evolution shapes cancer.

Casás-Selves M, Degregori J.

Evolution (N Y). 2011 Dec;4(4):624-634.

PMID:
23705033
[PubMed]
Free PMC Article
16.

Aging-associated changes in hematopoiesis and leukemogenesis: what's the connection?

Henry CJ, Marusyk A, DeGregori J.

Aging (Albany NY). 2011 Jun;3(6):643-56. Review.

PMID:
21765201
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Evolved tumor suppression: why are we so good at not getting cancer?

DeGregori J.

Cancer Res. 2011 Jun 1;71(11):3739-44. doi: 10.1158/0008-5472.CAN-11-0342. Epub 2011 May 24.

PMID:
21610109
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Strong foreign promoters contribute to innate inflammatory responses induced by adenovirus transducing vectors.

Schaack J, Bennett ML, Shapiro GS, DeGregori J, McManaman JL, Moorhead JW.

Virology. 2011 Mar 30;412(1):28-35. doi: 10.1016/j.virol.2010.12.054. Epub 2011 Jan 20.

PMID:
21255815
[PubMed - indexed for MEDLINE]
Free Article
19.

Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis.

Henry CJ, Marusyk A, Zaberezhnyy V, Adane B, DeGregori J.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21713-8. doi: 10.1073/pnas.1005486107. Epub 2010 Nov 22.

PMID:
21098275
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Ionizing radiation and hematopoietic malignancies: altering the adaptive landscape.

Fleenor CJ, Marusyk A, DeGregori J.

Cell Cycle. 2010 Aug 1;9(15):3005-11. Epub 2010 Aug 7.

PMID:
20676038
[PubMed - indexed for MEDLINE]
Free PMC Article
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