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Results: 1 to 20 of 230

1.

The HIV-1 integrase mutant R263A/K264A is two-fold defective for TRN-SR2 binding and viral nuclear import.

De Houwer S, Demeulemeester J, Thys W, Rocha S, Dirix L, Gijsbers R, Christ F, Debyser Z.

J Biol Chem. 2014 Jul 25. pii: jbc.M113.533281. [Epub ahead of print]

PMID:
25063804
[PubMed - as supplied by publisher]
2.

Structure of transportin SR2, a karyopherin involved in human disease, in complex with Ran.

Tsirkone VG, Beutels KG, Demeulemeester J, Debyser Z, Christ F, Strelkov SV.

Acta Crystallogr F Struct Biol Commun. 2014 Jun;70(Pt 6):723-9. doi: 10.1107/S2053230X14009492. Epub 2014 May 24.

PMID:
24915079
[PubMed - in process]
3.

Switching STRATEGIES in HIV treatment.

Schrijvers R, Debyser Z.

Lancet Infect Dis. 2014 Jul;14(7):537-40. doi: 10.1016/S1473-3099(14)70743-1. Epub 2014 Jun 5. No abstract available.

PMID:
24908549
[PubMed - in process]
4.

4-Substituted 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as a Novel Class of HIV-1 Integrase Inhibitors.

Billamboz M, Suchaud V, Bailly F, Lion C, Demeulemeester J, Calmels C, Andréola ML, Christ F, Debyser Z, Cotelle P.

ACS Med Chem Lett. 2013 May 17;4(7):606-11. doi: 10.1021/ml400009t. eCollection 2013 Jul 11.

PMID:
24900718
[PubMed]
Free PMC Article
5.

Bioluminescence imaging of stroke-induced endogenous neural stem cell response.

Vandeputte C, Reumers V, Aelvoet SA, Thiry I, De Swaef S, Van den Haute C, Pascual-Brazo J, Farr TD, Vande Velde G, Hoehn M, Himmelreich U, Van Laere K, Debyser Z, Gijsbers R, Baekelandt V.

Neurobiol Dis. 2014 Sep;69:144-55. doi: 10.1016/j.nbd.2014.05.014. Epub 2014 May 27.

PMID:
24878507
[PubMed - in process]
6.

Investigation of a novel series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as human immunodeficiency virus type 1 integrase inhibitors.

Suchaud V, Bailly F, Lion C, Calmels C, Andréola ML, Christ F, Debyser Z, Cotelle P.

J Med Chem. 2014 Jun 12;57(11):4640-60. doi: 10.1021/jm500109z. Epub 2014 May 14.

PMID:
24793360
[PubMed - in process]
7.

Optimization of multimodal imaging of mesenchymal stem cells using the human sodium iodide symporter for PET and Cerenkov luminescence imaging.

Wolfs E, Holvoet B, Gijsbers R, Casteels C, Roberts SJ, Struys T, Maris M, Ibrahimi A, Debyser Z, Van Laere K, Verfaillie CM, Deroose CM.

PLoS One. 2014 Apr 18;9(4):e94833. doi: 10.1371/journal.pone.0094833. eCollection 2014.

PMID:
24747914
[PubMed - in process]
Free PMC Article
8.

Diketoacid chelating ligands as dual inhibitors of HIV-1 integration process.

Rogolino D, Carcelli M, Compari C, De Luca L, Ferro S, Fisicaro E, Rispoli G, Neamati N, Debyser Z, Christ F, Chimirri A.

Eur J Med Chem. 2014 May 6;78:425-30. doi: 10.1016/j.ejmech.2014.03.070. Epub 2014 Mar 25.

PMID:
24704615
[PubMed - in process]
9.

LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 - 2014).

Demeulemeester J, Chaltin P, Marchand A, De Maeyer M, Debyser Z, Christ F.

Expert Opin Ther Pat. 2014 Jun;24(6):609-32. doi: 10.1517/13543776.2014.898753. Epub 2014 Mar 25.

PMID:
24666332
[PubMed - in process]
10.

HIV virions as nanoscopic test tubes for probing oligomerization of the integrase enzyme.

Borrenberghs D, Thys W, Rocha S, Demeulemeester J, Weydert C, Dedecker P, Hofkens J, Debyser Z, Hendrix J.

ACS Nano. 2014 Apr 22;8(4):3531-45. doi: 10.1021/nn406615v. Epub 2014 Apr 2.

PMID:
24654558
[PubMed - in process]
11.

Structure, mechanics, and binding mode heterogeneity of LEDGF/p75-DNA nucleoprotein complexes revealed by scanning force microscopy.

Vanderlinden W, Lipfert J, Demeulemeester J, Debyser Z, De Feyter S.

Nanoscale. 2014 May 7;6(9):4611-9. doi: 10.1039/c4nr00022f.

PMID:
24632996
[PubMed - in process]
12.

A new potential approach to block HIV-1 replication via protein-protein interaction and strand-transfer inhibition.

Ferro S, De Luca L, Lo Surdo G, Morreale F, Christ F, Debyser Z, Gitto R, Chimirri A.

Bioorg Med Chem. 2014 Apr 1;22(7):2269-79. doi: 10.1016/j.bmc.2014.02.012. Epub 2014 Feb 20.

PMID:
24618511
[PubMed - in process]
13.

Immunological ignorance allows long-term gene expression after perinatal recombinant adeno-associated virus-mediated gene transfer to murine airways.

Carlon MS, Vidović D, Dooley J, da Cunha MM, Maris M, Lampi Y, Toelen J, Van den Haute C, Baekelandt V, Deprest J, Verbeken E, Liston A, Gijsbers R, Debyser Z.

Hum Gene Ther. 2014 Jun;25(6):517-28. doi: 10.1089/hum.2013.196. Epub 2014 Mar 26.

PMID:
24548076
[PubMed - in process]
14.

Rational design of LEDGINs as first allosteric integrase inhibitors for the treatment of HIV infection.

Desimmie BA, Demeulemeester J, Christ F, Debyser Z.

Drug Discov Today Technol. 2013 Dec;10(4):e517-22. doi: 10.1016/j.ddtec.2012.10.002.

PMID:
24451643
[PubMed - in process]
15.

Viral vectors expressing a single microRNA-based short-hairpin RNA result in potent gene silencing in vitro and in vivo.

Osório L, Gijsbers R, Oliveras-Salvá M, Michiels A, Debyser Z, Van den Haute C, Baekelandt V.

J Biotechnol. 2014 Jan;169:71-81. doi: 10.1016/j.jbiotec.2013.11.004. Epub 2013 Nov 16.

PMID:
24252659
[PubMed - in process]
16.

The BET family of proteins targets moloney murine leukemia virus integration near transcription start sites.

De Rijck J, de Kogel C, Demeulemeester J, Vets S, El Ashkar S, Malani N, Bushman FD, Landuyt B, Husson SJ, Busschots K, Gijsbers R, Debyser Z.

Cell Rep. 2013 Nov 27;5(4):886-94. doi: 10.1016/j.celrep.2013.09.040. Epub 2013 Oct 31.

PMID:
24183673
[PubMed - in process]
Free Article
17.

Identification of small peptides inhibiting the integrase-LEDGF/p75 interaction through targeting the cellular co-factor.

Cavalluzzo C, Christ F, Voet A, Sharma A, Singh BK, Zhang KY, Lescrinier E, De Maeyer M, Debyser Z, Van der Eycken E.

J Pept Sci. 2013 Oct;19(10):651-8. doi: 10.1002/psc.2543. Epub 2013 Aug 27.

PMID:
24014475
[PubMed - indexed for MEDLINE]
18.

New scaffolds of natural origin as Integrase-LEDGF/p75 interaction inhibitors: virtual screening and activity assays.

De Luca L, Morreale F, Christ F, Debyser Z, Ferro S, Gitto R.

Eur J Med Chem. 2013 Oct;68:405-11. doi: 10.1016/j.ejmech.2013.07.025. Epub 2013 Aug 9.

PMID:
23994868
[PubMed - in process]
19.

Discovery of a novel 5-carbonyl-1H-imidazole-4-carboxamide class of inhibitors of the HIV-1 integrase-LEDGF/p75 interaction.

Serrao E, Xu ZL, Debnath B, Christ F, Debyser Z, Long YQ, Neamati N.

Bioorg Med Chem. 2013 Oct 1;21(19):5963-72. doi: 10.1016/j.bmc.2013.07.047. Epub 2013 Aug 2.

PMID:
23985689
[PubMed - indexed for MEDLINE]
Free Article
20.

Interaction of transportin-SR2 with Ras-related nuclear protein (Ran) GTPase.

Taltynov O, Demeulemeester J, Christ F, De Houwer S, Tsirkone VG, Gerard M, Weeks SD, Strelkov SV, Debyser Z.

J Biol Chem. 2013 Aug 30;288(35):25603-13. doi: 10.1074/jbc.M113.484345. Epub 2013 Jul 22.

PMID:
23878195
[PubMed - indexed for MEDLINE]

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