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Results: 1 to 20 of 245

1.

Retroviral integration: Site matters: Mechanisms and consequences of retroviral integration site selection.

Demeulemeester J, De Rijck J, Gijsbers R, Debyser Z.

Bioessays. 2015 Aug 21. doi: 10.1002/bies.201500051. [Epub ahead of print]

PMID:
26293289
2.

Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif.

Tesina P, Čermáková K, Hořejší M, Procházková K, Fábry M, Sharma S, Christ F, Demeulemeester J, Debyser Z, Rijck JD, Veverka V, Řezáčová P.

Nat Commun. 2015 Aug 6;6:7968. doi: 10.1038/ncomms8968.

PMID:
26245978
3.

PET imaging of TSPO in a rat model of local neuroinflammation induced by intracerebral injection of lipopolysaccharide.

Ory D, Planas A, Dresselaers T, Gsell W, Postnov A, Celen S, Casteels C, Himmelreich U, Debyser Z, Van Laere K, Verbruggen A, Bormans G.

Nucl Med Biol. 2015 Jun 23. pii: S0969-8051(15)00110-9. doi: 10.1016/j.nucmedbio.2015.06.010. [Epub ahead of print]

PMID:
26220690
4.

Discovery of N-aryl-naphthylamines as in vitro inhibitors of the interaction between HIV integrase and the cofactor LEDGF/p75.

Cuzzucoli Crucitti G, Pescatori L, Messore A, Madia VN, Pupo G, Saccoliti F, Scipione L, Tortorella S, Di Leva FS, Cosconati S, Novellino E, Debyser Z, Christ F, Costi R, Di Santo R.

Eur J Med Chem. 2015 Aug 28;101:288-94. doi: 10.1016/j.ejmech.2015.06.036. Epub 2015 Jun 22.

PMID:
26150289
5.

Evaluation of the expression pattern of rAAV2/1, 2/5, 2/7, 2/8, and 2/9 serotypes with different promoters in the mouse visual cortex.

Scheyltjens I, Laramée ME, Van den Haute C, Gijsbers R, Debyser Z, Baekelandt V, Vreysen S, Arckens L.

J Comp Neurol. 2015 May 27. doi: 10.1002/cne.23819. [Epub ahead of print]

PMID:
26012540
6.

Optimization of rhodanine scaffold for the development of protein-protein interaction inhibitors.

Ferro S, De Luca L, Agharbaoui FE, Christ F, Debyser Z, Gitto R.

Bioorg Med Chem. 2015 Jul 1;23(13):3208-14. doi: 10.1016/j.bmc.2015.04.072. Epub 2015 May 2.

PMID:
25999203
7.

HIV-1 IN/Pol recruits LEDGF/p75 into viral particles.

Desimmie BA, Weydert C, Schrijvers R, Vets S, Demeulemeester J, Proost P, Paron I, De Rijck J, Mast J, Bannert N, Gijsbers R, Christ F, Debyser Z.

Retrovirology. 2015 Feb 12;12:16. doi: 10.1186/s12977-014-0134-4.

8.

Five-drug antiretroviral therapy for primary HIV infection?

Debyser Z, Schrijvers R.

Lancet Infect Dis. 2015 Apr;15(4):362-3. doi: 10.1016/S1473-3099(14)71014-X. Epub 2015 Feb 18. No abstract available.

PMID:
25701559
9.

FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease.

Van der Perren A, Macchi F, Toelen J, Carlon MS, Maris M, de Loor H, Kuypers DR, Gijsbers R, Van den Haute C, Debyser Z, Baekelandt V.

Neurobiol Aging. 2015 Mar;36(3):1559-68. doi: 10.1016/j.neurobiolaging.2015.01.014. Epub 2015 Jan 21.

PMID:
25660193
10.

Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors.

Van der Perren A, Toelen J, Casteels C, Macchi F, Van Rompuy AS, Sarre S, Casadei N, Nuber S, Himmelreich U, Osorio Garcia MI, Michotte Y, D'Hooge R, Bormans G, Van Laere K, Gijsbers R, Van den Haute C, Debyser Z, Baekelandt V.

Neurobiol Aging. 2015 Mar;36(3):1543-58. doi: 10.1016/j.neurobiolaging.2014.11.015. Epub 2014 Dec 17.

PMID:
25599874
11.

Host factors for retroviral integration site selection.

Debyser Z, Christ F, De Rijck J, Gijsbers R.

Trends Biochem Sci. 2015 Feb;40(2):108-16. doi: 10.1016/j.tibs.2014.12.001. Epub 2014 Dec 31.

PMID:
25555456
12.

HIV-1 integrase variants retarget viral integration and are associated with disease progression in a chronic infection cohort.

Demeulemeester J, Vets S, Schrijvers R, Madlala P, De Maeyer M, De Rijck J, Ndung'u T, Debyser Z, Gijsbers R.

Cell Host Microbe. 2014 Nov 12;16(5):651-62. doi: 10.1016/j.chom.2014.09.016. Epub 2014 Nov 12.

PMID:
25525795
13.

Noninvasive bioluminescence imaging of α-synuclein oligomerization in mouse brain using split firefly luciferase reporters.

Aelvoet SA, Ibrahimi A, Macchi F, Gijsbers R, Van den Haute C, Debyser Z, Baekelandt V.

J Neurosci. 2014 Dec 3;34(49):16518-32. doi: 10.1523/JNEUROSCI.4933-13.2014.

14.

Design and discovery of 5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamide inhibitors of HIV-1 integrase.

Zhang D, Debnath B, Yu S, Sanchez TW, Christ F, Liu Y, Debyser Z, Neamati N, Zhao G.

Bioorg Med Chem. 2014 Oct 1;22(19):5446-53. doi: 10.1016/j.bmc.2014.07.036. Epub 2014 Jul 30.

PMID:
25150089
15.

BET-independent MLV-based Vectors Target Away From Promoters and Regulatory Elements.

El Ashkar S, De Rijck J, Demeulemeester J, Vets S, Madlala P, Cermakova K, Debyser Z, Gijsbers R.

Mol Ther Nucleic Acids. 2014 Jul 29;3:e179. doi: 10.1038/mtna.2014.33.

16.

The HIV-1 integrase mutant R263A/K264A is 2-fold defective for TRN-SR2 binding and viral nuclear import.

De Houwer S, Demeulemeester J, Thys W, Rocha S, Dirix L, Gijsbers R, Christ F, Debyser Z.

J Biol Chem. 2014 Sep 5;289(36):25351-61. doi: 10.1074/jbc.M113.533281. Epub 2014 Jul 25.

PMID:
25063804
17.

Structure of transportin SR2, a karyopherin involved in human disease, in complex with Ran.

Tsirkone VG, Beutels KG, Demeulemeester J, Debyser Z, Christ F, Strelkov SV.

Acta Crystallogr F Struct Biol Commun. 2014 Jun;70(Pt 6):723-9. doi: 10.1107/S2053230X14009492. Epub 2014 May 24.

PMID:
24915079
18.

Switching STRATEGIES in HIV treatment.

Schrijvers R, Debyser Z.

Lancet Infect Dis. 2014 Jul;14(7):537-40. doi: 10.1016/S1473-3099(14)70743-1. Epub 2014 Jun 5. No abstract available. Erratum in: Lancet Infect Dis. 2014 Jul;14(7):548.

PMID:
24908549
19.

4-Substituted 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as a Novel Class of HIV-1 Integrase Inhibitors.

Billamboz M, Suchaud V, Bailly F, Lion C, Demeulemeester J, Calmels C, Andréola ML, Christ F, Debyser Z, Cotelle P.

ACS Med Chem Lett. 2013 May 17;4(7):606-11. doi: 10.1021/ml400009t. eCollection 2013 Jul 11.

20.

Bioluminescence imaging of stroke-induced endogenous neural stem cell response.

Vandeputte C, Reumers V, Aelvoet SA, Thiry I, De Swaef S, Van den Haute C, Pascual-Brazo J, Farr TD, Vande Velde G, Hoehn M, Himmelreich U, Van Laere K, Debyser Z, Gijsbers R, Baekelandt V.

Neurobiol Dis. 2014 Sep;69:144-55. doi: 10.1016/j.nbd.2014.05.014. Epub 2014 May 27.

PMID:
24878507
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