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Genome-wide computational analysis reveals cardiomyocyte-specific transcriptional Cis-regulatory motifs that enable efficient cardiac gene therapy.

Rincon MY, Sarcar S, Danso-Abeam D, Keyaerts M, Matrai J, Samara-Kuko E, Acosta-Sanchez A, Athanasopoulos T, Dickson G, Lahoutte T, De Bleser P, VandenDriessche T, Chuah MK.

Mol Ther. 2015 Jan;23(1):43-52. doi: 10.1038/mt.2014.178. Epub 2014 Sep 8.


Liver-specific transcriptional modules identified by genome-wide in silico analysis enable efficient gene therapy in mice and non-human primates.

Chuah MK, Petrus I, De Bleser P, Le Guiner C, Gernoux G, Adjali O, Nair N, Willems J, Evens H, Rincon MY, Matrai J, Di Matteo M, Samara-Kuko E, Yan B, Acosta-Sanchez A, Meliani A, Cherel G, Blouin V, Christophe O, Moullier P, Mingozzi F, VandenDriessche T.

Mol Ther. 2014 Sep;22(9):1605-13. doi: 10.1038/mt.2014.114. Epub 2014 Jun 23.


Computationally designed liver-specific transcriptional modules and hyperactive factor IX improve hepatic gene therapy.

Nair N, Rincon MY, Evens H, Sarcar S, Dastidar S, Samara-Kuko E, Ghandeharian O, Man Viecelli H, Thöny B, De Bleser P, VandenDriessche T, Chuah MK.

Blood. 2014 May 15;123(20):3195-9. doi: 10.1182/blood-2013-10-534032. Epub 2014 Mar 17. Erratum in: Blood. 2015 Mar 19;125(12):2007. Dosage error in article text.


PhysBinder: Improving the prediction of transcription factor binding sites by flexible inclusion of biophysical properties.

Broos S, Soete A, Hooghe B, Moran R, van Roy F, De Bleser P.

Nucleic Acids Res. 2013 Jul;41(Web Server issue):W531-4. doi: 10.1093/nar/gkt288. Epub 2013 Apr 24.


A flexible integrative approach based on random forest improves prediction of transcription factor binding sites.

Hooghe B, Broos S, van Roy F, De Bleser P.

Nucleic Acids Res. 2012 Aug;40(14):e106. doi: 10.1093/nar/gks283. Epub 2012 Apr 5.


Nanobodies® specific for respiratory syncytial virus fusion protein protect against infection by inhibition of fusion.

Schepens B, Ibañez LI, De Baets S, Hultberg A, Bogaert P, De Bleser P, Vervalle F, Verrips T, Melero J, Vandevelde W, Vanlandschoot P, Saelens X.

J Infect Dis. 2011 Dec 1;204(11):1692-701. doi: 10.1093/infdis/jir622. Epub 2011 Oct 12.


ConTra v2: a tool to identify transcription factor binding sites across species, update 2011.

Broos S, Hulpiau P, Galle J, Hooghe B, Van Roy F, De Bleser P.

Nucleic Acids Res. 2011 Jul;39(Web Server issue):W74-8. doi: 10.1093/nar/gkr355. Epub 2011 May 16.


Human metallothionein expression under normal and pathological conditions: mechanisms of gene regulation based on in silico promoter analysis.

Laukens D, Waeytens A, De Bleser P, Cuvelier C, De Vos M.

Crit Rev Eukaryot Gene Expr. 2009;19(4):301-17. Review.


Low nucleosome occupancy is encoded around functional human transcription factor binding sites.

Daenen F, van Roy F, De Bleser PJ.

BMC Genomics. 2008 Jul 15;9:332. doi: 10.1186/1471-2164-9-332.


ConTra: a promoter alignment analysis tool for identification of transcription factor binding sites across species.

Hooghe B, Hulpiau P, van Roy F, De Bleser P.

Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W128-32. doi: 10.1093/nar/gkn195. Epub 2008 May 3.


ORegAnno: an open-access community-driven resource for regulatory annotation.

Griffith OL, Montgomery SB, Bernier B, Chu B, Kasaian K, Aerts S, Mahony S, Sleumer MC, Bilenky M, Haeussler M, Griffith M, Gallo SM, Giardine B, Hooghe B, Van Loo P, Blanco E, Ticoll A, Lithwick S, Portales-Casamar E, Donaldson IJ, Robertson G, Wadelius C, De Bleser P, Vlieghe D, Halfon MS, Wasserman W, Hardison R, Bergman CM, Jones SJ; Open Regulatory Annotation Consortium.

Nucleic Acids Res. 2008 Jan;36(Database issue):D107-13. Epub 2007 Nov 15.


A new generation of JASPAR, the open-access repository for transcription factor binding site profiles.

Vlieghe D, Sandelin A, De Bleser PJ, Vleminckx K, Wasserman WW, van Roy F, Lenhard B.

Nucleic Acids Res. 2006 Jan 1;34(Database issue):D95-7.


Actin filament formation, reorganization and migration are impaired in hepatic stellate cells under influence of trichostatin A, a histone deacetylase inhibitor.

Rombouts K, Knittel T, Machesky L, Braet F, Wielant A, Hellemans K, De Bleser P, Gelman I, Ramadori G, Geerts A.

J Hepatol. 2002 Dec;37(6):788-96.


Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblasts.

Rombouts K, Niki T, Greenwel P, Vandermonde A, Wielant A, Hellemans K, De Bleser P, Yoshida M, Schuppan D, Rojkind M, Geerts A.

Exp Cell Res. 2002 Aug 15;278(2):184-97.


Characteristics of the hepatic stellate cell-selective carrier mannose 6-phosphate modified albumin (M6P(28)-HSA).

Beljaars L, Olinga P, Molema G, de Bleser P, Geerts A, Groothuis GM, Meijer DK, Poelstra K.

Liver. 2001 Oct;21(5):320-8.


Identification of tumor necrosis factor (TNF) amino acids crucial for binding to the murine p75 TNF receptor and construction of receptor-selective mutants.

Ameloot P, Fiers W, De Bleser P, Ware CF, Vandenabeele P, Brouckaert P.

J Biol Chem. 2001 Oct 5;276(40):37426-30. Epub 2001 Jul 11.


Renal antioxidant enzymes and fibrosis-related markers in the rat adriamycin model.

Van den Branden C, Ceyssens B, De Craemer D, Pauwels M, Vanden Houte K, De Bleser P, Hellemans K, Geerts A, Verbeelen D.

Nephron. 2000 Oct;86(2):167-75.


Successful targeting to rat hepatic stellate cells using albumin modified with cyclic peptides that recognize the collagen type VI receptor.

Beljaars L, Molema G, Schuppan D, Geerts A, De Bleser PJ, Weert B, Meijer DK, Poelstra K.

J Biol Chem. 2000 Apr 28;275(17):12743-51.


Insulin-like growth factor II receptors in human brain and their absence in astrogliotic plaques in multiple sclerosis.

Wilczak N, De Bleser P, Luiten P, Geerts A, Teelken A, De Keyser J.

Brain Res. 2000 Apr 28;863(1-2):282-8.

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