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Results: 1 to 20 of 38

1.

Liver-Specific Transcriptional Modules Identified by Genome-Wide In Silico Analysis Enable Efficient Gene Therapy in Mice and Non-Human Primates.

Chuah MK, Petrus I, De Bleser P, Le Guiner C, Gernoux G, Adjali O, Nair N, Willems J, Evens H, Rincon MY, Matrai J, Di Matteo M, Samara-Kuko E, Yan B, Acosta-Sanchez A, Meliani A, Cherel G, Blouin V, Christophe O, Moullier P, Mingozzi F, VandenDriessche T.

Mol Ther. 2014 Jun 23. doi: 10.1038/mt.2014.114. [Epub ahead of print]

PMID:
24954473
[PubMed - as supplied by publisher]
2.

Computationally designed liver-specific transcriptional modules and hyperactive factor IX improve hepatic gene therapy.

Nair N, Rincon MY, Evens H, Sarcar S, Dastidar S, Samara-Kuko E, Ghandeharian O, Man Viecelli H, Thöny B, De Bleser P, VandenDriessche T, Chuah MK.

Blood. 2014 May 15;123(20):3195-9. doi: 10.1182/blood-2013-10-534032. Epub 2014 Mar 17.

PMID:
24637359
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

PhysBinder: Improving the prediction of transcription factor binding sites by flexible inclusion of biophysical properties.

Broos S, Soete A, Hooghe B, Moran R, van Roy F, De Bleser P.

Nucleic Acids Res. 2013 Jul;41(Web Server issue):W531-4. doi: 10.1093/nar/gkt288. Epub 2013 Apr 24.

PMID:
23620286
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

A flexible integrative approach based on random forest improves prediction of transcription factor binding sites.

Hooghe B, Broos S, van Roy F, De Bleser P.

Nucleic Acids Res. 2012 Aug;40(14):e106. doi: 10.1093/nar/gks283. Epub 2012 Apr 5.

PMID:
22492513
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Nanobodies® specific for respiratory syncytial virus fusion protein protect against infection by inhibition of fusion.

Schepens B, Ibañez LI, De Baets S, Hultberg A, Bogaert P, De Bleser P, Vervalle F, Verrips T, Melero J, Vandevelde W, Vanlandschoot P, Saelens X.

J Infect Dis. 2011 Dec 1;204(11):1692-701. doi: 10.1093/infdis/jir622. Epub 2011 Oct 12.

PMID:
21998474
[PubMed - indexed for MEDLINE]
Free Article
6.

ConTra v2: a tool to identify transcription factor binding sites across species, update 2011.

Broos S, Hulpiau P, Galle J, Hooghe B, Van Roy F, De Bleser P.

Nucleic Acids Res. 2011 Jul;39(Web Server issue):W74-8. doi: 10.1093/nar/gkr355. Epub 2011 May 16.

PMID:
21576231
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Human metallothionein expression under normal and pathological conditions: mechanisms of gene regulation based on in silico promoter analysis.

Laukens D, Waeytens A, De Bleser P, Cuvelier C, De Vos M.

Crit Rev Eukaryot Gene Expr. 2009;19(4):301-17. Review.

PMID:
19817707
[PubMed - indexed for MEDLINE]
8.

Low nucleosome occupancy is encoded around functional human transcription factor binding sites.

Daenen F, van Roy F, De Bleser PJ.

BMC Genomics. 2008 Jul 15;9:332. doi: 10.1186/1471-2164-9-332.

PMID:
18627598
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

ConTra: a promoter alignment analysis tool for identification of transcription factor binding sites across species.

Hooghe B, Hulpiau P, van Roy F, De Bleser P.

Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W128-32. doi: 10.1093/nar/gkn195. Epub 2008 May 3.

PMID:
18453628
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

ORegAnno: an open-access community-driven resource for regulatory annotation.

Griffith OL, Montgomery SB, Bernier B, Chu B, Kasaian K, Aerts S, Mahony S, Sleumer MC, Bilenky M, Haeussler M, Griffith M, Gallo SM, Giardine B, Hooghe B, Van Loo P, Blanco E, Ticoll A, Lithwick S, Portales-Casamar E, Donaldson IJ, Robertson G, Wadelius C, De Bleser P, Vlieghe D, Halfon MS, Wasserman W, Hardison R, Bergman CM, Jones SJ; Open Regulatory Annotation Consortium.

Nucleic Acids Res. 2008 Jan;36(Database issue):D107-13. Epub 2007 Nov 15.

PMID:
18006570
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

A distance difference matrix approach to identifying transcription factors that regulate differential gene expression.

De Bleser P, Hooghe B, Vlieghe D, van Roy F.

Genome Biol. 2007;8(5):R83.

PMID:
17504544
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

A new generation of JASPAR, the open-access repository for transcription factor binding site profiles.

Vlieghe D, Sandelin A, De Bleser PJ, Vleminckx K, Wasserman WW, van Roy F, Lenhard B.

Nucleic Acids Res. 2006 Jan 1;34(Database issue):D95-7.

PMID:
16381983
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Actin filament formation, reorganization and migration are impaired in hepatic stellate cells under influence of trichostatin A, a histone deacetylase inhibitor.

Rombouts K, Knittel T, Machesky L, Braet F, Wielant A, Hellemans K, De Bleser P, Gelman I, Ramadori G, Geerts A.

J Hepatol. 2002 Dec;37(6):788-96.

PMID:
12445420
[PubMed - indexed for MEDLINE]
14.

Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblasts.

Rombouts K, Niki T, Greenwel P, Vandermonde A, Wielant A, Hellemans K, De Bleser P, Yoshida M, Schuppan D, Rojkind M, Geerts A.

Exp Cell Res. 2002 Aug 15;278(2):184-97.

PMID:
12169274
[PubMed - indexed for MEDLINE]
15.

Characteristics of the hepatic stellate cell-selective carrier mannose 6-phosphate modified albumin (M6P(28)-HSA).

Beljaars L, Olinga P, Molema G, de Bleser P, Geerts A, Groothuis GM, Meijer DK, Poelstra K.

Liver. 2001 Oct;21(5):320-8.

PMID:
11589768
[PubMed - indexed for MEDLINE]
16.

Identification of tumor necrosis factor (TNF) amino acids crucial for binding to the murine p75 TNF receptor and construction of receptor-selective mutants.

Ameloot P, Fiers W, De Bleser P, Ware CF, Vandenabeele P, Brouckaert P.

J Biol Chem. 2001 Oct 5;276(40):37426-30. Epub 2001 Jul 11.

PMID:
11448951
[PubMed - indexed for MEDLINE]
Free Article
17.

Renal antioxidant enzymes and fibrosis-related markers in the rat adriamycin model.

Van den Branden C, Ceyssens B, De Craemer D, Pauwels M, Vanden Houte K, De Bleser P, Hellemans K, Geerts A, Verbeelen D.

Nephron. 2000 Oct;86(2):167-75.

PMID:
11014987
[PubMed - indexed for MEDLINE]
18.

Successful targeting to rat hepatic stellate cells using albumin modified with cyclic peptides that recognize the collagen type VI receptor.

Beljaars L, Molema G, Schuppan D, Geerts A, De Bleser PJ, Weert B, Meijer DK, Poelstra K.

J Biol Chem. 2000 Apr 28;275(17):12743-51.

PMID:
10777570
[PubMed - indexed for MEDLINE]
Free Article
19.

Insulin-like growth factor II receptors in human brain and their absence in astrogliotic plaques in multiple sclerosis.

Wilczak N, De Bleser P, Luiten P, Geerts A, Teelken A, De Keyser J.

Brain Res. 2000 Apr 28;863(1-2):282-8.

PMID:
10773220
[PubMed - indexed for MEDLINE]
20.

Antioxidant enzyme gene expression in rats with remnant kidney induced chronic renal failure.

Van Den Branden C, Ceyssens B, De Craemer D, De Bleser P, Hellemans K, Geerts A, Verbeelen D.

Exp Nephrol. 2000 Mar-Apr;8(2):91-6.

PMID:
10729748
[PubMed - indexed for MEDLINE]

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