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Items: 1 to 20 of 30

1.

Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations.

Bueno R, Stawiski EW, Goldstein LD, Durinck S, De Rienzo A, Modrusan Z, Gnad F, Nguyen TT, Jaiswal BS, Chirieac LR, Sciaranghella D, Dao N, Gustafson CE, Munir KJ, Hackney JA, Chaudhuri A, Gupta R, Guillory J, Toy K, Ha C, Chen YJ, Stinson J, Chaudhuri S, Zhang N, Wu TD, Sugarbaker DJ, de Sauvage FJ, Richards WG, Seshagiri S.

Nat Genet. 2016 Apr;48(4):407-16. doi: 10.1038/ng.3520. Epub 2016 Feb 29.

PMID:
26928227
2.

Gender-Specific Molecular and Clinical Features Underlie Malignant Pleural Mesothelioma.

De Rienzo A, Archer MA, Yeap BY, Dao N, Sciaranghella D, Sideris AC, Zheng Y, Holman AG, Wang YE, Dal Cin PS, Fletcher JA, Rubio R, Croft L, Quackenbush J, Sugarbaker PE, Munir KJ, Battilana JR, Gustafson CE, Chirieac LR, Ching SM, Wong J, Tay LC, Rudd S, Hercus R, Sugarbaker DJ, Richards WG, Bueno R.

Cancer Res. 2016 Jan 15;76(2):319-28. doi: 10.1158/0008-5472.CAN-15-0751. Epub 2015 Nov 10.

PMID:
26554828
3.

Mithramycin Depletes Specificity Protein 1 and Activates p53 to Mediate Senescence and Apoptosis of Malignant Pleural Mesothelioma Cells.

Rao M, Atay SM, Shukla V, Hong Y, Upham T, Ripley RT, Hong JA, Zhang M, Reardon E, Fetsch P, Miettinen M, Li X, Peer CJ, Sissung T, Figg WD, De Rienzo A, Bueno R, Schrump DS.

Clin Cancer Res. 2016 Mar 1;22(5):1197-210. doi: 10.1158/1078-0432.CCR-14-3379. Epub 2015 Oct 12.

PMID:
26459178
4.

Gene expression ratio test distinguishes normal lung from lung tumors in solid tissue and FNA biopsies.

De Rienzo A, Yeap BY, Cibas ES, Richards WG, Dong L, Gill RR, Sugarbaker DJ, Bueno R.

J Mol Diagn. 2014 Mar;16(2):267-72. doi: 10.1016/j.jmoldx.2013.11.008. Epub 2014 Jan 9.

5.

Sequential binary gene ratio tests define a novel molecular diagnostic strategy for malignant pleural mesothelioma.

De Rienzo A, Richards WG, Yeap BY, Coleman MH, Sugarbaker PE, Chirieac LR, Wang YE, Quackenbush J, Jensen RV, Bueno R.

Clin Cancer Res. 2013 May 1;19(9):2493-502. doi: 10.1158/1078-0432.CCR-12-2117. Epub 2013 Mar 14.

6.

Polycomb repressor complex-2 is a novel target for mesothelioma therapy.

Kemp CD, Rao M, Xi S, Inchauste S, Mani H, Fetsch P, Filie A, Zhang M, Hong JA, Walker RL, Zhu YJ, Ripley RT, Mathur A, Liu F, Yang M, Meltzer PA, Marquez VE, De Rienzo A, Bueno R, Schrump DS.

Clin Cancer Res. 2012 Jan 1;18(1):77-90. doi: 10.1158/1078-0432.CCR-11-0962. Epub 2011 Oct 25.

7.

Fine-needle aspiration biopsies for gene expression ratio-based diagnostic and prognostic tests in malignant pleural mesothelioma.

De Rienzo A, Dong L, Yeap BY, Jensen RV, Richards WG, Gordon GJ, Sugarbaker DJ, Bueno R.

Clin Cancer Res. 2011 Jan 15;17(2):310-6. doi: 10.1158/1078-0432.CCR-10-0806. Epub 2010 Nov 18.

8.

Second generation sequencing of the mesothelioma tumor genome.

Bueno R, De Rienzo A, Dong L, Gordon GJ, Hercus CF, Richards WG, Jensen RV, Anwar A, Maulik G, Chirieac LR, Ho KF, Taillon BE, Turcotte CL, Hercus RG, Gullans SR, Sugarbaker DJ.

PLoS One. 2010 May 13;5(5):e10612. doi: 10.1371/journal.pone.0010612.

9.

Differentially expressed alternatively spliced genes in malignant pleural mesothelioma identified using massively parallel transcriptome sequencing.

Dong L, Jensen RV, De Rienzo A, Gordon GJ, Xu Y, Sugarbaker DJ, Bueno R.

BMC Med Genet. 2009 Dec 31;10:149. doi: 10.1186/1471-2350-10-149.

10.

Akt regulates drug-induced cell death through Bcl-w downregulation.

Garofalo M, Quintavalle C, Zanca C, De Rienzo A, Romano G, Acunzo M, Puca L, Incoronato M, Croce CM, Condorelli G.

PLoS One. 2008;3(12):e4070. doi: 10.1371/journal.pone.0004070. Epub 2008 Dec 30.

11.

Transcriptome sequencing of malignant pleural mesothelioma tumors.

Sugarbaker DJ, Richards WG, Gordon GJ, Dong L, De Rienzo A, Maulik G, Glickman JN, Chirieac LR, Hartman ML, Taillon BE, Du L, Bouffard P, Kingsmore SF, Miller NA, Farmer AD, Jensen RV, Gullans SR, Bueno R.

Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3521-6. doi: 10.1073/pnas.0712399105. Epub 2008 Feb 26.

12.

Potentiation of paclitaxel activity by the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin in human ovarian carcinoma cell lines with high levels of activated AKT.

Sain N, Krishnan B, Ormerod MG, De Rienzo A, Liu WM, Kaye SB, Workman P, Jackman AL.

Mol Cancer Ther. 2006 May;5(5):1197-208.

13.

A mouse model recapitulating molecular features of human mesothelioma.

Altomare DA, Vaslet CA, Skele KL, De Rienzo A, Devarajan K, Jhanwar SC, McClatchey AI, Kane AB, Testa JR.

Cancer Res. 2005 Sep 15;65(18):8090-5.

14.

Human and mouse mesotheliomas exhibit elevated AKT/PKB activity, which can be targeted pharmacologically to inhibit tumor cell growth.

Altomare DA, You H, Xiao GH, Ramos-Nino ME, Skele KL, De Rienzo A, Jhanwar SC, Mossman BT, Kane AB, Testa JR.

Oncogene. 2005 Sep 8;24(40):6080-9.

PMID:
15897870
15.

Replacement of K-Ras with H-Ras supports normal embryonic development despite inducing cardiovascular pathology in adult mice.

Potenza N, Vecchione C, Notte A, De Rienzo A, Rosica A, Bauer L, Affuso A, De Felice M, Russo T, Poulet R, Cifelli G, De Vita G, Lembo G, Di Lauro R.

EMBO Rep. 2005 May;6(5):432-7.

16.

AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth.

Altomare DA, Wang HQ, Skele KL, De Rienzo A, Klein-Szanto AJ, Godwin AK, Testa JR.

Oncogene. 2004 Jul 29;23(34):5853-7.

PMID:
15208673
17.

Frequent activation of AKT2 kinase in human pancreatic carcinomas.

Altomare DA, Tanno S, De Rienzo A, Klein-Szanto AJ, Tanno S, Skele KL, Hoffman JP, Testa JR.

J Cell Biochem. 2002;87(4):470-6. Erratum in: J Cell Biochem. 2003 Jan 1;88(1):470.

PMID:
14735903
18.

Neurofibromatosis 2 and malignant mesothelioma.

Baser ME, De Rienzo A, Altomare D, Balsara BR, Hedrick NM, Gutmann DH, Pitts LH, Jackler RK, Testa JR.

Neurology. 2002 Jul 23;59(2):290-1.

PMID:
12136076
19.

Second family with hearing impairment linked to 19q13 and refined DFNA4 localisation.

Mirghomizadeh F, Bardtke B, Devoto M, Pfister M, Oeken J, K├Ânig E, Vitale E, Riccio A, De Rienzo A, Zenner HP, Blin N.

Eur J Hum Genet. 2002 Feb;10(2):95-9.

20.

SV40 infection induces telomerase activity in human mesothelial cells.

Foddis R, De Rienzo A, Broccoli D, Bocchetta M, Stekala E, Rizzo P, Tosolini A, Grobelny JV, Jhanwar SC, Pass HI, Testa JR, Carbone M.

Oncogene. 2002 Feb 21;21(9):1434-42.

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