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A transfectant RK13 cell line permissive to classical caprine scrapie prion propagation.

Dassanayake RP, Zhuang D, Truscott TC, Madsen-Bouterse SA, O'Rourke KI, Schneider DA.

Prion. 2016 Mar 3;10(2):153-64. doi: 10.1080/19336896.2016.1166324.


Classical scrapie prions are associated with peripheral blood monocytes and T-lymphocytes from naturally infected sheep.

Dassanayake RP, Madsen-Bouterse SA, Truscott TC, Zhuang D, Mousel MR, Davis WC, Schneider DA.

BMC Vet Res. 2016 Feb 4;12:27. doi: 10.1186/s12917-016-0651-6.


Sensitive and specific detection of classical scrapie prions in the brains of goats by real-time quaking-induced conversion.

Dassanayake RP, Orrú CD, Hughson AG, Caughey B, Graça T, Zhuang D, Madsen-Bouterse SA, Knowles DP, Schneider DA.

J Gen Virol. 2016 Mar;97(3):803-12. doi: 10.1099/jgv.0.000367. Epub 2015 Dec 10.


PRNP variants in goats reduce sensitivity of detection of PrP(Sc) by immunoassay.

Madsen-Bouterse SA, Schneider DA, Dassanayake RP, Truscott TC, Zhuang D, Kumpula-McWhirter N, O'Rourke KI.

J Vet Diagn Invest. 2015 May;27(3):332-43. doi: 10.1177/1040638715585865.


Role of the PRNP S127 allele in experimental infection of goats with classical caprine scrapie.

Dassanayake RP, White SN, Madsen-Bouterse SA, Schneider DA, O'Rourke KI.

Anim Genet. 2015 Jun;46(3):341. doi: 10.1111/age.12291. No abstract available.


The placenta shed from goats with classical scrapie is infectious to goat kids and lambs.

Schneider DA, Madsen-Bouterse SA, Zhuang D, Truscott TC, Dassanayake RP, O'Rourke KI.

J Gen Virol. 2015 Aug;96(8):2464-9. doi: 10.1099/vir.0.000151. Epub 2015 Apr 17.


Classical natural ovine scrapie prions detected in practical volumes of blood by lamb and transgenic mouse bioassays.

Dassanayake RP, Truscott TC, Zhuang D, Schneider DA, Madsen-Bouterse SA, Young AJ, Stanton JB, Davis WC, O'Rourke KI.

J Vet Sci. 2015;16(2):179-86. Epub 2014 Dec 24.


PCR assay detects Mannheimia haemolytica in culture-negative pneumonic lung tissues of bighorn sheep (Ovis canadensis) from outbreaks in the western USA, 2009-2010.

Shanthalingam S, Goldy A, Bavananthasivam J, Subramaniam R, Batra SA, Kugadas A, Raghavan B, Dassanayake RP, Jennings-Gaines JE, Killion HJ, Edwards WH, Ramsey JM, Anderson NJ, Wolff PL, Mansfield K, Bruning D, Srikumaran S.

J Wildl Dis. 2014 Jan;50(1):1-10. doi: 10.7589/2012-09-225. Epub 2013 Oct 25.


Contribution of Helicobacter hepaticus cytolethal distending toxin subunits to human epithelial cell cycle arrest and apoptotic death in vitro.

Liyanage NP, Dassanayake RP, Kuszynski CA, Duhamel GE.

Helicobacter. 2013 Dec;18(6):433-43. doi: 10.1111/hel.12084. Epub 2013 Jul 29.


Accumulation profiles of PrP(Sc) in hemal nodes of naturally and experimentally scrapie-infected sheep.

Dassanayake RP, Truscott TC, Özyiğit MÖ, Zhuang D, Schneider DA, O'Rourke KI.

BMC Vet Res. 2013 Apr 19;9:82. doi: 10.1186/1746-6148-9-82.


Role of Bibersteinia trehalosi, respiratory syncytial virus, and parainfluenza-3 virus in bighorn sheep pneumonia.

Dassanayake RP, Shanthalingam S, Subramaniam R, Herndon CN, Bavananthasivam J, Haldorson GJ, Foreyt WJ, Evermann JF, Herrmann-Hoesing LM, Knowles DP, Srikumaran S.

Vet Microbiol. 2013 Feb 22;162(1):166-72. doi: 10.1016/j.vetmic.2012.08.029. Epub 2012 Sep 7.


Proximity-dependent inhibition of growth of Mannheimia haemolytica by Pasteurella multocida.

Bavananthasivam J, Dassanayake RP, Kugadas A, Shanthalingam S, Call DR, Knowles DP, Srikumaran S.

Appl Environ Microbiol. 2012 Sep;78(18):6683-8. doi: 10.1128/AEM.01119-12. Epub 2012 Jul 13.


Disease-associated prion protein in neural and lymphoid tissues of mink (Mustela vison) inoculated with transmissible mink encephalopathy.

Schneider DA, Harrington RD, Zhuang D, Yan H, Truscott TC, Dassanayake RP, O'Rourke KI.

J Comp Pathol. 2012 Nov;147(4):508-21. doi: 10.1016/j.jcpa.2012.03.008. Epub 2012 May 16.


Transmissibility of caprine scrapie in ovine transgenic mice.

O'Rourke KI, Schneider DA, Spraker TR, Dassanayake RP, Highland MA, Zhuang D, Truscott TC.

BMC Vet Res. 2012 Apr 2;8:42. doi: 10.1186/1746-6148-8-42.


Cell-surface expression of PrPC and the presence of scrapie prions in the blood of goats.

Dassanayake RP, Schneider DA, Herrmann-Hoesing LM, Truscott TC, Davis WC, O'Rourke KI.

J Gen Virol. 2012 May;93(Pt 5):1127-31. doi: 10.1099/vir.0.039032-0. Epub 2012 Jan 25.


Classical scrapie prions in ovine blood are associated with B lymphocytes and platelet-rich plasma.

Dassanayake RP, Schneider DA, Truscott TC, Young AJ, Zhuang D, O'Rourke KI.

BMC Vet Res. 2011 Nov 23;7:75. doi: 10.1186/1746-6148-7-75.


Defective bacterial clearance is responsible for the enhanced lung pathology characteristic of Mannheimia haemolytica pneumonia in bighorn sheep.

Subramaniam R, Herndon CN, Shanthalingam S, Dassanayake RP, Bavananthasivam J, Potter KA, Knowles DP, Foreyt WJ, Srikumaran S.

Vet Microbiol. 2011 Dec 15;153(3-4):332-8. doi: 10.1016/j.vetmic.2011.06.008. Epub 2011 Jun 22.


Co-expression of ovine LPS receptor CD14 with Mannheimia haemolytica leukotoxin receptor LFA-1 or Mac-1 does not enhance leukotoxin-induced cytotoxicity.

Dassanayake RP, Lawrence PK, Knowles DP, Davis WC, Foreyt WJ, Srikumaran S.

Vet Immunol Immunopathol. 2011 May 15;141(1-2):84-91. doi: 10.1016/j.vetimm.2011.02.010. Epub 2011 Feb 25.


Transmission of Mannheimia haemolytica from domestic sheep (Ovis aries) to bighorn sheep (Ovis canadensis): unequivocal demonstration with green fluorescent protein-tagged organisms.

Lawrence PK, Shanthalingam S, Dassanayake RP, Subramaniam R, Herndon CN, Knowles DP, Rurangirwa FR, Foreyt WJ, Wayman G, Marciel AM, Highlander SK, Srikumaran S.

J Wildl Dis. 2010 Jul;46(3):706-17. Erratum in: J Wildl Dis. 2010 Oct;46(4):1346-7.


Molecular cloning of interleukin-1β, interleukin-8, and tumor necrosis factor-α of bighorn sheep (Ovis canadensis) and comparison with those of other species.

Herndon CN, Dassanayake RP, Foreyt WJ, Srikumaran S.

Vet Immunol Immunopathol. 2010 Nov 15;138(1-2):139-43. doi: 10.1016/j.vetimm.2010.06.014. Epub 2010 Jun 25.

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