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Results: 1 to 20 of 623


Biguanides and targeted anti-cancer treatments.

Hanly EK, Darzynkiewicz Z, Tiwari RK.

Genes Cancer. 2015 Mar;6(3-4):82-3. No abstract available.


Expression of the p12 subunit of human DNA polymerase δ (Pol δ), CDK inhibitor p21(WAF1), Cdt1, cyclin A, PCNA and Ki-67 in relation to DNA replication in individual cells.

Zhao H, Zhang S, Xu D, Lee MY, Zhang Z, Lee EY, Darzynkiewicz Z.

Cell Cycle. 2014;13(22):3529-40. doi: 10.4161/15384101.2014.958910.


Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes.

Kowalska J, Wypijewska del Nogal A, Darzynkiewicz ZM, Buck J, Nicola C, Kuhn AN, Lukaszewicz M, Zuberek J, Strenkowska M, Ziemniak M, Maciejczyk M, Bojarska E, Rhoads RE, Darzynkiewicz E, Sahin U, Jemielity J.

Nucleic Acids Res. 2014;42(16):10245-64. doi: 10.1093/nar/gku757. Epub 2014 Aug 22.


Attenuation of replication stress-induced premature cellular senescence to assess anti-aging modalities.

Zhao H, Darzynkiewicz Z.

Curr Protoc Cytom. 2014 Jul 1;69:9.47.1-9.47.10. doi: 10.1002/0471142956.cy0947s69.


Different rates of DNA replication at early versus late S-phase sections: multiscale modeling of stochastic events related to DNA content/EdU (5-ethynyl-2'deoxyuridine) incorporation distributions.

Li B, Zhao H, Rybak P, Dobrucki JW, Darzynkiewicz Z, Kimmel M.

Cytometry A. 2014 Sep;85(9):785-97. doi: 10.1002/cyto.a.22484. Epub 2014 Jun 3.


Cytotoxic activity of the amphibian ribonucleases onconase and r-amphinase on tumor cells from B cell lymphoproliferative disorders.

Smolewski P, Witkowska M, Zwolinska M, Cebula-Obrzut B, Majchrzak A, Jeske A, Darzynkiewicz Z, Ardelt W, Ardelt B, Robak T.

Int J Oncol. 2014 Jul;45(1):419-25. doi: 10.3892/ijo.2014.2405. Epub 2014 Apr 28.


In search of antiaging modalities: evaluation of mTOR- and ROS/DNA damage-signaling by cytometry.

Darzynkiewicz Z, Zhao H, Halicka HD, Li J, Lee YS, Hsieh TC, Wu JM.

Cytometry A. 2014 May;85(5):386-99. doi: 10.1002/cyto.a.22452. Epub 2014 Feb 22. Review.


Disruption of mutated BRAF signaling modulates thyroid cancer phenotype.

Hanly EK, Rajoria S, Darzynkiewicz Z, Zhao H, Suriano R, Tuli N, George AL, Bednarczyk R, Shin EJ, Geliebter J, Tiwari RK.

BMC Res Notes. 2014 Mar 28;7:187. doi: 10.1186/1756-0500-7-187.


Multivariate analysis of apoptotic markers versus cell cycle phase in living human cancer cells by microfluidic cytometry.

Akagi J, Skommer J, Matuszek A, Takeda K, Fujimura Y, Khoshmanesh K, Kalantar-Zadeh K, Mitchell A, Errington R, Smith PJ, Darzynkiewicz Z, Wlodkowic D.

Proc SPIE Int Soc Opt Eng. 2013 Mar 9;8615. doi: 10.1117/12.2001474.


In vitro cytotoxicity of ranpirnase (onconase) in combination with components of R-CHOP regimen against diffuse large B cell lymphoma (DLBCL) cell line.

Majchrzak A, Witkowska M, Mędra A, Zwolińska M, Bogusz J, Cebula-Obrzut B, Darzynkiewicz Z, Robak T, Smolewski P.

Postepy Hig Med Dosw (Online). 2013 Dec 2;67:1166-72.


NFAT5 is protective against ischemic acute kidney injury.

Hao S, Bellner L, Zhao H, Ratliff BB, Darzynkiewicz Z, Vio CP, Ferreri NR.

Hypertension. 2014 Mar;63(3):e46-52. doi: 10.1161/HYPERTENSIONAHA.113.02476. Epub 2013 Dec 30.


The tail that wags the dog: p12, the smallest subunit of DNA polymerase δ, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progression.

Lee MY, Zhang S, Lin SH, Wang X, Darzynkiewicz Z, Zhang Z, Lee EY.

Cell Cycle. 2014;13(1):23-31. doi: 10.4161/cc.27407. Epub 2013 Dec 3.


Myron Melamed, 1927-2013.

Darzynkiewicz Z, Kamentsky L, Holden E.

Cytometry A. 2013 Dec;83(12):1047-50. doi: 10.1002/cyto.a.22413. No abstract available.


DNA damage signaling, impairment of cell cycle progression, and apoptosis triggered by 5-ethynyl-2'-deoxyuridine incorporated into DNA.

Zhao H, Halicka HD, Li J, Biela E, Berniak K, Dobrucki J, Darzynkiewicz Z.

Cytometry A. 2013 Nov;83(11):979-88. doi: 10.1002/cyto.a.22396. Epub 2013 Sep 30.


PDIP38 is translocated to the spliceosomes/nuclear speckles in response to UV-induced DNA damage and is required for UV-induced alternative splicing of MDM2.

Wong A, Zhang S, Mordue D, Wu JM, Zhang Z, Darzynkiewicz Z, Lee EY, Lee MY.

Cell Cycle. 2013 Oct 1;12(19):3184-93. doi: 10.4161/cc.26221. Epub 2013 Sep 3.


Berberine suppresses gero-conversion from cell cycle arrest to senescence.

Zhao H, Halicka HD, Li J, Darzynkiewicz Z.

Aging (Albany NY). 2013 Aug;5(8):623-36.


New insights into cell cycle and DNA damage response machineries through high-resolution AMICO quantitative imaging cytometry.

Tarnok A, Darzynkiewicz Z.

Cell Prolif. 2013 Oct;46(5):497-500. doi: 10.1111/cpr.12050. Epub 2013 Aug 17.


A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phase.

Zhang S, Zhao H, Darzynkiewicz Z, Zhou P, Zhang Z, Lee EY, Lee MY.

J Biol Chem. 2013 Oct 11;288(41):29550-61. doi: 10.1074/jbc.M113.490466. Epub 2013 Aug 2.


Analysis of spatial correlations between patterns of DNA damage response and DNA replication in nuclei of cells subjected to replication stress or oxidative damage.

Bernas T, Berniak K, Rybak P, Zarębski M, Zhao H, Darzynkiewicz Z, Dobrucki JW.

Cytometry A. 2013 Oct;83(10):925-32. doi: 10.1002/cyto.a.22325. Epub 2013 Jul 30.


Relationship between DNA damage response, initiated by camptothecin or oxidative stress, and DNA replication, analyzed by quantitative 3D image analysis.

Berniak K, Rybak P, Bernas T, Zarębski M, Biela E, Zhao H, Darzynkiewicz Z, Dobrucki JW.

Cytometry A. 2013 Oct;83(10):913-24. doi: 10.1002/cyto.a.22327. Epub 2013 Jul 11.

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