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AIDS. 2008 Oct 18;22(16):2165-77. doi: 10.1097/QAD.0b013e328311d18b.

Incidence of cancer in children perinatally exposed to nucleoside reverse transcriptase inhibitors.

Collaborators (533)

Brusquet Y, Opimel P, Tadrist B, Thevenieau D, Tramier D, Boulanger JC, Douadi Y, Gondry J, Horle B, Pautard B, Roussel C, Schmidt JL, Smail A, Vergne C, Achard BC, Chennebault JM, Fournie A, Grosieux P, Rialland X, Allizy C, Brault D, Genet P, Piquet RT, Rozan MA, Couchy B, Sibille G, Elmrabt SS, Bastien BC, Lonrenzi PO, Salvetti A, Turquini BF, Cayla C, Chabanier C, Guerre P, Hernandorena X, Bassignot A, Bettinger Lab M, Chirouze C, Estavoyer JM, Leroy J, Maillet R, Schaal JP, Bajer A, Balde P, Deny P, Benoist L, Carbillon L, Jeantils V, Lachassinne E, Rodriguez A, Uzan-Cohen M, Beylot J, Brun JL, Douard D, Elleau C, Fleury H, Guyon F, Horovitz J, Lacoste LJ, Masquelier B, Morlat P, Pontgahet P, Ragnaud RD, Schaeffer V, Gilles I, Zenaty D, Gantzer A, Colin-Gorki AM, Barjot P, Brouard J, Freymuth F, Goubin P, Muller G, Petit J, Six M, Delattre P, Elenga N, Magnien C, Patient G, Bornarel D, Chambrin V, Clech L, Dehan M, Dommergues FL, Frydman R, Keros L, Vial M, De Curtis A, Levardon M, Mazy F, Crenn-Hebert C, Engelmann P, Ferreira C, Floch-Tudal C, Gaba C, Joras M, Mandelbrot L, Marty L, Mazy F, Meier F, Coicaud M, Lagrue A, Meriem D, Blasquez DC, Devidas A, Lotfy N, Botto BP, Cesbron P, Cordier F, Devulder G, Duval-Arnould M, Kingue-Ekollo C, Cortey A, Delacroix I, Elharrar B, Garrait V, Huraux-Rendu C, Paniel JB, Touboul C, Buisson M, Guerin MN, Kohli MS, Reynaud I, Rousseau T, Sagot P, Guth EV, Boddaert M, Denavit MF, Garnier J, Roudiere TS, Lahsinat K, Paquet M, Pia P, Allouche C, Elhaik PC, Toure K, Farvacque R, Grall F, Khanfar MA, N'guyen R, All-Issa K, Cosnefroy C, Dallot MC, Fillipini KL, Routier C, Cabie A, Cecile W, Hatchuel Y, Mezin R, Ouka M, Sainte-Rose D, Balde P, Dauptain G, Lobut JB, Gervais A, Jault T, Jrad I, Pathier D, Lagny sur Marne AP, Algava G, Chalvon Dermesay A, Ouaknine DF, Gourdel B, Lanty C, Lerudulier C, Pfeiffer F, Beal G, Carre N, Harzic M, Hentgen JM, Lasfargues P, Messaoudi F, Teboul, Bader-Meunier B, Desfraissy JF, Goujard C, Fridmann S, Peretti D, Chout MM, Bocket L, Codaccioni X, D'Angelo S, Delmas S, Hammou Y, Mazingue F, Vanderstichele S, Alain J, Denis F, Rogez S, Tabaste JL, Venot C, Abbara A, Bailly Salin P, Blanchard I, Bronstein R, Dalvilic S, De San Pedro LY, Seaume H, Andre BY, Brochier C, Communal PH, Cotte L, Kebaili L, Raudrant D, Ritter J, Roussouly MJ, Tardy TV, Berardi JC, Botto C, DeLanete A, Doumet A, Furioli J, Granier F, Grise SJ, Wipff P, Blanc B, Cravello L, Deboisse P, Gallais H, Michel G, Pelloux TC, Thuret I, Crumiere C, Demachy MC, Karaoui L, Lefevre V, Michel F, Morel B, Kleitz le LB, Pauly-Ravelly I, Ponge B, Robichez SD, Camus M, Dehlinger M, Echard M, Mullard C, Rideau F, Ropert TP, Benos P, Boulot P, Bouzinger DH, Guigue N, Laffargue F, Lalande M, Nicolas J, Reynes J, Segondy B, Sobierajski J, Vendrel, Heller-Roussin B, Saint-Leger S, Winter C, Delaporte MO, Hubert C, May T, Neimann L, Schweitzer M, Karoubi P, De Sarcus B, Auger M, Billaudel S, Brunet-François C, Boog G, Ferre V, Mechinaud F, Reliquet V, Winer N, Berterottiere D, Boto, Allione J, Bongain A, Cottalorda J, Couderc A, Deville A, Durant J, Galiba E, Gillet JY, Monpoux F, Arnaut A, Barbuat C, Carles MJ, Dendale J, Ferrer C, Rouannet I, Sotto A, Arsac P, Barthez BD, Mesnard L, Tescher M, Werner E, De Gennes C, Devianne, Drisset, Isart V, Razon, Bachelard G, Bachelard B, Medus M, Roudil, Bardinet F, Bataille, Duffilot D, Samar K, Sow MT, Strobel M, Nisand I, Pavard, Rousset MC, Blum L, Danne O, Hervio P, Mouchnino G, Muray, Beguinot I, Graesslin O, Ingrand D, Munzer M, Quereux C, Remy G, Rouger C, Saniez D, Borsa-Lebas F, Brossard V, Buffet-Janvresse C, Clavier B, Debab Y, Marpeau L, Vannier JP, Berger C, Billiemaz K, Fresard A, Pozzetto B, Stephan JL, Varlet JL, Allemon MC, Ekoukou D, Ghibaudo N, Khuong MA, Luzolo A, Mechali D, Normand V, Poupard MP, Retbi J, Retbi JM, Rotten D, Seffert, Guyot B, Michelon, Narcy P, Bissuel F, De Caunes F, Elouedghiri, Laborde O, Walter V, Jeny R, Robin, Belaisch-Allart J, Segard L, Brettes, Cheneau CD, Dreyfus M, Entz-Werle N, Favreau JJ, Fischer P, Lang JM, Langer B, Lutz P, Nisand I, Partisani M, Ritter, Treisser A, Vayssiere C, Weill M, Clement, Colau JC, Armand, Berrebi A, Cohen M, De Coster P, Lecuyer I, Massip P, Perez-Baronne, Puel J, Reme JM, Borderon JC, Barin F, Lansac, Lionnet C, Marchand SN, Pascale, Perrotin F, Potin J, Sigogneau H, Hugon N, Finance, Le Faou, Dussaix E, Bantsimba J, Bonnard C, Camuss A, Chace A, Guillot F, Jubin C, Maria B, Montaland F, Patey O, Richier L, Stampf F, Tran Van P, Boulanger MC, Broyard A, Caruge, Caubel P, Chitrit Y, Delassus JL, Goldenstein, Le Pennec M, Poulen, Scart G, Zakaria A, Lacroix-Coutry A, Sturbois G, Commeau A, Parnet Mathieu F, Ayral D, De Kermadec S, Brival, Cabrol D, Clement D, Compagnucci A, Desfeux P, Fikenstein, Firtion G, Goupil I, Henrion R, Launay O, Mandelbrot L, Pannier E, Pons JC, Taulera, Bardin C, De Bievre P, Gras V, Labussiere E, Lafay Pillet MC, Parat S, Taurelle R, Bensaid P, Blot P, Boissinot Ch, Cotten G, Faye A, Levine M, Ottenwalter A, Oury JF, Schaller F, Vilmer E, Chenon, Dollfus C, Gabarg-Chenon A, Tabone, Vaudre G, Dubois M, Brunner C, Ciraru-Vigneron N, Peynet J, Colonna R, Sanson-Lepors, Truc, Cheynier JM, Hatem-Gantzer G, Heller-Roussin B, Rami M, Fritel, Lebrette MG, Nicolas JC, Uzan M, Wallet A, Bouillie J, Bui E, Carbonne B, Meyohas MC, Milliez J, Rodriguez J, Schrub S, Agut H, Bricaire F, Daher S, Diop A, Darbois Y, De Montgolfier, Dermer E, Deville-Chabrol A, Dommergues M, Huraux JM, Noseda G, Pauchard M, Tubiana R, Boccara JF, Francoual C, Krivine A, Lebon P, Carlus Moncomble C, Cohen H, Benachi A, Blanche S, Burgard M, Diop A, Parat S, Rouzioux C, Viard JP, Aufrant C, Allal, Bastian H, Batallan A, Brun-Vezinet F, Bernard, Damond F, Darai E, Faucher P, Longuet P, Madelenat P, Matheron S, Mazy F, Moreau G, Proust A, Rajguru M, Simon F, Berkane N, Chaux MC, Herve F, Lebrette MG, Uzan S.

Author information

  • 1Inserm, U822, Le Kremlin-Bicêtre, France.

Erratum in

  • AIDS. 2012 May 15;26(8):1047. Carbillon, François F [corrected to Carbillon, L].

Abstract

CONTEXT:

Long-term studies of tolerance to perinatal exposure to antiretroviral nucleoside reverse transcriptase inhibitors are required, in view of the potential genotoxicity of some of these molecules.

OBJECTIVE:

To evaluate the incidence of cancers in uninfected children born to HIV-infected mothers.

METHOD:

Cancers were detected in a nationwide prospective cohort of children born to HIV-infected mothers by standardized questionnaire during the prospective follow-up period of 2 years; thereafter, they were detected by spontaneous pharmacovigilance declaration and by crosschecking data with the national registries of childhood cancer. Standardized incidence ratio for incidence comparisons with general population.

RESULTS:

Ten cases of cancer were detected among the 9127 exposed HIV-uninfected children (median age: 5.4 years, 53 052 person-years of follow-up). The overall incidence did not differ significantly from that expected for the general population: 10 cases observed versus 8.9 and 9.6 expected depending on whether 1990-1999 or 2000-2004 national rates were used as reference [standardized incidence ratio of 1.1 (0.3-1.5) and 1.0 (0.5-1.9)]. Five cases of central nervous system cancer were observed (standardized incidence ratio of 3.1 [1.0-7.2] P = 0.05 and 2.4 [0.8-5.6], P = 0.12). The relative risk of cancer for children exposed to didanosine-lamivudine combination was higher than that for zidovudine monotherapy [hazard ratio: 13.6 (2.5-73.9)].

CONCLUSION:

This study did not evidence an overall increase in cancer risk in nucleoside reverse transcriptase inhibitor exposed children until 5 years of age. Results suggesting associations with specific nucleoside reverse transcriptase inhibitor combinations need further investigations. A longer surveillance, including differential analysis of the different cancer sites and various nucleoside reverse transcriptase inhibitors administered is warranted.

PMID:
18832880
[PubMed - indexed for MEDLINE]
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