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Treatment of Clostridium difficile infection in mice with vancomycin alone is as effective as treatment with vancomycin and metronidazole in combination.

Erikstrup LT, Aarup M, Hagemann-Madsen R, Dagnaes-Hansen F, Kristensen B, Olsen KE, Fuursted K.

BMJ Open Gastroenterol. 2015 Nov 2;2(1):e000038. doi: 10.1136/bmjgast-2015-000038. eCollection 2015.


Robust Lentiviral Gene Delivery But Limited Transduction Capacity of Commonly Used Adeno-Associated Viral Serotypes in Xenotransplanted Human Skin.

Jakobsen M, Askou AL, Stenderup K, Rosada C, Dagnæs-Hansen F, Jensen TG, Corydon TJ, Mikkelsen JG, Aagaard L.

Hum Gene Ther Methods. 2015 Aug;26(4):123-33. doi: 10.1089/hgtb.2014.135.


Restoration of Haemoglobin Level Using Hydrodynamic Gene Therapy with Erythropoietin Does Not Alleviate the Disease Progression in an Anaemic Mouse Model for TGFβ1-Induced Chronic Kidney Disease.

Pedersen L, Wogensen L, Marcussen N, Cecchi CR, Dalsgaard T, Dagnæs-Hansen F.

PLoS One. 2015 Jun 5;10(6):e0128367. doi: 10.1371/journal.pone.0128367. eCollection 2015.


A tissue-engineered therapeutic device inhibits tumor growth in vitro and in vivo.

Sun M, Wang M, Chen M, Dagnaes-Hansen F, Le DQ, Baatrup A, Horsman MR, Kjems J, Bünger CE.

Acta Biomater. 2015 May;18:21-9. doi: 10.1016/j.actbio.2015.02.004. Epub 2015 Feb 14.


A modified chronic infection model for testing treatment of Staphylococcus aureus biofilms on implants.

Jørgensen NP, Meyer RL, Dagnæs-Hansen F, Fuursted K, Petersen E.

PLoS One. 2014 Oct 3;9(10):e103688. doi: 10.1371/journal.pone.0103688. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0118124. Meyer, Rikke [corrected to Meyer, Rikke L].


Cellular disposal of miR23b by RAB27-dependent exosome release is linked to acquisition of metastatic properties.

Ostenfeld MS, Jeppesen DK, Laurberg JR, Boysen AT, Bramsen JB, Primdal-Bengtson B, Hendrix A, Lamy P, Dagnaes-Hansen F, Rasmussen MH, Bui KH, Fristrup N, Christensen EI, Nordentoft I, Morth JP, Jensen JB, Pedersen JS, Beck M, Theodorescu D, Borre M, Howard KA, Dyrskjøt L, Ørntoft TF.

Cancer Res. 2014 Oct 15;74(20):5758-71. doi: 10.1158/0008-5472.CAN-13-3512. Epub 2014 Sep 26.


Macrophage-mediated nanoparticle delivery to the periodontal lesions in established murine model via Pg-LPS induction.

Ma Z, Dagnaes-Hansen F, Løvschall H, Song W, Nielsen GK, Yang C, Wang Q, Kjems J, Gao S.

J Oral Pathol Med. 2015 Aug;44(7):538-42. doi: 10.1111/jop.12269. Epub 2014 Sep 25.


Megalin-mediated specific uptake of chitosan/siRNA nanoparticles in mouse kidney proximal tubule epithelial cells enables AQP1 gene silencing.

Gao S, Hein S, Dagnæs-Hansen F, Weyer K, Yang C, Nielsen R, Christensen EI, Fenton RA, Kjems J.

Theranostics. 2014 Aug 13;4(10):1039-51. doi: 10.7150/thno.7866. eCollection 2014.


Functional screening identifies miRNAs influencing apoptosis and proliferation in colorectal cancer.

Christensen LL, Holm A, Rantala J, Kallioniemi O, Rasmussen MH, Ostenfeld MS, Dagnaes-Hansen F, Øster B, Schepeler T, Tobiasen H, Thorsen K, Sieber OM, Gibbs P, Lamy P, Hansen TF, Jakobsen A, Riising EM, Helin K, Lubinski J, Hagemann-Madsen R, Laurberg S, Ørntoft TF, Andersen CL.

PLoS One. 2014 Jun 3;9(6):e96767. doi: 10.1371/journal.pone.0096767. eCollection 2014.


Induction of atherosclerosis in mice and hamsters without germline genetic engineering.

Bjørklund MM, Hollensen AK, Hagensen MK, Dagnaes-Hansen F, Christoffersen C, Mikkelsen JG, Bentzon JF.

Circ Res. 2014 May 23;114(11):1684-9. doi: 10.1161/CIRCRESAHA.114.302937. Epub 2014 Mar 27.


A novel homologous model for gene therapy of dwarfism by non-viral transfer of the mouse growth hormone gene into immunocompetent dwarf mice.

Cecchi CR, Higuti E, Oliveira NA, Lima ER, Jakobsen M, Dagnaes-Hansen F, Gissel H, Aagaard L, Jensen TG, Jorge AA, Bartolini P, Peroni CN.

Curr Gene Ther. 2014 Feb;14(1):44-51.


The inflammatory response in blood and in remote organs following acute kidney injury.

Brøchner AC, Dagnaes-Hansen F, Højberg-Holm J, Toft P.

APMIS. 2014 May;122(5):399-404. doi: 10.1111/apm.12157. Epub 2013 Sep 6.


A simple method for deriving functional MSCs and applied for osteogenesis in 3D scaffolds.

Zou L, Luo Y, Chen M, Wang G, Ding M, Petersen CC, Kang R, Dagnaes-Hansen F, Zeng Y, Lv N, Ma Q, Le DQ, Besenbacher F, Bolund L, Jensen TG, Kjems J, Pu WT, Bünger C.

Sci Rep. 2013;3:2243. doi: 10.1038/srep02243.


Directing HER4 mRNA expression towards the CYT2 isoform by antisense oligonucleotide decreases growth of breast cancer cells in vitro and in vivo.

Nielsen TO, Sorensen S, Dagnæs-Hansen F, Kjems J, Sorensen BS.

Br J Cancer. 2013 Jun 11;108(11):2291-8. doi: 10.1038/bjc.2013.247. Epub 2013 May 21.


Optimized siRNA-PEG conjugates for extended blood circulation and reduced urine excretion in mice.

Iversen F, Yang C, Dagnæs-Hansen F, Schaffert DH, Kjems J, Gao S.

Theranostics. 2013;3(3):201-9. doi: 10.7150/thno.5743. Epub 2013 Feb 25.


Protection and Systemic Translocation of siRNA Following Oral Administration of Chitosan/siRNA Nanoparticles.

Ballarín-González B, Dagnaes-Hansen F, Fenton RA, Gao S, Hein S, Dong M, Kjems J, Howard KA.

Mol Ther Nucleic Acids. 2013 Mar 5;2:e76. doi: 10.1038/mtna.2013.2.


Mitochondria and the lectin pathway of complement.

Brinkmann CR, Jensen L, Dagnæs-Hansen F, Holm IE, Endo Y, Fujita T, Thiel S, Jensenius JC, Degn SE.

J Biol Chem. 2013 Mar 22;288(12):8016-27. doi: 10.1074/jbc.M112.430249. Epub 2013 Feb 1.


Diabetes-induced changes in mannan-binding lectin levels and complement activation in a mouse model of type 1 diabetes.

Ostergaard JA, Bjerre M, Dagnaes-Hansen F, Hansen TK, Thiel S, Flyvbjerg A.

Scand J Immunol. 2013 Mar;77(3):187-94. doi: 10.1111/sji.12027.


Bone formation and resorption are both increased in experimental autoimmune arthritis.

Keller KK, Thomsen JS, Stengaard-Pedersen K, Dagnæs-Hansen F, Nyengaard JR, Hauge EM.

PLoS One. 2012;7(12):e53034. doi: 10.1371/journal.pone.0053034. Epub 2012 Dec 27.


Spatial distribution of transgenic protein after gene electrotransfer to porcine muscle.

Spanggaard I, Corydon T, Hojman P, Gissel H, Dagnaes-Hansen F, Jensen TG, Gehl J.

Hum Gene Ther Methods. 2012 Dec;23(6):387-92. doi: 10.1089/hgtb.2012.173. Epub 2013 Jan 11.

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