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Results: 1 to 20 of 46

1.

Increased Tumor Ascorbate is Associated with Extended Disease-Free Survival and Decreased Hypoxia-Inducible Factor-1 Activation in Human Colorectal Cancer.

Kuiper C, Dachs GU, Munn D, Currie MJ, Robinson BA, Pearson JF, Vissers MC.

Front Oncol. 2014 Feb 4;4:10. doi: 10.3389/fonc.2014.00010. eCollection 2014.

PMID:
24551593
[PubMed]
Free PMC Article
2.

Intracellular ascorbate enhances hypoxia-inducible factor (HIF)-hydroxylase activity and preferentially suppresses the HIF-1 transcriptional response.

Kuiper C, Dachs GU, Currie MJ, Vissers MC.

Free Radic Biol Med. 2014 Apr;69:308-17. doi: 10.1016/j.freeradbiomed.2014.01.033. Epub 2014 Feb 2.

PMID:
24495550
[PubMed - in process]
3.

Marginal effects of glucose, insulin and insulin-like growth factor on chemotherapy response in endothelial and colorectal cancer cells.

Volkova E, Robinson BA, Willis J, Currie MJ, Dachs GU.

Oncol Lett. 2014 Feb;7(2):311-320. Epub 2013 Nov 27.

PMID:
24396438
[PubMed]
Free PMC Article
4.

Consumption of vitamin C is below recommended daily intake in many cancer patients and healthy volunteers in Christchurch.

Dachs GU, Munn DG, Carr AC, Vissers MC, Robinson BA.

N Z Med J. 2014 Mar 7;127(1390):73-6. No abstract available.

PMID:
24670594
[PubMed - indexed for MEDLINE]
5.

Immunohistochemical analysis of cancer stem cell markers in invasive breast carcinoma and associated ductal carcinoma in situ: relationships with markers of tumor hypoxia and microvascularity.

Currie MJ, Beardsley BE, Harris GC, Gunningham SP, Dachs GU, Dijkstra B, Morrin HR, Wells JE, Robinson BA.

Hum Pathol. 2013 Mar;44(3):402-11. doi: 10.1016/j.humpath.2012.06.004. Epub 2012 Oct 1.

PMID:
23036368
[PubMed - indexed for MEDLINE]
6.

Characterisation of enzyme prodrug gene therapy combinations in coated spheroids and vascular networks in vitro.

Hunt MA, Li D, Hay MP, Currie MJ, Robinson BA, Patterson AV, Dachs GU.

J Gene Med. 2012 Jan;14(1):62-74. doi: 10.1002/jgm.1635.

PMID:
22147660
[PubMed - indexed for MEDLINE]
7.

Diflavin oxidoreductases activate the bioreductive prodrug PR-104A under hypoxia.

Guise CP, Abbattista MR, Tipparaju SR, Lambie NK, Su J, Li D, Wilson WR, Dachs GU, Patterson AV.

Mol Pharmacol. 2012 Jan;81(1):31-40. doi: 10.1124/mol.111.073759. Epub 2011 Oct 7.

PMID:
21984255
[PubMed - indexed for MEDLINE]
Free Article
8.

Angiogenesis and host immune response contribute to the aggressive character of non-melanoma skin cancers in renal transplant recipients.

Mackenzie KA, Miller AP, Hock BD, Gardner J, Simcock JW, Roake JA, Dachs GU, Robinson BA, Currie MJ.

Histopathology. 2011 May;58(6):875-85. doi: 10.1111/j.1365-2559.2011.03845.x.

PMID:
21585427
[PubMed - indexed for MEDLINE]
9.

Association of angiopoietin-2, C-reactive protein and markers of obesity and insulin resistance with survival outcome in colorectal cancer.

Volkova E, Willis JA, Wells JE, Robinson BA, Dachs GU, Currie MJ.

Br J Cancer. 2011 Jan 4;104(1):51-9. doi: 10.1038/sj.bjc.6606005. Epub 2010 Nov 16.

PMID:
21081932
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

A profile of prognostic and molecular factors in European and Māori breast cancer patients.

Dachs GU, Kano M, Volkova E, Morrin HR, Davey VC, Harris GC, Cheale M, Frampton C, Currie MJ, Wells JE, Robinson BA.

BMC Cancer. 2010 Oct 10;10:543. doi: 10.1186/1471-2407-10-543.

PMID:
20932344
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Optimizing transfection of primary human umbilical vein endothelial cells using commercially available chemical transfection reagents.

Hunt MA, Currie MJ, Robinson BA, Dachs GU.

J Biomol Tech. 2010 Jul;21(2):66-72.

PMID:
20592869
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Low ascorbate levels are associated with increased hypoxia-inducible factor-1 activity and an aggressive tumor phenotype in endometrial cancer.

Kuiper C, Molenaar IG, Dachs GU, Currie MJ, Sykes PH, Vissers MC.

Cancer Res. 2010 Jul 15;70(14):5749-58. doi: 10.1158/0008-5472.CAN-10-0263. Epub 2010 Jun 22.

PMID:
20570889
[PubMed - indexed for MEDLINE]
Free Article
13.

The bioreductive prodrug PR-104A is activated under aerobic conditions by human aldo-keto reductase 1C3.

Guise CP, Abbattista MR, Singleton RS, Holford SD, Connolly J, Dachs GU, Fox SB, Pollock R, Harvey J, Guilford P, Doñate F, Wilson WR, Patterson AV.

Cancer Res. 2010 Feb 15;70(4):1573-84. doi: 10.1158/0008-5472.CAN-09-3237. Epub 2010 Feb 9.

PMID:
20145130
[PubMed - indexed for MEDLINE]
Free Article
14.

In vivo characterization of horseradish peroxidase with indole-3-acetic acid and 5-bromoindole-3-acetic acid for gene therapy of cancer.

Tupper J, Stratford MR, Hill S, Tozer GM, Dachs GU.

Cancer Gene Ther. 2010 Jun;17(6):420-8. doi: 10.1038/cgt.2009.86. Epub 2010 Jan 15.

PMID:
20075982
[PubMed - indexed for MEDLINE]
15.

Bystander or no bystander for gene directed enzyme prodrug therapy.

Dachs GU, Hunt MA, Syddall S, Singleton DC, Patterson AV.

Molecules. 2009 Nov 10;14(11):4517-45. doi: 10.3390/molecules14114517. Review.

PMID:
19924084
[PubMed - indexed for MEDLINE]
Free Article
16.

Cancer disparities in indigenous Polynesian populations: Māori, Native Hawaiians, and Pacific people.

Dachs GU, Currie MJ, McKenzie F, Jeffreys M, Cox B, Foliaki S, Le Marchand L, Robinson BA.

Lancet Oncol. 2008 May;9(5):473-84. doi: 10.1016/S1470-2045(08)70127-X. Review.

PMID:
18452858
[PubMed - indexed for MEDLINE]
17.

The angiogenic factor thymidine phosphorylase up-regulates the cell adhesion molecule P-selectin in human vascular endothelial cells and is associated with P-selectin expression in breast cancers.

Gunningham SP, Currie MJ, Morrin HR, Tan EY, Turley H, Dachs GU, Watson AI, Frampton C, Robinson BA, Fox SB.

J Pathol. 2007 Jul;212(3):335-44.

PMID:
17487938
[PubMed - indexed for MEDLINE]
18.

Modulation of hypoxia-inducible factor-1 alpha in cultured primary cells by intracellular ascorbate.

Vissers MC, Gunningham SP, Morrison MJ, Dachs GU, Currie MJ.

Free Radic Biol Med. 2007 Mar 15;42(6):765-72. Epub 2006 Nov 30.

PMID:
17320759
[PubMed - indexed for MEDLINE]
19.

Anti-vascular agent Combretastatin A-4-P modulates hypoxia inducible factor-1 and gene expression.

Dachs GU, Steele AJ, Coralli C, Kanthou C, Brooks AC, Gunningham SP, Currie MJ, Watson AI, Robinson BA, Tozer GM.

BMC Cancer. 2006 Dec 7;6:280.

PMID:
17156434
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1.

Williams KJ, Telfer BA, Xenaki D, Sheridan MR, Desbaillets I, Peters HJ, Honess D, Harris AL, Dachs GU, van der Kogel A, Stratford IJ.

Radiother Oncol. 2005 Apr;75(1):89-98. Epub 2005 Apr 18.

PMID:
15878106
[PubMed - indexed for MEDLINE]

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