Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 1
1997 1
2005 3
2006 3
2007 5
2008 1
2009 6
2010 2
2011 6
2012 6
2013 4
2014 5
2015 8
2016 3
2017 3
2018 4
2019 8
2020 8
2021 5
2022 15
2023 13
2024 2

Text availability

Article attribute

Article type

Publication date

Search Results

97 results

Results by year

Filters applied: . Clear all
Page 1
Increased gene copy number of DEFA1/DEFA3 worsens sepsis by inducing endothelial pyroptosis.
Chen Q, Yang Y, Hou J, Shu Q, Yin Y, Fu W, Han F, Hou T, Zeng C, Nemeth E, Linzmeier R, Ganz T, Fang X. Chen Q, et al. Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3161-3170. doi: 10.1073/pnas.1812947116. Epub 2019 Feb 4. Proc Natl Acad Sci U S A. 2019. PMID: 30718392 Free PMC article.
A genetic association study found that increased copy number of the HNP-encoding gene DEFA1/DEFA3 is a risk factor for organ dysfunction during sepsis development. ...We show that mice with high copy number of DEFA1/DEFA3 genes have more severe sepsis-related vital …
A genetic association study found that increased copy number of the HNP-encoding gene DEFA1/DEFA3 is a risk factor for organ dysfunct …
Correlation of DEFA1 gene copy number variation with intestinal involvement in Behcet's disease.
Ahn JK, Cha HS, Lee J, Jeon CH, Koh EM. Ahn JK, et al. J Korean Med Sci. 2012 Jan;27(1):107-9. doi: 10.3346/jkms.2012.27.1.107. Epub 2011 Dec 19. J Korean Med Sci. 2012. PMID: 22219625 Free PMC article.
Most samples (31.1%) had a CN of 5 with a mean CN of 5.4 0.2. There was no significant difference in the CN of the DEFA1 gene between BD patients and HC. A high DEFA1 gene CN was significantly associated with intestinal involvement in BD patients. Variable DEFA1 …
Most samples (31.1%) had a CN of 5 with a mean CN of 5.4 0.2. There was no significant difference in the CN of the DEFA1 gene between …
Low-Copy Number Polymorphism in DEFA1/DEFA3 Is Associated with Susceptibility to Hospital-Acquired Infections in Critically Ill Patients.
Zhao J, Gu Q, Wang L, Xu W, Chu L, Wang Y, Li Z, Wu S, Xu J, Hu Z, Shu Q, Fang X. Zhao J, et al. Mediators Inflamm. 2018 May 22;2018:2152650. doi: 10.1155/2018/2152650. eCollection 2018. Mediators Inflamm. 2018. PMID: 29950924 Free PMC article.
To identify potential associations between DEFA1/DEFA3 CNV and hospital-acquired infections (HAIs), we enrolled 106 patients with HAIs and 109 controls in the intensive care unit (ICU) and examined their DEFA1/DEFA3 CNVs. ...Therefore, lower DEFA1/DEFA3 copy …
To identify potential associations between DEFA1/DEFA3 CNV and hospital-acquired infections (HAIs), we enrolled 106 patients with HAI …
Elevated Levels of Neutrophil Activated Proteins, Alpha-Defensins (DEFA1), Calprotectin (S100A8/A9) and Myeloperoxidase (MPO) Are Associated With Disease Severity in COVID-19 Patients.
Shrivastava S, Chelluboina S, Jedge P, Doke P, Palkar S, Mishra AC, Arankalle VA. Shrivastava S, et al. Front Cell Infect Microbiol. 2021 Oct 21;11:751232. doi: 10.3389/fcimb.2021.751232. eCollection 2021. Front Cell Infect Microbiol. 2021. PMID: 34746027 Free PMC article.
Surprisingly, DEFA1 levels were higher in severe than mild patients in first week of onset of disease (p=0.004). Odds-ratio analysis showed that DEFA1 could act as potential biomarker in predicting disease severity (OR=11.34). ...
Surprisingly, DEFA1 levels were higher in severe than mild patients in first week of onset of disease (p=0.004). Odds-ratio analysis …
ATF4 Deficiency Promotes Intestinal Inflammation in Mice by Reducing Uptake of Glutamine and Expression of Antimicrobial Peptides.
Hu X, Deng J, Yu T, Chen S, Ge Y, Zhou Z, Guo Y, Ying H, Zhai Q, Chen Y, Yuan F, Niu Y, Shu W, Chen H, Ma C, Liu Z, Guo F. Hu X, et al. Gastroenterology. 2019 Mar;156(4):1098-1111. doi: 10.1053/j.gastro.2018.11.033. Epub 2018 Nov 16. Gastroenterology. 2019. PMID: 30452920
Some mice were given injections of recombinant defensin alpha1 (DEFA1) and supplementation of l-alanyl-glutamine or glutamine in drinking water. ...Injections of DEFA1 reduced the severity of spontaneous enteritis and DSS-induced colitis in Atf4deltaIEC mice. ...
Some mice were given injections of recombinant defensin alpha1 (DEFA1) and supplementation of l-alanyl-glutamine or glutamine in drin …
Increased genomic copy number of DEFA1/DEFA3 is associated with susceptibility to severe sepsis in Chinese Han population.
Chen Q, Hakimi M, Wu S, Jin Y, Cheng B, Wang H, Xie G, Ganz T, Linzmeier RM, Fang X. Chen Q, et al. Anesthesiology. 2010 Jun;112(6):1428-34. doi: 10.1097/ALN.0b013e3181d968eb. Anesthesiology. 2010. PMID: 20502117 Free article.
CONCLUSIONS: DEFA1/DEFA3 is an important genetic component participating in host immune response to severe sepsis. A higher copy number of DEFA1/DEFA3 (>8 copies) is significantly associated with the risk of severe sepsis....
CONCLUSIONS: DEFA1/DEFA3 is an important genetic component participating in host immune response to severe sepsis. A higher copy numb …
PPBP and DEFA1/DEFA3 genes in hyperlipidaemia as feasible synergistic inflammatory biomarkers for coronary heart disease.
Maneerat Y, Prasongsukarn K, Benjathummarak S, Dechkhajorn W. Maneerat Y, et al. Lipids Health Dis. 2017 Apr 19;16(1):80. doi: 10.1186/s12944-017-0471-0. Lipids Health Dis. 2017. PMID: 28420383 Free PMC article.
Eight selected genes expressed only in H and CHD groups were validated by real-time quantitative reverse transcription PCR and plasma protein determination. RESULTS: alpha-defensin (DEFA1/DEFA3), pro-platelet basic protein (PPBP), and beta and alpha2 hemoglobin mRNA expres …
Eight selected genes expressed only in H and CHD groups were validated by real-time quantitative reverse transcription PCR and plasma protei …
Excellent Diagnostic Characteristics for Ultrafast Gene Profiling of DEFA1-IL1B-LTF in Detection of Prosthetic Joint Infections.
Fillerova R, Gallo J, Radvansky M, Kraiczova V, Kudelka M, Kriegova E. Fillerova R, et al. J Clin Microbiol. 2017 Sep;55(9):2686-2697. doi: 10.1128/JCM.00558-17. Epub 2017 Jun 21. J Clin Microbiol. 2017. PMID: 28637910 Free PMC article.

Advanced data-mining algorithms were applied for data analysis. For PJI, we detected elevated mRNA expression levels of DEFA1 (P < 0.0001), IL1B (P < 0.0001), LTF (P < 0.0001), TLR1 (P = 0.02), and BPI (P = 0.01) in comparison to those in tissues from aseptic case

…
Advanced data-mining algorithms were applied for data analysis. For PJI, we detected elevated mRNA expression levels of DEFA1 (P < …
97 results