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Items: 1 to 20 of 28


Complex Negative Regulation of TLR9 by Multiple Proteolytic Cleavage Events.

Sinha SS, Cameron J, Brooks JC, Leifer CA.

J Immunol. 2016 Aug 15;197(4):1343-52. doi: 10.4049/jimmunol.1502357. Epub 2016 Jul 15.


Molecular mechanisms of regulation of Toll-like receptor signaling.

Leifer CA, Medvedev AE.

J Leukoc Biol. 2016 Jun 24. pii: jlb.2MR0316-117RR. [Epub ahead of print] Review.


TLR9 stability and signaling are regulated by phosphorylation and cell stress.

Hasan M, Gruber E, Cameron J, Leifer CA.

J Leukoc Biol. 2016 Mar 8. pii: jlb.2A0815-337R. [Epub ahead of print]


Recombinant M2e outer membrane vesicle vaccines protect against lethal influenza A challenge in BALB/c mice.

Rappazzo CG, Watkins HC, Guarino CM, Chau A, Lopez JL, DeLisa MP, Leifer CA, Whittaker GR, Putnam D.

Vaccine. 2016 Mar 4;34(10):1252-8. doi: 10.1016/j.vaccine.2016.01.028. Epub 2016 Jan 29.


Electrostatically self-assembled biodegradable microparticles from pseudoproteins and polysaccharide: fabrication, characterization, and biological properties.

Potuck AN, Weed BL, Leifer CA, Chu CC.

Biomacromolecules. 2015 Feb 9;16(2):564-77. doi: 10.1021/bm5016255. Epub 2015 Jan 17.


Linking genetic variation in human Toll-like receptor 5 genes to the gut microbiome's potential to cause inflammation.

Leifer CA, McConkey C, Li S, Chassaing B, Gewirtz AT, Ley RE.

Immunol Lett. 2014 Dec;162(2 Pt A):3-9. doi: 10.1016/j.imlet.2014.07.017. Epub 2014 Oct 2. Review.


Discordant results obtained with Francisella tularensis during in vitro and in vivo immunological studies are attributable to compromised bacterial structural integrity.

Singh A, Rahman T, Malik M, Hickey AJ, Leifer CA, Hazlett KR, Sellati TJ.

PLoS One. 2013;8(3):e58513. doi: 10.1371/journal.pone.0058513. Epub 2013 Mar 12.


Participation of MyD88 and interleukin-33 as innate drivers of Th2 immunity to Trichinella spiralis.

Scalfone LK, Nel HJ, Gagliardo LF, Cameron JL, Al-Shokri S, Leifer CA, Fallon PG, Appleton JA.

Infect Immun. 2013 Apr;81(4):1354-63. doi: 10.1128/IAI.01307-12. Epub 2013 Feb 12.


Traditional biochemical assays for studying toll-like receptor 9.

Leifer CA, Rose WA 2nd, Botelho F.

J Immunoassay Immunochem. 2013;34(1):1-15. doi: 10.1080/15321819.2012.666222. Review.


Multifunctional role of dextran sulfate sodium for in vivo modeling of intestinal diseases.

Rose WA 2nd, Sakamoto K, Leifer CA.

BMC Immunol. 2012 Aug 1;13:41. doi: 10.1186/1471-2172-13-41.


Heterozygous carriage of a dysfunctional Toll-like receptor 9 allele affects CpG oligonucleotide responses in B cells.

Knezević J, Pavlinić D, Rose WA 2nd, Leifer CA, Bendelja K, Gabrilovac J, Parcina M, Lauc G, Kubarenko AV, Petricevic B, Vrbanec D, Bulat-Kardum L, Bekeredjian-Ding I, Pavelić J, Dembić Z, Weber AN.

J Biol Chem. 2012 Jul 13;287(29):24544-53. doi: 10.1074/jbc.M111.337477. Epub 2012 May 21.


Heat shock protein gp96 regulates Toll-like receptor 9 proteolytic processing and conformational stability.

Brooks JC, Sun W, Chiosis G, Leifer CA.

Biochem Biophys Res Commun. 2012 May 18;421(4):780-4. doi: 10.1016/j.bbrc.2012.04.083. Epub 2012 Apr 23.


Negative regulation of signaling by a soluble form of toll-like receptor 9.

Chockalingam A, Cameron JL, Brooks JC, Leifer CA.

Eur J Immunol. 2011 Aug;41(8):2176-84. doi: 10.1002/eji.201041034. Epub 2011 Jul 4.


Early response of mucosal epithelial cells during Toxoplasma gondii infection.

Ju CH, Chockalingam A, Leifer CA.

J Immunol. 2009 Dec 1;183(11):7420-7. doi: 10.4049/jimmunol.0900640. Epub 2009 Nov 16.


MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosis.

Bowdish DM, Sakamoto K, Kim MJ, Kroos M, Mukhopadhyay S, Leifer CA, Tryggvason K, Gordon S, Russell DG.

PLoS Pathog. 2009 Jun;5(6):e1000474. doi: 10.1371/journal.ppat.1000474. Epub 2009 Jun 12.


TLR9 traffics through the Golgi complex to localize to endolysosomes and respond to CpG DNA.

Chockalingam A, Brooks JC, Cameron JL, Blum LK, Leifer CA.

Immunol Cell Biol. 2009 Mar-Apr;87(3):209-17. doi: 10.1038/icb.2008.101. Epub 2008 Dec 16.


Inhibition of TLR3 and TLR4 function and expression in human dendritic cells by helminth parasites.

Semnani RT, Venugopal PG, Leifer CA, Mostböck S, Sabzevari H, Nutman TB.

Blood. 2008 Aug 15;112(4):1290-8. doi: 10.1182/blood-2008-04-149856. Epub 2008 Jun 9.


Cytoplasmic targeting motifs control localization of toll-like receptor 9.

Leifer CA, Brooks JC, Hoelzer K, Lopez J, Kennedy MN, Mazzoni A, Segal DM.

J Biol Chem. 2006 Nov 17;281(46):35585-92. Epub 2006 Sep 21.


Dendritic cell modulation by mast cells controls the Th1/Th2 balance in responding T cells.

Mazzoni A, Siraganian RP, Leifer CA, Segal DM.

J Immunol. 2006 Sep 15;177(6):3577-81.

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