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330 results

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Page 1
Cyclobutanone Analogues of beta-Lactam Antibiotics: beta-Lactamase Inhibitors with Untapped Potential?
Devi P, Rutledge PJ. Devi P, et al. Chembiochem. 2017 Feb 16;18(4):338-351. doi: 10.1002/cbic.201600529. Epub 2017 Feb 7. Chembiochem. 2017. PMID: 27992105 Review.
However the effective treatment of an increasing range of microbial infections is threatened by bacterial resistance to beta-lactams: the prolonged, widespread (and at times reckless) use of these drugs has spawned widespread resistance, which renders them ineffective against man …
However the effective treatment of an increasing range of microbial infections is threatened by bacterial resistance to beta-lactams: the pr …
Recent advances in ring-opening of cyclobutanone oximes for capturing SO(2), CO or O(2)via a radical process.
Zhong LJ, Fan JH, Chen P, Huang PF, Xiong BQ, Tang KW, Liu Y. Zhong LJ, et al. Org Biomol Chem. 2023 Dec 20;22(1):10-24. doi: 10.1039/d3ob01762a. Org Biomol Chem. 2023. PMID: 38018531 Review.
Cyclobutanone oximes and their derivatives are pivotal core structural motifs in organic chemistry. ...In this updated report, the strategies for trapping SO(2), CO or O(2)via iminyl-radical-triggered ring-opening of cyclobutanone oximes are summarized....
Cyclobutanone oximes and their derivatives are pivotal core structural motifs in organic chemistry. ...In this updated report, the st …
Cyclobutanone Mimics of Intermediates in Metallo-beta-Lactamase Catalysis.
Abboud MI, Kosmopoulou M, Krismanich AP, Johnson JW, Hinchliffe P, Brem J, Claridge TDW, Spencer J, Schofield CJ, Dmitrienko GI. Abboud MI, et al. Chemistry. 2018 Apr 17;24(22):5734-5737. doi: 10.1002/chem.201705886. Epub 2018 Jan 17. Chemistry. 2018. PMID: 29250863 Free PMC article.
NMR experiments using (19) F-labeled SPM-1 imply the cyclobutanone binds to SPM-1 with micromolar affinity. A crystal structure of the SPM-1:cyclobutanone complex reveals binding of the hydrated cyclobutanone through interactions with one of the zinc ions, st …
NMR experiments using (19) F-labeled SPM-1 imply the cyclobutanone binds to SPM-1 with micromolar affinity. A crystal structure of th …
Cyclobutanone Inhibitors of Diaminopimelate Desuccinylase (DapE) as Potential New Antibiotics.
Habeeb Mohammad TS, Kelley EH, Reidl CT, Konczak K, Beulke M, Javier J, Olsen KW, Becker DP. Habeeb Mohammad TS, et al. Int J Mol Sci. 2024 Jan 22;25(2):1339. doi: 10.3390/ijms25021339. Int J Mol Sci. 2024. PMID: 38279338 Free PMC article.
Based on our previous success in using cyclobutanone derivatives as enzyme inhibitors, we have designed and prepared a 37-member library of alpha-aminocyclobutanone amides and sulfonamides, screened for inhibition of the bacterial enzyme diaminopimelate desuccinylase (DapE …
Based on our previous success in using cyclobutanone derivatives as enzyme inhibitors, we have designed and prepared a 37-member libr …
Cyclobutanone Inhibitor of Cobalt-Functionalized Metallo-gamma-Lactonase AiiA with Cyclobutanone Ring Opening in the Active Site.
Reidl CT, Mascarenhas R, Mohammad TSH, Lutz MR Jr, Thomas PW, Fast W, Liu D, Becker DP. Reidl CT, et al. ACS Omega. 2021 May 17;6(21):13567-13578. doi: 10.1021/acsomega.0c06348. eCollection 2021 Jun 1. ACS Omega. 2021. PMID: 34095651 Free PMC article.
An alpha-amido cyclobutanone possessing a C10 hydrocarbon tail was designed as a potential transition-state mimetic for the quorum-quenching metallo-gamma-lactonase autoinducer inactivator A (AiiA) with the support of in-house modeling techniques and found to be a competit …
An alpha-amido cyclobutanone possessing a C10 hydrocarbon tail was designed as a potential transition-state mimetic for the quorum-qu …
Palladium-Catalyzed Carbene Coupling Reactions of Cyclobutanone N-Sulfonylhydrazones.
Ning X, Chen Y, Hu F, Xia Y. Ning X, et al. Org Lett. 2021 Nov 5;23(21):8348-8352. doi: 10.1021/acs.orglett.1c03052. Epub 2021 Oct 8. Org Lett. 2021. PMID: 34623163
Described herein are the palladium-catalyzed cross-coupling reactions of cyclobutanone-derived N-sulfonylhydrazones with aryl or benzyl halides, suggesting that the metal carbene process and beta-hydride elimination can smoothly occur in strained ring systems. ...
Described herein are the palladium-catalyzed cross-coupling reactions of cyclobutanone-derived N-sulfonylhydrazones with aryl or benz …
Cyclopentanone and cyclobutanone.
Yufit DS, Howard JA. Yufit DS, et al. Acta Crystallogr C. 2011 Mar;67(Pt 3):o104-6. doi: 10.1107/S0108270111004069. Epub 2011 Feb 9. Acta Crystallogr C. 2011. PMID: 21368407
Crystals of cyclopentanone, C(5)H(8)O, and cyclobutanone, C(4)H(6)O, have been grown in situ on a diffractometer. ...
Crystals of cyclopentanone, C(5)H(8)O, and cyclobutanone, C(4)H(6)O, have been grown in situ on a diffractometer. ...
Palladium-Catalyzed Cyclization Coupling with Cyclobutanone-Derived N-Tosylhydrazones: Synthesis of Benzofuran-3-Cyclobutylidenes and Spirocyclobutanes.
Sun J, Ye H, Zhang H, Wu XX. Sun J, et al. J Org Chem. 2023 Feb 3;88(3):1568-1577. doi: 10.1021/acs.joc.2c02620. Epub 2023 Jan 17. J Org Chem. 2023. PMID: 36648061
A palladium-catalyzed cyclization coupling of iodoarene-tethered alkynes with cyclobutanone-derived N-tosylhydrazones is reported, providing a convenient and efficient approach to benzofuran-3-cyclobutylidenes. ...
A palladium-catalyzed cyclization coupling of iodoarene-tethered alkynes with cyclobutanone-derived N-tosylhydrazones is reported, pr …
Construction of Chiral Cyclobutanone-Fused 4-Aminoquinolines via Sequential Chiral Phosphoric Acid and Palladium Catalysis.
Zhang S, Jin RS, Niu YF, Zeng XP. Zhang S, et al. J Org Chem. 2023 Apr 7;88(7):4627-4632. doi: 10.1021/acs.joc.3c00098. Epub 2023 Mar 23. J Org Chem. 2023. PMID: 36951514
A one-pot catalytic asymmetric route to novel chiral quaternary-carbon-containing cyclobutanone-fused 4-aminoquinoline derivatives in good to high yields and enantioselectivities is described. ...
A one-pot catalytic asymmetric route to novel chiral quaternary-carbon-containing cyclobutanone-fused 4-aminoquinoline derivatives in …
A three-component reaction of cyclobutanone oxime esters, sulfur dioxide and N-alkyl-N-methacryloyl benzamides.
Ye S, Zhuang C, Lv J, Zhang C, Chen Q, Wu Z, Wu J, Xia H. Ye S, et al. Org Biomol Chem. 2023 Nov 22;21(45):9021-9028. doi: 10.1039/d3ob01439h. Org Biomol Chem. 2023. PMID: 37927060
A three-component reaction of cyclobutanone oxime esters, DABCO.(SO(2))(2) and N-alkyl-N-methacryloyl benzamides is described. ...
A three-component reaction of cyclobutanone oxime esters, DABCO.(SO(2))(2) and N-alkyl-N-methacryloyl benzamides is described. ...
330 results