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Results: 1 to 20 of 39


Control of Plasma Membrane Permeability by ABC Transporters.

Khakhina S, Johnson SS, Manoharlal R, Russo SB, Blugeon C, Lemoine S, Sunshine AB, Dunham MJ, Cowart LA, Devaux F, Moye-Rowley WS.

Eukaryot Cell. 2015 May;14(5):442-53. doi: 10.1128/EC.00021-15. Epub 2015 Feb 27.


Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity.

Jaishy B, Zhang Q, Chung HS, Riehle C, Soto J, Jenkins S, Abel P, Cowart LA, Van Eyk JE, Abel ED.

J Lipid Res. 2015 Mar;56(3):546-61. doi: 10.1194/jlr.M055152. Epub 2014 Dec 21.


Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis.

Rachidi S, Sun S, Wu BX, Jones E, Drake RR, Ogretmen B, Cowart LA, Clarke CJ, Hannun YA, Chiosis G, Liu B, Li Z.

J Hepatol. 2015 Apr;62(4):879-88. doi: 10.1016/j.jhep.2014.11.010. Epub 2014 Nov 22.


Acid sphingomyelinase plays a key role in palmitic acid-amplified inflammatory signaling triggered by lipopolysaccharide at low concentrations in macrophages.

Jin J, Zhang X, Lu Z, Perry DM, Li Y, Russo SB, Cowart LA, Hannun YA, Huang Y.

Am J Physiol Endocrinol Metab. 2013 Oct 1;305(7):E853-67. doi: 10.1152/ajpendo.00251.2013. Epub 2013 Aug 6.


Fatty acids differentially regulate insulin resistance through endoplasm reticulum stress-mediated induction of tribbles homologue 3: a potential link between dietary fat composition and the pathophysiological outcomes of obesity.

Geng T, Hu W, Broadwater MH, Snider JM, Bielawski J, Russo SB, Schwacke JH, Ross J, Cowart LA.

Diabetologia. 2013 Sep;56(9):2078-87. doi: 10.1007/s00125-013-2973-2. Epub 2013 Jul 3.


From data towards knowledge: revealing the architecture of signaling systems by unifying knowledge mining and data mining of systematic perturbation data.

Lu S, Jin B, Cowart LA, Lu X.

PLoS One. 2013 Apr 23;8(4):e61134. doi: 10.1371/journal.pone.0061134. Print 2013.


The yeast oxysterol binding protein Kes1 maintains sphingolipid levels.

LeBlanc MA, Fairn GD, Russo SB, Czyz O, Zaremberg V, Cowart LA, McMaster CR.

PLoS One. 2013 Apr 4;8(4):e60485. doi: 10.1371/journal.pone.0060485. Print 2013.


Sphingolipids in obesity, type 2 diabetes, and metabolic disease.

Russo SB, Ross JS, Cowart LA.

Handb Exp Pharmacol. 2013;(216):373-401. doi: 10.1007/978-3-7091-1511-4_19. Review.


Myristate-derived d16:0 sphingolipids constitute a cardiac sphingolipid pool with distinct synthetic routes and functional properties.

Russo SB, Tidhar R, Futerman AH, Cowart LA.

J Biol Chem. 2013 May 10;288(19):13397-409. doi: 10.1074/jbc.M112.428185. Epub 2013 Mar 25.


Revealing functionally coherent subsets using a spectral clustering and an information integration approach.

Richards AJ, Schwacke JH, Rohrer B, Cowart LA, Lu X.

BMC Syst Biol. 2012;6 Suppl 3:S7. doi: 10.1186/1752-0509-6-S3-S7. Epub 2012 Dec 17.


Ceramide synthase 5 mediates lipid-induced autophagy and hypertrophy in cardiomyocytes.

Russo SB, Baicu CF, Van Laer A, Geng T, Kasiganesan H, Zile MR, Cowart LA.

J Clin Invest. 2012 Nov;122(11):3919-30.


Sphingoid bases and the serine catabolic enzyme CHA1 define a novel feedforward/feedback mechanism in the response to serine availability.

Montefusco DJ, Newcomb B, Gandy JL, Brice SE, Matmati N, Cowart LA, Hannun YA.

J Biol Chem. 2012 Mar 16;287(12):9280-9. doi: 10.1074/jbc.M111.313445. Epub 2012 Jan 25.


Sphingolipid metabolism and analysis in metabolic disease.

Brice SE, Cowart LA.

Adv Exp Med Biol. 2011;721:1-17. doi: 10.1007/978-1-4614-0650-1_1. Review.


Differential regulation of dihydroceramide desaturase by palmitate versus monounsaturated fatty acids: implications for insulin resistance.

Hu W, Ross J, Geng T, Brice SE, Cowart LA.

J Biol Chem. 2011 May 13;286(19):16596-605. doi: 10.1074/jbc.M110.186916. Epub 2011 Mar 15.


Regulation of yeast nutrient permease endocytosis by ATP-binding cassette transporters and a seven-transmembrane protein, RSB1.

Johnson SS, Hanson PK, Manoharlal R, Brice SE, Cowart LA, Moye-Rowley WS.

J Biol Chem. 2010 Nov 12;285(46):35792-802. doi: 10.1074/jbc.M110.162883. Epub 2010 Sep 8.


Sphingolipids mediate formation of mRNA processing bodies during the heat-stress response of Saccharomyces cerevisiae.

Cowart LA, Gandy JL, Tholanikunnel B, Hannun YA.

Biochem J. 2010 Oct 1;431(1):31-8. doi: 10.1042/BJ20100307.


A novel role for sphingolipid metabolism in oxidant-mediated skeletal muscle fatigue. Focus on "Sphingomyelinase stimulates oxidant signaling to weaken skeletal muscle and promote fatigue".

Cowart LA.

Am J Physiol Cell Physiol. 2010 Sep;299(3):C549-51. doi: 10.1152/ajpcell.00236.2010. Epub 2010 Jun 23. No abstract available.


Assessing the functional coherence of gene sets with metrics based on the Gene Ontology graph.

Richards AJ, Muller B, Shotwell M, Cowart LA, Rohrer B, Lu X.

Bioinformatics. 2010 Jun 15;26(12):i79-87. doi: 10.1093/bioinformatics/btq203.


Revealing a signaling role of phytosphingosine-1-phosphate in yeast.

Cowart LA, Shotwell M, Worley ML, Richards AJ, Montefusco DJ, Hannun YA, Lu X.

Mol Syst Biol. 2010;6:349. doi: 10.1038/msb.2010.3. Epub 2010 Feb 16.

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