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Results: 1 to 20 of 125

1.

Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus.

Prieto GA, Snigdha S, Baglietto-Vargas D, Smith ED, Berchtold NC, Tong L, Ajami D, LaFerla FM, Rebek J Jr, Cotman CW.

Proc Natl Acad Sci U S A. 2015 Aug 24. pii: 201514486. [Epub ahead of print]

2.

A multiancestral genome-wide exome array study of Alzheimer disease, frontotemporal dementia, and progressive supranuclear palsy.

Chen JA, Wang Q, Davis-Turak J, Li Y, Karydas AM, Hsu SC, Sears RL, Chatzopoulou D, Huang AY, Wojta KJ, Klein E, Lee J, Beekly DL, Boxer A, Faber KM, Haase CM, Miller J, Poon WW, Rosen A, Rosen H, Sapozhnikova A, Shapira J, Varpetian A, Foroud TM, Levenson RW, Levey AI, Kukull WA, Mendez MF, Ringman J, Chui H, Cotman C, DeCarli C, Miller BL, Geschwind DH, Coppola G.

JAMA Neurol. 2015 Apr;72(4):414-22. doi: 10.1001/jamaneurol.2014.4040.

PMID:
25706306
3.

Rapamycin and interleukin-1β impair brain-derived neurotrophic factor-dependent neuron survival by modulating autophagy.

Smith ED, Prieto GA, Tong L, Sears-Kraxberger I, Rice JD, Steward O, Cotman CW.

J Biol Chem. 2014 Jul 25;289(30):20615-29.

4.

Brain gene expression patterns differentiate mild cognitive impairment from normal aged and Alzheimer's disease.

Berchtold NC, Sabbagh MN, Beach TG, Kim RC, Cribbs DH, Cotman CW.

Neurobiol Aging. 2014 Sep;35(9):1961-72. doi: 10.1016/j.neurobiolaging.2014.03.031. Epub 2014 Apr 2.

PMID:
24786631
5.

Exercise enhances memory consolidation in the aging brain.

Snigdha S, de Rivera C, Milgram NW, Cotman CW.

Front Aging Neurosci. 2014 Feb 3;6:3. doi: 10.3389/fnagi.2014.00003. eCollection 2014.

6.

TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions.

Gallagher MD, Suh E, Grossman M, Elman L, McCluskey L, Van Swieten JC, Al-Sarraj S, Neumann M, Gelpi E, Ghetti B, Rohrer JD, Halliday G, Van Broeckhoven C, Seilhean D, Shaw PJ, Frosch MP, Alafuzoff I, Antonell A, Bogdanovic N, Brooks W, Cairns NJ, Cooper-Knock J, Cotman C, Cras P, Cruts M, De Deyn PP, DeCarli C, Dobson-Stone C, Engelborghs S, Fox N, Galasko D, Gearing M, Gijselinck I, Grafman J, Hartikainen P, Hatanpaa KJ, Highley JR, Hodges J, Hulette C, Ince PG, Jin LW, Kirby J, Kofler J, Kril J, Kwok JB, Levey A, Lieberman A, Llado A, Martin JJ, Masliah E, McDermott CJ, McKee A, McLean C, Mead S, Miller CA, Miller J, Munoz DG, Murrell J, Paulson H, Piguet O, Rossor M, Sanchez-Valle R, Sano M, Schneider J, Silbert LC, Spina S, van der Zee J, Van Langenhove T, Warren J, Wharton SB, White CL 3rd, Woltjer RL, Trojanowski JQ, Lee VM, Van Deerlin V, Chen-Plotkin AS.

Acta Neuropathol. 2014 Mar;127(3):407-18. doi: 10.1007/s00401-013-1239-x. Epub 2014 Jan 19.

7.

Age-related downregulation of the CaV3.1 T-type calcium channel as a mediator of amyloid beta production.

Rice RA, Berchtold NC, Cotman CW, Green KN.

Neurobiol Aging. 2014 May;35(5):1002-11. doi: 10.1016/j.neurobiolaging.2013.10.090. Epub 2013 Oct 30.

8.

Preserving cognition, quality of life, physical health and functional ability in Alzheimer's disease: the effect of physical exercise (ADEX trial): rationale and design.

Hoffmann K, Frederiksen KS, Sobol NA, Beyer N, Vogel A, Simonsen AH, Johannsen P, Lolk A, Terkelsen O, Cotman CW, Hasselbalch SG, Waldemar G.

Neuroepidemiology. 2013;41(3-4):198-207. doi: 10.1159/000354632. Epub 2013 Oct 15.

9.

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau.

Blair LJ, Nordhues BA, Hill SE, Scaglione KM, O'Leary JC 3rd, Fontaine SN, Breydo L, Zhang B, Li P, Wang L, Cotman C, Paulson HL, Muschol M, Uversky VN, Klengel T, Binder EB, Kayed R, Golde TE, Berchtold N, Dickey CA.

J Clin Invest. 2013 Oct;123(10):4158-69. doi: 10.1172/JCI69003. Epub 2013 Sep 3.

10.

Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models.

Frost JL, Le KX, Cynis H, Ekpo E, Kleinschmidt M, Palmour RM, Ervin FR, Snigdha S, Cotman CW, Saido TC, Vassar RJ, St George-Hyslop P, Ikezu T, Schilling S, Demuth HU, Lemere CA.

Am J Pathol. 2013 Aug;183(2):369-81. doi: 10.1016/j.ajpath.2013.05.005. Epub 2013 Jun 7.

11.

Exercise and sodium butyrate transform a subthreshold learning event into long-term memory via a brain-derived neurotrophic factor-dependent mechanism.

Intlekofer KA, Berchtold NC, Malvaez M, Carlos AJ, McQuown SC, Cunningham MJ, Wood MA, Cotman CW.

Neuropsychopharmacology. 2013 Sep;38(10):2027-34. doi: 10.1038/npp.2013.104. Epub 2013 Apr 24.

12.

β-Amyloid (Aβ) oligomers impair brain-derived neurotrophic factor retrograde trafficking by down-regulating ubiquitin C-terminal hydrolase, UCH-L1.

Poon WW, Carlos AJ, Aguilar BL, Berchtold NC, Kawano CK, Zograbyan V, Yaopruke T, Shelanski M, Cotman CW.

J Biol Chem. 2013 Jun 7;288(23):16937-48. doi: 10.1074/jbc.M113.463711. Epub 2013 Apr 18.

13.

A preclinical cognitive test battery to parallel the National Institute of Health Toolbox in humans: bridging the translational gap.

Snigdha S, Milgram NW, Willis SL, Albert M, Weintraub S, Fortin NJ, Cotman CW.

Neurobiol Aging. 2013 Jul;34(7):1891-901. doi: 10.1016/j.neurobiolaging.2013.01.018. Epub 2013 Feb 20. Review.

14.

Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease.

Berchtold NC, Coleman PD, Cribbs DH, Rogers J, Gillen DL, Cotman CW.

Neurobiol Aging. 2013 Jun;34(6):1653-61. doi: 10.1016/j.neurobiolaging.2012.11.024. Epub 2012 Dec 27.

15.

Brain-derived neurotrophic factor-dependent synaptic plasticity is suppressed by interleukin-1β via p38 mitogen-activated protein kinase.

Tong L, Prieto GA, Kramár EA, Smith ED, Cribbs DH, Lynch G, Cotman CW.

J Neurosci. 2012 Dec 5;32(49):17714-24. doi: 10.1523/JNEUROSCI.1253-12.2012.

16.

Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes.

Sárvári M, Hrabovszky E, Kalló I, Solymosi N, Likó I, Berchtold N, Cotman C, Liposits Z.

J Neuroinflammation. 2012 Dec 3;9:264. doi: 10.1186/1742-2094-9-264.

17.
18.

Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study.

Cribbs DH, Berchtold NC, Perreau V, Coleman PD, Rogers J, Tenner AJ, Cotman CW.

J Neuroinflammation. 2012 Jul 23;9:179. doi: 10.1186/1742-2094-9-179.

19.

Age-specific effects of voluntary exercise on memory and the older brain.

Siette J, Westbrook RF, Cotman C, Sidhu K, Zhu W, Sachdev P, Valenzuela MJ.

Biol Psychiatry. 2013 Mar 1;73(5):435-42. doi: 10.1016/j.biopsych.2012.05.034. Epub 2012 Jul 15.

20.

Exercise counteracts declining hippocampal function in aging and Alzheimer's disease.

Intlekofer KA, Cotman CW.

Neurobiol Dis. 2013 Sep;57:47-55. doi: 10.1016/j.nbd.2012.06.011. Epub 2012 Jun 30. Review.

PMID:
22750524
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