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Results: 1 to 20 of 77

1.

The pterocarpanquinone LQB-118 inhibits tumor cell proliferation by downregulation of c-Myc and cyclins D1 and B1 mRNA and upregulation of p21 cell cycle inhibitor expression.

Martino T, Magalhães FC, Justo GA, Coelho MG, Netto CD, Costa PR, Sabino KC.

Bioorg Med Chem. 2014 Jun 15;22(12):3115-22. doi: 10.1016/j.bmc.2014.04.025. Epub 2014 Apr 20.

PMID:
24794748
[PubMed - in process]
2.

BMAA in shellfish from two Portuguese transitional water bodies suggests the marine dinoflagellate Gymnodinium catenatum as a potential BMAA source.

Lage S, Costa PR, Moita T, Eriksson J, Rasmussen U, Rydberg SJ.

Aquat Toxicol. 2014 Jul;152:131-8. doi: 10.1016/j.aquatox.2014.03.029. Epub 2014 Apr 12.

PMID:
24747603
[PubMed - indexed for MEDLINE]
3.

11a-N-Tosyl-5-deoxi-pterocarpan (LQB-223), a promising prototype for targeting MDR leukemia cell lines.

Buarque CD, Salustiano EJ, Fraga KC, Alves BR, Costa PR.

Eur J Med Chem. 2014 May 6;78:190-7. doi: 10.1016/j.ejmech.2014.03.039. Epub 2014 Mar 15.

PMID:
24681983
[PubMed - in process]
4.

Theoretical and experimental studies of new modified isoflavonoids as potential inhibitors of topoisomerase I from Plasmodium falciparum.

Cortopassi WA, Penna-Coutinho J, Aguiar AC, Pimentel AS, Buarque CD, Costa PR, Alves BR, França TC, Krettli AU.

PLoS One. 2014 Mar 20;9(3):e91191. doi: 10.1371/journal.pone.0091191. eCollection 2014.

PMID:
24651068
[PubMed - in process]
Free PMC Article
5.

Uptake, transfer and elimination kinetics of paralytic shellfish toxins in common octopus (Octopus vulgaris).

Lopes VM, Baptista M, Repolho T, Rosa R, Costa PR.

Aquat Toxicol. 2014 Jan;146:205-11. doi: 10.1016/j.aquatox.2013.11.011. Epub 2013 Nov 23.

PMID:
24316438
[PubMed - indexed for MEDLINE]
6.

Complications after pancreatectomies: prospective study after ISGFP and ISGPS new classifications.

Amico EC, Alves JR, João SA, Guimarães PL, Barreto EJ, Barreto LS, Costa PR, Medeiros JA.

Arq Bras Cir Dig. 2013 Jul-Sep;26(3):213-8. English, Portuguese.

PMID:
24190380
[PubMed - in process]
Free Article
7.

CD4+ T-cell activation impairs serogroup C Neisseria meningitis vaccine response in HIV-infected children.

Milagres LG, Costa PR, Santos BA, Silva GP, Cruz AC, Pereira-Manfro WF, Ferreira B, Barreto DM, Frota AC, Kalil J, Hofer CB, Kallas EG.

AIDS. 2013 Nov 13;27(17):2697-705. doi: 10.1097/QAD.0000000000000007.

PMID:
24149087
[PubMed - indexed for MEDLINE]
8.

Nutritional variables and work-related accidents: A case-control study.

de Medeiros MA, Zangirolani LT, Cordeiro RC, da Costa PR, Diez-Garcia RW.

Work. 2013 Sep 4. [Epub ahead of print]

PMID:
24004763
[PubMed - as supplied by publisher]
9.

Cooperative RNA polymerase molecules behavior on a stochastic sequence-dependent model for transcription elongation.

Costa PR, Acencio ML, Lemke N.

PLoS One. 2013;8(2):e57328. doi: 10.1371/journal.pone.0057328. Epub 2013 Feb 21.

PMID:
23437369
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Evaluation of coumarin and neoflavone derivatives as HCV NS5B polymerase inhibitors.

Nichols DB, Leão RA, Basu A, Chudayeu M, de Moraes Pde F, Talele TT, Costa PR, Kaushik-Basu N.

Chem Biol Drug Des. 2013 May;81(5):607-14. doi: 10.1111/cbdd.12105. Epub 2013 Apr 4.

PMID:
23311976
[PubMed - indexed for MEDLINE]
11.

LQB-118, an orally active pterocarpanquinone, induces selective oxidative stress and apoptosis in Leishmania amazonensis.

Ribeiro GA, Cunha-Júnior EF, Pinheiro RO, da-Silva SA, Canto-Cavalheiro MM, da Silva AJ, Costa PR, Netto CD, Melo RC, Almeida-Amaral EE, Torres-Santos EC.

J Antimicrob Chemother. 2013 Apr;68(4):789-99. doi: 10.1093/jac/dks498. Epub 2013 Jan 3.

PMID:
23288404
[PubMed - indexed for MEDLINE]
Free Article
12.

Early immunologic and virologic predictors of clinical HIV-1 disease progression.

Mahnke YD, Song K, Sauer MM, Nason MC, Giret MT, Carvalho KI, Costa PR, Roederer M, Kallás EG.

AIDS. 2013 Mar 13;27(5):697-706. doi: 10.1097/QAD.0b013e32835ce2e9.

PMID:
23211771
[PubMed - indexed for MEDLINE]
13.

Frequency of subtype B and F1 dual infection in HIV-1 positive, Brazilian men who have sex with men.

Soares de Oliveira AC, Pessôa de Farias R, da Costa AC, Sauer MM, Bassichetto KC, Oliveira SM, Costa PR, Tomiyama C, Tomiyama HT, Sabino EC, Kallas EG, Sanabani SS.

Virol J. 2012 Sep 29;9:223. doi: 10.1186/1743-422X-9-223.

PMID:
23021203
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

The pterocarpanquinone LQB 118 induces apoptosis in tumor cells through the intrinsic pathway and the endoplasmic reticulum stress pathway.

de Sá Bacelar T, da Silva AJ, Costa PR, Rumjanek VM.

Anticancer Drugs. 2013 Jan;24(1):73-83. doi: 10.1097/CAD.0b013e3283592da8.

PMID:
22960938
[PubMed - indexed for MEDLINE]
15.

The therapeutical potential of a novel pterocarpanquinone LQB-118 to target inhibitor of apoptosis proteins in acute myeloid leukemia cells.

de Souza Reis FR, de Faria FC, Castro CP, de Souza PS, da Cunha Vasconcelos F, Bello RD, da Silva AJ, Costa PR, Maia RC.

Anticancer Agents Med Chem. 2013 Feb;13(2):341-51.

PMID:
22721384
[PubMed - indexed for MEDLINE]
16.

Hydroxybenzoate paralytic shellfish toxins induce transient GST activity depletion and chromosomal damage in white seabream (Diplodus sargus).

Costa PR, Pereira P, Guilherme S, Barata M, Santos MA, Pacheco M, Pousão-Ferreira P.

Mar Environ Res. 2012 Aug;79:63-9. doi: 10.1016/j.marenvres.2012.05.004. Epub 2012 May 29.

PMID:
22710085
[PubMed - indexed for MEDLINE]
17.

Low-cost ultra-wide genotyping using Roche/454 pyrosequencing for surveillance of HIV drug resistance.

Dudley DM, Chin EN, Bimber BN, Sanabani SS, Tarosso LF, Costa PR, Sauer MM, Kallas EG, O'Connor DH.

PLoS One. 2012;7(5):e36494. doi: 10.1371/journal.pone.0036494. Epub 2012 May 4.

PMID:
22574170
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

2-Acetylpyridine- and 2-benzoylpyridine-derived hydrazones and their gallium(III) complexes are highly cytotoxic to glioma cells.

Despaigne AA, Parrilha GL, Izidoro JB, da Costa PR, dos Santos RG, Piro OE, Castellano EE, Rocha WR, Beraldo H.

Eur J Med Chem. 2012 Apr;50:163-72. doi: 10.1016/j.ejmech.2012.01.051. Epub 2012 Feb 2.

PMID:
22357115
[PubMed - indexed for MEDLINE]
19.

A new type of pterocarpanquinone that affects Toxoplasma gondii tachyzoites in vitro.

Portes Jde A, Netto CD, da Silva AJ, Costa PR, DaMatta RA, dos Santos TA, De Souza W, Seabra SH.

Vet Parasitol. 2012 May 25;186(3-4):261-9. doi: 10.1016/j.vetpar.2011.11.008. Epub 2011 Nov 7.

PMID:
22177332
[PubMed - indexed for MEDLINE]
20.

Biotransformation modulation and genotoxicity in white seabream upon exposure to paralytic shellfish toxins produced by Gymnodinium catenatum.

Costa PR, Pereira P, Guilherme S, Barata M, Nicolau L, Santos MA, Pacheco M, Pousão-Ferreira P.

Aquat Toxicol. 2012 Jan 15;106-107:42-7. doi: 10.1016/j.aquatox.2011.08.023. Epub 2011 Sep 6.

PMID:
22057254
[PubMed - indexed for MEDLINE]

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