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Results: 1 to 20 of 219

1.

Physical workload during firefighting in Chilean volunteers.

Herrera JA, Cohen FE, Simón ES.

Work. 2012;41 Suppl 1:432-6. doi: 10.3233/WOR-2012-0193-432.

PMID:
22316762
2.

Protease-sensitive synthetic prions.

Colby DW, Wain R, Baskakov IV, Legname G, Palmer CG, Nguyen HO, Lemus A, Cohen FE, DeArmond SJ, Prusiner SB.

PLoS Pathog. 2010 Jan 22;6(1):e1000736. doi: 10.1371/journal.ppat.1000736.

3.

Molecular modeling of the misfolded insulin subunit and amyloid fibril.

Choi JH, May BC, Wille H, Cohen FE.

Biophys J. 2009 Dec 16;97(12):3187-95. doi: 10.1016/j.bpj.2009.09.042.

4.

Natural and synthetic prion structure from X-ray fiber diffraction.

Wille H, Bian W, McDonald M, Kendall A, Colby DW, Bloch L, Ollesch J, Borovinskiy AL, Cohen FE, Prusiner SB, Stubbs G.

Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):16990-5. doi: 10.1073/pnas.0909006106. Epub 2009 Sep 28.

5.

Site-directed mutagenesis demonstrates the plasticity of the beta helix: implications for the structure of the misfolded prion protein.

Choi JH, May BC, Govaerts C, Cohen FE.

Structure. 2009 Jul 15;17(7):1014-23. doi: 10.1016/j.str.2009.05.013.

6.

Genes contributing to prion pathogenesis.

Tamgüney G, Giles K, Glidden DV, Lessard P, Wille H, Tremblay P, Groth DF, Yehiely F, Korth C, Moore RC, Tatzelt J, Rubinstein E, Boucheix C, Yang X, Stanley P, Lisanti MP, Dwek RA, Rudd PM, Moskovitz J, Epstein CJ, Cruz TD, Kuziel WA, Maeda N, Sap J, Ashe KH, Carlson GA, Tesseur I, Wyss-Coray T, Mucke L, Weisgraber KH, Mahley RW, Cohen FE, Prusiner SB.

J Gen Virol. 2008 Jul;89(Pt 7):1777-88. doi: 10.1099/vir.0.2008/001255-0.

7.

Analysis of the sequence and structural features of the left-handed beta-helical fold.

Choi JH, Govaerts C, May BC, Cohen FE.

Proteins. 2008 Oct;73(1):150-60. doi: 10.1002/prot.22051.

PMID:
18398908
8.

Cell division modulates prion accumulation in cultured cells.

Ghaemmaghami S, Phuan PW, Perkins B, Ullman J, May BC, Cohen FE, Prusiner SB.

Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):17971-6. Epub 2007 Nov 7.

9.

Electron crystallography of the scrapie prion protein complexed with heavy metals.

Wille H, Govaerts C, Borovinskiy A, Latawiec D, Downing KH, Cohen FE, Prusiner SB.

Arch Biochem Biophys. 2007 Nov 15;467(2):239-48. Epub 2007 Aug 23.

10.

Discriminating between cellular and misfolded prion protein by using affinity to 9-aminoacridine compounds.

Phuan PW, Zorn JA, Safar J, Giles K, Prusiner SB, Cohen FE, May BC.

J Gen Virol. 2007 Apr;88(Pt 4):1392-401.

11.

Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro.

Caffrey CR, Steverding D, Swenerton RK, Kelly B, Walshe D, Debnath A, Zhou YM, Doyle PS, Fafarman AT, Zorn JA, Land KM, Beauchene J, Schreiber K, Moll H, Ponte-Sucre A, Schirmeister T, Saravanamuthu A, Fairlamb AH, Cohen FE, McKerrow JH, Weisman JL, May BC.

Antimicrob Agents Chemother. 2007 Jun;51(6):2164-72. Epub 2007 Mar 19.

12.

Automatic extraction of protein point mutations using a graph bigram association.

Lee LC, Horn F, Cohen FE.

PLoS Comput Biol. 2007 Feb 2;3(2):e16.

13.

Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: parallel synthesis, bioactivity, and in vitro pharmacokinetics.

May BC, Zorn JA, Witkop J, Sherrill J, Wallace AC, Legname G, Prusiner SB, Cohen FE.

J Med Chem. 2007 Jan 11;50(1):65-73. Erratum in: J Med Chem. 2007 Mar 8;50(5):1086.

PMID:
17201410
14.

Continuum of prion protein structures enciphers a multitude of prion isolate-specified phenotypes.

Legname G, Nguyen HO, Peretz D, Cohen FE, DeArmond SJ, Prusiner SB.

Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19105-10. Epub 2006 Dec 1.

15.

Directed evolution of an anti-prion protein scFv fragment to an affinity of 1 pM and its structural interpretation.

Luginbühl B, Kanyo Z, Jones RM, Fletterick RJ, Prusiner SB, Cohen FE, Williamson RA, Burton DR, Plückthun A.

J Mol Biol. 2006 Oct 13;363(1):75-97. Epub 2006 Jul 21.

PMID:
16962610
16.

Searching for new antimalarial therapeutics amongst known drugs.

Weisman JL, Liou AP, Shelat AA, Cohen FE, Guy RK, DeRisi JL.

Chem Biol Drug Des. 2006 Jun;67(6):409-16.

17.

Structure-activity relationship study of 9-aminoacridine compounds in scrapie-infected neuroblastoma cells.

May BC, Witkop J, Sherrill J, Anderson MO, Madrid PB, Zorn JA, Prusiner SB, Cohen FE, Guy RK.

Bioorg Med Chem Lett. 2006 Sep 15;16(18):4913-6. Epub 2006 Jul 24.

PMID:
16860557
18.

Developing therapeutics for the diseases of protein misfolding.

May BC, Govaerts C, Cohen FE.

Neurology. 2006 Jan 24;66(2 Suppl 1):S118-22. Review.

PMID:
16432139
19.

Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target.

Ye S, Huang Y, Müllendorff K, Dong L, Giedt G, Meng EC, Cohen FE, Kuntz ID, Weisgraber KH, Mahley RW.

Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18700-5. Epub 2005 Dec 12.

20.

Strain-specified characteristics of mouse synthetic prions.

Legname G, Nguyen HO, Baskakov IV, Cohen FE, Dearmond SJ, Prusiner SB.

Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2168-73. Epub 2005 Jan 25. Erratum in: Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14642.

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