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The WTX tumor suppressor enhances p53 acetylation by CBP/p300.
Kim WJ, Rivera MN, Coffman EJ, Haber DA. Kim WJ, et al. Among authors: coffman ej. Mol Cell. 2012 Mar 9;45(5):587-97. doi: 10.1016/j.molcel.2011.12.025. Epub 2012 Jan 26. Mol Cell. 2012. PMID: 22285752 Free PMC article.
BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors.
Faber AC, Corcoran RB, Ebi H, Sequist LV, Waltman BA, Chung E, Incio J, Digumarthy SR, Pollack SF, Song Y, Muzikansky A, Lifshits E, Roberge S, Coffman EJ, Benes CH, Gómez HL, Baselga J, Arteaga CL, Rivera MN, Dias-Santagata D, Jain RK, Engelman JA. Faber AC, et al. Among authors: coffman ej. Cancer Discov. 2011 Sep;1(4):352-65. doi: 10.1158/2159-8290.CD-11-0106. Epub 2011 Jul 22. Cancer Discov. 2011. PMID: 22145099 Free PMC article.
The WTX tumor suppressor regulates mesenchymal progenitor cell fate specification.
Moisan A, Rivera MN, Lotinun S, Akhavanfard S, Coffman EJ, Cook EB, Stoykova S, Mukherjee S, Schoonmaker JA, Burger A, Kim WJ, Kronenberg HM, Baron R, Haber DA, Bardeesy N. Moisan A, et al. Among authors: coffman ej. Dev Cell. 2011 May 17;20(5):583-596. doi: 10.1016/j.devcel.2011.03.013. Dev Cell. 2011. PMID: 21571217 Free PMC article.
Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers.
Ting DT, Lipson D, Paul S, Brannigan BW, Akhavanfard S, Coffman EJ, Contino G, Deshpande V, Iafrate AJ, Letovsky S, Rivera MN, Bardeesy N, Maheswaran S, Haber DA. Ting DT, et al. Among authors: coffman ej. Science. 2011 Feb 4;331(6017):593-6. doi: 10.1126/science.1200801. Epub 2011 Jan 13. Science. 2011. PMID: 21233348 Free PMC article.
The tumor suppressor WTX shuttles to the nucleus and modulates WT1 activity.
Rivera MN, Kim WJ, Wells J, Stone A, Burger A, Coffman EJ, Zhang J, Haber DA. Rivera MN, et al. Among authors: coffman ej. Proc Natl Acad Sci U S A. 2009 May 19;106(20):8338-43. doi: 10.1073/pnas.0811349106. Epub 2009 May 4. Proc Natl Acad Sci U S A. 2009. PMID: 19416806 Free PMC article.