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Results: 1 to 20 of 238


Re-programming CHO cell metabolism using miR-23 tips the balance towards a highly productive phenotype.

Kelly PS, Breen L, Gallagher C, Kelly S, Henry M, Lao NT, Meleady P, O'Gorman D, Clynes M, Barron N.

Biotechnol J. 2015 Jul;10(7):1029-40. doi: 10.1002/biot.201500101. Epub 2015 Jun 24.


Towards next generation CHO cell biology: Bioinformatics methods for RNA-Seq-based expression profiling.

Monger C, Kelly PS, Gallagher C, Clynes M, Barron N, Clarke C.

Biotechnol J. 2015 Jul;10(7):950-66. doi: 10.1002/biot.201500107. Epub 2015 Jun 9.


How well do radiographic, clinical and self-reported diagnoses of knee osteoarthritis agree? Findings from the Hertfordshire cohort study.

Parsons C, Clynes M, Syddall H, Jagannath D, Litwic A, van der Pas S, Cooper C, Dennison EM, Edwards MH; EPOSA research group.

Springerplus. 2015 Apr 15;4:177. doi: 10.1186/s40064-015-0949-z. eCollection 2015.


Circulating miRNAs miR-34a and miR-150 associated with colorectal cancer progression.

Aherne ST, Madden SF, Hughes DJ, Pardini B, Naccarati A, Levy M, Vodicka P, Neary P, Dowling P, Clynes M.

BMC Cancer. 2015 Apr 30;15:329. doi: 10.1186/s12885-015-1327-5.


Influence of multidrug resistance and drug transport proteins on chemotherapy drug metabolism.

Joyce H, McCann A, Clynes M, Larkin A.

Expert Opin Drug Metab Toxicol. 2015 May;11(5):795-809. doi: 10.1517/17425255.2015.1028356. Epub 2015 Apr 2.


Prolonged pre-incubation increases the susceptibility of Galleria mellonella larvae to bacterial and fungal infection.

Browne N, Surlis C, Maher A, Gallagher C, Carolan JC, Clynes M, Kavanagh K.

Virulence. 2015 Jul 4;6(5):458-65. doi: 10.1080/21505594.2015.1021540. Epub 2015 Mar 18.


Predictive biomarkers for dasatinib treatment in melanoma.

Eustace AJ, Kennedy S, Larkin AM, Mahgoub T, Tryfonopoulos D, O'Driscoll L, Clynes M, Crown J, O'Donovan N.

Oncoscience. 2014 Mar 12;1(2):158-66. eCollection 2014.


Glycosylation patterns of kidney proteins differ in rat diabetic nephropathy.

Ravidà A, Musante L, Kreivi M, Miinalainen I, Byrne B, Saraswat M, Henry M, Meleady P, Clynes M, Holthofer H.

Kidney Int. 2015 May;87(5):963-74. doi: 10.1038/ki.2014.387. Epub 2015 Jan 14.


Elevated levels of 14-3-3 proteins, serotonin, gamma enolase and pyruvate kinase identified in clinical samples from patients diagnosed with colorectal cancer.

Dowling P, Hughes DJ, Larkin AM, Meiller J, Henry M, Meleady P, Lynch V, Pardini B, Naccarati A, Levy M, Vodicka P, Neary P, Clynes M.

Clin Chim Acta. 2015 Feb 20;441:133-41. doi: 10.1016/j.cca.2014.12.005. Epub 2014 Dec 23.


Conserved microRNA function as a basis for Chinese hamster ovary cell engineering.

Kelly PS, Gallagher C, Clynes M, Barron N.

Biotechnol Lett. 2015 Apr;37(4):787-98. doi: 10.1007/s10529-014-1751-7. Epub 2014 Dec 21.


Abnormal levels of heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) in tumour tissue and blood samples from patients diagnosed with lung cancer.

Dowling P, Pollard D, Larkin A, Henry M, Meleady P, Gately K, O'Byrne K, Barr MP, Lynch V, Ballot J, Crown J, Moriarty M, O'Brien E, Morgan R, Clynes M.

Mol Biosyst. 2015 Mar;11(3):743-52. doi: 10.1039/c4mb00384e. Epub 2014 Dec 8.


Identification of proteins found to be significantly altered when comparing the serum proteome from Multiple Myeloma patients with varying degrees of bone disease.

Dowling P, Hayes C, Ting KR, Hameed A, Meiller J, Mitsiades C, Anderson KC, Clynes M, Clarke C, Richardson P, O'Gorman P.

BMC Genomics. 2014 Oct 17;15:904. doi: 10.1186/1471-2164-15-904.


Exposure of a corneal epithelial cell line (hTCEpi) to Demodex-associated Bacillus proteins results in an inflammatory response.

McMahon FW, Gallagher C, O'Reilly N, Clynes M, O'Sullivan F, Kavanagh K.

Invest Ophthalmol Vis Sci. 2014 Oct 2;55(10):7019-28. doi: 10.1167/iovs.14-15018.


Bone disease in multiple myeloma: pathophysiology and management.

Hameed A, Brady JJ, Dowling P, Clynes M, O'Gorman P.

Cancer Growth Metastasis. 2014 Aug 10;7:33-42. doi: 10.4137/CGM.S16817. eCollection 2014. Review.


Further evidence of the developmental origins of osteoarthritis: results from the Hertfordshire Cohort Study.

Clynes MA, Parsons C, Edwards MH, Jameson KA, Harvey NC, Sayer AA, Cooper C, Dennison EM.

J Dev Orig Health Dis. 2014 Dec;5(6):453-8. doi: 10.1017/S2040174414000373. Epub 2014 Aug 26.


Comparative transcriptomic analysis of cultivated limbal epithelium and donor corneal tissue reveals altered wound healing gene expression.

Gallagher C, Clarke C, Aherne ST, Katikireddy KR, Doolan P, Lynch V, Shaw S, Bobart-Hone A, Murphy C, Clynes M, Power W, O'Sullivan F.

Invest Ophthalmol Vis Sci. 2014 Aug 14;55(9):5795-805. doi: 10.1167/iovs.14-14664.


PP2A inhibition overcomes acquired resistance to HER2 targeted therapy.

McDermott MS, Browne BC, Conlon NT, O'Brien NA, Slamon DJ, Henry M, Meleady P, Clynes M, Dowling P, Crown J, O'Donovan N.

Mol Cancer. 2014 Jun 24;13:157. doi: 10.1186/1476-4598-13-157.


A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy.

Pohl K, Hayes E, Keenan J, Henry M, Meleady P, Molloy K, Jundi B, Bergin DA, McCarthy C, McElvaney OJ, White MM, Clynes M, Reeves EP, McElvaney NG.

Blood. 2014 Aug 14;124(7):999-1009. doi: 10.1182/blood-2014-02-555268. Epub 2014 Jun 16.


Identification and functional validation of RAD23B as a potential protein in human breast cancer progression.

Linge A, Maurya P, Friedrich K, Baretton GB, Kelly S, Henry M, Clynes M, Larkin A, Meleady P.

J Proteome Res. 2014 Jul 3;13(7):3212-22. doi: 10.1021/pr4012156. Epub 2014 Jun 19.


Intricate effects of primary motor neuronopathy on contractile proteins and metabolic muscle enzymes as revealed by label-free mass spectrometry.

Holland A, Schmitt-John T, Dowling P, Meleady P, Henry M, Clynes M, Ohlendieck K.

Biosci Rep. 2014 Jul 1;34(4). pii: e00119. doi: 10.1042/BSR20140029.

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