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Results: 1 to 20 of 145

1.

Microbiota controls the homeostasis of glial cells in the gut lamina propria.

Kabouridis PS, Lasrado R, McCallum S, Chng SH, Snippert HJ, Clevers H, Pettersson S, Pachnis V.

Neuron. 2015 Jan 21;85(2):289-95. doi: 10.1016/j.neuron.2014.12.037. Epub 2015 Jan 8.

2.

Long-term culture of genome-stable bipotent stem cells from adult human liver.

Huch M, Gehart H, van Boxtel R, Hamer K, Blokzijl F, Verstegen MM, Ellis E, van Wenum M, Fuchs SA, de Ligt J, van de Wetering M, Sasaki N, Boers SJ, Kemperman H, de Jonge J, Ijzermans JN, Nieuwenhuis EE, Hoekstra R, Strom S, Vries RR, van der Laan LJ, Cuppen E, Clevers H.

Cell. 2015 Jan 15;160(1-2):299-312. doi: 10.1016/j.cell.2014.11.050. Epub 2014 Dec 18.

3.

Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2.

Simmini S, Bialecka M, Huch M, Kester L, van de Wetering M, Sato T, Beck F, van Oudenaarden A, Clevers H, Deschamps J.

Nat Commun. 2014 Dec 11;5:5728. doi: 10.1038/ncomms6728.

4.

Targeting development of incretin-producing cells increases insulin secretion.

Petersen N, Reimann F, van Es JH, van den Berg BM, Kroone C, Pais R, Jansen E, Clevers H, Gribble FM, de Koning EJ.

J Clin Invest. 2015 Jan;125(1):379-85. doi: 10.1172/JCI75838. Epub 2014 Dec 15.

5.

Robust cre-mediated recombination in small intestinal stem cells utilizing the olfm4 locus.

Schuijers J, van der Flier LG, van Es J, Clevers H.

Stem Cell Reports. 2014 Aug 12;3(2):234-41. doi: 10.1016/j.stemcr.2014.05.018. Epub 2014 Jun 26.

6.

Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition.

Bolden JE, Tasdemir N, Dow LE, van Es JH, Wilkinson JE, Zhao Z, Clevers H, Lowe SW.

Cell Rep. 2014 Sep 25;8(6):1919-29. doi: 10.1016/j.celrep.2014.08.025. Epub 2014 Sep 18.

7.

Genome sequencing of normal cells reveals developmental lineages and mutational processes.

Behjati S, Huch M, van Boxtel R, Karthaus W, Wedge DC, Tamuri AU, Martincorena I, Petljak M, Alexandrov LB, Gundem G, Tarpey PS, Roerink S, Blokker J, Maddison M, Mudie L, Robinson B, Nik-Zainal S, Campbell P, Goldman N, van de Wetering M, Cuppen E, Clevers H, Stratton MR.

Nature. 2014 Sep 18;513(7518):422-5. doi: 10.1038/nature13448. Epub 2014 Jun 29.

8.

Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell-derived IFN-γ.

Farin HF, Karthaus WR, Kujala P, Rakhshandehroo M, Schwank G, Vries RG, Kalkhoven E, Nieuwenhuis EE, Clevers H.

J Exp Med. 2014 Jun 30;211(7):1393-405. doi: 10.1084/jem.20130753.

9.

Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells.

Forster R, Chiba K, Schaeffer L, Regalado SG, Lai CS, Gao Q, Kiani S, Farin HF, Clevers H, Cost GJ, Chan A, Rebar EJ, Urnov FD, Gregory PD, Pachter L, Jaenisch R, Hockemeyer D.

Stem Cell Reports. 2014 Jun 3;2(6):838-52. doi: 10.1016/j.stemcr.2014.05.001. eCollection 2014 Jun 3. Erratum in: Stem Cell Reports. 2014 Jul 8;3(1):215.

10.

Polarizing intestinal epithelial cells electrically through Ror2.

Cao L, McCaig CD, Scott RH, Zhao S, Milne G, Clevers H, Zhao M, Pu J.

J Cell Sci. 2014 Aug 1;127(Pt 15):3233-9. doi: 10.1242/jcs.146357. Epub 2014 Jun 13.

11.

STRAD pseudokinases regulate axogenesis and LKB1 stability.

Veleva-Rotse BO, Smart JL, Baas AF, Edmonds B, Zhao ZM, Brown A, Klug LR, Hansen K, Reilly G, Gardner AP, Subbiah K, Gaucher EA, Clevers H, Barnes AP.

Neural Dev. 2014 Mar 4;9:5. doi: 10.1186/1749-8104-9-5.

12.

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength.

de Lau W, Peng WC, Gros P, Clevers H.

Genes Dev. 2014 Feb 15;28(4):305-16. doi: 10.1101/gad.235473.113. Review.

13.

Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging.

Ritsma L, Ellenbroek SI, Zomer A, Snippert HJ, de Sauvage FJ, Simons BD, Clevers H, van Rheenen J.

Nature. 2014 Mar 20;507(7492):362-5. doi: 10.1038/nature12972. Epub 2014 Feb 16.

14.

Ovarian LGR5 is critical for successful pregnancy.

Sun X, Terakawa J, Clevers H, Barker N, Daikoku T, Dey SK.

FASEB J. 2014 May;28(5):2380-9. doi: 10.1096/fj.13-248344. Epub 2014 Jan 27.

15.

Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development.

Liu X, Chen X, Zhong B, Wang A, Wang X, Chu F, Nurieva RI, Yan X, Chen P, van der Flier LG, Nakatsukasa H, Neelapu SS, Chen W, Clevers H, Tian Q, Qi H, Wei L, Dong C.

Nature. 2014 Mar 27;507(7493):513-8. doi: 10.1038/nature12910. Epub 2014 Jan 19.

16.

Wnt-induced transcriptional activation is exclusively mediated by TCF/LEF.

Schuijers J, Mokry M, Hatzis P, Cuppen E, Clevers H.

EMBO J. 2014 Jan 13;33(2):146-56. doi: 10.1002/embj.201385358. Epub 2014 Jan 10.

17.

Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion.

Snippert HJ, Schepers AG, van Es JH, Simons BD, Clevers H.

EMBO Rep. 2014 Jan;15(1):62-9. doi: 10.1002/embr.201337799. Epub 2013 Dec 15.

18.

Structures of Wnt-antagonist ZNRF3 and its complex with R-spondin 1 and implications for signaling.

Peng WC, de Lau W, Madoori PK, Forneris F, Granneman JC, Clevers H, Gros P.

PLoS One. 2013 Dec 12;8(12):e83110. doi: 10.1371/journal.pone.0083110. eCollection 2013.

19.

TTC7A mutations disrupt intestinal epithelial apicobasal polarity.

Bigorgne AE, Farin HF, Lemoine R, Mahlaoui N, Lambert N, Gil M, Schulz A, Philippet P, Schlesser P, Abrahamsen TG, Oymar K, Davies EG, Ellingsen CL, Leteurtre E, Moreau-Massart B, Berrebi D, Bole-Feysot C, Nischke P, Brousse N, Fischer A, Clevers H, de Saint Basile G.

J Clin Invest. 2014 Jan;124(1):328-37.

20.

Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny.

Yin X, Farin HF, van Es JH, Clevers H, Langer R, Karp JM.

Nat Methods. 2014 Jan;11(1):106-12. doi: 10.1038/nmeth.2737. Epub 2013 Dec 1.

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