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Results: 1 to 20 of 448

1.

Sequential cancer mutations in cultured human intestinal stem cells.

Drost J, van Jaarsveld RH, Ponsioen B, Zimberlin C, van Boxtel R, Buijs A, Sachs N, Overmeer RM, Offerhaus GJ, Begthel H, Korving J, van de Wetering M, Schwank G, Logtenberg M, Cuppen E, Snippert HJ, Medema JP, Kops GJ, Clevers H.

Nature. 2015 Apr 29. doi: 10.1038/nature14415. [Epub ahead of print]

PMID:
25924068
2.

Efficient intracellular delivery of native proteins.

D'Astolfo DS, Pagliero RJ, Pras A, Karthaus WR, Clevers H, Prasad V, Lebbink RJ, Rehmann H, Geijsen N.

Cell. 2015 Apr 23;161(3):674-90. doi: 10.1016/j.cell.2015.03.028.

PMID:
25910214
3.

Frizzled7 Functions as a Wnt Receptor in Intestinal Epithelial Lgr5+ Stem Cells.

Flanagan DJ, Phesse TJ, Barker N, Schwab RH, Amin N, Malaterre J, Stange DE, Nowell CJ, Currie SA, Saw JT, Beuchert E, Ramsay RG, Sansom OJ, Ernst M, Clevers H, Vincan E.

Stem Cell Reports. 2015 Apr 15. pii: S2213-6711(15)00097-1. doi: 10.1016/j.stemcr.2015.03.003. [Epub ahead of print]

4.

An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth.

Kundu P, Genander M, Strååt K, Classon J, Ridgway RA, Tan EH, Björk J, Martling A, van Es J, Sansom OJ, Clevers H, Pettersson S, Frisén J.

Sci Transl Med. 2015 Apr 1;7(281):281ra44. doi: 10.1126/scitranslmed.3010567.

PMID:
25834110
5.

Premigratory and migratory neural crest cells are multipotent in vivo.

Baggiolini A, Varum S, Mateos JM, Bettosini D, John N, Bonalli M, Ziegler U, Dimou L, Clevers H, Furrer R, Sommer L.

Cell Stem Cell. 2015 Mar 5;16(3):314-22. doi: 10.1016/j.stem.2015.02.017.

PMID:
25748934
6.

Germline deletions in the tumour suppressor gene FOCAD are associated with polyposis and colorectal cancer development.

Weren RD, Venkatachalam R, Cazier JB, Farin HF, Kets CM, de Voer RM, Vreede L, Verwiel ET, van Asseldonk M, Kamping EJ, Kiemeney LA, Neveling K, Aben KK, Carvajal-Carmona L, Nagtegaal ID, Schackert HK, Clevers H, van de Wetering M, Tomlinson IP, Ligtenberg MJ, Hoogerbrugge N, Geurts van Kessel A, Kuiper RP.

J Pathol. 2015 Feb 25. doi: 10.1002/path.4520. [Epub ahead of print]

PMID:
25712196
7.

Generation and analysis of mouse intestinal tumors and organoids harboring APC and K-Ras mutations.

van Es JH, Clevers H.

Methods Mol Biol. 2015;1267:125-44. doi: 10.1007/978-1-4939-2297-0_6.

PMID:
25636467
8.

Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts.

Schuijers J, Junker JP, Mokry M, Hatzis P, Koo BK, Sasselli V, van der Flier LG, Cuppen E, van Oudenaarden A, Clevers H.

Cell Stem Cell. 2015 Feb 5;16(2):158-70. doi: 10.1016/j.stem.2014.12.006. Epub 2015 Jan 22.

PMID:
25620640
9.

Microbiota controls the homeostasis of glial cells in the gut lamina propria.

Kabouridis PS, Lasrado R, McCallum S, Chng SH, Snippert HJ, Clevers H, Pettersson S, Pachnis V.

Neuron. 2015 Jan 21;85(2):289-95. doi: 10.1016/j.neuron.2014.12.037. Epub 2015 Jan 8.

10.

Organoid models of human and mouse ductal pancreatic cancer.

Boj SF, Hwang CI, Baker LA, Chio II, Engle DD, Corbo V, Jager M, Ponz-Sarvise M, Tiriac H, Spector MS, Gracanin A, Oni T, Yu KH, van Boxtel R, Huch M, Rivera KD, Wilson JP, Feigin ME, Öhlund D, Handly-Santana A, Ardito-Abraham CM, Ludwig M, Elyada E, Alagesan B, Biffi G, Yordanov GN, Delcuze B, Creighton B, Wright K, Park Y, Morsink FH, Molenaar IQ, Borel Rinkes IH, Cuppen E, Hao Y, Jin Y, Nijman IJ, Iacobuzio-Donahue C, Leach SD, Pappin DJ, Hammell M, Klimstra DS, Basturk O, Hruban RH, Offerhaus GJ, Vries RG, Clevers H, Tuveson DA.

Cell. 2015 Jan 15;160(1-2):324-38. doi: 10.1016/j.cell.2014.12.021. Epub 2014 Dec 31.

PMID:
25557080
11.

Long-term culture of genome-stable bipotent stem cells from adult human liver.

Huch M, Gehart H, van Boxtel R, Hamer K, Blokzijl F, Verstegen MM, Ellis E, van Wenum M, Fuchs SA, de Ligt J, van de Wetering M, Sasaki N, Boers SJ, Kemperman H, de Jonge J, Ijzermans JN, Nieuwenhuis EE, Hoekstra R, Strom S, Vries RR, van der Laan LJ, Cuppen E, Clevers H.

Cell. 2015 Jan 15;160(1-2):299-312. doi: 10.1016/j.cell.2014.11.050. Epub 2014 Dec 18.

12.

Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2.

Simmini S, Bialecka M, Huch M, Kester L, van de Wetering M, Sato T, Beck F, van Oudenaarden A, Clevers H, Deschamps J.

Nat Commun. 2014 Dec 11;5:5728. doi: 10.1038/ncomms6728.

13.

Targeting development of incretin-producing cells increases insulin secretion.

Petersen N, Reimann F, van Es JH, van den Berg BM, Kroone C, Pais R, Jansen E, Clevers H, Gribble FM, de Koning EJ.

J Clin Invest. 2015 Jan;125(1):379-85. doi: 10.1172/JCI75838. Epub 2014 Dec 15.

PMID:
25500886
14.

Large-scale identification of coregulated enhancer networks in the adult human brain.

Vermunt MW, Reinink P, Korving J, de Bruijn E, Creyghton PM, Basak O, Geeven G, Toonen PW, Lansu N, Meunier C, van Heesch S; Netherlands Brain Bank, Clevers H, de Laat W, Cuppen E, Creyghton MP.

Cell Rep. 2014 Oct 23;9(2):767-79. doi: 10.1016/j.celrep.2014.09.023. Epub 2014 Oct 16.

15.

Plasticity within stem cell hierarchies in mammalian epithelia.

Tetteh PW, Farin HF, Clevers H.

Trends Cell Biol. 2015 Feb;25(2):100-8. doi: 10.1016/j.tcb.2014.09.003. Epub 2014 Oct 9. Review.

PMID:
25308311
16.

In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.

Bartfeld S, Bayram T, van de Wetering M, Huch M, Begthel H, Kujala P, Vries R, Peters PJ, Clevers H.

Gastroenterology. 2015 Jan;148(1):126-136.e6. doi: 10.1053/j.gastro.2014.09.042. Epub 2014 Oct 13.

17.

Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control.

Clevers H, Loh KM, Nusse R.

Science. 2014 Oct 3;346(6205):1248012. doi: 10.1126/science.1248012. Epub 2014 Oct 2. Review.

PMID:
25278615
18.

A20 controls intestinal homeostasis through cell-specific activities.

Vereecke L, Vieira-Silva S, Billiet T, van Es JH, Mc Guire C, Slowicka K, Sze M, van den Born M, De Hertogh G, Clevers H, Raes J, Rutgeerts P, Vermeire S, Beyaert R, van Loo G.

Nat Commun. 2014 Sep 30;5:5103. doi: 10.1038/ncomms6103.

PMID:
25267258
19.

Robust cre-mediated recombination in small intestinal stem cells utilizing the olfm4 locus.

Schuijers J, van der Flier LG, van Es J, Clevers H.

Stem Cell Reports. 2014 Aug 12;3(2):234-41. doi: 10.1016/j.stemcr.2014.05.018. Epub 2014 Jun 26.

20.

Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition.

Bolden JE, Tasdemir N, Dow LE, van Es JH, Wilkinson JE, Zhao Z, Clevers H, Lowe SW.

Cell Rep. 2014 Sep 25;8(6):1919-29. doi: 10.1016/j.celrep.2014.08.025. Epub 2014 Sep 18.

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