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Results: 1 to 20 of 197

1.

Discovery, SAR, and X-ray Binding Mode Study of BCATm Inhibitors from a Novel DNA-Encoded Library.

Deng H, Zhou J, Sundersingh FS, Summerfield J, Somers D, Messer JA, Satz AL, Ancellin N, Arico-Muendel CC, Sargent Bedard KL, Beljean A, Belyanskaya SL, Bingham R, Smith SE, Boursier E, Carter P, Centrella PA, Clark MA, Chung CW, Davie CP, Delorey JL, Ding Y, Franklin GJ, Grady LC, Herry K, Hobbs C, Kollmann CS, Morgan BA, Pothier Kaushansky LJ, Zhou Q.

ACS Med Chem Lett. 2015 Jul 21;6(8):919-24. doi: 10.1021/acsmedchemlett.5b00179. eCollection 2015 Aug 13.

PMID:
26288694
2.

Structure-Based Optimization of Naphthyridones into Potent ATAD2 Bromodomain Inhibitors.

Bamborough P, Chung CW, Furze RC, Grandi P, Michon AM, Sheppard RJ, Barnett H, Diallo H, Dixon DP, Douault C, Jones EJ, Karamshi B, Mitchell DJ, Prinjha RK, Rau C, Watson RJ, Werner T, Demont EH.

J Med Chem. 2015 Aug 13;58(15):6151-78. doi: 10.1021/acs.jmedchem.5b00773. Epub 2015 Jul 31.

PMID:
26230603
3.

Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors.

Demont EH, Chung CW, Furze RC, Grandi P, Michon AM, Wellaway C, Barrett N, Bridges AM, Craggs PD, Diallo H, Dixon DP, Douault C, Emmons AJ, Jones EJ, Karamshi BV, Locke K, Mitchell DJ, Mouzon BH, Prinjha RK, Roberts AD, Sheppard RJ, Watson RJ, Bamborough P.

J Med Chem. 2015 Jul 23;58(14):5649-73. doi: 10.1021/acs.jmedchem.5b00772. Epub 2015 Jul 9.

PMID:
26155854
4.

The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits.

Bertrand SM, Ancellin N, Beaufils B, Bingham RP, Borthwick JA, Boullay AB, Boursier E, Carter PS, Chung CW, Churcher I, Dodic N, Fouchet MH, Fournier C, Francis PL, Gummer LA, Herry K, Hobbs A, Hobbs CI, Homes P, Jamieson C, Nicodeme E, Pickett SD, Reid IH, Simpson GL, Sloan LA, Smith SE, Somers DO, Spitzfaden C, Suckling CJ, Valko K, Washio Y, Young RJ.

J Med Chem. 2015 Jul 2. [Epub ahead of print]

PMID:
26090771
5.

Enhancement of Corneal Visibility in Optical Coherence Tomography Images Using Corneal Adaptive Compensation.

Girard MJ, Ang M, Chung CW, Farook M, Strouthidis N, Mehta JS, Mari JM.

Transl Vis Sci Technol. 2015 May 15;4(3):3. eCollection 2015 May.

6.
7.

Cisplatin-incorporated nanoparticles of methoxy poly(ethylene glycol)-b-poly(L-glutamic acid) copolymer.

Yoo JJ, Jeong YI, Chung CW, Kang DH.

J Nanosci Nanotechnol. 2014 Aug;14(8):6256-60.

PMID:
25936099
8.

Effect of 5-aminolevulinic acid-encapsulate liposomes on photodynamic therapy in human cholangiocarcinoma cells.

Choi KH, Chung CW, Kim CH, Kim do H, Jeong YI, Kang DH.

J Nanosci Nanotechnol. 2014 Aug;14(8):5628-32.

PMID:
25935979
9.

Effect of Microorganism Sporosarcina pasteurii on the Hydration of Cement Paste.

Lee JC, Lee CJ, Chun WY, Kim WJ, Chung CW.

J Microbiol Biotechnol. 2015 Aug 28;25(8):1328-38. doi: 10.4014/jmb.1411.11037.

10.

Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition.

Theodoulou NH, Bamborough P, Bannister AJ, Becher I, Bit RA, Che KH, Chung CW, Dittmann A, Drewes G, Drewry DH, Gordon L, Grandi P, Leveridge M, Lindon M, Michon AM, Molnar J, Robson SC, Tomkinson NC, Kouzarides T, Prinjha RK, Humphreys PG.

J Med Chem. 2015 Apr 30. [Epub ahead of print]

PMID:
25856009
11.

Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.

Chen P, Chaikuad A, Bamborough P, Bantscheff M, Bountra C, Chung CW, Fedorov O, Grandi P, Jung D, Lesniak R, Lindon M, Müller S, Philpott M, Prinjha R, Rogers C, Selenski C, Tallant C, Werner T, Willson TM, Knapp S, Drewry DH.

J Med Chem. 2015 Apr 6. [Epub ahead of print]

PMID:
25799074
12.

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.

Lewis HD, Liddle J, Coote JE, Atkinson SJ, Barker MD, Bax BD, Bicker KL, Bingham RP, Campbell M, Chen YH, Chung CW, Craggs PD, Davis RP, Eberhard D, Joberty G, Lind KE, Locke K, Maller C, Martinod K, Patten C, Polyakova O, Rise CE, Rüdiger M, Sheppard RJ, Slade DJ, Thomas P, Thorpe J, Yao G, Drewes G, Wagner DD, Thompson PR, Prinjha RK, Wilson DM.

Nat Chem Biol. 2015 Mar;11(3):189-91. doi: 10.1038/nchembio.1735. Epub 2015 Jan 26.

PMID:
25622091
13.

1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain.

Demont EH, Bamborough P, Chung CW, Craggs PD, Fallon D, Gordon LJ, Grandi P, Hobbs CI, Hussain J, Jones EJ, Le Gall A, Michon AM, Mitchell DJ, Prinjha RK, Roberts AD, Sheppard RJ, Watson RJ.

ACS Med Chem Lett. 2014 Sep 10;5(11):1190-5. doi: 10.1021/ml5002932. eCollection 2014 Nov 13.

PMID:
25408830
14.

Paclitaxel-incorporated nanoparticles using block copolymers composed of poly(ethylene glycol)/poly(3-hydroxyoctanoate).

Kim HY, Ryu JH, Chu CW, Son GM, Jeong YI, Kwak TW, Kim do H, Chung CW, Rhee YH, Kang DH, Kim HW.

Nanoscale Res Lett. 2014 Sep 24;9(1):525. doi: 10.1186/1556-276X-9-525. eCollection 2014.

15.

Kruidenier et al. reply.

Kruidenier L, Chung CW, Cheng Z, Liddle J, Che K, Joberty G, Bantscheff M, Bountra C, Bridges A, Diallo H, Eberhard D, Hutchinson S, Jones E, Katso R, Leveridge M, Mander PK, Mosley J, Ramirez-Molina C, Rowland P, Schofield CJ, Sheppard RJ, Smith JE, Swales C, Tanner R, Thomas P, Tumber A, Drewes G, Oppermann U, Patel DJ, Lee K, Wilson DM.

Nature. 2014 Oct 2;514(7520):E2. doi: 10.1038/nature13689. No abstract available.

PMID:
25279927
16.

Defensive mechanism in cholangiocarcinoma cells against oxidative stress induced by chlorin e6-based photodynamic therapy.

Lee HM, Chung CW, Kim CH, Kim do H, Kwak TW, Jeong YI, Kang DH.

Drug Des Devel Ther. 2014 Sep 18;8:1451-62. doi: 10.2147/DDDT.S62265. eCollection 2014.

17.

The discovery of I-BET726 (GSK1324726A), a potent tetrahydroquinoline ApoA1 up-regulator and selective BET bromodomain inhibitor.

Gosmini R, Nguyen VL, Toum J, Simon C, Brusq JM, Krysa G, Mirguet O, Riou-Eymard AM, Boursier EV, Trottet L, Bamborough P, Clark H, Chung CW, Cutler L, Demont EH, Kaur R, Lewis AJ, Schilling MB, Soden PE, Taylor S, Walker AL, Walker MD, Prinjha RK, Nicodème E.

J Med Chem. 2014 Oct 9;57(19):8111-31. doi: 10.1021/jm5010539. Epub 2014 Sep 24.

PMID:
25249180
18.

Evaluating the efficacy of the current diagnosis-related group reimbursement system for laparoscopic appendectomy at a single institute in Korea.

Yoo RN, Chung CW, Kim JW.

Ann Surg Treat Res. 2014 Sep;87(3):148-55. doi: 10.4174/astr.2014.87.3.148. Epub 2014 Aug 26. Erratum in: Ann Surg Treat Res. 2014 Oct;87(4):222.

19.

Health behaviors and risk factors associated with chronic kidney disease in Korean patients with diabetes: the Fourth Korean National Health and Nutritional Examination Survey.

Lee SJ, Chung CW.

Asian Nurs Res (Korean Soc Nurs Sci). 2014 Mar;8(1):8-14. doi: 10.1016/j.anr.2013.11.001. Epub 2013 Nov 27.

20.

Flexible and transparent polyimide films containing two-dimensional alumina nanosheets templated by graphene oxide for improved barrier property.

Tseng IH, Tsai MH, Chung CW.

ACS Appl Mater Interfaces. 2014 Aug 13;6(15):13098-105. doi: 10.1021/am502962b. Epub 2014 Jul 16.

PMID:
25029634
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