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Items: 17


Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system.

Shim H, Wu C, Ramsamooj S, Bosch KN, Chen Z, Emerling BM, Yun J, Liu H, Choo-Wing R, Yang Z, Wulf GM, Kuchroo VK, Cantley LC.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7596-601. doi: 10.1073/pnas.1600934113. Epub 2016 Jun 16.


Role of Nitric Oxide Isoforms in Vascular and Alveolar Development and Lung Injury in Vascular Endothelial Growth Factor Overexpressing Neonatal Mice Lungs.

Syed MA, Choo-Wing R, Homer RJ, Bhandari V.

PLoS One. 2016 Jan 22;11(1):e0147588. doi: 10.1371/journal.pone.0147588. eCollection 2016.


Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors.

Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC.

Cell. 2013 Nov 7;155(4):844-57. doi: 10.1016/j.cell.2013.09.057.


A critical regulatory role for macrophage migration inhibitory factor in hyperoxia-induced injury in the developing murine lung.

Sun H, Choo-Wing R, Sureshbabu A, Fan J, Leng L, Yu S, Jiang D, Noble P, Homer RJ, Bucala R, Bhandari V.

PLoS One. 2013 Apr 29;8(4):e60560. doi: 10.1371/journal.pone.0060560. Print 2013.


Hyperoxia and interferon-γ-induced injury in developing lungs occur via cyclooxygenase-2 and the endoplasmic reticulum stress-dependent pathway.

Choo-Wing R, Syed MA, Harijith A, Bowen B, Pryhuber G, Janér C, Andersson S, Homer RJ, Bhandari V.

Am J Respir Cell Mol Biol. 2013 Jun;48(6):749-57. doi: 10.1165/rcmb.2012-0381OC.


Small molecular modulation of macrophage migration inhibitory factor in the hyperoxia-induced mouse model of bronchopulmonary dysplasia.

Sun H, Choo-Wing R, Fan J, Leng L, Syed MA, Hare AA, Jorgensen WL, Bucala R, Bhandari V.

Respir Res. 2013 Feb 28;14:27. doi: 10.1186/1465-9921-14-27.


Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival in clear cell renal cell carcinoma patients.

Emerling BM, Benes CH, Poulogiannis G, Bell EL, Courtney K, Liu H, Choo-Wing R, Bellinger G, Tsukazawa KS, Brown V, Signoretti S, Soltoff SP, Cantley LC.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3483-8. doi: 10.1073/pnas.1222435110. Epub 2013 Feb 1.


Ryanodine receptors contribute to bile acid-induced pathological calcium signaling and pancreatitis in mice.

Husain SZ, Orabi AI, Muili KA, Luo Y, Sarwar S, Mahmood SM, Wang D, Choo-Wing R, Singh VP, Parness J, Ananthanaravanan M, Bhandari V, Perides G.

Am J Physiol Gastrointest Liver Physiol. 2012 Jun 15;302(12):G1423-33. doi: 10.1152/ajpgi.00546.2011. Epub 2012 Apr 19.


Increased hyperoxia-induced lung injury in nitric oxide synthase 2 null mice is mediated via angiopoietin 2.

Bhandari V, Choo-Wing R, Harijith A, Sun H, Syed MA, Homer RJ, Elias JA.

Am J Respir Cell Mol Biol. 2012 May;46(5):668-76. doi: 10.1165/rcmb.2011-0074OC. Epub 2012 Jan 6.


A potential role of the JNK pathway in hyperoxia-induced cell death, myofibroblast transdifferentiation and TGF-β1-mediated injury in the developing murine lung.

Li Z, Choo-Wing R, Sun H, Sureshbabu A, Sakurai R, Rehan VK, Bhandari V.

BMC Cell Biol. 2011 Dec 15;12:54. doi: 10.1186/1471-2121-12-54.


A role for matrix metalloproteinase 9 in IFNγ-mediated injury in developing lungs: relevance to bronchopulmonary dysplasia.

Harijith A, Choo-Wing R, Cataltepe S, Yasumatsu R, Aghai ZH, Janér J, Andersson S, Homer RJ, Bhandari V.

Am J Respir Cell Mol Biol. 2011 May;44(5):621-30. doi: 10.1165/rcmb.2010-0058OC. Epub 2011 Jan 7.


Dantrolene mitigates caerulein-induced pancreatitis in vivo in mice.

Orabi AI, Shah AU, Ahmad MU, Choo-Wing R, Parness J, Jain D, Bhandari V, Husain SZ.

Am J Physiol Gastrointest Liver Physiol. 2010 Jul;299(1):G196-204. doi: 10.1152/ajpgi.00498.2009. Epub 2010 May 6.


Developmental regulation of NO-mediated VEGF-induced effects in the lung.

Bhandari V, Choo-Wing R, Lee CG, Yusuf K, Nedrelow JH, Ambalavanan N, Malkus H, Homer RJ, Elias JA.

Am J Respir Cell Mol Biol. 2008 Oct;39(4):420-30. doi: 10.1165/rcmb.2007-0024OC. Epub 2008 Apr 25.


Increased hyperoxia-induced mortality and acute lung injury in IL-13 null mice.

Bhandari V, Choo-Wing R, Homer RJ, Elias JA.

J Immunol. 2007 Apr 15;178(8):4993-5000.


Developmental differences in the responses of IL-6 and IL-13 transgenic mice exposed to hyperoxia.

Choo-Wing R, Nedrelow JH, Homer RJ, Elias JA, Bhandari V.

Am J Physiol Lung Cell Mol Physiol. 2007 Jul;293(1):L142-50. Epub 2007 Mar 30.


Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death.

Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR, Elias JA.

Nat Med. 2006 Nov;12(11):1286-93. Epub 2006 Nov 5.


Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung.

Bhandari V, Choo-Wing R, Chapoval SP, Lee CG, Tang C, Kim YK, Ma B, Baluk P, Lin MI, McDonald DM, Homer RJ, Sessa WC, Elias JA.

Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):11021-6. Epub 2006 Jul 10.

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