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Gamma-linolenic acid, Dihommo-gamma linolenic, Eicosanoids and Inflammatory Processes.

Sergeant S, Rahbar E, Chilton FH.

Eur J Pharmacol. 2016 Apr 12. pii: S0014-2999(16)30234-5. doi: 10.1016/j.ejphar.2016.04.020. [Epub ahead of print]


Alterations in levels and ratios of n-3 and n-6 polyunsaturated fatty acids in the temporal cortex and liver of vervet monkeys from birth to early adulthood.

Miller LR, Jorgensen MJ, Kaplan JR, Seeds MC, Rahbar E, Morgan TM, Welborn A, Chilton SM, Gillis J, Hester A, Rukstalis M, Sergeant S, Chilton FH.

Physiol Behav. 2016 Mar 15;156:71-8. doi: 10.1016/j.physbeh.2015.12.009. Epub 2015 Dec 17.


Impact of methods used to express levels of circulating fatty acids on the degree and direction of associations with blood lipids in humans.

Sergeant S, Ruczinski I, Ivester P, Lee TC, Morgan TM, Nicklas BJ, Mathias RA, Chilton FH.

Br J Nutr. 2016 Jan 28;115(2):251-61. doi: 10.1017/S0007114515004341. Epub 2015 Nov 30.


The impact of polyunsaturated fatty acid-based dietary supplements on disease biomarkers in a metabolic syndrome/diabetes population.

Lee TC, Ivester P, Hester AG, Sergeant S, Case LD, Morgan T, Kouba EO, Chilton FH.

Lipids Health Dis. 2014 Dec 16;13:196. doi: 10.1186/1476-511X-13-196.


LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma.

Kazani S, Arm JP, Boyce J, Chhay H, Dutile S, Wechsler ME, Govindarajulu U, Ivester P, Ainsworth HC, Sergeant S, Chilton FH, Israel E.

Springerplus. 2014 Nov 6;3:661. doi: 10.1186/2193-1801-3-661. eCollection 2014.


Relationship between a common variant in the fatty acid desaturase (FADS) cluster and eicosanoid generation in humans.

Hester AG, Murphy RC, Uhlson CJ, Ivester P, Lee TC, Sergeant S, Miller LR, Howard TD, Mathias RA, Chilton FH.

J Biol Chem. 2014 Aug 8;289(32):22482-9. doi: 10.1074/jbc.M114.579557. Epub 2014 Jun 24.


Diet-gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases.

Chilton FH, Murphy RC, Wilson BA, Sergeant S, Ainsworth H, Seeds MC, Mathias RA.

Nutrients. 2014 May 21;6(5):1993-2022. doi: 10.3390/nu6051993. Review.


DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver.

Howard TD, Mathias RA, Seeds MC, Herrington DM, Hixson JE, Shimmin LC, Hawkins GA, Sellers M, Ainsworth HC, Sergeant S, Miller LR, Chilton FH.

PLoS One. 2014 May 19;9(5):e97510. doi: 10.1371/journal.pone.0097510. eCollection 2014.


Impact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics.

Arm JP, Boyce JA, Wang L, Chhay H, Zahid M, Patil V, Govindarajulu U, Ivester P, Weaver KL, Sergeant S, Israel E, Chilton FH.

Lipids Health Dis. 2013 Oct 2;12:141. doi: 10.1186/1476-511X-12-141.


Stearidonic and γ-linolenic acids in echium oil improves glucose disposal in insulin resistant monkeys.

Kavanagh K, Flynn DM, Jenkins KA, Wilson MD, Chilton FH.

Prostaglandins Leukot Essent Fatty Acids. 2013 Jul;89(1):39-45. doi: 10.1016/j.plefa.2013.04.003. Epub 2013 May 7.


Adaptive evolution of the FADS gene cluster within Africa.

Mathias RA, Fu W, Akey JM, Ainsworth HC, Torgerson DG, Ruczinski I, Sergeant S, Barnes KC, Chilton FH.

PLoS One. 2012;7(9):e44926. doi: 10.1371/journal.pone.0044926. Epub 2012 Sep 19.


Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome.

Sergeant S, Hugenschmidt CE, Rudock ME, Ziegler JT, Ivester P, Ainsworth HC, Vaidya D, Case LD, Langefeld CD, Freedman BI, Bowden DW, Mathias RA, Chilton FH.

Br J Nutr. 2012 Feb;107(4):547-55. doi: 10.1017/S0007114511003230. Epub 2011 Jul 4.


The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans.

Mathias RA, Sergeant S, Ruczinski I, Torgerson DG, Hugenschmidt CE, Kubala M, Vaidya D, Suktitipat B, Ziegler JT, Ivester P, Case D, Yanek LR, Freedman BI, Rudock ME, Barnes KC, Langefeld CD, Becker LC, Bowden DW, Becker DM, Chilton FH.

BMC Genet. 2011 May 20;12:50. doi: 10.1186/1471-2156-12-50.


Dietary fish oil modestly attenuates the effect of age on diastolic function but has no effect on memory or brain inflammation in aged rats.

Sergeant S, McQuail JA, Riddle DR, Chilton FH, Ortmeier SB, Jessup JA, Groban L, Nicolle MM.

J Gerontol A Biol Sci Med Sci. 2011 May;66(5):521-33. doi: 10.1093/gerona/glr017. Epub 2011 Mar 10.


Depression and altered serum lipids in cynomolgus monkeys consuming a Western diet.

Chilton FH, Lee TC, Willard SL, Ivester P, Sergeant S, Register TC, Shively CA.

Physiol Behav. 2011 Aug 3;104(2):222-7. doi: 10.1016/j.physbeh.2011.01.013. Epub 2011 Jan 20.


FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population.

Mathias RA, Vergara C, Gao L, Rafaels N, Hand T, Campbell M, Bickel C, Ivester P, Sergeant S, Barnes KC, Chilton FH.

J Lipid Res. 2010 Sep;51(9):2766-74. doi: 10.1194/jlr.M008359. Epub 2010 Jun 19.


Effect of a multifaceted, church-based wellness program on metabolic syndrome in 41 overweight or obese congregants.

Ivester P, Sergeant S, Danhauer SC, Case LD, Lamb A, Chilton BG, Delar B, Hollingshead ML, Weaver KL, Chilton FH.

Prev Chronic Dis. 2010 Jul;7(4):A81. Epub 2010 Jun 15.


Nonpharmacologic treatment of dyslipidemia.

Houston MC, Fazio S, Chilton FH, Wise DE, Jones KB, Barringer TA, Bramlet DA.

Prog Cardiovasc Dis. 2009 Sep-Oct;52(2):61-94. doi: 10.1016/j.pcad.2009.02.002. Review. No abstract available.


Effect of dietary fatty acids on inflammatory gene expression in healthy humans.

Weaver KL, Ivester P, Seeds M, Case LD, Arm JP, Chilton FH.

J Biol Chem. 2009 Jun 5;284(23):15400-7. doi: 10.1074/jbc.M109.004861. Epub 2009 Apr 9.

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