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WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors.

Anastas JN, Kulikauskas RM, Tamir T, Rizos H, Long GV, von Euw EM, Yang PT, Chen HW, Haydu L, Toroni RA, Lucero OM, Chien AJ, Moon RT.

J Clin Invest. 2014 Jul;124(7):2877-90. doi: 10.1172/JCI70156. Epub 2014 May 27.


Targeted BRAF inhibition impacts survival in melanoma patients with high levels of Wnt/β-catenin signaling.

Chien AJ, Haydu LE, Biechele TL, Kulikauskas RM, Rizos H, Kefford RF, Scolyer RA, Moon RT, Long GV.

PLoS One. 2014 Apr 14;9(4):e94748. doi: 10.1371/journal.pone.0094748. eCollection 2014.


Phase I dose-escalation study of 5-day intermittent oral lapatinib therapy in patients with human epidermal growth factor receptor 2-overexpressing breast cancer.

Chien AJ, Munster PN, Melisko ME, Rugo HS, Park JW, Goga A, Auerback G, Khanafshar E, Ordovas K, Koch KM, Moasser MM.

J Clin Oncol. 2014 May 10;32(14):1472-9. doi: 10.1200/JCO.2013.52.1161. Epub 2014 Apr 7.


FAM129B is a novel regulator of Wnt/β-catenin signal transduction in melanoma cells.

Conrad W, Major MB, Cleary MA, Ferrer M, Roberts B, Marine S, Chung N, Arthur WT, Moon RT, Berndt JD, Chien AJ.

Version 2. F1000Res. 2013 May 31 [revised 2013 Oct 10];2:134. doi: 10.12688/f1000research.2-134.v2. eCollection 2013.


Protein kinase PKN1 represses Wnt/β-catenin signaling in human melanoma cells.

James RG, Bosch KA, Kulikauskas RM, Yang PT, Robin NC, Toroni RA, Biechele TL, Berndt JD, von Haller PD, Eng JK, Wolf-Yadlin A, Chien AJ, Moon RT.

J Biol Chem. 2013 Nov 29;288(48):34658-70. doi: 10.1074/jbc.M113.500314. Epub 2013 Oct 10.


Activation of Wnt/β-catenin signaling increases apoptosis in melanoma cells treated with trail.

Zimmerman ZF, Kulikauskas RM, Bomsztyk K, Moon RT, Chien AJ.

PLoS One. 2013 Jul 15;8(7):e69593. doi: 10.1371/journal.pone.0069593. Print 2013.


Developing safety criteria for introducing new agents into neoadjuvant trials.

DeMichele A, Berry DA, Zujewski J, Hunsberger S, Rubinstein L, Tomaszewski JE, Kelloff G, Perlmutter J, Buxton M, Lyandres J, Albain KS, Benz C, Chien AJ, Haluska P, Leyland-Jones B, Liu MC, Munster P, Olopade O, Park JW, Parker BA, Pusztai L, Tripathy D, Rugo H, Yee D, Esserman L.

Clin Cancer Res. 2013 Jun 1;19(11):2817-23. doi: 10.1158/1078-0432.CCR-12-2620. Epub 2013 Mar 7. Review.


WNT7B mediates autocrine Wnt/β-catenin signaling and anchorage-independent growth in pancreatic adenocarcinoma.

Arensman MD, Kovochich AN, Kulikauskas RM, Lay AR, Yang PT, Li X, Donahue T, Major MB, Moon RT, Chien AJ, Dawson DW.

Oncogene. 2014 Feb 13;33(7):899-908. doi: 10.1038/onc.2013.23. Epub 2013 Feb 18.


Emerging treatment options for the management of brain metastases in patients with HER2-positive metastatic breast cancer.

Chien AJ, Rugo HS.

Breast Cancer Res Treat. 2013 Jan;137(1):1-12. doi: 10.1007/s10549-012-2328-6. Epub 2012 Nov 10. Review.


WLS inhibits melanoma cell proliferation through the β-catenin signalling pathway and induces spontaneous metastasis.

Yang PT, Anastas JN, Toroni RA, Shinohara MM, Goodson JM, Bosserhoff AK, Chien AJ, Moon RT.

EMBO Mol Med. 2012 Dec;4(12):1294-307. doi: 10.1002/emmm.201201486. Epub 2012 Nov 6.


Targeting Wnt pathways in disease.

Zimmerman ZF, Moon RT, Chien AJ.

Cold Spring Harb Perspect Biol. 2012 Nov 1;4(11). pii: a008086. doi: 10.1101/cshperspect.a008086. Review.


FAM123A binds to microtubules and inhibits the guanine nucleotide exchange factor ARHGEF2 to decrease actomyosin contractility.

Siesser PF, Motolese M, Walker MP, Goldfarb D, Gewain K, Yan F, Kulikauskas RM, Chien AJ, Wordeman L, Major MB.

Sci Signal. 2012 Sep 4;5(240):ra64. doi: 10.1126/scisignal.2002871.


Regulating the response to targeted MEK inhibition in melanoma: enhancing apoptosis in NRAS- and BRAF-mutant melanoma cells with Wnt/β-catenin activation.

Conrad WH, Swift RD, Biechele TL, Kulikauskas RM, Moon RT, Chien AJ.

Cell Cycle. 2012 Oct 15;11(20):3724-30. doi: 10.4161/cc.21645. Epub 2012 Aug 16.


Wnt/β-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma.

Biechele TL, Kulikauskas RM, Toroni RA, Lucero OM, Swift RD, James RG, Robin NC, Dawson DW, Moon RT, Chien AJ.

Sci Signal. 2012 Jan 10;5(206):ra3. doi: 10.1126/scisignal.2002274.


A phase II study of lapatinib and bevacizumab as treatment for HER2-overexpressing metastatic breast cancer.

Rugo HS, Chien AJ, Franco SX, Stopeck AT, Glencer A, Lahiri S, Arbushites MC, Scott J, Park JW, Hudis C, Nulsen B, Dickler MN.

Breast Cancer Res Treat. 2012 Jul;134(1):13-20. doi: 10.1007/s10549-011-1918-z. Epub 2011 Dec 24.


Dysregulation of Wnt/β-catenin signaling in gastrointestinal cancers.

White BD, Chien AJ, Dawson DW.

Gastroenterology. 2012 Feb;142(2):219-32. doi: 10.1053/j.gastro.2011.12.001. Epub 2011 Dec 8. Review.


Pretreatment fertility counseling and fertility preservation improve quality of life in reproductive age women with cancer.

Letourneau JM, Ebbel EE, Katz PP, Katz A, Ai WZ, Chien AJ, Melisko ME, Cedars MI, Rosen MP.

Cancer. 2012 Mar 15;118(6):1710-7. doi: 10.1002/cncr.26459. Epub 2011 Sep 1.


Acute ovarian failure underestimates age-specific reproductive impairment for young women undergoing chemotherapy for cancer.

Letourneau JM, Ebbel EE, Katz PP, Oktay KH, McCulloch CE, Ai WZ, Chien AJ, Melisko ME, Cedars MI, Rosen MP.

Cancer. 2012 Apr 1;118(7):1933-9. doi: 10.1002/cncr.26403. Epub 2011 Aug 17.


Chemical-genetic screen identifies riluzole as an enhancer of Wnt/β-catenin signaling in melanoma.

Biechele TL, Camp ND, Fass DM, Kulikauskas RM, Robin NC, White BD, Taraska CM, Moore EC, Muster J, Karmacharya R, Haggarty SJ, Chien AJ, Moon RT.

Chem Biol. 2010 Nov 24;17(11):1177-82. doi: 10.1016/j.chembiol.2010.08.012.


A re-evaluation of the "oncogenic" nature of Wnt/beta-catenin signaling in melanoma and other cancers.

Lucero OM, Dawson DW, Moon RT, Chien AJ.

Curr Oncol Rep. 2010 Sep;12(5):314-8. doi: 10.1007/s11912-010-0114-3. Review.

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