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Results: 1 to 20 of 149

1.

Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation.

Phee H, Au-Yeung BB, Pryshchep O, O'Hagan KL, Fairbairn SG, Radu M, Kosoff R, Mollenauer M, Cheng D, Chernoff J, Weiss A.

Elife. 2014 May 13;3:e02270. doi: 10.7554/eLife.02270.

PMID:
24843022
[PubMed]
Free PMC Article
2.

A Pak1/Erk signaling module acts through Gata6 to regulate cardiovascular development in zebrafish.

Kelly ML, Astsaturov A, Rhodes J, Chernoff J.

Dev Cell. 2014 May 12;29(3):350-9. doi: 10.1016/j.devcel.2014.04.003.

PMID:
24823378
[PubMed - indexed for MEDLINE]
3.

Activation of cAMP signaling attenuates impaired hepatic glucose disposal in aged male p21-activated protein kinase-1 knockout mice.

Chiang YT, Ip W, Shao W, Song ZE, Chernoff J, Jin T.

Endocrinology. 2014 Jun;155(6):2122-32. doi: 10.1210/en.2013-1743. Epub 2014 Mar 31.

PMID:
24684301
[PubMed - indexed for MEDLINE]
4.

PAK signalling during the development and progression of cancer.

Radu M, Semenova G, Kosoff R, Chernoff J.

Nat Rev Cancer. 2014 Jan;14(1):13-25. Review.

PMID:
24505617
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Analysis of PTP1B sumoylation.

Saha S, Chernoff J.

Methods. 2014 Jan 15;65(2):201-6. doi: 10.1016/j.ymeth.2013.09.012. Epub 2013 Sep 25.

PMID:
24076082
[PubMed - in process]
6.

p21-Activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils.

Itakura A, Aslan JE, Kusanto BT, Phillips KG, Porter JE, Newton PK, Nan X, Insall RH, Chernoff J, McCarty OJ.

PLoS One. 2013 Sep 3;8(9):e73063. doi: 10.1371/journal.pone.0073063. eCollection 2013.

PMID:
24019894
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas.

Licciulli S, Maksimoska J, Zhou C, Troutman S, Kota S, Liu Q, Duron S, Campbell D, Chernoff J, Field J, Marmorstein R, Kissil JL.

J Biol Chem. 2013 Oct 4;288(40):29105-14. doi: 10.1074/jbc.M113.510933. Epub 2013 Aug 19.

PMID:
23960073
[PubMed - indexed for MEDLINE]
8.

Targeting Cdc42 in cancer.

Arias-Romero LE, Chernoff J.

Expert Opin Ther Targets. 2013 Nov;17(11):1263-73. doi: 10.1517/14728222.2013.828037. Epub 2013 Aug 19. Review.

PMID:
23957315
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation.

Aslan JE, Baker SM, Loren CP, Haley KM, Itakura A, Pang J, Greenberg DL, David LL, Manser E, Chernoff J, McCarty OJ.

Am J Physiol Cell Physiol. 2013 Sep;305(5):C519-28. doi: 10.1152/ajpcell.00418.2012. Epub 2013 Jun 19.

PMID:
23784547
[PubMed - indexed for MEDLINE]
10.

ArhGAP15, a Rac-specific GTPase-activating protein, plays a dual role in inhibiting small GTPase signaling.

Radu M, Rawat SJ, Beeser A, Iliuk A, Tao WA, Chernoff J.

J Biol Chem. 2013 Jul 19;288(29):21117-25. doi: 10.1074/jbc.M113.459719. Epub 2013 Jun 11.

PMID:
23760270
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Role of p21-activated kinases in cardiovascular development and function.

Kelly ML, Astsaturov A, Chernoff J.

Cell Mol Life Sci. 2013 Nov;70(22):4223-8. doi: 10.1007/s00018-013-1347-8. Epub 2013 May 4. Review.

PMID:
23640572
[PubMed - indexed for MEDLINE]
12.

p21 activated kinase signaling coordinates glycoprotein receptor VI-mediated platelet aggregation, lamellipodia formation, and aggregate stability under shear.

Aslan JE, Itakura A, Haley KM, Tormoen GW, Loren CP, Baker SM, Pang J, Chernoff J, McCarty OJ.

Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1544-51. doi: 10.1161/ATVBAHA.112.301165. Epub 2013 May 2.

PMID:
23640496
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells.

Arias-Romero LE, Villamar-Cruz O, Huang M, Hoeflich KP, Chernoff J.

Cancer Res. 2013 Jun 15;73(12):3671-82. doi: 10.1158/0008-5472.CAN-12-4453. Epub 2013 Apr 10.

PMID:
23576562
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

An in vivo assay to test blood vessel permeability.

Radu M, Chernoff J.

J Vis Exp. 2013 Mar 16;(73):e50062. doi: 10.3791/50062.

PMID:
23524912
[PubMed - indexed for MEDLINE]
15.

The tumor suppressor Mst1 promotes changes in the cellular redox state by phosphorylation and inactivation of peroxiredoxin-1 protein.

Rawat SJ, Creasy CL, Peterson JR, Chernoff J.

J Biol Chem. 2013 Mar 22;288(12):8762-71. doi: 10.1074/jbc.M112.414524. Epub 2013 Feb 5.

PMID:
23386615
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment.

Dorrance AM, De Vita S, Radu M, Reddy PN, McGuinness MK, Harris CE, Mathieu R, Lane SW, Kosoff R, Milsom MD, Chernoff J, Williams DA.

Blood. 2013 Mar 28;121(13):2474-82. doi: 10.1182/blood-2012-10-460709. Epub 2013 Jan 18.

PMID:
23335370
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

p-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways.

Huynh N, Yim M, Chernoff J, Shulkes A, Baldwin GS, He H.

Am J Physiol Gastrointest Liver Physiol. 2013 Mar 15;304(6):G561-7. doi: 10.1152/ajpgi.00218.2012. Epub 2013 Jan 10.

PMID:
23306081
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

p21-activated kinase inhibitors.

Rudolph J, Crawford JJ, Hoeflich KP, Chernoff J.

Enzymes. 2013;34 Pt. B:157-80. doi: 10.1016/B978-0-12-420146-0.00007-X. Epub 2013 Nov 7. Review.

PMID:
25034104
[PubMed - indexed for MEDLINE]
19.

Pak2 kinase restrains mast cell FcεRI receptor signaling through modulation of Rho protein guanine nucleotide exchange factor (GEF) activity.

Kosoff R, Chow HY, Radu M, Chernoff J.

J Biol Chem. 2013 Jan 11;288(2):974-83. doi: 10.1074/jbc.M112.422295. Epub 2012 Nov 30.

PMID:
23204526
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

P21-activated protein kinase 1 (Pak1) mediates the cross talk between insulin and β-catenin on proglucagon gene expression and its ablation affects glucose homeostasis in male C57BL/6 mice.

Chiang YA, Shao W, Xu XX, Chernoff J, Jin T.

Endocrinology. 2013 Jan;154(1):77-88. doi: 10.1210/en.2012-1781. Epub 2012 Nov 26.

PMID:
23183186
[PubMed - indexed for MEDLINE]

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