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Items: 1 to 20 of 164


Does salmon calcitonin cause cancer? A review and meta-analysis.

Wells G, Chernoff J, Gilligan JP, Krause DS.

Osteoporos Int. 2016 Jan;27(1):13-9. doi: 10.1007/s00198-015-3339-z. Epub 2015 Oct 5.


p21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 Pathway.

Radu M, Lyle K, Hoeflich KP, Villamar-Cruz O, Koeppen H, Chernoff J.

Mol Cell Biol. 2015 Dec;35(23):3990-4005. doi: 10.1128/MCB.00630-15. Epub 2015 Sep 21.


Effects of p21-activated kinase 1 inhibition on 11q13-amplified ovarian cancer cells.

Prudnikova TY, Villamar-Cruz O, Rawat SJ, Cai KQ, Chernoff J.

Oncogene. 2015 Aug 10. doi: 10.1038/onc.2015.278. [Epub ahead of print]


PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome.

Pandolfi A, Stanley RF, Yu Y, Bartholdy B, Pendurti G, Gritsman K, Boultwood J, Chernoff J, Verma A, Steidl U.

Blood. 2015 Aug 27;126(9):1118-27. doi: 10.1182/blood-2014-12-618801. Epub 2015 Jul 13.


Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance.

O'Hagan KL, Choi J, Pryshchep O, Chernoff J, Phee H.

J Immunol. 2015 Aug 15;195(4):1564-77. doi: 10.4049/jimmunol.1500843. Epub 2015 Jul 8.


Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice.

Singh NK, Kotla S, Dyukova E, Traylor JG Jr, Orr AW, Chernoff J, Marion TN, Rao GN.

Nat Commun. 2015 Jun 24;6:7450. doi: 10.1038/ncomms8450.


Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents.

Ong CC, Gierke S, Pitt C, Sagolla M, Cheng CK, Zhou W, Jubb AM, Strickland L, Schmidt M, Duron SG, Campbell DA, Zheng W, Dehdashti S, Shen M, Yang N, Behnke ML, Huang W, McKew JC, Chernoff J, Forrest WF, Haverty PM, Chin SF, Rakha EA, Green AR, Ellis IO, Caldas C, O'Brien T, Friedman LS, Koeppen H, Rudolph J, Hoeflich KP.

Breast Cancer Res. 2015 Apr 23;17:59. doi: 10.1186/s13058-015-0564-5.


Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization.

Kosoff RE, Aslan JE, Kostyak JC, Dulaimi E, Chow HY, Prudnikova TY, Radu M, Kunapuli SP, McCarty OJ, Chernoff J.

Blood. 2015 May 7;125(19):2995-3005. doi: 10.1182/blood-2014-10-604504. Epub 2015 Mar 30.


Regulation of mammalian Ste20 (Mst) kinases.

Rawat SJ, Chernoff J.

Trends Biochem Sci. 2015 Mar;40(3):149-56. doi: 10.1016/j.tibs.2015.01.001. Epub 2015 Feb 6. Review.


Group I Paks as therapeutic targets in NF2-deficient meningioma.

Chow HY, Dong B, Duron SG, Campbell DA, Ong CC, Hoeflich KP, Chang LS, Welling DB, Yang ZJ, Chernoff J.

Oncotarget. 2015 Feb 10;6(4):1981-94.


Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation.

Zeng Y, Broxmeyer HE, Staser K, Chitteti BR, Park SJ, Hahn S, Cooper S, Sun Z, Jiang L, Yang X, Yuan J, Kosoff R, Sandusky G, Srour EF, Chernoff J, Clapp DW.

Stem Cells. 2015 May;33(5):1630-41. doi: 10.1002/stem.1951.


Potential compensation among group I PAK members in hindlimb ischemia and wound healing.

Elsherif L, Ozler M, Zayed MA, Shen JH, Chernoff J, Faber JE, Parise LV.

PLoS One. 2014 Nov 7;9(11):e112239. doi: 10.1371/journal.pone.0112239. eCollection 2014.


Molecular pathways: targeting the kinase effectors of RHO-family GTPases.

Prudnikova TY, Rawat SJ, Chernoff J.

Clin Cancer Res. 2015 Jan 1;21(1):24-9. doi: 10.1158/1078-0432.CCR-14-0827. Epub 2014 Oct 21. Erratum in: Clin Cancer Res. 2015 Apr 1;21(7):1772.


Gq-mediated Akt translocation to the membrane: a novel PIP3-independent mechanism in platelets.

Badolia R, Manne BK, Dangelmaier C, Chernoff J, Kunapuli SP.

Blood. 2015 Jan 1;125(1):175-84. doi: 10.1182/blood-2014-05-576306. Epub 2014 Oct 20.


Molecular pathways: targeting RAC-p21-activated serine-threonine kinase signaling in RAS-driven cancers.

Baker NM, Yee Chow H, Chernoff J, Der CJ.

Clin Cancer Res. 2014 Sep 15;20(18):4740-6. doi: 10.1158/1078-0432.CCR-13-1727. Review.


Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation.

Phee H, Au-Yeung BB, Pryshchep O, O'Hagan KL, Fairbairn SG, Radu M, Kosoff R, Mollenauer M, Cheng D, Chernoff J, Weiss A.

Elife. 2014 May 13;3:e02270. doi: 10.7554/eLife.02270.


A Pak1/Erk signaling module acts through Gata6 to regulate cardiovascular development in zebrafish.

Kelly ML, Astsaturov A, Rhodes J, Chernoff J.

Dev Cell. 2014 May 12;29(3):350-9. doi: 10.1016/j.devcel.2014.04.003.


Activation of cAMP signaling attenuates impaired hepatic glucose disposal in aged male p21-activated protein kinase-1 knockout mice.

Chiang YT, Ip W, Shao W, Song ZE, Chernoff J, Jin T.

Endocrinology. 2014 Jun;155(6):2122-32. doi: 10.1210/en.2013-1743. Epub 2014 Mar 31.


PAK signalling during the development and progression of cancer.

Radu M, Semenova G, Kosoff R, Chernoff J.

Nat Rev Cancer. 2014 Jan;14(1):13-25. Review.


Analysis of PTP1B sumoylation.

Saha S, Chernoff J.

Methods. 2014 Jan 15;65(2):201-6. doi: 10.1016/j.ymeth.2013.09.012. Epub 2013 Sep 25.

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