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Results: 1 to 20 of 45

1.

Chromatin modifiers and remodellers: regulators of cellular differentiation.

Chen T, Dent SY.

Nat Rev Genet. 2014 Feb;15(2):93-106. doi: 10.1038/nrg3607. Epub 2013 Dec 24. Review.

PMID:
24366184
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells.

Kim SJ, Zhao H, Hardikar S, Singh AK, Goodell MA, Chen T.

Blood. 2013 Dec 12;122(25):4086-9. doi: 10.1182/blood-2013-02-483487. Epub 2013 Oct 28.

PMID:
24167195
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Small molecule R1498 as a well-tolerated and orally active kinase inhibitor for hepatocellular carcinoma and gastric cancer treatment via targeting angiogenesis and mitosis pathways.

Zhang C, Wu X, Zhang M, Zhu L, Zhao R, Xu D, Lin Z, Liang C, Chen T, Chen L, Ren Y, Zhang J, Qin N, Zhang X.

PLoS One. 2013 Jun 5;8(6):e65264. doi: 10.1371/journal.pone.0065264. Print 2013.

PMID:
23755206
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Tet family of 5-methylcytosine dioxygenases in mammalian development.

Zhao H, Chen T.

J Hum Genet. 2013 Jul;58(7):421-7. doi: 10.1038/jhg.2013.63. Epub 2013 May 30. Review.

PMID:
23719188
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

A hypomorphic lsd1 allele results in heart development defects in mice.

Nicholson TB, Singh AK, Su H, Hevi S, Wang J, Bajko J, Li M, Valdez R, Goetschkes M, Capodieci P, Loureiro J, Cheng X, Li E, Kinzel B, Labow M, Chen T.

PLoS One. 2013 Apr 24;8(4):e60913. doi: 10.1371/journal.pone.0060913. Print 2013.

PMID:
23637775
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Pharmacokinetic optimization of class-selective histone deacetylase inhibitors and identification of associated candidate predictive biomarkers of hepatocellular carcinoma tumor response.

Wong JC, Tang G, Wu X, Liang C, Zhang Z, Guo L, Peng Z, Zhang W, Lin X, Wang Z, Mei J, Chen J, Pan S, Zhang N, Liu Y, Zhou M, Feng L, Zhao W, Li S, Zhang C, Zhang M, Rong Y, Jin TG, Zhang X, Ren S, Ji Y, Zhao R, She J, Ren Y, Xu C, Chen D, Cai J, Shan S, Pan D, Ning Z, Lu X, Chen T, He Y, Chen L.

J Med Chem. 2012 Oct 25;55(20):8903-25. doi: 10.1021/jm3011838. Epub 2012 Oct 12.

PMID:
23061376
[PubMed - indexed for MEDLINE]
7.

DNA methyltransferase 1 (Dnmt1) mutation affects Snrpn imprinting in the mouse male germ line.

Saferali A, Moussette S, Chan D, Trasler J, Chen T, Rozen R, Naumova AK.

Genome. 2012 Sep;55(9):673-82. doi: 10.1139/g2012-056. Epub 2012 Sep 11.

PMID:
22967183
[PubMed - indexed for MEDLINE]
8.

Overcoming erlotinib resistance with tailored treatment regimen in patient-derived xenografts from naïve Asian NSCLC patients.

Yang M, Shan B, Li Q, Song X, Cai J, Deng J, Zhang L, Du Z, Lu J, Chen T, Wery JP, Chen Y, Li Q.

Int J Cancer. 2013 Jan 15;132(2):E74-84. doi: 10.1002/ijc.27813. Epub 2012 Oct 3.

PMID:
22948846
[PubMed - indexed for MEDLINE]
9.

Retraction: Defective heart development in hypomorphic LSD1 mice.

Nicholson TB, Su H, Hevi S, Wang J, Bajko J, Li M, Valdez R, Loureiro J, Cheng X, Li E, Kinzel B, Labow M, Chen T.

Cell Res. 2012 Apr 10. doi: 10.1038/cr.2012.60. [Epub ahead of print] No abstract available.

PMID:
22491473
[PubMed - as supplied by publisher]
10.

Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells.

Stadtfeld M, Apostolou E, Ferrari F, Choi J, Walsh RM, Chen T, Ooi SS, Kim SY, Bestor TH, Shioda T, Park PJ, Hochedlinger K.

Nat Genet. 2012 Mar 4;44(4):398-405, S1-2. doi: 10.1038/ng.1110.

PMID:
22387999
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

WITHDRAWN: Defective heart development in hypomorphic LSD1 mice.

Nicholson TB, Su H, Hevi S, Wang J, Bajko J, Li M, Valdez R, Loureiro J, Cheng X, Li E, Kinzel B, Labow M, Chen T.

Cell Res. 2011 Dec 6. doi: 10.1038/cr.2011.194. [Epub ahead of print]

PMID:
22143567
[PubMed - as supplied by publisher]
12.

Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells.

Xu Y, Wu F, Tan L, Kong L, Xiong L, Deng J, Barbera AJ, Zheng L, Zhang H, Huang S, Min J, Nicholson T, Chen T, Xu G, Shi Y, Zhang K, Shi YG.

Mol Cell. 2011 May 20;42(4):451-64. doi: 10.1016/j.molcel.2011.04.005. Epub 2011 Apr 21.

PMID:
21514197
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Mechanistic and functional links between histone methylation and DNA methylation.

Chen T.

Prog Mol Biol Transl Sci. 2011;101:335-48. doi: 10.1016/B978-0-12-387685-0.00010-X. Review.

PMID:
21507357
[PubMed - indexed for MEDLINE]
14.

Regulation and function of DNA methylation in plants and animals.

He XJ, Chen T, Zhu JK.

Cell Res. 2011 Mar;21(3):442-65. doi: 10.1038/cr.2011.23. Epub 2011 Feb 15. Review.

PMID:
21321601
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

DOT1L regulates dystrophin expression and is critical for cardiac function.

Nguyen AT, Xiao B, Neppl RL, Kallin EM, Li J, Chen T, Wang DZ, Xiao X, Zhang Y.

Genes Dev. 2011 Feb 1;25(3):263-74. doi: 10.1101/gad.2018511.

PMID:
21289070
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells.

Cho HS, Suzuki T, Dohmae N, Hayami S, Unoki M, Yoshimatsu M, Toyokawa G, Takawa M, Chen T, Kurash JK, Field HI, Ponder BA, Nakamura Y, Hamamoto R.

Cancer Res. 2011 Feb 1;71(3):655-60. doi: 10.1158/0008-5472.CAN-10-2446. Epub 2010 Nov 29.

PMID:
21115810
[PubMed - indexed for MEDLINE]
Free Article
17.

Allele-specific H3K79 Di- versus trimethylation distinguishes opposite parental alleles at imprinted regions.

Singh P, Han L, Rivas GE, Lee DH, Nicholson TB, Larson GP, Chen T, Szabó PE.

Mol Cell Biol. 2010 Jun;30(11):2693-707. doi: 10.1128/MCB.01537-09. Epub 2010 Mar 29.

PMID:
20351169
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

KMT1E mediated H3K9 methylation is required for the maintenance of embryonic stem cells by repressing trophectoderm differentiation.

Lohmann F, Loureiro J, Su H, Fang Q, Lei H, Lewis T, Yang Y, Labow M, Li E, Chen T, Kadam S.

Stem Cells. 2010 Feb;28(2):201-12. doi: 10.1002/stem.278.

PMID:
20014010
[PubMed - indexed for MEDLINE]
Free Article
19.

KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints.

Ciccone DN, Su H, Hevi S, Gay F, Lei H, Bajko J, Xu G, Li E, Chen T.

Nature. 2009 Sep 17;461(7262):415-8. doi: 10.1038/nature08315. Epub 2009 Sep 2.

PMID:
19727073
[PubMed - indexed for MEDLINE]
20.

The physiological and pathophysiological role of PRMT1-mediated protein arginine methylation.

Nicholson TB, Chen T, Richard S.

Pharmacol Res. 2009 Dec;60(6):466-74. doi: 10.1016/j.phrs.2009.07.006. Epub 2009 Jul 28. Review.

PMID:
19643181
[PubMed - indexed for MEDLINE]
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