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Results: 1 to 20 of 122


A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury.

Dal-Secco D, Wang J, Zeng Z, Kolaczkowska E, Wong CH, Petri B, Ransohoff RM, Charo IF, Jenne CN, Kubes P.

J Exp Med. 2015 Apr 6;212(4):447-56. doi: 10.1084/jem.20141539. Epub 2015 Mar 23.


Differential roles of microglia and monocytes in the inflamed central nervous system.

Yamasaki R, Lu H, Butovsky O, Ohno N, Rietsch AM, Cialic R, Wu PM, Doykan CE, Lin J, Cotleur AC, Kidd G, Zorlu MM, Sun N, Hu W, Liu L, Lee JC, Taylor SE, Uehlein L, Dixon D, Gu J, Floruta CM, Zhu M, Charo IF, Weiner HL, Ransohoff RM.

J Exp Med. 2014 Jul 28;211(8):1533-49. doi: 10.1084/jem.20132477. Epub 2014 Jul 7.


Alkylsulfone-containing trisubstituted cyclohexanes as potent and bioavailable chemokine receptor 2 (CCR2) antagonists.

Cherney RJ, Mo R, Yang MG, Xiao Z, Zhao Q, Mandlekar S, Cvijic ME, Charo IF, Barrish JC, Decicco CP, Carter PH.

Bioorg Med Chem Lett. 2014 Apr 1;24(7):1843-5. doi: 10.1016/j.bmcl.2014.02.013. Epub 2014 Feb 21.


CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice.

Sennlaub F, Auvynet C, Calippe B, Lavalette S, Poupel L, Hu SJ, Dominguez E, Camelo S, Levy O, Guyon E, Saederup N, Charo IF, Rooijen NV, Nandrot E, Bourges JL, Behar-Cohen F, Sahel JA, Guillonneau X, Raoul W, Combadiere C.

EMBO Mol Med. 2013 Nov;5(11):1775-93. doi: 10.1002/emmm.201302692. Epub 2013 Oct 21.


B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction.

Zouggari Y, Ait-Oufella H, Bonnin P, Simon T, Sage AP, Guérin C, Vilar J, Caligiuri G, Tsiantoulas D, Laurans L, Dumeau E, Kotti S, Bruneval P, Charo IF, Binder CJ, Danchin N, Tedgui A, Tedder TF, Silvestre JS, Mallat Z.

Nat Med. 2013 Oct;19(10):1273-80. doi: 10.1038/nm.3284. Epub 2013 Sep 15.


Dual effect of chemokine CCL7/MCP-3 in the development of renal tubulointerstitial fibrosis.

Gonzalez J, Mouttalib S, Delage C, Calise D, Maoret JJ, Pradère JP, Klein J, Buffin-Meyer B, Van der Veen B, Charo IF, Heeringa P, Duchene J, Bascands JL, Schanstra JP.

Biochem Biophys Res Commun. 2013 Aug 23;438(2):257-63. doi: 10.1016/j.bbrc.2013.07.025. Epub 2013 Jul 19.


Regulation of adaptive immunity by the fractalkine receptor during autoimmune inflammation.

Garcia JA, Pino PA, Mizutani M, Cardona SM, Charo IF, Ransohoff RM, Forsthuber TG, Cardona AE.

J Immunol. 2013 Aug 1;191(3):1063-72. doi: 10.4049/jimmunol.1300040. Epub 2013 Jul 1.


Blinding the monocytes to protect the heart.

Charo IF.

Circulation. 2013 May 21;127(20):2006-8. doi: 10.1161/CIRCULATIONAHA.113.003045. Epub 2013 Apr 24. No abstract available.


Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells.

Varvel NH, Grathwohl SA, Baumann F, Liebig C, Bosch A, Brawek B, Thal DR, Charo IF, Heppner FL, Aguzzi A, Garaschuk O, Ransohoff RM, Jucker M.

Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):18150-5. doi: 10.1073/pnas.1210150109. Epub 2012 Oct 15.


Characterization of CCX140-B, an orally bioavailable antagonist of the CCR2 chemokine receptor, for the treatment of type 2 diabetes and associated complications.

Sullivan TJ, Dairaghi DJ, Krasinski A, Miao Z, Wang Y, Zhao BN, Baumgart T, Berahovich R, Ertl LS, Pennell A, Seitz L, Miao S, Ungashe S, Wei Z, Johnson D, Boring L, Tsou CL, Charo IF, Bekker P, Schall TJ, Jaen JC.

J Pharmacol Exp Ther. 2012 Jun 5. doi: 10.1124/jpet.111.190918. Epub 2012 Jun 5. Retraction in: J Pharmacol Exp Ther. 2012 Jul;342(1):234.


Resolving postoperative neuroinflammation and cognitive decline.

Terrando N, Eriksson LI, Ryu JK, Yang T, Monaco C, Feldmann M, Jonsson Fagerlund M, Charo IF, Akassoglou K, Maze M.

Ann Neurol. 2011 Dec;70(6):986-95. doi: 10.1002/ana.22664.


The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood.

Mizutani M, Pino PA, Saederup N, Charo IF, Ransohoff RM, Cardona AE.

J Immunol. 2012 Jan 1;188(1):29-36. doi: 10.4049/jimmunol.1100421. Epub 2011 Nov 11.


Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine.

Lewis KL, Caton ML, Bogunovic M, Greter M, Grajkowska LT, Ng D, Klinakis A, Charo IF, Jung S, Gommerman JL, Ivanov II, Liu K, Merad M, Reizis B.

Immunity. 2011 Nov 23;35(5):780-91. doi: 10.1016/j.immuni.2011.08.013. Epub 2011 Oct 20.


Anti-inflammatory therapeutics for the treatment of atherosclerosis.

Charo IF, Taub R.

Nat Rev Drug Discov. 2011 May;10(5):365-76. doi: 10.1038/nrd3444. Review.


Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells.

Islam SA, Chang DS, Colvin RA, Byrne MH, McCully ML, Moser B, Lira SA, Charo IF, Luster AD.

Nat Immunol. 2011 Feb;12(2):167-77. doi: 10.1038/ni.1984. Epub 2011 Jan 9.


Selective chemokine receptor usage by central nervous system myeloid cells in CCR2-red fluorescent protein knock-in mice.

Saederup N, Cardona AE, Croft K, Mizutani M, Cotleur AC, Tsou CL, Ransohoff RM, Charo IF.

PLoS One. 2010 Oct 27;5(10):e13693. doi: 10.1371/journal.pone.0013693.


Macrophages recruited via CCR2 produce insulin-like growth factor-1 to repair acute skeletal muscle injury.

Lu H, Huang D, Saederup N, Charo IF, Ransohoff RM, Zhou L.

FASEB J. 2011 Jan;25(1):358-69. doi: 10.1096/fj.10-171579. Epub 2010 Oct 1.


Zmynd15 encodes a histone deacetylase-dependent transcriptional repressor essential for spermiogenesis and male fertility.

Yan W, Si Y, Slaymaker S, Li J, Zheng H, Young DL, Aslanian A, Saunders L, Verdin E, Charo IF.

J Biol Chem. 2010 Oct 8;285(41):31418-26. doi: 10.1074/jbc.M110.116418. Epub 2010 Jul 30.


Neutrophil-dominant experimental autoimmune uveitis in CC-chemokine receptor 2 knockout mice.

Sonoda KH, Yoshimura T, Egashira K, Charo IF, Ishibashi T.

Acta Ophthalmol. 2011 Mar;89(2):e180-8. doi: 10.1111/j.1755-3768.2010.01953.x.


CCR2 mediates hematopoietic stem and progenitor cell trafficking to sites of inflammation in mice.

Si Y, Tsou CL, Croft K, Charo IF.

J Clin Invest. 2010 Apr;120(4):1192-203. doi: 10.1172/JCI40310. Epub 2010 Mar 15.

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