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Further characterisation of transmissible spongiform encephalopathy phenotypes after inoculation of cattle with two temporally separated sources of sheep scrapie from Great Britain.

Konold T, Nonno R, Spiropoulos J, Chaplin MJ, Stack MJ, Hawkins SA, Cawthraw S, Wilesmith JW, Wells GA, Agrimi U, Di Bari MA, Andréoletti O, Espinosa JC, Aguilar-Calvo P, Torres JM.

BMC Res Notes. 2015 Jul 24;8:312. doi: 10.1186/s13104-015-1260-3.


Does the Presence of Scrapie Affect the Ability of Current Statutory Discriminatory Tests To Detect the Presence of Bovine Spongiform Encephalopathy?

Simmons MM, Chaplin MJ, Vickery CM, Simon S, Davis L, Denyer M, Lockey R, Stack MJ, O'Connor MJ, Bishop K, Gough KC, Maddison BC, Thorne L, Spiropoulos J.

J Clin Microbiol. 2015 Aug;53(8):2593-604. doi: 10.1128/JCM.00508-15. Epub 2015 Jun 3.


Phenotype shift from atypical scrapie to CH1641 following experimental transmission in sheep.

Simmons MM, Moore SJ, Lockey R, Chaplin MJ, Konold T, Vickery C, Spiropoulos J.

PLoS One. 2015 Feb 24;10(2):e0117063. doi: 10.1371/journal.pone.0117063. eCollection 2015.


The pathological and molecular but not clinical phenotypes are maintained after second passage of experimental atypical bovine spongiform encephalopathy in cattle.

Konold T, Phelan LJ, Clifford D, Chaplin MJ, Cawthraw S, Stack MJ, Simmons MM.

BMC Vet Res. 2014 Oct 2;10:243. doi: 10.1186/s12917-014-0243-2.


Unsuccessful oral transmission of scrapie from British sheep to cattle.

Konold T, Spiropoulos J, Chaplin MJ, Stack MJ, Hawkins SA, Wilesmith JW, Wells GA.

Vet Rec. 2013 Aug 3;173(5):118. doi: 10.1136/vr.101286. Epub 2013 May 30. No abstract available.


Four BSE cases with an L-BSE molecular profile in cattle from Great Britain.

Stack MJ, Chaplin MJ, Davis LA, Everitt S, Simmons MM, Windl O, Hope J, Burke P.

Vet Rec. 2013 Jan 19;172(3):70. doi: 10.1136/vr.101158. Epub 2012 Dec 18.


Experimental H-type and L-type bovine spongiform encephalopathy in cattle: observation of two clinical syndromes and diagnostic challenges.

Konold T, Bone GE, Clifford D, Chaplin MJ, Cawthraw S, Stack MJ, Simmons MM.

BMC Vet Res. 2012 Mar 8;8:22. doi: 10.1186/1746-6148-8-22.


Studies of the transmissibility of the agent of bovine spongiform encephalopathy to the domestic chicken.

Moore J, Hawkins SA, Austin AR, Konold T, Green RB, Blamire IW, Dexter I, Stack MJ, Chaplin MJ, Langeveld JP, Simmons MM, Spencer YI, Webb PR, Dawson M, Wells GA.

BMC Res Notes. 2011 Nov 17;4:501. doi: 10.1186/1756-0500-4-501.


Detection and localisation of PrP(Sc) in the liver of sheep infected with scrapie and bovine spongiform encephalopathy.

Everest SJ, Ramsay AM, Chaplin MJ, Everitt S, Stack MJ, Neale MH, Jeffrey M, Moore SJ, Bellworthy SJ, Terry LA.

PLoS One. 2011 May 12;6(5):e19737. doi: 10.1371/journal.pone.0019737.


Experimental oral transmission of atypical scrapie to sheep.

Simmons MM, Moore SJ, Konold T, Thurston L, Terry LA, Thorne L, Lockey R, Vickery C, Hawkins SA, Chaplin MJ, Spiropoulos J.

Emerg Infect Dis. 2011 May;17(5):848-54. doi: 10.3201/eid1705.101654.


Experimental bovine spongiform encephalopathy: detection of PrP(Sc) in the small intestine relative to exposure dose and age.

Stack MJ, Moore SJ, Vidal-Diez A, Arnold ME, Jones EM, Spencer YI, Webb P, Spiropoulos J, Powell L, Bellerby P, Thurston L, Cooper J, Chaplin MJ, Davis LA, Everitt S, Focosi-Snyman R, Hawkins SA, Simmons MM, Wells GA.

J Comp Pathol. 2011 Aug-Oct;145(2-3):289-301. doi: 10.1016/j.jcpa.2011.01.010. Epub 2011 Mar 8.


Atypical scrapie/Nor98 in a sheep from New Zealand.

Kittelberger R, Chaplin MJ, Simmons MM, Ramirez-Villaescusa A, McIntyre L, MacDiarmid SC, Hannah MJ, Jenner J, Bueno R, Bayliss D, Black H, Pigott CJ, O'Keefe JS.

J Vet Diagn Invest. 2010 Nov;22(6):863-75. Erratum in: J Vet Diagn Invest. 2011 Jan;23(1):178.


The natural atypical scrapie phenotype is preserved on experimental transmission and sub-passage in PRNP homologous sheep.

Simmons MM, Konold T, Thurston L, Bellworthy SJ, Chaplin MJ, Moore SJ.

BMC Vet Res. 2010 Mar 10;6:14. doi: 10.1186/1746-6148-6-14.


Third atypical BSE case in Great Britain with an H-type molecular profile.

Stack MJ, Focosi-Snyman R, Cawthraw S, Davis L, Chaplin MJ, Burke PJ.

Vet Rec. 2009 Nov 14;165(20):605-6. No abstract available.


Transmissibility studies of vacuolar changes in the rostral colliculus of pigs.

Konold T, Spiropoulos J, Chaplin MJ, Thorne L, Spencer YI, Wells GA, Hawkins SA.

BMC Vet Res. 2009 Sep 18;5:35. doi: 10.1186/1746-6148-5-35.


Immunohistochemical and biochemical characteristics of BSE and CWD in experimentally infected European red deer (Cervus elaphus elaphus).

Martin S, Jeffrey M, González L, Sisó S, Reid HW, Steele P, Dagleish MP, Stack MJ, Chaplin MJ, Balachandran A.

BMC Vet Res. 2009 Jul 27;5:26. doi: 10.1186/1746-6148-5-26.


Atypical scrapie in sheep from a UK research flock which is free from classical scrapie.

Simmons HA, Simmons MM, Spencer YI, Chaplin MJ, Povey G, Davis A, Ortiz-Pelaez A, Hunter N, Matthews D, Wrathall AE.

BMC Vet Res. 2009 Feb 10;5:8. doi: 10.1186/1746-6148-5-8.


Pruritus is a common feature in sheep infected with the BSE agent.

Konold T, Bone G, Vidal-Diez A, Tortosa R, Davis A, Dexter G, Hill P, Jeffrey M, Simmons MM, Chaplin MJ, Bellworthy SJ, Berthelin-Baker C.

BMC Vet Res. 2008 Apr 29;4:16. doi: 10.1186/1746-6148-4-16.


First case of H-type bovine spongiform encephalopathy identified in Great Britain.

Terry LA, Jenkins R, Thorne L, Everest SJ, Chaplin MJ, Davis LA, Stack MJ.

Vet Rec. 2007 Jun 23;160(25):873-4. No abstract available.


Postmortem diagnosis of preclinical and clinical scrapie in sheep by the detection of disease-associated PrP in their rectal mucosa.

González L, Dagleish MP, Bellworthy SJ, Sisó S, Stack MJ, Chaplin MJ, Davis LA, Hawkins SA, Hughes J, Jeffrey M.

Vet Rec. 2006 Mar 11;158(10):325-31.

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