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Items: 17


Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway.

Saxton RA, Knockenhauer KE, Wolfson RL, Chantranupong L, Pacold ME, Wang T, Schwartz TU, Sabatini DM.

Science. 2015 Nov 19. pii: aad2087. [Epub ahead of print]


Sestrin2 is a leucine sensor for the mTORC1 pathway.

Wolfson RL, Chantranupong L, Saxton RA, Shen K, Scaria SM, Cantor JR, Sabatini DM.

Science. 2015 Oct 8. pii: aab2674. [Epub ahead of print]


Nutrient-sensing mechanisms across evolution.

Chantranupong L, Wolfson RL, Sabatini DM.

Cell. 2015 Mar 26;161(1):67-83. doi: 10.1016/j.cell.2015.02.041. Review.


Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.

Wang S, Tsun ZY, Wolfson RL, Shen K, Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L, Comb W, Wang T, Bar-Peled L, Zoncu R, Straub C, Kim C, Park J, Sabatini BL, Sabatini DM.

Science. 2015 Jan 9;347(6218):188-94. doi: 10.1126/science.1257132. Epub 2015 Jan 7.


The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1.

Chantranupong L, Wolfson RL, Orozco JM, Saxton RA, Scaria SM, Bar-Peled L, Spooner E, Isasa M, Gygi SP, Sabatini DM.

Cell Rep. 2014 Oct 9;9(1):1-8. doi: 10.1016/j.celrep.2014.09.014. Epub 2014 Sep 25.


The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.

Tsun ZY, Bar-Peled L, Chantranupong L, Zoncu R, Wang T, Kim C, Spooner E, Sabatini DM.

Mol Cell. 2013 Nov 21;52(4):495-505. doi: 10.1016/j.molcel.2013.09.016. Epub 2013 Oct 3.


A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.

Bar-Peled L, Chantranupong L, Cherniack AD, Chen WW, Ottina KA, Grabiner BC, Spear ED, Carter SL, Meyerson M, Sabatini DM.

Science. 2013 May 31;340(6136):1100-6. doi: 10.1126/science.1232044.


Uncoupling intramolecular processing and substrate hydrolysis in the N-terminal nucleophile hydrolase hASRGL1 by circular permutation.

Li W, Cantor JR, Yogesha SD, Yang S, Chantranupong L, Liu JQ, Agnello G, Georgiou G, Stone EM, Zhang Y.

ACS Chem Biol. 2012 Nov 16;7(11):1840-7. doi: 10.1021/cb300232n. Epub 2012 Aug 29.


SCHEMA-designed variants of human Arginase I and II reveal sequence elements important to stability and catalysis.

Romero PA, Stone E, Lamb C, Chantranupong L, Krause A, Miklos AE, Hughes RA, Fechtel B, Ellington AD, Arnold FH, Georgiou G.

ACS Synth Biol. 2012 Jun 15;1(6):221-8.


A unifying model for mTORC1-mediated regulation of mRNA translation.

Thoreen CC, Chantranupong L, Keys HR, Wang T, Gray NS, Sabatini DM.

Nature. 2012 May 2;485(7396):109-13. doi: 10.1038/nature11083.


A common, non-optimal phenotypic endpoint in experimental adaptations of bacteriophage lysis time.

Chantranupong L, Heineman RH.

BMC Evol Biol. 2012 Mar 19;12:37. doi: 10.1186/1471-2148-12-37.


Strategies for optimizing the serum persistence of engineered human arginase I for cancer therapy.

Stone E, Chantranupong L, Gonzalez C, O'Neal J, Rani M, VanDenBerg C, Georgiou G.

J Control Release. 2012 Feb 28;158(1):171-9. doi: 10.1016/j.jconrel.2011.09.097. Epub 2011 Oct 6.


The second-shell metal ligands of human arginase affect coordination of the nucleophile and substrate.

Stone EM, Chantranupong L, Georgiou G.

Biochemistry. 2010 Dec 14;49(49):10582-8. doi: 10.1021/bi101542t. Epub 2010 Nov 12.


Replacing Mn(2+) with Co(2+) in human arginase i enhances cytotoxicity toward l-arginine auxotrophic cancer cell lines.

Stone EM, Glazer ES, Chantranupong L, Cherukuri P, Breece RM, Tierney DL, Curley SA, Iverson BL, Georgiou G.

ACS Chem Biol. 2010 Mar 19;5(3):333-42. doi: 10.1021/cb900267j. Erratum in: ACS Chem Biol. 2010 Aug 20;5(8):797.


The human asparaginase-like protein 1 hASRGL1 is an Ntn hydrolase with beta-aspartyl peptidase activity.

Cantor JR, Stone EM, Chantranupong L, Georgiou G.

Biochemistry. 2009 Nov 24;48(46):11026-31. doi: 10.1021/bi901397h.


Nonradiative and radiative electron capture in collisions of He+ ions with C atoms below 1000 eV.

Kimura M, Dalgarno A, Chantranupong L, Li Y, Hirsch G, Buenker RJ.

Phys Rev A. 1994 Apr;49(4):2541-2544. No abstract available.

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