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Results: 18

1.

A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics.

Chaikuad A, M C Tacconi E, Zimmer J, Liang Y, Gray NS, Tarsounas M, Knapp S.

Nat Chem Biol. 2014 Sep 7. doi: 10.1038/nchembio.1629. [Epub ahead of print]

PMID:
25195011
[PubMed - as supplied by publisher]
2.

Modulation of the chromatin phosphoproteome by the Haspin protein kinase.

Maiolica A, de Medina-Redondo M, Schoof EM, Chaikuad A, Villa F, Gatti M, Jeganathan S, Lou HJ, Novy K, Hauri S, Toprak UH, Herzog F, Meraldi P, Penengo L, Turk BE, Knapp S, Linding R, Aebersold R.

Mol Cell Proteomics. 2014 Jul;13(7):1724-40. doi: 10.1074/mcp.M113.034819. Epub 2014 Apr 14.

PMID:
24732914
[PubMed - in process]
3.

Copper is required for oncogenic BRAF signalling and tumorigenesis.

Brady DC, Crowe MS, Turski ML, Hobbs GA, Yao X, Chaikuad A, Knapp S, Xiao K, Campbell SL, Thiele DJ, Counter CM.

Nature. 2014 May 22;509(7501):492-6. doi: 10.1038/nature13180. Epub 2014 Apr 9.

PMID:
24717435
[PubMed - indexed for MEDLINE]
4.

Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies.

Chaikuad A, Keates T, Vincke C, Kaufholz M, Zenn M, Zimmermann B, Gutiérrez C, Zhang RG, Hatzos-Skintges C, Joachimiak A, Muyldermans S, Herberg FW, Knapp S, Müller S.

Biochem J. 2014 Apr 1;459(1):59-69. doi: 10.1042/BJ20131399.

PMID:
24438162
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain.

Ferguson FM, Fedorov O, Chaikuad A, Philpott M, Muniz JR, Felletar I, von Delft F, Heightman T, Knapp S, Abell C, Ciulli A.

J Med Chem. 2013 Dec 27;56(24):10183-7. doi: 10.1021/jm401582c. Epub 2013 Dec 13.

PMID:
24304323
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Mechanism and consequence of the autoactivation of p38α mitogen-activated protein kinase promoted by TAB1.

De Nicola GF, Martin ED, Chaikuad A, Bassi R, Clark J, Martino L, Verma S, Sicard P, Tata R, Atkinson RA, Knapp S, Conte MR, Marber MS.

Nat Struct Mol Biol. 2013 Oct;20(10):1182-90. doi: 10.1038/nsmb.2668. Epub 2013 Sep 15.

PMID:
24037507
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

A new class of small molecule inhibitor of BMP signaling.

Sanvitale CE, Kerr G, Chaikuad A, Ramel MC, Mohedas AH, Reichert S, Wang Y, Triffitt JT, Cuny GD, Yu PB, Hill CS, Bullock AN.

PLoS One. 2013 Apr 30;8(4):e62721. doi: 10.1371/journal.pone.0062721. Print 2013.

PMID:
23646137
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.

Canning P, Cooper CD, Krojer T, Murray JW, Pike AC, Chaikuad A, Keates T, Thangaratnarajah C, Hojzan V, Ayinampudi V, Marsden BD, Gileadi O, Knapp S, von Delft F, Bullock AN.

J Biol Chem. 2013 Mar 15;288(11):7803-14. doi: 10.1074/jbc.M112.437996. Epub 2013 Jan 24. Erratum in: J Biol Chem. 2013 Sep 27;388(39):28304. Ayinampudi, Vikram [added].

PMID:
23349464
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva.

Chaikuad A, Alfano I, Kerr G, Sanvitale CE, Boergermann JH, Triffitt JT, von Delft F, Knapp S, Knaus P, Bullock AN.

J Biol Chem. 2012 Oct 26;287(44):36990-8. doi: 10.1074/jbc.M112.365932. Epub 2012 Sep 12.

PMID:
22977237
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family.

Chaikuad A, Pilka ES, De Riso A, von Delft F, Kavanagh KL, Vénien-Bryan C, Oppermann U, Yue WW.

BMC Struct Biol. 2012 Jun 21;12:14. doi: 10.1186/1472-6807-12-14.

PMID:
22720794
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.

Chaikuad A, Froese DS, Berridge G, von Delft F, Oppermann U, Yue WW.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21028-33. doi: 10.1073/pnas.1113921108. Epub 2011 Dec 12.

PMID:
22160680
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Structural and kinetic evidence that catalytic reaction of human UDP-glucose 6-dehydrogenase involves covalent thiohemiacetal and thioester enzyme intermediates.

Egger S, Chaikuad A, Klimacek M, Kavanagh KL, Oppermann U, Nidetzky B.

J Biol Chem. 2012 Jan 13;287(3):2119-29. doi: 10.1074/jbc.M111.313015. Epub 2011 Nov 28.

PMID:
22123821
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Structure and mechanism of human UDP-glucose 6-dehydrogenase.

Egger S, Chaikuad A, Kavanagh KL, Oppermann U, Nidetzky B.

J Biol Chem. 2011 Jul 8;286(27):23877-87. doi: 10.1074/jbc.M111.234682. Epub 2011 Apr 18.

PMID:
21502315
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Structure and kinetic characterization of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase, GAPDS.

Chaikuad A, Shafqat N, Al-Mokhtar R, Cameron G, Clarke AR, Brady RL, Oppermann U, Frayne J, Yue WW.

Biochem J. 2011 Apr 15;435(2):401-9. doi: 10.1042/BJ20101442.

PMID:
21269272
[PubMed - indexed for MEDLINE]
Free Article
15.

UDP-glucose dehydrogenase: structure and function of a potential drug target.

Egger S, Chaikuad A, Kavanagh KL, Oppermann U, Nidetzky B.

Biochem Soc Trans. 2010 Oct;38(5):1378-85. doi: 10.1042/BST0381378. Review.

PMID:
20863317
[PubMed - indexed for MEDLINE]
16.

Structural comparison of human mammalian ste20-like kinases.

Record CJ, Chaikuad A, Rellos P, Das S, Pike AC, Fedorov O, Marsden BD, Knapp S, Lee WH.

PLoS One. 2010 Aug 6;5(8):e11905. doi: 10.1371/journal.pone.0011905.

PMID:
20730082
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Conservation of structure and activity in Plasmodium purine nucleoside phosphorylases.

Chaikuad A, Brady RL.

BMC Struct Biol. 2009 Jul 3;9:42. doi: 10.1186/1472-6807-9-42.

PMID:
19575810
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Structure of lactate dehydrogenase from Plasmodium vivax: complexes with NADH and APADH.

Chaikuad A, Fairweather V, Conners R, Joseph-Horne T, Turgut-Balik D, Brady RL.

Biochemistry. 2005 Dec 13;44(49):16221-8.

PMID:
16331982
[PubMed - indexed for MEDLINE]

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