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Results: 1 to 20 of 220

1.

Crystal Structures of PRK1 in Complex with the Clinical Compounds Lestaurtinib and Tofacitinib Reveal Ligand Induced Conformational Changes.

Chamberlain P, Delker S, Pagarigan B, Mahmoudi A, Jackson P, Abbasian M, Muir J, Raheja N, Cathers B.

PLoS One. 2014 Aug 11;9(8):e103638. doi: 10.1371/journal.pone.0103638. eCollection 2014.

PMID:
25111382
[PubMed - in process]
Free PMC Article
2.

Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs.

Chamberlain PP, Lopez-Girona A, Miller K, Carmel G, Pagarigan B, Chie-Leon B, Rychak E, Corral LG, Ren YJ, Wang M, Riley M, Delker SL, Ito T, Ando H, Mori T, Hirano Y, Handa H, Hakoshima T, Daniel TO, Cathers BE.

Nat Struct Mol Biol. 2014 Aug 10. doi: 10.1038/nsmb.2874. [Epub ahead of print]

PMID:
25108355
[PubMed - as supplied by publisher]
3.

In vivo murine model of acquired resistance in myeloma reveals differential mechanisms for lenalidomide and pomalidomide in combination with dexamethasone.

Ocio EM, Fernández-Lázaro D, San-Segundo L, López-Corral L, Corchete LA, Gutiérrez NC, Garayoa M, Paíno T, García-Gómez A, Delgado M, Montero JC, Díaz-Rodríguez E, Mateos MV, Pandiella A, Couto S, Wang M, Bjorklund CC, San Miguel JF.

Leukemia. 2014 Aug 8. doi: 10.1038/leu.2014.238. [Epub ahead of print]

PMID:
25102946
[PubMed - as supplied by publisher]
4.

Effect of particle size on the speed and resolution of chiral separations using supercritical fluid chromatography.

Biba M, Regalado EL, Wu N, Welch CJ.

J Chromatogr A. 2014 Jul 12. pii: S0021-9673(14)01079-6. doi: 10.1016/j.chroma.2014.07.010. [Epub ahead of print]

PMID:
25082525
[PubMed - as supplied by publisher]
5.

Erratum to: No clinically significant drug interactions between lenalidomide and P-glycoprotein substrates and inhibitors: results from controlled phase I studies in healthy volunteers.

Chen N, Weiss D, Reyes J, Liu L, Kasserra C, Wang X, Zhou S, Kumar G, Weiss L, Palmisano M.

Cancer Chemother Pharmacol. 2014 Aug 1. [Epub ahead of print] No abstract available.

PMID:
25082519
[PubMed - as supplied by publisher]
6.

Recommendations from a global cross-company data sharing initiative on the incorporation of recovery phase animals in safety assessment studies to support first-in-human clinical trials.

Sewell F, Chapman K, Baldrick P, Brewster D, Broadmeadow A, Brown P, Burns-Naas LA, Clarke J, Constan A, Couch J, Czupalla O, Danks A, DeGeorge J, de Haan L, Hettinger K, Hill M, Festag M, Jacobs A, Jacobson-Kram D, Kopytek S, Lorenz H, Moesgaard SG, Moore E, Pasanen M, Perry R, Ragan I, Robinson S, Schmitt PM, Short B, Lima BS, Smith D, Sparrow S, van Bekkum Y, Jones D.

Regul Toxicol Pharmacol. 2014 Jul 29. pii: S0273-2300(14)00173-1. doi: 10.1016/j.yrtph.2014.07.018. [Epub ahead of print]

PMID:
25078890
[PubMed - as supplied by publisher]
Free Article
7.
8.

The interaction between checkpoint kinase 1 (Chk1) and the mini-chromosome maintenance (MCM) complex is required for DNA damage-induced Chk1 phosphorylation.

Han X, Aslanian A, Fu K, Tsuji T, Zhang Y.

J Biol Chem. 2014 Jul 21. pii: jbc.M114.575035. [Epub ahead of print]

PMID:
25049228
[PubMed - as supplied by publisher]
Free Article
9.

Lenalidomide inhibits the proliferation of chronic lymphocytic leukemia cells via a cereblon/p21WAF1/Cip1-dependent mechanism independent of functional p53.

Fecteau JF, Corral LG, Ghia EM, Gaidarova S, Futalan D, Bharati IS, Cathers B, Schwaederlé M, Cui B, Lopez-Girona A, Messmer D, Kipps TJ.

Blood. 2014 Jul 2. pii: blood-2014-03-559591. [Epub ahead of print]

PMID:
24990888
[PubMed - as supplied by publisher]
10.

The impact of co-administration of ketoconazole and rifampin on the pharmacokinetics of apremilast in healthy volunteers.

Liu Y, Zhou S, Wan Y, Wu A, Palmisano M.

Br J Clin Pharmacol. 2014 Jun 24. doi: 10.1111/bcp.12448. [Epub ahead of print]

PMID:
24962564
[PubMed - as supplied by publisher]
11.

Thymine DNA Glycosylase is a CRL4Cdt2 Substrate.

Slenn TJ, Morris B, Havens CG, Freeman RM Jr, Takahashi TS, Walter JC.

J Biol Chem. 2014 Jun 19. pii: jbc.M114.574194. [Epub ahead of print]

PMID:
24947512
[PubMed - as supplied by publisher]
Free Article
12.

A phase I/II study of lenalidomide in combination with sunitinib in patients with advanced or metastatic renal cell carcinoma.

Rini B, Redman B, Garcia JA, Burris HA 3rd, Li S, Fandi A, Beck R, Jungnelius U, Infante JR.

Ann Oncol. 2014 Jun 8. pii: mdu212. [Epub ahead of print]

PMID:
24914044
[PubMed - as supplied by publisher]
13.

The impact of Nucleofection® on the activation state of primary human CD4 T cells.

Zhang M, Ma Z, Selliah N, Weiss G, Genin A, Finkel TH, Cron RQ.

J Immunol Methods. 2014 Jun;408:123-31. doi: 10.1016/j.jim.2014.05.014. Epub 2014 Jun 5.

PMID:
24910411
[PubMed - in process]
14.
15.

Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity.

Schafer PH, Parton A, Capone L, Cedzik D, Brady H, Evans JF, Man HW, Muller GW, Stirling DI, Chopra R.

Cell Signal. 2014 Sep;26(9):2016-29. doi: 10.1016/j.cellsig.2014.05.014. Epub 2014 May 29.

PMID:
24882690
[PubMed - in process]
Free Article
16.

FDA Approval: Ado-trastuzumab Emtansine for the Treatment of Patients with HER2-Positive Metastatic Breast Cancer.

Amiri-Kordestani L, Blumenthal GM, Xu QC, Zhang L, Tang SW, Ha L, Weinberg WC, Chi B, Candau-Chacon R, Hughes P, Russell AM, Pope Miksinski S, Chen XH, McGuinn WD, Palmby T, Schrieber SJ, Liu Q, Wang J, Song P, Mehrotra N, Skarupa L, Clouse K, Al-Hakim A, Sridhara R, Ibrahim A, Justice R, Pazdur R, Cortazar P.

Clin Cancer Res. 2014 May 30. pii: clincanres.0012.2014. [Epub ahead of print]

PMID:
24879797
[PubMed - as supplied by publisher]
17.

Embryo-fetal exposure and developmental outcome of thalidomide following oral and intravaginal administration to pregnant rabbits.

Hui JY, Hoffmann M, Kumar G.

Reprod Toxicol. 2014 May 22. pii: S0890-6238(14)00078-1. doi: 10.1016/j.reprotox.2014.05.002. [Epub ahead of print]

PMID:
24859269
[PubMed - as supplied by publisher]
18.

Modeling and simulation to probe the pharmacokinetic disposition of pomalidomide R- and S-enantiomers.

Li Y, Zhou S, Hoffmann M, Kumar G, Palmisano M.

J Pharmacol Exp Ther. 2014 Aug;350(2):265-72. doi: 10.1124/jpet.114.215251. Epub 2014 May 15.

PMID:
24833703
[PubMed - in process]
19.

Introduction to the HESI DART Drugs in Semen Consortium.

Chen CL, Beyer BK, Breslin WJ, DeLise AM, Hui JY, Moffat GJ, Thompson KE.

Reprod Toxicol. 2014 May 4. pii: S0890-6238(14)00064-1. doi: 10.1016/j.reprotox.2014.04.007. [Epub ahead of print] No abstract available.

PMID:
24803405
[PubMed - as supplied by publisher]
20.

Quantification of XRCC and DNA-PK proteins in cancer cell lines and human tumors by LC-MS/MS.

Myers MV, Maxwell SE, Wang X.

Bioanalysis. 2014 May 2. [Epub ahead of print]

PMID:
24785829
[PubMed - as supplied by publisher]
Free Article

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