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Results: 1 to 20 of 303

1.

Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis.

Wong JC, Weinfurtner KM, Alzamora MD, Kogan SC, Burgess MR, Zhang Y, Nakitandwe J, Ma J, Cheng J, Chen SC, Ho TT, Flach J, Reynaud D, Passegué E, Downing JR, Shannon K.

Elife. 2015 Jul 20;4. doi: 10.7554/eLife.07839. [Epub ahead of print]

2.

Clinical Features and Survival of 338 Multiple Myeloma Patients Treated with Hematopoietic Stem Cell Transplantation or Conventional Chemotherapy.

Pérez R, Durán MS, Mayans J, Soler A, Castillo I, Jurado M, Ribas P, Menchaca Echevarria MC, Hernandez MT, Lopez Garcia-Carreño MD, Echeveste Gutierrez A, Bailen Garcia A, Lopez S, Baquero J, Ramirez G.

Eur J Haematol. 2015 Jul 17. doi: 10.1111/ejh.12611. [Epub ahead of print]

PMID:
26190662
3.

A Dual Color Immunohistochemistry Assay for Measurement of Cereblon in Multiple Myeloma Patient Samples.

Ren Y, Wang M, Couto S, Hansel DE, Miller K, Lopez-Girona A, Bjorklund CC, Gandhi AK, Thakurta A, Chopra R, Breider M.

Appl Immunohistochem Mol Morphol. 2015 Jul 16. [Epub ahead of print]

PMID:
26186254
4.

A phase I dose-escalation study to assess safety, tolerability, pharmacokinetics, and preliminary efficacy of the dual mTORC1/mTORC2 kinase inhibitor CC-223 in patients with advanced solid tumors or multiple myeloma.

Bendell JC, Kelley RK, Shih KC, Grabowsky JA, Bergsland E, Jones S, Martin T, Infante JR, Mischel PS, Matsutani T, Xu S, Wong L, Liu Y, Wu X, Mortensen DS, Chopra R, Hege K, Munster PN.

Cancer. 2015 Jul 15. doi: 10.1002/cncr.29422. [Epub ahead of print]

PMID:
26177599
5.

SPARC Expression Did Not Predict Efficacy of nab-Paclitaxel Plus Gemcitabine or Gemcitabine Alone for Metastatic Pancreatic Cancer in an Exploratory Analysis of the Phase III MPACT Trial.

Hidalgo M, Plaza C, Musteanu M, Illei P, Brachmann CB, Heise C, Pierce DW, Lopez-Casas PP, Menendez C, Tabernero J, Romano A, Wei X, Lopez-Rios F, Von Hoff DD.

Clin Cancer Res. 2015 Jul 13. pii: clincanres.3222.2014. [Epub ahead of print]

PMID:
26169969
6.

Impact of prior treatment and depth of response on survival in MM-003, a randomized phase 3 study comparing pomalidomide plus low-dose dexamethasone versus high-dose dexamethasone in relapsed/refractory multiple myeloma.

San Miguel JF, Weisel KC, Song KW, Delforge M, Karlin L, Goldschmidt H, Moreau P, Banos A, Oriol A, Garderet L, Cavo M, Ivanova V, Alegre A, Martinez-Lopez J, Chen C, Renner C, Bahlis NJ, Yu X, Teasdale T, Sternas L, Jacques C, Zaki MH, Dimopoulos MA.

Haematologica. 2015 Jul 9. pii: haematol.2015.125864. [Epub ahead of print]

7.

Microbial species delineation using whole genome sequences.

Varghese NJ, Mukherjee S, Ivanova N, Konstantinidis KT, Mavrommatis K, Kyrpides NC, Pati A.

Nucleic Acids Res. 2015 Jul 6. pii: gkv657. [Epub ahead of print]

8.

Pomalidomide and Low-Dose Dexamethasone Improves Health-Related Quality of Life and Prolongs Time to Worsening in Relapsed/Refractory Patients With Multiple Myeloma Enrolled in the MM-003 Randomized Phase III Trial.

Weisel K, Dimopoulos M, Song KW, Moreau P, Palumbo A, Belch A, Schey S, Sonneveld P, Sternas L, Yu X, Amatya R, Gibson CJ, Zaki M, Jacques C, San Miguel J.

Clin Lymphoma Myeloma Leuk. 2015 Jun 6. pii: S2152-2650(15)00363-8. doi: 10.1016/j.clml.2015.05.007. [Epub ahead of print]

PMID:
26149712
9.

Development and psychometric validation of a brief comprehensive health status assessment scale in older patients with hematological malignancies: The GAH Scale.

Bonanad S, De la Rubia J, Gironella M, Pérez Persona E, González B, Fernández Lago C, Arnan M, Zudaire M, Hernández Rivas JA, Soler A, Marrero C, Olivier C, Altés A, Valcárcel D, Hernández MT, Oiartzabal I, Fernández Ordoño R, Arnao M, Esquerra A, Sarrá J, González-Barca E, González J, Calvo X, Nomdedeu M, García Guiñón A, Ramírez Payer A, Casado A, López S, Durán M, Marcos M, Cruz-Jentoft AJ; GAH Group.

J Geriatr Oncol. 2015 Jun 29. pii: S1879-4068(15)00053-3. doi: 10.1016/j.jgo.2015.03.003. [Epub ahead of print]

PMID:
26139300
10.

Importance of investigating epigenetic alterations for industry and regulators: An appraisal of current efforts by the Health and Environmental Sciences Institute.

Miousse IR, Currie R, Datta K, Ellinger-Ziegelbauer H, French JE, Harrill AH, Koturbash I, Lawton M, Mann D, Meehan RR, Moggs JG, O'Lone R, Rasoulpour RJ, Pera RA, Thompson K.

Toxicology. 2015 Jun 29;335:11-19. doi: 10.1016/j.tox.2015.06.009. [Epub ahead of print] Review.

PMID:
26134581
11.

Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS.

Krönke J, Fink EC, Hollenbach PW, MacBeth KJ, Hurst SN, Udeshi ND, Chamberlain PP, Mani DR, Man HW, Gandhi AK, Svinkina T, Schneider RK, McConkey M, Järås M, Griffiths E, Wetzler M, Bullinger L, Cathers BE, Carr SA, Chopra R, Ebert BL.

Nature. 2015 Jul 9;523(7559):183-8. doi: 10.1038/nature14610. Epub 2015 Jul 1.

PMID:
26131937
12.

RAP-011 improves erythropoiesis in zebrafish model of Diamond-Blackfan anemia through antagonizing lefty1.

Ear J, Huang H, Wilson T, Tehrani Z, Lindgren A, Sung V, Laadem A, Daniel TO, Chopra R, Lin S.

Blood. 2015 Jun 24. pii: blood-2015-01-622522. [Epub ahead of print]

PMID:
26109203
13.

Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115.

Mortensen DS, Perrin-Ninkovic SM, Shevlin G, Elsner J, Zhao J, Whitefield B, Tehrani L, Sapienza J, Riggs JR, Parnes JS, Papa P, Packard G, Lee BG, Harris R, Correa M, Bahmanyar S, Richardson SJ, Peng SX, Leisten J, Khambatta G, Hickman M, Gamez JC, Bisonette RR, Apuy J, Cathers BE, Canan SS, Moghaddam MF, Raymon HK, Worland P, Narla RK, Fultz KE, Sankar S.

J Med Chem. 2015 Jul 23;58(14):5599-608. doi: 10.1021/acs.jmedchem.5b00627. Epub 2015 Jul 8.

PMID:
26102506
14.

The pharmacokinetic effect of coadministration of apremilast and methotrexate in individuals with rheumatoid arthritis and psoriatic arthritis.

Liu Y, Zhou S, Nissel J, Wu A, Lau H, Palmisano M.

Clin Pharmacol Drug Dev. 2014 Nov;3(6):456-465. Epub 2014 May 8.

15.

Pancreatic cancer: Patient and caregiver perceptions on diagnosis, psychological impact, and importance of support.

Engebretson A, Matrisian L, Thompson C.

Pancreatology. 2015 May 29. pii: S1424-3903(15)00572-4. doi: 10.1016/j.pan.2015.05.471. [Epub ahead of print]

PMID:
26092655
16.

Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, in patients with moderate to severe plaque psoriasis: Results of a phase III, randomized, controlled trial (Efficacy and Safety Trial Evaluating the Effects of Apremilast in Psoriasis [ESTEEM] 1).

Papp K, Reich K, Leonardi CL, Kircik L, Chimenti S, Langley RG, Hu C, Stevens RM, Day RM, Gordon KB, Korman NJ, Griffiths CE.

J Am Acad Dermatol. 2015 Jul;73(1):37-49. doi: 10.1016/j.jaad.2015.03.049.

17.

Discovery of Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor CC-223.

Mortensen DS, Perrin-Ninkovic SM, Shevlin G, Zhao J, Packard G, Bahmanyar S, Correa M, Elsner J, Harris R, Lee BG, Papa P, Parnes JS, Riggs JR, Sapienza J, Tehrani L, Whitefield B, Apuy J, Bisonette RR, Gamez JC, Hickman M, Khambatta G, Leisten J, Peng SX, Richardson SJ, Cathers BE, Canan SS, Moghaddam MF, Raymon HK, Worland P, Narla RK, Fultz KE, Sankar S.

J Med Chem. 2015 Jul 9;58(13):5323-33. doi: 10.1021/acs.jmedchem.5b00626. Epub 2015 Jun 26.

PMID:
26083478
18.

Angiogenic properties of human placenta-derived adherent cells and efficacy in hindlimb ischemia.

Francki A, Labazzo K, He S, Baum EZ, Abbot SE, Herzberg U, Hofgartner W, Hariri R; Celgene Cellular Therapeutics Research Group.

J Vasc Surg. 2015 Jun 5. pii: S0741-5214(15)00901-5. doi: 10.1016/j.jvs.2015.04.387. [Epub ahead of print]

PMID:
26054585
19.

Evaluation of CYP3A-mediated drug-drug Interactions with romidepsin in patients with advanced cancer.

Laille E, Patel M, Jones SF, Burris HA, Infante J, Lemech C, Liu L, Arkenau HT.

J Clin Pharmacol. 2015 Jun 4. doi: 10.1002/jcph.560. [Epub ahead of print]

PMID:
26053962
20.

Best practices for the use of itraconazole as a replacement for ketoconazole in drug-drug interaction studies.

Liu L, Bello A, Dresser MJ, Heald D, Komjathy SF, O'Mara E, Rogge M, Stoch SA, Robertson SM.

J Clin Pharmacol. 2015 Jun 4. doi: 10.1002/jcph.562. [Epub ahead of print]

PMID:
26044116
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