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Results: 1 to 20 of 82

1.

Endoplasmic Reticulum Stress Sensor Protein Kinase R-Like Endoplasmic Reticulum Kinase (PERK) Protects Against Pressure Overload-Induced Heart Failure and Lung Remodeling.

Liu X, Kwak D, Lu Z, Xu X, Fassett J, Wang H, Wei Y, Cavener DR, Hu X, Hall J, Bache RJ, Chen Y.

Hypertension. 2014 Jun 23. pii: HYPERTENSIONAHA.114.03811. [Epub ahead of print]

PMID:
24958502
[PubMed - as supplied by publisher]
2.

Perk gene dosage regulates glucose homeostasis by modulating pancreatic β-cell functions.

Wang R, Munoz EE, Zhu S, McGrath BC, Cavener DR.

PLoS One. 2014 Jun 10;9(6):e99684. doi: 10.1371/journal.pone.0099684. eCollection 2014.

PMID:
24915520
[PubMed - in process]
Free PMC Article
3.

The eIF2α kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression.

Trinh MA, Ma T, Kaphzan H, Bhattacharya A, Antion MD, Cavener DR, Hoeffer CA, Klann E.

Learn Mem. 2014 Apr 16;21(5):298-304. doi: 10.1101/lm.032219.113.

PMID:
24741110
[PubMed - in process]
4.

Genetic inactivation of PERK signaling in mouse oligodendrocytes: normal developmental myelination with increased susceptibility to inflammatory demyelination.

Hussien Y, Cavener DR, Popko B.

Glia. 2014 May;62(5):680-91. doi: 10.1002/glia.22634. Epub 2014 Jan 31.

PMID:
24481666
[PubMed - in process]
5.

25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages.

Shibata N, Carlin AF, Spann NJ, Saijo K, Morello CS, McDonald JG, Romanoski CE, Maurya MR, Kaikkonen MU, Lam MT, Crotti A, Reichart D, Fox JN, Quehenberger O, Raetz CR, Sullards MC, Murphy RC, Merrill AH Jr, Brown HA, Dennis EA, Fahy E, Subramaniam S, Cavener DR, Spector DH, Russell DW, Glass CK.

J Biol Chem. 2013 Dec 13;288(50):35812-23. doi: 10.1074/jbc.M113.519637. Epub 2013 Nov 4.

PMID:
24189069
[PubMed - indexed for MEDLINE]
6.

GCN2 in the brain programs PPARγ2 and triglyceride storage in the liver during perinatal development in response to maternal dietary fat.

Xu X, Hu J, McGrath BC, Cavener DR.

PLoS One. 2013 Oct 10;8(10):e75917. doi: 10.1371/journal.pone.0075917. eCollection 2013.

PMID:
24130751
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Insulin secretion and Ca2+ dynamics in β-cells are regulated by PERK (EIF2AK3) in concert with calcineurin.

Wang R, McGrath BC, Kopp RF, Roe MW, Tang X, Chen G, Cavener DR.

J Biol Chem. 2013 Nov 22;288(47):33824-36. doi: 10.1074/jbc.M113.503664. Epub 2013 Oct 10.

PMID:
24114838
[PubMed - indexed for MEDLINE]
8.

Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits.

Ma T, Trinh MA, Wexler AJ, Bourbon C, Gatti E, Pierre P, Cavener DR, Klann E.

Nat Neurosci. 2013 Sep;16(9):1299-305. doi: 10.1038/nn.3486. Epub 2013 Aug 11.

PMID:
23933749
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

GCN2 regulates the CCAAT enhancer binding protein beta and hepatic gluconeogenesis.

Xu X, Hu J, McGrath BC, Cavener DR.

Am J Physiol Endocrinol Metab. 2013 Oct 15;305(8):E1007-17. doi: 10.1152/ajpendo.00063.2013. Epub 2013 Jul 30.

PMID:
23900421
[PubMed - indexed for MEDLINE]
10.

Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility.

Trinh MA, Kaphzan H, Wek RC, Pierre P, Cavener DR, Klann E.

Cell Rep. 2012 Jun 28;1(6):676-88. doi: 10.1016/j.celrep.2012.04.010. Epub 2012 May 24.

PMID:
22813743
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Hyperthermia induces the ER stress pathway.

Xu X, Gupta S, Hu W, McGrath BC, Cavener DR.

PLoS One. 2011;6(8):e23740. doi: 10.1371/journal.pone.0023740. Epub 2011 Aug 18.

PMID:
21876766
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Endoplasmic reticulum stress response mediated by the PERK-eIF2(alpha)-ATF4 pathway is involved in osteoblast differentiation induced by BMP2.

Saito A, Ochiai K, Kondo S, Tsumagari K, Murakami T, Cavener DR, Imaizumi K.

J Biol Chem. 2011 Feb 11;286(6):4809-18. doi: 10.1074/jbc.M110.152900. Epub 2010 Dec 6.

PMID:
21135100
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

PERK in beta cell biology and insulin biogenesis.

Cavener DR, Gupta S, McGrath BC.

Trends Endocrinol Metab. 2010 Dec;21(12):714-21. doi: 10.1016/j.tem.2010.08.005. Epub 2010 Sep 17. Review.

PMID:
20850340
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway.

Gupta S, McGrath B, Cavener DR.

Diabetes. 2010 Aug;59(8):1937-47. doi: 10.2337/db09-1064. Epub 2010 Jun 8.

PMID:
20530744
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

PERK regulates the proliferation and development of insulin-secreting beta-cell tumors in the endocrine pancreas of mice.

Gupta S, McGrath B, Cavener DR.

PLoS One. 2009 Nov 24;4(11):e8008. doi: 10.1371/journal.pone.0008008.

PMID:
19956728
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase.

Bunpo P, Dudley A, Cundiff JK, Cavener DR, Wek RC, Anthony TG.

J Biol Chem. 2009 Nov 20;284(47):32742-9. doi: 10.1074/jbc.M109.047910. Epub 2009 Sep 25.

PMID:
19783659
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation.

Feng D, Wei J, Gupta S, McGrath BC, Cavener DR.

BMC Cell Biol. 2009 Sep 4;10:61. doi: 10.1186/1471-2121-10-61.

PMID:
19732428
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver.

Dang Do AN, Kimball SR, Cavener DR, Jefferson LS.

Physiol Genomics. 2009 Aug 7;38(3):328-41. doi: 10.1152/physiolgenomics.90396.2008. Epub 2009 Jun 9.

PMID:
19509078
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Sleeping Beauty, awake! Regulation of insulin gene expression by methylation of histone H3.

Cavener DR.

Diabetes. 2009 Jan;58(1):28-9. doi: 10.2337/db08-1520. No abstract available.

PMID:
19114729
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation.

Bobrovnikova-Marjon E, Hatzivassiliou G, Grigoriadou C, Romero M, Cavener DR, Thompson CB, Diehl JA.

Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16314-9. doi: 10.1073/pnas.0808517105. Epub 2008 Oct 13.

PMID:
18852460
[PubMed - indexed for MEDLINE]
Free PMC Article

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