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Repression of the eIF2α kinase PERK alleviates mGluR-LTD impairments in a mouse model of Alzheimer's disease.

Yang W, Zhou X, Zimmermann HR, Cavener DR, Klann E, Ma T.

Neurobiol Aging. 2016 May;41:19-24. doi: 10.1016/j.neurobiolaging.2016.02.005. Epub 2016 Feb 13.


Endoplasmic reticulum stress sensor protein kinase R-like endoplasmic reticulum kinase (PERK) protects against pressure overload-induced heart failure and lung remodeling.

Liu X, Kwak D, Lu Z, Xu X, Fassett J, Wang H, Wei Y, Cavener DR, Hu X, Hall J, Bache RJ, Chen Y.

Hypertension. 2014 Oct;64(4):738-44. doi: 10.1161/HYPERTENSIONAHA.114.03811. Epub 2014 Jun 23.


Perk gene dosage regulates glucose homeostasis by modulating pancreatic β-cell functions.

Wang R, Munoz EE, Zhu S, McGrath BC, Cavener DR.

PLoS One. 2014 Jun 10;9(6):e99684. doi: 10.1371/journal.pone.0099684. eCollection 2014.


The eIF2α kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression.

Trinh MA, Ma T, Kaphzan H, Bhattacharya A, Antion MD, Cavener DR, Hoeffer CA, Klann E.

Learn Mem. 2014 Apr 16;21(5):298-304. doi: 10.1101/lm.032219.113.


Genetic inactivation of PERK signaling in mouse oligodendrocytes: normal developmental myelination with increased susceptibility to inflammatory demyelination.

Hussien Y, Cavener DR, Popko B.

Glia. 2014 May;62(5):680-91. doi: 10.1002/glia.22634. Epub 2014 Jan 31.


25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages.

Shibata N, Carlin AF, Spann NJ, Saijo K, Morello CS, McDonald JG, Romanoski CE, Maurya MR, Kaikkonen MU, Lam MT, Crotti A, Reichart D, Fox JN, Quehenberger O, Raetz CR, Sullards MC, Murphy RC, Merrill AH Jr, Brown HA, Dennis EA, Fahy E, Subramaniam S, Cavener DR, Spector DH, Russell DW, Glass CK.

J Biol Chem. 2013 Dec 13;288(50):35812-23. doi: 10.1074/jbc.M113.519637. Epub 2013 Nov 4.


GCN2 in the brain programs PPARγ2 and triglyceride storage in the liver during perinatal development in response to maternal dietary fat.

Xu X, Hu J, McGrath BC, Cavener DR.

PLoS One. 2013 Oct 10;8(10):e75917. doi: 10.1371/journal.pone.0075917. eCollection 2013.


Insulin secretion and Ca2+ dynamics in β-cells are regulated by PERK (EIF2AK3) in concert with calcineurin.

Wang R, McGrath BC, Kopp RF, Roe MW, Tang X, Chen G, Cavener DR.

J Biol Chem. 2013 Nov 22;288(47):33824-36. doi: 10.1074/jbc.M113.503664. Epub 2013 Oct 10.


Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits.

Ma T, Trinh MA, Wexler AJ, Bourbon C, Gatti E, Pierre P, Cavener DR, Klann E.

Nat Neurosci. 2013 Sep;16(9):1299-305. doi: 10.1038/nn.3486. Epub 2013 Aug 11.


GCN2 regulates the CCAAT enhancer binding protein beta and hepatic gluconeogenesis.

Xu X, Hu J, McGrath BC, Cavener DR.

Am J Physiol Endocrinol Metab. 2013 Oct 15;305(8):E1007-17. doi: 10.1152/ajpendo.00063.2013. Epub 2013 Jul 30.


Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility.

Trinh MA, Kaphzan H, Wek RC, Pierre P, Cavener DR, Klann E.

Cell Rep. 2012 Jun 28;1(6):676-88. doi: 10.1016/j.celrep.2012.04.010. Epub 2012 May 24.


Hyperthermia induces the ER stress pathway.

Xu X, Gupta S, Hu W, McGrath BC, Cavener DR.

PLoS One. 2011;6(8):e23740. doi: 10.1371/journal.pone.0023740. Epub 2011 Aug 18.


Endoplasmic reticulum stress response mediated by the PERK-eIF2(alpha)-ATF4 pathway is involved in osteoblast differentiation induced by BMP2.

Saito A, Ochiai K, Kondo S, Tsumagari K, Murakami T, Cavener DR, Imaizumi K.

J Biol Chem. 2011 Feb 11;286(6):4809-18. doi: 10.1074/jbc.M110.152900. Epub 2010 Dec 6.


PERK in beta cell biology and insulin biogenesis.

Cavener DR, Gupta S, McGrath BC.

Trends Endocrinol Metab. 2010 Dec;21(12):714-21. doi: 10.1016/j.tem.2010.08.005. Epub 2010 Sep 17. Review.


PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway.

Gupta S, McGrath B, Cavener DR.

Diabetes. 2010 Aug;59(8):1937-47. doi: 10.2337/db09-1064. Epub 2010 Jun 8.


PERK regulates the proliferation and development of insulin-secreting beta-cell tumors in the endocrine pancreas of mice.

Gupta S, McGrath B, Cavener DR.

PLoS One. 2009 Nov 24;4(11):e8008. doi: 10.1371/journal.pone.0008008.


GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase.

Bunpo P, Dudley A, Cundiff JK, Cavener DR, Wek RC, Anthony TG.

J Biol Chem. 2009 Nov 20;284(47):32742-9. doi: 10.1074/jbc.M109.047910. Epub 2009 Sep 25.


Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation.

Feng D, Wei J, Gupta S, McGrath BC, Cavener DR.

BMC Cell Biol. 2009 Sep 4;10:61. doi: 10.1186/1471-2121-10-61.


eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver.

Dang Do AN, Kimball SR, Cavener DR, Jefferson LS.

Physiol Genomics. 2009 Aug 7;38(3):328-41. doi: 10.1152/physiolgenomics.90396.2008. Epub 2009 Jun 9.


Sleeping Beauty, awake! Regulation of insulin gene expression by methylation of histone H3.

Cavener DR.

Diabetes. 2009 Jan;58(1):28-9. doi: 10.2337/db08-1520. No abstract available.

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