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Results: 1 to 20 of 591

1.

Introducing conformal prediction in predictive modeling for regulatory purposes. A transparent and flexible alternative to applicability domain determination.

Norinder U, Carlsson L, Boyer S, Eklund M.

Regul Toxicol Pharmacol. 2015 Mar;71(2):279-84. doi: 10.1016/j.yrtph.2014.12.021. Epub 2015 Jan 2.

PMID:
25559551
2.

Exploring In Silico Prediction of the Unbound Brain-to-Plasma Drug Concentration Ratio: Model Validation, Renewal, and Interpretation.

Varadharajan S, Winiwarter S, Carlsson L, Engkvist O, Anantha A, Kogej T, Fridén M, Stålring J, Chen H.

J Pharm Sci. 2015 Mar;104(3):1197-206. doi: 10.1002/jps.24301. Epub 2014 Dec 24.

PMID:
25546343
3.

Psychological aspects of eating behavior as predictors of 10-y weight changes after surgical and conventional treatment of severe obesity: results from the Swedish Obese Subjects intervention study.

Konttinen H, Peltonen M, Sjöström L, Carlsson L, Karlsson J.

Am J Clin Nutr. 2015 Jan;101(1):16-24. doi: 10.3945/ajcn.114.095182. Epub 2014 Nov 12.

PMID:
25527746
4.

Body composition through adult life: Swedish reference data on body composition.

Larsson I, Lissner L, Samuelson G, Fors H, Lantz H, Näslund I, Carlsson LM, Sjöström L, Bosaeus I.

Eur J Clin Nutr. 2014 Dec 17. doi: 10.1038/ejcn.2014.268. [Epub ahead of print]

PMID:
25514897
5.

Scaling predictive modeling in drug development with cloud computing.

Moghadam BT, Alvarsson J, Holm M, Eklund M, Carlsson L, Spjuth O.

J Chem Inf Model. 2015 Jan 26;55(1):19-25. doi: 10.1021/ci500580y. Epub 2015 Jan 8.

PMID:
25493610
6.

How experimental errors influence drug metabolism and pharmacokinetic QSAR/QSPR models.

Wenlock MC, Carlsson LA.

J Chem Inf Model. 2015 Jan 26;55(1):125-34. doi: 10.1021/ci500535s. Epub 2014 Dec 24.

7.

The GH receptor exon 3 deleted/full-length polymorphism is associated with central adiposity in the general population.

Glad CA, Carlsson LM, Melander O, Almgren P, Sjöström L, Nilsson S, Larsson I, Svensson PA, Johannsson G.

Eur J Endocrinol. 2015 Feb;172(2):123-8. doi: 10.1530/EJE-14-0723. Epub 2014 Nov 12.

PMID:
25391539
8.

Molecular subtype and tumor characteristics of breast cancer metastases as assessed by gene expression significantly influence patient post-relapse survival.

Tobin NP, Harrell JC, Lövrot J, Egyhazi Brage S, Frostvik Stolt M, Carlsson L, Einbeigi Z, Linderholm B, Loman N, Malmberg M, Walz T, Fernö M, Perou CM, Bergh J, Hatschek T, Lindström LS; TEX Trialists Group.

Ann Oncol. 2015 Jan;26(1):81-8. doi: 10.1093/annonc/mdu498. Epub 2014 Oct 31.

9.

COL6A3 is regulated by leptin in human adipose tissue and reduced in obesity.

McCulloch LJ, Rawling TJ, Sjöholm K, Franck N, Dankel SN, Price EJ, Knight B, Liversedge NH, Mellgren G, Nystrom F, Carlsson LM, Kos K.

Endocrinology. 2015 Jan;156(1):134-46. doi: 10.1210/en.2014-1042.

PMID:
25337653
10.

Benchmarking study of parameter variation when using signature fingerprints together with support vector machines.

Alvarsson J, Eklund M, Andersson C, Carlsson L, Spjuth O, Wikberg JE.

J Chem Inf Model. 2014 Nov 24;54(11):3211-7. doi: 10.1021/ci500344v. Epub 2014 Oct 28.

PMID:
25318024
11.

Computational derivation of structural alerts from large toxicology data sets.

Ahlberg E, Carlsson L, Boyer S.

J Chem Inf Model. 2014 Oct 27;54(10):2945-52. doi: 10.1021/ci500314a. Epub 2014 Oct 13.

PMID:
25275755
12.

Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease.

Dongiovanni P, Petta S, Maglio C, Fracanzani AL, Pipitone R, Mozzi E, Motta BM, Kaminska D, Rametta R, Grimaudo S, Pelusi S, Montalcini T, Alisi A, Maggioni M, Kärjä V, Borén J, Käkelä P, Di Marco V, Xing C, Nobili V, Dallapiccola B, Craxi A, Pihlajamäki J, Fargion S, Sjöström L, Carlsson LM, Romeo S, Valenti L.

Hepatology. 2015 Feb;61(2):506-14. doi: 10.1002/hep.27490.

PMID:
25251399
13.

Ligand-based target prediction with signature fingerprints.

Alvarsson J, Eklund M, Engkvist O, Spjuth O, Carlsson L, Wikberg JE, Noeske T.

J Chem Inf Model. 2014 Oct 27;54(10):2647-53. doi: 10.1021/ci500361u. Epub 2014 Oct 3.

PMID:
25230336
14.

Is the acetylcholine-regulated inwardly rectifying potassium current a viable antiarrhythmic target? Translational discrepancies of AZD2927 and A7071 in dogs and humans.

Walfridsson H, Anfinsen OG, Berggren A, Frison L, Jensen S, Linhardt G, Nordkam AC, Sundqvist M, Carlsson L.

Europace. 2015 Mar;17(3):473-82. doi: 10.1093/europace/euu192. Epub 2014 Jul 31.

PMID:
25082948
15.

Association of bariatric surgery with long-term remission of type 2 diabetes and with microvascular and macrovascular complications.

Sjöström L, Peltonen M, Jacobson P, Ahlin S, Andersson-Assarsson J, Anveden Å, Bouchard C, Carlsson B, Karason K, Lönroth H, Näslund I, Sjöström E, Taube M, Wedel H, Svensson PA, Sjöholm K, Carlsson LM.

JAMA. 2014 Jun 11;311(22):2297-304. doi: 10.1001/jama.2014.5988.

PMID:
24915261
16.

Tracking of a dietary pattern and its components over 10-years in the severely obese.

Johns DJ, Lindroos AK, Jebb SA, Sjöström L, Carlsson LM, Ambrosini GL.

PLoS One. 2014 May 19;9(5):e97457. doi: 10.1371/journal.pone.0097457. eCollection 2014.

17.

The incidence of albuminuria after bariatric surgery and usual care in Swedish Obese Subjects (SOS): a prospective controlled intervention trial.

Carlsson LM, Romeo S, Jacobson P, Burza MA, Maglio C, Sjöholm K, Svensson PA, Haraldsson B, Peltonen M, Sjöström L.

Int J Obes (Lond). 2015 Jan;39(1):169-75. doi: 10.1038/ijo.2014.72. Epub 2014 May 6.

18.

Introducing conformal prediction in predictive modeling. A transparent and flexible alternative to applicability domain determination.

Norinder U, Carlsson L, Boyer S, Eklund M.

J Chem Inf Model. 2014 Jun 23;54(6):1596-603. doi: 10.1021/ci5001168. Epub 2014 May 21.

PMID:
24797111
19.

Adipose tissue-derived human serum amyloid a does not affect atherosclerotic lesion area in hSAA1+/-/ApoE-/- mice.

Ahlin S, Olsson M, Wilhelmson AS, Skålén K, Borén J, Carlsson LM, Svensson PA, Sjöholm K.

PLoS One. 2014 Apr 21;9(4):e95468. doi: 10.1371/journal.pone.0095468. eCollection 2014.

20.

Cardiac safety assays.

Heijman J, Voigt N, Carlsson LG, Dobrev D.

Curr Opin Pharmacol. 2014 Apr;15:16-21. doi: 10.1016/j.coph.2013.11.004. Epub 2013 Nov 27. Review.

PMID:
24721649
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