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Results: 1 to 20 of 79


RTCB-1 mediates neuroprotection via XBP-1 mRNA splicing in the unfolded protein response pathway.

Ray A, Zhang S, Rentas C, Caldwell KA, Caldwell GA.

J Neurosci. 2014 Nov 26;34(48):16076-85. doi: 10.1523/JNEUROSCI.1945-14.2014.


Phenazine derivatives cause proteotoxicity and stress in C. elegans.

Ray A, Rentas C, Caldwell GA, Caldwell KA.

Neurosci Lett. 2015 Jan 1;584:23-7. doi: 10.1016/j.neulet.2014.09.055. Epub 2014 Oct 7.


Phosphatidylethanolamine deficiency disrupts α-synuclein homeostasis in yeast and worm models of Parkinson disease.

Wang S, Zhang S, Liou LC, Ren Q, Zhang Z, Caldwell GA, Caldwell KA, Witt SN.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):E3976-85. doi: 10.1073/pnas.1411694111. Epub 2014 Sep 8.


Calcineurin determines toxic versus beneficial responses to α-synuclein.

Caraveo G, Auluck PK, Whitesell L, Chung CY, Baru V, Mosharov EV, Yan X, Ben-Johny M, Soste M, Picotti P, Kim H, Caldwell KA, Caldwell GA, Sulzer D, Yue DT, Lindquist S.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):E3544-52. doi: 10.1073/pnas.1413201111. Epub 2014 Aug 13.


The glycolytic enzyme, GPI, is a functionally conserved modifier of dopaminergic neurodegeneration in Parkinson's models.

Knight AL, Yan X, Hamamichi S, Ajjuri RR, Mazzulli JR, Zhang MW, Daigle JG, Zhang S, Borom AR, Roberts LR, Lee SK, DeLeon SM, Viollet-Djelassi C, Krainc D, O'Donnell JM, Caldwell KA, Caldwell GA.

Cell Metab. 2014 Jul 1;20(1):145-57. doi: 10.1016/j.cmet.2014.04.017. Epub 2014 May 29.


Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity.

Matlack KE, Tardiff DF, Narayan P, Hamamichi S, Caldwell KA, Caldwell GA, Lindquist S.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4013-8. doi: 10.1073/pnas.1402228111. Epub 2014 Mar 3.


The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans.

Bornhorst J, Chakraborty S, Meyer S, Lohren H, Brinkhaus SG, Knight AL, Caldwell KA, Caldwell GA, Karst U, Schwerdtle T, Bowman A, Aschner M.

Metallomics. 2014 Mar;6(3):476-90. doi: 10.1039/c3mt00325f. Epub 2014 Jan 22.


Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events.

Jackrel ME, DeSantis ME, Martinez BA, Castellano LM, Stewart RM, Caldwell KA, Caldwell GA, Shorter J.

Cell. 2014 Jan 16;156(1-2):170-82. doi: 10.1016/j.cell.2013.11.047.


Mitochondrial dysfunction, oxidative stress, and neurodegeneration elicited by a bacterial metabolite in a C. elegans Parkinson's model.

Ray A, Martinez BA, Berkowitz LA, Caldwell GA, Caldwell KA.

Cell Death Dis. 2014 Jan 9;5:e984. doi: 10.1038/cddis.2013.513.


TorsinA rescues ER-associated stress and locomotive defects in C. elegans models of ALS.

Thompson ML, Chen P, Yan X, Kim H, Borom AR, Roberts NB, Caldwell KA, Caldwell GA.

Dis Model Mech. 2014 Feb;7(2):233-43. doi: 10.1242/dmm.013615. Epub 2013 Dec 5.


Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.

Tardiff DF, Jui NT, Khurana V, Tambe MA, Thompson ML, Chung CY, Kamadurai HB, Kim HT, Lancaster AK, Caldwell KA, Caldwell GA, Rochet JC, Buchwald SL, Lindquist S.

Science. 2013 Nov 22;342(6161):979-83. doi: 10.1126/science.1245321. Epub 2013 Oct 24.


Invertebrate models of dystonia.

Caldwell KA, Shu Y, Roberts NB, Caldwell GA, O'Donnell JM.

Curr Neuropharmacol. 2013 Jan;11(1):16-29. doi: 10.2174/157015913804999504.


Protective role of DNJ-27/ERdj5 in Caenorhabditis elegans models of human neurodegenerative diseases.

Muñoz-Lobato F, Rodríguez-Palero MJ, Naranjo-Galindo FJ, Shephard F, Gaffney CJ, Szewczyk NJ, Hamamichi S, Caldwell KA, Caldwell GA, Link CD, Miranda-Vizuete A.

Antioxid Redox Signal. 2014 Jan 10;20(2):217-35. doi: 10.1089/ars.2012.5051. Epub 2013 Jul 3.


Lysosomal impairment in Parkinson's disease.

Dehay B, Martinez-Vicente M, Caldwell GA, Caldwell KA, Yue Z, Cookson MR, Klein C, Vila M, Bezard E.

Mov Disord. 2013 Jun;28(6):725-32. doi: 10.1002/mds.25462. Epub 2013 Apr 11. Review.


Valproic acid ameliorates C. elegans dopaminergic neurodegeneration with implications for ERK-MAPK signaling.

Kautu BB, Carrasquilla A, Hicks ML, Caldwell KA, Caldwell GA.

Neurosci Lett. 2013 Apr 29;541:116-9. doi: 10.1016/j.neulet.2013.02.026. Epub 2013 Feb 26.


Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity.

Usenovic M, Knight AL, Ray A, Wong V, Brown KR, Caldwell GA, Caldwell KA, Stagljar I, Krainc D.

Hum Mol Genet. 2012 Sep 1;21(17):3785-94. doi: 10.1093/hmg/dds206. Epub 2012 May 29.


A predictable worm: application of Caenorhabditis elegans for mechanistic investigation of movement disorders.

Dexter PM, Caldwell KA, Caldwell GA.

Neurotherapeutics. 2012 Apr;9(2):393-404. doi: 10.1007/s13311-012-0109-x. Review.


Functional analysis of VPS41-mediated neuroprotection in Caenorhabditis elegans and mammalian models of Parkinson's disease.

Harrington AJ, Yacoubian TA, Slone SR, Caldwell KA, Caldwell GA.

J Neurosci. 2012 Feb 8;32(6):2142-53. doi: 10.1523/JNEUROSCI.2606-11.2012.


Different 8-hydroxyquinolines protect models of TDP-43 protein, α-synuclein, and polyglutamine proteotoxicity through distinct mechanisms.

Tardiff DF, Tucci ML, Caldwell KA, Caldwell GA, Lindquist S.

J Biol Chem. 2012 Feb 3;287(6):4107-20. doi: 10.1074/jbc.M111.308668. Epub 2011 Dec 6.


Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast.

Treusch S, Hamamichi S, Goodman JL, Matlack KE, Chung CY, Baru V, Shulman JM, Parrado A, Bevis BJ, Valastyan JS, Han H, Lindhagen-Persson M, Reiman EM, Evans DA, Bennett DA, Olofsson A, DeJager PL, Tanzi RE, Caldwell KA, Caldwell GA, Lindquist S.

Science. 2011 Dec 2;334(6060):1241-5. doi: 10.1126/science.1213210. Epub 2011 Oct 27.

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