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284 results

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Page 1
CSTA plays a role in osteoclast formation and bone resorption by mediating the DAP12/TREM2 pathway.
Wei R, Zhang L, Hu W, Wu J, Zhang W. Wei R, et al. Biochem Biophys Res Commun. 2022 Oct 30;627:12-20. doi: 10.1016/j.bbrc.2022.08.033. Epub 2022 Aug 15. Biochem Biophys Res Commun. 2022. PMID: 36007331 Free article.
However, the exact role of CSTA in osteoporosis remains unknown. In this study, we examined the role of CSTA in the formation, differentiation, and bone resorption of osteoclasts. ...Suppression of CSTA decreased DAP12 and TREM2 expression, whereas overexpres …
However, the exact role of CSTA in osteoporosis remains unknown. In this study, we examined the role of CSTA in the formation, …
Correlated with better prognosis, CSTA inhibits metastasis of nasopharyngeal carcinoma cells via suppressing AKT signaling through promoting METTL3 degradation.
Liu ZJ, Zheng LS, Li CZ, Peng LX, Mei Y, Lang YH, Xu L, Meng DF, Peng XS, Wang MD, Xie DH, Guo LL, Ding LY, Huang BJ, Qian CN. Liu ZJ, et al. Biochim Biophys Acta Mol Basis Dis. 2023 Jun;1869(5):166696. doi: 10.1016/j.bbadis.2023.166696. Epub 2023 Mar 22. Biochim Biophys Acta Mol Basis Dis. 2023. PMID: 36963524
Transcriptome sequencing and western blot analysis revealed that CSTA inhibited the phosphorylation of AKT. Moreover, activating AKT using AKT agonist SG79 rescued the motility of CSTA-overexpressing NPC cells, whereas, treatment with AKT inhibitor MK2206 inhibited …
Transcriptome sequencing and western blot analysis revealed that CSTA inhibited the phosphorylation of AKT. Moreover, activating AKT …
Decreased CSTA expression promotes lymphatic metastasis and predicts poor survival in oral squamous cell carcinoma.
Wang Y, Wang L, Li X, Qu X, Han N, Ruan M, Zhang C. Wang Y, et al. Arch Oral Biol. 2021 Jun;126:105116. doi: 10.1016/j.archoralbio.2021.105116. Epub 2021 Mar 31. Arch Oral Biol. 2021. PMID: 33831734
CSTA expression was markedly downregulated in primary OSCC tissues, and low CSTA expression significantly correlated with high tumor grade (P = 0.001), nodal metastasis (P = 0.028), and poor overall survival (P < 0.001). ...CSTA may play an essential role
CSTA expression was markedly downregulated in primary OSCC tissues, and low CSTA expression significantly correlated with high
Skin chronological aging drives age-related bone loss via secretion of cystatin-A.
Liang W, Chen Q, Cheng S, Wei R, Li Y, Yao C, Ouyang Z, Kang D, Chen A, Liu Z, Li K, Bai X, Li Q, Huang B. Liang W, et al. Nat Aging. 2022 Oct;2(10):906-922. doi: 10.1038/s43587-022-00285-x. Epub 2022 Oct 6. Nat Aging. 2022. PMID: 37118283
In contrast, topical application of calcipotriol stimulates Csta production in the epidermis and alleviates osteoporosis. These results reveal a mode of endocrine regulation of bone metabolism in the skin, and identify Csta as an epidermally derived hormone linking …
In contrast, topical application of calcipotriol stimulates Csta production in the epidermis and alleviates osteoporosis. These resul …
Function and Regulation of the Pyruvate Transporter CstA in Escherichia coli.
Gasperotti A, Göing S, Fajardo-Ruiz E, Forné I, Jung K. Gasperotti A, et al. Int J Mol Sci. 2020 Nov 28;21(23):9068. doi: 10.3390/ijms21239068. Int J Mol Sci. 2020. PMID: 33260635 Free PMC article.
To meet the cellular pyruvate requirements, the enterobacterium Escherichia coli has at least three pyruvate uptake systems-the H(+)/pyruvate symporter BtsT, and two thus far less well-characterized transporters, YhjX and CstA. BtsT and CstA belong to the putative c …
To meet the cellular pyruvate requirements, the enterobacterium Escherichia coli has at least three pyruvate uptake systems-the H(+)/pyruvat …
Peptide Transporter CstA Imports Pyruvate in Escherichia coli K-12.
Hwang S, Choe D, Yoo M, Cho S, Kim SC, Cho S, Cho BK. Hwang S, et al. J Bacteriol. 2018 Mar 12;200(7):e00771-17. doi: 10.1128/JB.00771-17. Print 2018 Apr 1. J Bacteriol. 2018. PMID: 29358499 Free PMC article.
Subsequently, their pyruvate transporter function was examined by conventional functional assays, such as those measuring growth inhibition by the toxic pyruvate analog and pyruvate uptake activity. The pyruvate transporter system comprises CstA and YbdD, which are known a …
Subsequently, their pyruvate transporter function was examined by conventional functional assays, such as those measuring growth inhibition …
A new risk model for CSTA, FAM83A, and MYCT1 predicts poor prognosis and is related to immune infiltration in lung squamous cell carcinoma.
Ding Y, Bian TT, Li QY, He JR, Guo Q, Wu CY, Chen SS. Ding Y, et al. Am J Transl Res. 2022 Nov 15;14(11):7705-7725. eCollection 2022. Am J Transl Res. 2022. PMID: 36505278 Free PMC article.
The expression of CSTA, FAM83A, and MYCT1 and high-risk scores were independent risk factors for a poor prognosis in LUSC. ...A risk model and nomogram based on CSTA, FAM83A, and MYCT1 can predict the prognosis of LUSC....
The expression of CSTA, FAM83A, and MYCT1 and high-risk scores were independent risk factors for a poor prognosis in LUSC. ...A risk …
Identification of Critical Biomarkers and Immune Infiltration in Rheumatoid Arthritis Based on WGCNA and LASSO Algorithm.
Jiang F, Zhou H, Shen H. Jiang F, et al. Front Immunol. 2022 Jun 29;13:925695. doi: 10.3389/fimmu.2022.925695. eCollection 2022. Front Immunol. 2022. PMID: 35844557 Free PMC article.
Six hub genes were identified as possible biomarkers for RA after a lasso analysis was performed on the data. Three hub genes, CKS2, CSTA, and LY96, were found to have high diagnostic value using ROC curve analysis. They were shown to be closely related to the concentratio …
Six hub genes were identified as possible biomarkers for RA after a lasso analysis was performed on the data. Three hub genes, CKS2, CSTA
Conformational analysis and chemical reactivity of the multidomain sulfurtransferase, Staphylococcus aureus CstA.
Higgins KA, Peng H, Luebke JL, Chang FM, Giedroc DP. Higgins KA, et al. Biochemistry. 2015 Apr 14;54(14):2385-98. doi: 10.1021/acs.biochem.5b00056. Epub 2015 Apr 1. Biochemistry. 2015. PMID: 25793461
Cysteine persulfides can be trapped on both C66 in CstA(Rhod) and on C66 and C128 in CstA(Rhod-TusA) when incubated with thiosulfate, sodium tetrasulfide (Na2S4), and in situ persulfurated SufS. C66A substitution in CstA(Rhod-TusA) abolishes C128 S-sulfhydrat …
Cysteine persulfides can be trapped on both C66 in CstA(Rhod) and on C66 and C128 in CstA(Rhod-TusA) when incubated with thios …
A Brucella abortus cstA mutant is defective for association with endoplasmic reticulum exit sites and displays altered trafficking in HeLa cells.
de Barsy M, Mirabella A, Letesson JJ, De Bolle X. de Barsy M, et al. Microbiology (Reading). 2012 Oct;158(Pt 10):2610-2618. doi: 10.1099/mic.0.060509-0. Epub 2012 Jul 19. Microbiology (Reading). 2012. PMID: 22820839 Free article.
We found that a tagged CstA is secreted in Brucella abortus culture medium. This secretion is independent of the type IV secretion system VirB and the flagellum, suggesting that CstA is secreted through another system. We also discovered that a B. abortus cstA
We found that a tagged CstA is secreted in Brucella abortus culture medium. This secretion is independent of the type IV secretion sy …
284 results