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Results: 10

1.

Tissue-specific gene silencing monitored in circulating RNA.

Sehgal A, Chen Q, Gibbings D, Sah DW, Bumcrot D.

RNA. 2014 Feb;20(2):143-9. doi: 10.1261/rna.042507.113. Epub 2013 Dec 19.

PMID:
24355758
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia.

Schmidt PJ, Toudjarska I, Sendamarai AK, Racie T, Milstein S, Bettencourt BR, Hettinger J, Bumcrot D, Fleming MD.

Blood. 2013 Feb 14;121(7):1200-8. doi: 10.1182/blood-2012-09-453977. Epub 2012 Dec 6.

PMID:
23223430
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Alpha-synuclein suppression by targeted small interfering RNA in the primate substantia nigra.

McCormack AL, Mak SK, Henderson JM, Bumcrot D, Farrer MJ, Di Monte DA.

PLoS One. 2010 Aug 11;5(8):e12122. doi: 10.1371/journal.pone.0012122.

PMID:
20711464
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Claudin-3 gene silencing with siRNA suppresses ovarian tumor growth and metastasis.

Huang YH, Bao Y, Peng W, Goldberg M, Love K, Bumcrot DA, Cole G, Langer R, Anderson DG, Sawicki JA.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3426-30. doi: 10.1073/pnas.0813348106. Epub 2009 Feb 10.

PMID:
19208807
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

In vivo silencing of alpha-synuclein using naked siRNA.

Lewis J, Melrose H, Bumcrot D, Hope A, Zehr C, Lincoln S, Braithwaite A, He Z, Ogholikhan S, Hinkle K, Kent C, Toudjarska I, Charisse K, Braich R, Pandey RK, Heckman M, Maraganore DM, Crook J, Farrer MJ.

Mol Neurodegener. 2008 Nov 1;3:19. doi: 10.1186/1750-1326-3-19.

PMID:
18976489
[PubMed]
Free PMC Article
6.

Assessing siRNA pharmacodynamics in a luciferase-expressing mouse.

Svensson RU, Shey MR, Ballas ZK, Dorkin JR, Goldberg M, Akinc A, Langer R, Anderson DG, Bumcrot D, Henry MD.

Mol Ther. 2008 Dec;16(12):1995-2001. doi: 10.1038/mt.2008.187. Epub 2008 Sep 9.

PMID:
18781145
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway.

John M, Constien R, Akinc A, Goldberg M, Moon YA, Spranger M, Hadwiger P, Soutschek J, Vornlocher HP, Manoharan M, Stoffel M, Langer R, Anderson DG, Horton JD, Koteliansky V, Bumcrot D.

Nature. 2007 Oct 11;449(7163):745-7. Epub 2007 Sep 26.

PMID:
17898712
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists.

Frank-Kamenetsky M, Zhang XM, Bottega S, Guicherit O, Wichterle H, Dudek H, Bumcrot D, Wang FY, Jones S, Shulok J, Rubin LL, Porter JA.

J Biol. 2002 Nov 6;1(2):10.

PMID:
12437772
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Proteolytic processing yields two secreted forms of sonic hedgehog.

Bumcrot DA, Takada R, McMahon AP.

Mol Cell Biol. 1995 Apr;15(4):2294-303. Erratum in: Mol Cell Biol 1995 May;15(5):2904.

PMID:
7891723
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

UHF-1, a factor required for maximal transcription of early and late sea urchin histone H4 genes: analysis of promoter-binding sites.

Lee IJ, Tung L, Bumcrot DA, Weinberg ES.

Mol Cell Biol. 1991 Feb;11(2):1048-61.

PMID:
1990266
[PubMed - indexed for MEDLINE]
Free PMC Article
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