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Items: 18


Reversal of hemochromatosis by apotransferrin in non-transfused and transfused Hbbth3/+ (heterozygous B1/B2 globin gene deletion) mice.

Gelderman MP, Baek JH, Yalamanoglu A, Puglia M, Vallelian F, Burla B, Vostal J, Schaer DJ, Buehler PW.

Haematologica. 2015 May;100(5):611-22. doi: 10.3324/haematol.2014.117325. Epub 2015 Jan 23.


Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development.

Schaer DJ, Vinchi F, Ingoglia G, Tolosano E, Buehler PW.

Front Physiol. 2014 Oct 28;5:415. doi: 10.3389/fphys.2014.00415. eCollection 2014. Review.


Modeling hemoglobin and hemoglobin:haptoglobin complex clearance in a non-rodent species-pharmacokinetic and therapeutic implications.

Boretti FS, Baek JH, Palmer AF, Schaer DJ, Buehler PW.

Front Physiol. 2014 Oct 9;5:385. doi: 10.3389/fphys.2014.00385. eCollection 2014.


Proteasome inhibition and oxidative reactions disrupt cellular homeostasis during heme stress.

Vallelian F, Deuel JW, Opitz L, Schaer CA, Puglia M, Lönn M, Engelsberger W, Schauer S, Karnaukhova E, Spahn DR, Stocker R, Buehler PW, Schaer DJ.

Cell Death Differ. 2015 Apr;22(4):597-611. doi: 10.1038/cdd.2014.154. Epub 2014 Oct 10.


Extracellular Hb enhances cardiac toxicity in endotoxemic guinea pigs: protective role of haptoglobin.

Baek JH, Zhang X, Williams MC, Schaer DJ, Buehler PW, D'Agnillo F.

Toxins (Basel). 2014 Mar 31;6(4):1244-59. doi: 10.3390/toxins6041244.


Cell-free hemoglobin and its scavenger proteins: new disease models leading the way to targeted therapies.

Schaer DJ, Buehler PW.

Cold Spring Harb Perspect Med. 2013 Jun 1;3(6). pii: a013433. doi: 10.1101/cshperspect.a013433. Review.


Haptoglobin preferentially binds β but not α subunits cross-linked hemoglobin tetramers with minimal effects on ligand and redox reactions.

Jia Y, Wood F, Buehler PW, Alayash AI.

PLoS One. 2013;8(3):e59841. doi: 10.1371/journal.pone.0059841. Epub 2013 Mar 29.


Human Hp1-1 and Hp2-2 phenotype-specific haptoglobin therapeutics are both effective in vitro and in guinea pigs to attenuate hemoglobin toxicity.

Lipiski M, Deuel JW, Baek JH, Engelsberger WR, Buehler PW, Schaer DJ.

Antioxid Redox Signal. 2013 Nov 10;19(14):1619-33. doi: 10.1089/ars.2012.5089. Epub 2013 Mar 28.


Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins.

Schaer DJ, Buehler PW, Alayash AI, Belcher JD, Vercellotti GM.

Blood. 2013 Feb 21;121(8):1276-84. doi: 10.1182/blood-2012-11-451229. Epub 2012 Dec 20. Review.


Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism.

Buehler PW, Baek JH, Lisk C, Connor I, Sullivan T, Kominsky D, Majka S, Stenmark KR, Nozik-Grayck E, Bonaventura J, Irwin DC.

Am J Physiol Lung Cell Mol Physiol. 2012 Aug 15;303(4):L312-26. doi: 10.1152/ajplung.00074.2012. Epub 2012 Jun 22.


Haptoglobin binding stabilizes hemoglobin ferryl iron and the globin radical on tyrosine β145.

Cooper CE, Schaer DJ, Buehler PW, Wilson MT, Reeder BJ, Silkstone G, Svistunenko DA, Bulow L, Alayash AI.

Antioxid Redox Signal. 2013 Jun 10;18(17):2264-73. doi: 10.1089/ars.2012.4547. Epub 2012 Aug 6.


Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy.

Baek JH, D'Agnillo F, Vallelian F, Pereira CP, Williams MC, Jia Y, Schaer DJ, Buehler PW.

J Clin Invest. 2012 Apr;122(4):1444-58. doi: 10.1172/JCI59770. Epub 2012 Mar 26.


Down selection of polymerized bovine hemoglobins for use as oxygen releasing therapeutics in a guinea pig model.

Baek JH, Zhou Y, Harris DR, Schaer DJ, Palmer AF, Buehler PW.

Toxicol Sci. 2012 Jun;127(2):567-81. doi: 10.1093/toxsci/kfs109. Epub 2012 Mar 12.


Blood-brain barrier disruption and oxidative stress in guinea pig after systemic exposure to modified cell-free hemoglobin.

Butt OI, Buehler PW, D'Agnillo F.

Am J Pathol. 2011 Mar;178(3):1316-28. doi: 10.1016/j.ajpath.2010.12.006.


Synthesis, biophysical properties and pharmacokinetics of ultrahigh molecular weight tense and relaxed state polymerized bovine hemoglobins.

Buehler PW, Zhou Y, Cabrales P, Jia Y, Sun G, Harris DR, Tsai AG, Intaglietta M, Palmer AF.

Biomaterials. 2010 May;31(13):3723-35. doi: 10.1016/j.biomaterials.2010.01.072. Epub 2010 Feb 10.


Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs.

Boretti FS, Buehler PW, D'Agnillo F, Kluge K, Glaus T, Butt OI, Jia Y, Goede J, Pereira CP, Maggiorini M, Schoedon G, Alayash AI, Schaer DJ.

J Clin Invest. 2009 Aug;119(8):2271-80. doi: 10.1172/JCI39115. Epub 2009 Jul 20.


Mixed S-nitrosylated polymerized bovine hemoglobin species moderate hemodynamic effects in acutely hypoxic rats.

Irwin D, Buehler PW, Alayash AI, Jia Y, Bonventura J, Foreman B, White M, Jacobs R, Piteo B, TissotvanPatot MC, Hamilton KL, Gotshall RW.

Am J Respir Cell Mol Biol. 2010 Feb;42(2):200-9. doi: 10.1165/rcmb.2008-0364OC. Epub 2009 Apr 24.


Ascorbate removes key precursors to oxidative damage by cell-free haemoglobin in vitro and in vivo.

Dunne J, Caron A, Menu P, Alayash AI, Buehler PW, Wilson MT, Silaghi-Dumitrescu R, Faivre B, Cooper CE.

Biochem J. 2006 Nov 1;399(3):513-24.

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