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Results: 1 to 20 of 196


Signal transduction in cancer.

Sever R, Brugge JS.

Cold Spring Harb Perspect Med. 2015 Apr 1;5(4). pii: a006098. doi: 10.1101/cshperspect.a006098. Review.


Correction: Mapping the dynamics of force transduction at cell-cell junctions of epithelial clusters.

Ng MR, Besser A, Brugge JS, Danuser G.

Elife. 2015 Feb 2;4:e06656. doi: 10.7554/eLife.06656. No abstract available.


Mapping the dynamics of force transduction at cell-cell junctions of epithelial clusters.

Ng MR, Besser A, Brugge JS, Danuser G.

Elife. 2014 Dec 5;3:e03282. doi: 10.7554/eLife.03282. Erratum in: Elife. 2015 Jan 15;4:e06656.


Live free or die: cell-cell adhesion regulates sensitivity to trail-induced apoptosis.

Gallegos LL, Brugge JS.

Dev Cell. 2014 Jul 14;30(1):3-4. doi: 10.1016/j.devcel.2014.06.031.


Mesenchymal gene program-expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance.

Davidowitz RA, Selfors LM, Iwanicki MP, Elias KM, Karst A, Piao H, Ince TA, Drage MG, Dering J, Konecny GE, Matulonis U, Mills GB, Slamon DJ, Drapkin R, Brugge JS.

J Clin Invest. 2014 Jun;124(6):2611-25. doi: 10.1172/JCI69815. Epub 2014 Apr 24.


Oncogene-like induction of cellular invasion from centrosome amplification.

Godinho SA, Picone R, Burute M, Dagher R, Su Y, Leung CT, Polyak K, Brugge JS, Théry M, Pellman D.

Nature. 2014 Jun 5;510(7503):167-71. doi: 10.1038/nature13277. Epub 2014 Apr 13.


Evidence for a multipotent mammary progenitor with pregnancy-specific activity.

Kaanta AS, Virtanen C, Selfors LM, Brugge JS, Neel BG.

Breast Cancer Res. 2013;15(4):R65.


Chaperone-mediated autophagy degrades mutant p53.

Vakifahmetoglu-Norberg H, Kim M, Xia HG, Iwanicki MP, Ofengeim D, Coloff JL, Pan L, Ince TA, Kroemer G, Brugge JS, Yuan J.

Genes Dev. 2013 Aug 1;27(15):1718-30. doi: 10.1101/gad.220897.113. Erratum in: Genes Dev. 2013 Sep 1;27(17):1947.


PDEF promotes luminal differentiation and acts as a survival factor for ER-positive breast cancer cells.

Buchwalter G, Hickey MM, Cromer A, Selfors LM, Gunawardane RN, Frishman J, Jeselsohn R, Lim E, Chi D, Fu X, Schiff R, Brown M, Brugge JS.

Cancer Cell. 2013 Jun 10;23(6):753-67. doi: 10.1016/j.ccr.2013.04.026.


Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals.

Albeck JG, Mills GB, Brugge JS.

Mol Cell. 2013 Jan 24;49(2):249-61. doi: 10.1016/j.molcel.2012.11.002. Epub 2012 Dec 6.


Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion.

Mouneimne G, Hansen SD, Selfors LM, Petrak L, Hickey MM, Gallegos LL, Simpson KJ, Lim J, Gertler FB, Hartwig JH, Mullins RD, Brugge JS.

Cancer Cell. 2012 Nov 13;22(5):615-30. doi: 10.1016/j.ccr.2012.09.027.


Substrate stiffness regulates cadherin-dependent collective migration through myosin-II contractility.

Ng MR, Besser A, Danuser G, Brugge JS.

J Cell Biol. 2012 Oct 29;199(3):545-63. doi: 10.1083/jcb.201207148. Epub 2012 Oct 22.


Into the deep: Refocusing on 3D.

Brugge JS.

Nat Cell Biol. 2012 Apr 2;14(4):332. doi: 10.1038/ncb2470. No abstract available.


Akt and ERK control the proliferative response of mammary epithelial cells to the growth factors IGF-1 and EGF through the cell cycle inhibitor p57Kip2.

Worster DT, Schmelzle T, Solimini NL, Lightcap ES, Millard B, Mills GB, Brugge JS, Albeck JG.

Sci Signal. 2012 Mar 6;5(214):ra19. doi: 10.1126/scisignal.2001986.


In vitro mesothelial clearance assay that models the early steps of ovarian cancer metastasis.

Davidowitz RA, Iwanicki MP, Brugge JS.

J Vis Exp. 2012 Feb 17;(60). pii: 3888. doi: 10.3791/3888.


Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells.

Muranen T, Selfors LM, Worster DT, Iwanicki MP, Song L, Morales FC, Gao S, Mills GB, Brugge JS.

Cancer Cell. 2012 Feb 14;21(2):227-39. doi: 10.1016/j.ccr.2011.12.024.


Outgrowth of single oncogene-expressing cells from suppressive epithelial environments.

Leung CT, Brugge JS.

Nature. 2012 Feb 8;482(7385):410-3. doi: 10.1038/nature10826.


Ovarian cancer spheroids use myosin-generated force to clear the mesothelium.

Iwanicki MP, Davidowitz RA, Ng MR, Besser A, Muranen T, Merritt M, Danuser G, Ince TA, Brugge JS.

Cancer Discov. 2011 Jul;1(2):144-57. doi: 10.1158/2159-8274.CD-11-0010. Erratum in: Cancer Discov. 2011 Dec;1(7):626. Ince, Tan [corrected to Ince, Tan A].


Extracellular matrix regulation of metabolism and implications for tumorigenesis.

Grassian AR, Coloff JL, Brugge JS.

Cold Spring Harb Symp Quant Biol. 2011;76:313-24. doi: 10.1101/sqb.2011.76.010967. Epub 2011 Nov 21. Review.


Intersection of FOXO- and RUNX1-mediated gene expression programs in single breast epithelial cells during morphogenesis and tumor progression.

Wang L, Brugge JS, Janes KA.

Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):E803-12. doi: 10.1073/pnas.1103423108. Epub 2011 Aug 22.

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