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Items: 20


A Guide to Differential Scanning Calorimetry of Membrane and Soluble Proteins in Detergents.

Yang Z, Brouillette CG.

Methods Enzymol. 2016;567:319-58. doi: 10.1016/bs.mie.2015.08.014. Epub 2015 Oct 20.


Restoration of NBD1 thermal stability is necessary and sufficient to correct ∆F508 CFTR folding and assembly.

He L, Aleksandrov AA, An J, Cui L, Yang Z, Brouillette CG, Riordan JR.

J Mol Biol. 2015 Jan 16;427(1):106-20. doi: 10.1016/j.jmb.2014.07.026. Epub 2014 Jul 30.


Membrane protein stability can be compromised by detergent interactions with the extramembranous soluble domains.

Yang Z, Wang C, Zhou Q, An J, Hildebrandt E, Aleksandrov LA, Kappes JC, DeLucas LJ, Riordan JR, Urbatsch IL, Hunt JF, Brouillette CG.

Protein Sci. 2014 Jun;23(6):769-89. doi: 10.1002/pro.2460. Epub 2014 May 3.


Conformational changes relevant to channel activity and folding within the first nucleotide binding domain of the cystic fibrosis transmembrane conductance regulator.

Hudson RP, Chong PA, Protasevich II, Vernon R, Noy E, Bihler H, An JL, Kalid O, Sela-Culang I, Mense M, Senderowitz H, Brouillette CG, Forman-Kay JD.

J Biol Chem. 2012 Aug 17;287(34):28480-94. doi: 10.1074/jbc.M112.371138. Epub 2012 Jun 21.


A gene optimization strategy that enhances production of fully functional P-glycoprotein in Pichia pastoris.

Bai J, Swartz DJ, Protasevich II, Brouillette CG, Harrell PM, Hildebrandt E, Gasser B, Mattanovich D, Ward A, Chang G, Urbatsch IL.

PLoS One. 2011;6(8):e22577. doi: 10.1371/journal.pone.0022577. Epub 2011 Aug 3.


Integrated biophysical studies implicate partial unfolding of NBD1 of CFTR in the molecular pathogenesis of F508del cystic fibrosis.

Wang C, Protasevich I, Yang Z, Seehausen D, Skalak T, Zhao X, Atwell S, Spencer Emtage J, Wetmore DR, Brouillette CG, Hunt JF.

Protein Sci. 2010 Oct;19(10):1932-47. doi: 10.1002/pro.480.


Thermal unfolding studies show the disease causing F508del mutation in CFTR thermodynamically destabilizes nucleotide-binding domain 1.

Protasevich I, Yang Z, Wang C, Atwell S, Zhao X, Emtage S, Wetmore D, Hunt JF, Brouillette CG.

Protein Sci. 2010 Oct;19(10):1917-31. doi: 10.1002/pro.479.


Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.

Atwell S, Brouillette CG, Conners K, Emtage S, Gheyi T, Guggino WB, Hendle J, Hunt JF, Lewis HA, Lu F, Protasevich II, Rodgers LA, Romero R, Wasserman SR, Weber PC, Wetmore D, Zhang FF, Zhao X.

Protein Eng Des Sel. 2010 May;23(5):375-84. doi: 10.1093/protein/gzq004. Epub 2010 Feb 11.


SAR studies for a new class of antibacterial NAD biosynthesis inhibitors.

Moro WB, Yang Z, Kane TA, Zhou Q, Harville S, Brouillette CG, Brouillette WJ.

J Comb Chem. 2009 Jul-Aug;11(4):617-25. doi: 10.1021/cc9000357.


Virtual screening to identify lead inhibitors for bacterial NAD synthetase (NADs).

Moro WB, Yang Z, Kane TA, Brouillette CG, Brouillette WJ.

Bioorg Med Chem Lett. 2009 Apr 1;19(7):2001-5. doi: 10.1016/j.bmcl.2009.02.034. Epub 2009 Feb 12.


Structure of nicotinic acid mononucleotide adenylyltransferase from Bacillus anthracis.

Lu S, Smith CD, Yang Z, Pruett PS, Nagy L, McCombs D, Delucas LJ, Brouillette WJ, Brouillette CG.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Oct 1;64(Pt 10):893-8. doi: 10.1107/S1744309108029102. Epub 2008 Sep 30.


Structural adaptation of an interacting non-native C-terminal helical extension revealed in the crystal structure of NAD+ synthetase from Bacillus anthracis.

McDonald HM, Pruett PS, Deivanayagam C, Protasevich II, Carson WM, DeLucas LJ, Brouillette WJ, Brouillette CG.

Acta Crystallogr D Biol Crystallogr. 2007 Aug;63(Pt 8):891-905. Epub 2007 Jul 17.


Antibacterial nicotinamide adenine dinucleotide synthetase inhibitors: amide- and ether-linked tethered dimers with alpha-amino acid end groups.

Velu SE, Mou L, Luan CH, Yang ZW, DeLucas LJ, Brouillette CG, Brouillette WJ.

J Med Chem. 2007 May 31;50(11):2612-21. Epub 2007 May 10.


Förster resonance energy transfer measurements are consistent with a helical bundle model for lipid-free apolipoprotein A-I.

Brouillette CG, Dong WJ, Yang ZW, Ray MJ, Protasevich II, Cheung HC, Engler JA.

Biochemistry. 2005 Dec 20;44(50):16413-25.


Tethered dimer inhibitors of NAD synthetase: parallel synthesis of an aryl-substituted SAR library.

Velu SE, Luan CH, Delucas LJ, Brouillette CG, Brouillette WJ.

J Comb Chem. 2005 Nov-Dec;7(6):898-904.


Engineering mouse apolipoprotein A-I into a monomeric, active protein useful for structural determination.

Ren X, Zhao L, Sivashanmugam A, Miao Y, Korando L, Yang Z, Reardon CA, Getz GS, Brouillette CG, Jerome WG, Wang J.

Biochemistry. 2005 Nov 15;44(45):14907-19.


Role of inhibitor aliphatic chain in the thermodynamics of inhibitor binding to Escherichia coli enoyl-ACP reductase and the Phe203Leu mutant: a proposed mechanism for drug resistance.

Protasevich II, Brouillette CG, Snow ME, Dunham S, Rubin JR, Gogliotti R, Siegel K.

Biochemistry. 2004 Oct 26;43(42):13380-9.


Dimethyl sulfoxide at 2.5% (v/v) alters the structural cooperativity and unfolding mechanism of dimeric bacterial NAD+ synthetase.

Yang ZW, Tendian SW, Carson WM, Brouillette WJ, Delucas LJ, Brouillette CG.

Protein Sci. 2004 Mar;13(3):830-41.


Deletion of DnaK's lid strengthens binding to the nucleotide exchange factor, GrpE: a kinetic and thermodynamic analysis.

Chesnokova LS, Slepenkov SV, Protasevich II, Sehorn MG, Brouillette CG, Witt SN.

Biochemistry. 2003 Aug 5;42(30):9028-40.


Tethered dimers as NAD synthetase inhibitors with antibacterial activity.

Velu SE, Cristofoli WA, Garcia GJ, Brouillette CG, Pierson MC, Luan CH, DeLucas LJ, Brouillette WJ.

J Med Chem. 2003 Jul 17;46(15):3371-81.

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