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Items: 1 to 20 of 145


A novel upstream enhancer of FOXP3, sensitive to methylation-induced silencing, exhibits dysregulated methylation in rheumatoid arthritis Treg cells.

Kennedy A, Schmidt EM, Cribbs AP, Penn H, Amjadi P, Syed K, Read JE, Green P, Gregory B, Brennan FM.

Eur J Immunol. 2014 Oct;44(10):2968-78. doi: 10.1002/eji.201444453. Epub 2014 Aug 18.


Treg cell function in rheumatoid arthritis is compromised by ctla-4 promoter methylation resulting in a failure to activate the indoleamine 2,3-dioxygenase pathway.

Cribbs AP, Kennedy A, Penn H, Read JE, Amjadi P, Green P, Syed K, Manka SW, Brennan FM, Gregory B, Williams RO.

Arthritis Rheumatol. 2014 Sep;66(9):2344-54. doi: 10.1002/art.38715.


Simplified production and concentration of lentiviral vectors to achieve high transduction in primary human T cells.

Cribbs AP, Kennedy A, Gregory B, Brennan FM.

BMC Biotechnol. 2013 Nov 12;13:98. doi: 10.1186/1472-6750-13-98.


Selective blockade of tumor necrosis factor receptor I inhibits proinflammatory cytokine and chemokine production in human rheumatoid arthritis synovial membrane cell cultures.

Schmidt EM, Davies M, Mistry P, Green P, Giddins G, Feldmann M, Stoop AA, Brennan FM.

Arthritis Rheum. 2013 Sep;65(9):2262-73. doi: 10.1002/art.38055.


CXCR4 and vascular cell adhesion molecule 1 are key chemokine/adhesion receptors in the migration of cytokine-activated T cells.

Bryant J, Ahern DJ, Brennan FM.

Arthritis Rheum. 2012 Jul;64(7):2137-46. doi: 10.1002/art.34394.


Production of TNF-α in macrophages activated by T cells, compared with lipopolysaccharide, uses distinct IL-10-dependent regulatory mechanism.

Agbanoma G, Li C, Ennis D, Palfreeman AC, Williams LM, Brennan FM.

J Immunol. 2012 Feb 1;188(3):1307-17. doi: 10.4049/jimmunol.1100625. Epub 2012 Jan 4.


Resistance to regulatory T cell-mediated suppression in rheumatoid arthritis can be bypassed by ectopic foxp3 expression in pathogenic synovial T cells.

Beavis PA, Gregory B, Green P, Cribbs AP, Kennedy A, Amjadi P, Palfreeman AC, Feldmann M, Brennan FM.

Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16717-22. doi: 10.1073/pnas.1112722108. Epub 2011 Sep 16.


Blockade of NKG2D ameliorates disease in mice with collagen-induced arthritis: a potential pathogenic role in chronic inflammatory arthritis.

Andersson AK, Sumariwalla PF, McCann FE, Amjadi P, Chang C, McNamee K, Tornehave D, Haase C, Agersø H, Stennicke VW, Ahern D, Ursø B, Trowsdale J, Feldmann M, Brennan FM.

Arthritis Rheum. 2011 Sep;63(9):2617-29. doi: 10.1002/art.30460.


The role of Natural Killer cells in the pathogenesis of rheumatoid arthritis: major contributors or essential homeostatic modulators?

Ahern DJ, Brennan FM.

Immunol Lett. 2011 May;136(2):115-21. doi: 10.1016/j.imlet.2010.11.001. Epub 2010 Nov 10. Review.


Activation of p38 mitogen-activated protein kinase is critical step for acquisition of effector function in cytokine-activated T cells, but acts as a negative regulator in T cells activated through the T-cell receptor.

Li C, Beavis P, Palfreeman AC, Amjadi P, Kennedy A, Brennan FM.

Immunology. 2011 Jan;132(1):104-10. doi: 10.1111/j.1365-2567.2010.03345.x. Epub 2010 Sep 28.


Nonsteroidal anti-inflammatory drugs increase TNF production in rheumatoid synovial membrane cultures and whole blood.

Page TH, Turner JJ, Brown AC, Timms EM, Inglis JJ, Brennan FM, Foxwell BM, Ray KP, Feldmann M.

J Immunol. 2010 Sep 15;185(6):3694-701. doi: 10.4049/jimmunol.1000906. Epub 2010 Aug 16.


Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis.

McCann FE, Palfreeman AC, Andrews M, Perocheau DP, Inglis JJ, Schafer P, Feldmann M, Williams RO, Brennan FM.

Arthritis Res Ther. 2010;12(3):R107. doi: 10.1186/ar3041. Epub 2010 Jun 2.


Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritis.

Hillyer P, Larché MJ, Bowman EP, McClanahan TK, de Waal Malefyt R, Schewitz LP, Giddins G, Feldmann M, Kastelein RA, Brennan FM.

Rheumatology (Oxford). 2009 Dec;48(12):1581-9. doi: 10.1093/rheumatology/kep293. Epub 2009 Oct 8.


TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines.

Kuai J, Gregory B, Hill A, Pittman DD, Feldman JL, Brown T, Carito B, O'Toole M, Ramsey R, Adolfsson O, Shields KM, Dower K, Hall JP, Kurdi Y, Beech JT, Nanchahal J, Feldmann M, Foxwell BM, Brennan FM, Winkler DG, Lin LL.

Rheumatology (Oxford). 2009 Nov;48(11):1352-8. doi: 10.1093/rheumatology/kep235. Epub 2009 Aug 27.


Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures.

Sacre SM, Lo A, Gregory B, Simmonds RE, Williams L, Feldmann M, Brennan FM, Foxwell BM.

J Immunol. 2008 Dec 1;181(11):8002-9.


Suppression of tumour necrosis factor production from mononuclear cells by a novel synthetic compound, CLX-090717.

Sumariwalla PF, Palmer CD, Pickford LB, Feldmann M, Foxwell BM, Brennan FM.

Rheumatology (Oxford). 2009 Jan;48(1):32-8. doi: 10.1093/rheumatology/ken398. Epub 2008 Nov 16.


Evidence that cytokines play a role in rheumatoid arthritis.

Brennan FM, McInnes IB.

J Clin Invest. 2008 Nov;118(11):3537-45. doi: 10.1172/JCI36389. Review.


Neutralizing IL-21 and IL-15 inhibits pro-inflammatory cytokine production in rheumatoid arthritis.

Andersson AK, Feldmann M, Brennan FM.

Scand J Immunol. 2008 Jul;68(1):103-11. doi: 10.1111/j.1365-3083.2008.02118.x. Epub 2008 May 9.


Interleukin-10 regulates TNF-alpha-converting enzyme (TACE/ADAM-17) involving a TIMP-3 dependent and independent mechanism.

Brennan FM, Green P, Amjadi P, Robertshaw HJ, Alvarez-Iglesias M, Takata M.

Eur J Immunol. 2008 Apr;38(4):1106-17. doi: 10.1002/eji.200737821.


Recent developments in the immunobiology of rheumatoid arthritis.

Andersson AK, Li C, Brennan FM.

Arthritis Res Ther. 2008;10(2):204. doi: 10.1186/ar2370. Epub 2008 Mar 14. Review.

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