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Results: 1 to 20 of 193

1.

Paradoxical effect of TrkA inhibition in Alzheimer's disease models.

Zhang Q, Descamps O, Hart MJ, Poksay KS, Spilman P, Kane DJ, Gorostiza O, John V, Bredesen DE.

J Alzheimers Dis. 2014;40(3):605-17. doi: 10.3233/JAD-130017.

PMID:
24531152
[PubMed - in process]
2.

The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model.

Spilman P, Descamps O, Gorostiza O, Peters-Libeu C, Poksay KS, Matalis A, Campagna J, Patent A, Rao R, John V, Bredesen DE.

Brain Res. 2014 Mar 10;1551:25-44. doi: 10.1016/j.brainres.2013.12.029. Epub 2013 Dec 31.

PMID:
24389031
[PubMed - in process]
3.

Correction: Moonlighting Peptides with Emerging Function.

Rodríguez Plaza JG, Villalón Rojas A, Herrera S, Garza-Ramos G, Torres Larios A, Amero C, Zarraga Granados G, Gutiérrez Aguilar M, Lara Ortiz MT, Polanco Gonzalez C, Uribe Carvajal S, Coria R, Peña Díaz A, Bredesen DE, Castro-Obregon S, Del Rio G.

PLoS One. 2013 Oct 23;8(10). doi: 10.1371/annotation/fc687f18-ce8e-4704-87a5-d6807953204e. eCollection 2013.

PMID:
24194802
[PubMed - as supplied by publisher]
Free PMC Article
4.

Neuroprotective Sirtuin ratio reversed by ApoE4.

Theendakara V, Patent A, Peters Libeu CA, Philpot B, Flores S, Descamps O, Poksay KS, Zhang Q, Cailing G, Hart M, John V, Rao RV, Bredesen DE.

Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18303-8. doi: 10.1073/pnas.1314145110. Epub 2013 Oct 21.

PMID:
24145446
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

AβPP-selective BACE inhibitors (ASBI): novel class of therapeutic agents for alzheimer's disease.

Descamps O, Spilman P, Zhang Q, Libeu CP, Poksay K, Gorostiza O, Campagna J, Jagodzinska B, Bredesen DE, John V.

J Alzheimers Dis. 2013;37(2):343-55. doi: 10.3233/JAD-130578.

PMID:
23948888
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Next generation therapeutics for Alzheimer's disease.

Bredesen DE, John V.

EMBO Mol Med. 2013 Jun;5(6):795-8. doi: 10.1002/emmm.201202307. Epub 2013 May 23.

PMID:
23703924
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

No consistent bioenergetic defects in presynaptic nerve terminals isolated from mouse models of Alzheimer's disease.

Choi SW, Gerencser AA, Ng R, Flynn JM, Melov S, Danielson SR, Gibson BW, Nicholls DG, Bredesen DE, Brand MD.

J Neurosci. 2012 Nov 21;32(47):16775-84. doi: 10.1523/JNEUROSCI.2414-12.2012.

PMID:
23175831
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

The small co-chaperone p23 overexpressing transgenic mouse.

Zhang J, Spilman P, Chen S, Gorostiza O, Matalis A, Niazi K, Bredesen DE, Rao RV.

J Neurosci Methods. 2013 Jan 30;212(2):190-4. doi: 10.1016/j.jneumeth.2012.09.022. Epub 2012 Sep 27.

PMID:
23022695
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Moonlighting peptides with emerging function.

Rodríguez Plaza JG, Villalón Rojas A, Herrera S, Garza-Ramos G, Torres Larios A, Amero C, Zarraga Granados G, Gutiérrez Aguilar M, Lara Ortiz MT, Polanco Gonzalez C, Uribe Carvajal S, Coria R, Peña Díaz A, Bredesen DE, Castro-Obregon S, del Rio G.

PLoS One. 2012;7(7):e40125. doi: 10.1371/journal.pone.0040125. Epub 2012 Jul 13.

PMID:
22808104
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Altering APP proteolysis: increasing sAPPalpha production by targeting dimerization of the APP ectodomain.

Libeu CA, Descamps O, Zhang Q, John V, Bredesen DE.

PLoS One. 2012;7(6):e40027. doi: 10.1371/journal.pone.0040027. Epub 2012 Jun 29.

PMID:
22768208
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Ayurvedic medicinal plants for Alzheimer's disease: a review.

Rao RV, Descamps O, John V, Bredesen DE.

Alzheimers Res Ther. 2012 Jun 29;4(3):22. doi: 10.1186/alzrt125.

PMID:
22747839
[PubMed]
Free PMC Article
12.

Do proteomics analyses provide insights into reduced oxidative stress in the brain of an Alzheimer disease transgenic mouse model with an M631L amyloid precursor protein substitution and thereby the importance of amyloid-beta-resident methionine 35 in Alzheimer disease pathogenesis?

Sultana R, Robinson RA, Lange MB, Fiorini A, Galvan V, Fombonne J, Baker A, Gorostiza O, Zhang J, Cai J, Pierce WM, Bredesen DE, Butterfield DA.

Antioxid Redox Signal. 2012 Dec 1;17(11):1507-14. Epub 2012 Jun 6.

PMID:
22500616
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Human embryonic stem cells express elevated levels of multiple pro-apoptotic BCL-2 family members.

Madden DT, Davila-Kruger D, Melov S, Bredesen DE.

PLoS One. 2011;6(12):e28530. doi: 10.1371/journal.pone.0028530. Epub 2011 Dec 9. Erratum in: PLoS One. 2012;7(9). doi:10.1371/annotation/38d5bc7f-42f2-4d1e-b293-1a003bb57812.

PMID:
22174832
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Endogenously EGFP-Labeled Mouse Embryonic Stem Cells.

Zhang J, Rao RV, Spilman P, Mangada J, Xie L, Vitelli C, Gorostiza OF, Madden DT, Zeng X, Jin K, Hart MJ, Bredesen DE, Galvan V.

Aging Dis. 2011 Feb;2(1):18-29.

PMID:
21874159
[PubMed]
Free PMC Article
15.

The small chaperone protein p23 and its cleaved product p19 in cellular stress.

Poksay KS, Banwait S, Crippen D, Mao X, Bredesen DE, Rao RV.

J Mol Neurosci. 2012 Feb;46(2):303-14. doi: 10.1007/s12031-011-9574-7. Epub 2011 Jun 21.

PMID:
21691801
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Structural and functional alterations in amyloid-β precursor protein induced by amyloid-β peptides.

Libeu CP, Poksay KS, John V, Bredesen DE.

J Alzheimers Dis. 2011;25(3):547-66. doi: 10.3233/JAD-2011-101938.

PMID:
21471643
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Induction of the C-terminal proteolytic cleavage of AβPP by statins.

Descamps O, Zhang Q, John V, Bredesen DE.

J Alzheimers Dis. 2011;25(1):51-7. doi: 10.3233/JAD-2011-101857.

PMID:
21422530
[PubMed - indexed for MEDLINE]
18.

Dependence receptors: from basic research to drug development.

Mehlen P, Bredesen DE.

Sci Signal. 2011 Jan 25;4(157):mr2. doi: 10.1126/scisignal.2001521.

PMID:
21266712
[PubMed - indexed for MEDLINE]
19.

Valosin-containing protein gene mutations: cellular phenotypes relevant to neurodegeneration.

Poksay KS, Madden DT, Peter AK, Niazi K, Banwait S, Crippen D, Bredesen DE, Rao RV.

J Mol Neurosci. 2011 Jun;44(2):91-102. doi: 10.1007/s12031-010-9489-8. Epub 2011 Jan 20.

PMID:
21249466
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Differential expression and redox proteomics analyses of an Alzheimer disease transgenic mouse model: effects of the amyloid-β peptide of amyloid precursor protein.

Robinson RA, Lange MB, Sultana R, Galvan V, Fombonne J, Gorostiza O, Zhang J, Warrier G, Cai J, Pierce WM, Bredesen DE, Butterfield DA.

Neuroscience. 2011 Mar 17;177:207-22. doi: 10.1016/j.neuroscience.2011.01.005. Epub 2011 Jan 9.

PMID:
21223993
[PubMed - indexed for MEDLINE]
Free PMC Article

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