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IRS2 and PTEN are key molecules in controlling insulin sensitivity in podocytes.

Santamaria B, Marquez E, Lay A, Carew RM, González-Rodríguez Á, Welsh GI, Ni L, Hale LJ, Ortiz A, Saleem MA, Brazil DP, Coward RJ, Valverde ÁM.

Biochim Biophys Acta. 2015 Dec;1853(12):3224-34. doi: 10.1016/j.bbamcr.2015.09.020. Epub 2015 Sep 16. Erratum in: Biochim Biophys Acta. 2016 Apr;1863(4):786.


Gremlin1 and chronic pancreatitis: a new clinical target and biomarker?

Brazil DP.

J Mol Med (Berl). 2015 Oct;93(10):1057-60. doi: 10.1007/s00109-015-1335-6. No abstract available.


Exendin-4 protects against post-myocardial infarction remodelling via specific actions on inflammation and the extracellular matrix.

Robinson E, Cassidy RS, Tate M, Zhao Y, Lockhart S, Calderwood D, Church R, McGahon MK, Brazil DP, McDermott BJ, Green BD, Grieve DJ.

Basic Res Cardiol. 2015 Mar;110(2):20. doi: 10.1007/s00395-015-0476-7. Epub 2015 Mar 1.


BMP signalling: agony and antagony in the family.

Brazil DP, Church RH, Surae S, Godson C, Martin F.

Trends Cell Biol. 2015 May;25(5):249-64. doi: 10.1016/j.tcb.2014.12.004. Epub 2015 Jan 12. Review.


Gremlin1 preferentially binds to bone morphogenetic protein-2 (BMP-2) and BMP-4 over BMP-7.

Church RH, Krishnakumar A, Urbanek A, Geschwindner S, Meneely J, Bianchi A, Basta B, Monaghan S, Elliot C, Strömstedt M, Ferguson N, Martin F, Brazil DP.

Biochem J. 2015 Feb 15;466(1):55-68. doi: 10.1042/BJ20140771.


Bone morphogenetic proteins and their antagonists: current and emerging clinical uses.

Ali IH, Brazil DP.

Br J Pharmacol. 2014 Aug;171(15):3620-32. doi: 10.1111/bph.12724. Review.


β-Lapachone alleviates alcoholic fatty liver disease in rats.

Shin S, Park J, Li Y, Min KN, Kong G, Hur GM, Kim JM, Shong M, Jung MS, Park JK, Jeong KH, Park MG, Kwak TH, Brazil DP, Park J.

Cell Signal. 2014 Feb;26(2):295-305. doi: 10.1016/j.cellsig.2013.11.020. Epub 2013 Nov 22.


Cyclic adenosine monophosphate-response element-binding protein mediates the proangiogenic or proinflammatory activity of gremlin.

Corsini M, Moroni E, Ravelli C, Andrés G, Grillo E, Ali IH, Brazil DP, Presta M, Mitola S.

Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):136-45. doi: 10.1161/ATVBAHA.113.302517. Epub 2013 Nov 14.


Insulin receptor substrate-2 is expressed in kidney epithelium and up-regulated in diabetic nephropathy.

Hookham MB, O'Donovan HC, Church RH, Mercier-Zuber A, Luzi L, Curran SP, Carew RM, Droguett A, Mezzano S, Schubert M, White MF, Crean JK, Brazil DP.

FEBS J. 2013 Jul;280(14):3232-43. doi: 10.1111/febs.12305. Epub 2013 May 29.


Cardiomyopathy and diastolic dysfunction in the embryo and neonate of a type 1 diabetic mouse model.

Corrigan N, Treacy A, Brazil DP, McAuliffe FM.

Reprod Sci. 2013 Jul;20(7):781-90. doi: 10.1177/1933719112466298. Epub 2012 Dec 26.


Fetal and maternal leptin in pre-gestational diabetic pregnancy.

Higgins MF, Russell NM, Brazil DP, Firth RG, McAuliffe FM.

Int J Gynaecol Obstet. 2013 Feb;120(2):169-72. doi: 10.1016/j.ijgo.2012.08.025. Epub 2012 Nov 28.


CCN2/CTGF increases expression of miR-302 microRNAs, which target the TGFβ type II receptor with implications for nephropathic cell phenotypes.

Faherty N, Curran SP, O'Donovan H, Martin F, Godson C, Brazil DP, Crean JK.

J Cell Sci. 2012 Dec 1;125(Pt 23):5621-9. doi: 10.1242/jcs.105528. Epub 2012 Sep 12.


PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage.

Li Y, Park J, Piao L, Kong G, Kim Y, Park KA, Zhang T, Hong J, Hur GM, Seok JH, Choi SW, Yoo BC, Hemmings BA, Brazil DP, Kim SH, Park J.

Cell Signal. 2013 Jan;25(1):74-84. doi: 10.1016/j.cellsig.2012.09.009. Epub 2012 Sep 11.


Maternal and fetal placental growth hormone and IGF axis in type 1 diabetic pregnancy.

Higgins MF, Russell NE, Crossey PA, Nyhan KC, Brazil DP, McAuliffe FM.

PLoS One. 2012;7(2):e29164. doi: 10.1371/journal.pone.0029164. Epub 2012 Feb 17. Erratum in: PLoS One. 2012;7(5). doi:10.1371/annotation/b3c08210-a703-4986-aa97-c8513c5aff5f.


Next-generation sequencing identifies TGF-β1-associated gene expression profiles in renal epithelial cells reiterated in human diabetic nephropathy.

Brennan EP, Morine MJ, Walsh DW, Roxburgh SA, Lindenmeyer MT, Brazil DP, Gaora PÓ, Roche HM, Sadlier DM, Cohen CD; GENIE Consortium, Godson C, Martin F.

Biochim Biophys Acta. 2012 Apr;1822(4):589-99. doi: 10.1016/j.bbadis.2012.01.008. Epub 2012 Jan 14.


Deletion of Gremlin1 increases cell proliferation and migration responses in mouse embryonic fibroblasts.

Curran SP, Hickey FB, Watson A, Godson C, Brazil DP.

Cell Signal. 2012 Apr;24(4):889-98. doi: 10.1016/j.cellsig.2011.12.008. Epub 2011 Dec 13.


Connective tissue growth factor antagonizes transforming growth factor-β1/Smad signalling in renal mesangial cells.

O'Donovan HC, Hickey F, Brazil DP, Kavanagh DH, Oliver N, Martin F, Godson C, Crean J.

Biochem J. 2012 Jan 1;441(1):499-510. doi: 10.1042/BJ20110910.


Insulin receptor substrate 2 and FoxO3a signalling are involved in E-cadherin expression and transforming growth factor-β1-induced repression in kidney epithelial cells.

Carew RM, Browne MB, Hickey FB, Brazil DP.

FEBS J. 2011 Sep;278(18):3370-80. doi: 10.1111/j.1742-4658.2011.08261.x. Epub 2011 Aug 16.


CTGF/CCN2 activates canonical Wnt signalling in mesangial cells through LRP6: implications for the pathogenesis of diabetic nephropathy.

Rooney B, O'Donovan H, Gaffney A, Browne M, Faherty N, Curran SP, Sadlier D, Godson C, Brazil DP, Crean J.

FEBS Lett. 2011 Feb 4;585(3):531-8. doi: 10.1016/j.febslet.2011.01.004. Epub 2011 Jan 14.

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