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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1984 1
1986 1
1989 1
1990 2
1991 4
1992 3
1993 1
1994 2
1995 1
1996 1
1997 1
1998 4
1999 4
2000 6
2001 7
2002 4
2003 8
2004 3
2005 7
2006 9
2007 2
2008 6
2009 8
2010 7
2011 13
2012 10
2013 12
2014 10
2015 14
2016 16
2017 11
2018 16
2019 17
2020 18
2021 16
2022 13
2023 16
2024 4

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254 results

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Page 1
Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Cardiovascular Diseases.
Wang M, Pan W, Xu Y, Zhang J, Wan J, Jiang H. Wang M, et al. J Inflamm Res. 2022 May 25;15:3083-3094. doi: 10.2147/JIR.S350109. eCollection 2022. J Inflamm Res. 2022. PMID: 35642214 Free PMC article. Review.
Microglia are tissue-resident macrophages of the central nervous system (CNS). In the CNS, microglia play an important role in the monitoring and intervention of synaptic and neuron-level activities. ...
Microglia are tissue-resident macrophages of the central nervous system (CNS). In the CNS, microglia play an important role in the mo …
Quantitative Mass Spectrometry Imaging of Biological Systems.
Unsihuay D, Mesa Sanchez D, Laskin J. Unsihuay D, et al. Annu Rev Phys Chem. 2021 Apr 20;72:307-329. doi: 10.1146/annurev-physchem-061020-053416. Epub 2021 Jan 13. Annu Rev Phys Chem. 2021. PMID: 33441032 Free PMC article. Review.
Mass spectrometry imaging (MSI) is a powerful, label-free technique that provides detailed maps of hundreds of molecules in complex samples with high sensitivity and subcellular spatial resolution. Accurate quantification in MSI relies on a detailed understanding of …
Mass spectrometry imaging (MSI) is a powerful, label-free technique that provides detailed maps of hundreds of molecules in complex s …
Computational solutions for spatial transcriptomics.
Kleino I, Frolovaitė P, Suomi T, Elo LL. Kleino I, et al. Comput Struct Biotechnol J. 2022 Sep 1;20:4870-4884. doi: 10.1016/j.csbj.2022.08.043. eCollection 2022. Comput Struct Biotechnol J. 2022. PMID: 36147664 Free PMC article. Review.
The scRNA-seq tools are modified for spatial transcriptomics or new solutions like deep learning-based joint analysis of expression, spatial, and image data are developed to extract biological information in the spatially resolved transcriptomes. The computat …
The scRNA-seq tools are modified for spatial transcriptomics or new solutions like deep learning-based joint analysis of expre …
Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution.
Masuda T, Sankowski R, Staszewski O, Böttcher C, Amann L, Sagar, Scheiwe C, Nessler S, Kunz P, van Loo G, Coenen VA, Reinacher PC, Michel A, Sure U, Gold R, Grün D, Priller J, Stadelmann C, Prinz M. Masuda T, et al. Nature. 2019 Feb;566(7744):388-392. doi: 10.1038/s41586-019-0924-x. Epub 2019 Feb 13. Nature. 2019. PMID: 30760929
However, little is known about the presence of spatially and temporally restricted subclasses of microglia in the central nervous system during development or disease. Here we combine massively parallel single-cell analysis, single-molecule fluorescence in situ hybr …
However, little is known about the presence of spatially and temporally restricted subclasses of microglia in the central nervous system dur …
Spatial analysis of drug absorption, distribution, metabolism, and toxicology using mass spectrometry imaging.
Spruill ML, Maletic-Savatic M, Martin H, Li F, Liu X. Spruill ML, et al. Biochem Pharmacol. 2022 Jul;201:115080. doi: 10.1016/j.bcp.2022.115080. Epub 2022 May 10. Biochem Pharmacol. 2022. PMID: 35561842 Free PMC article. Review.
Mass spectrometry imaging (MSI) is emerging as a powerful analytical tool for detection, quantification, and simultaneous spatial molecular imaging of endogenous and exogenous molecules via in situ mass spectrometry analysis of thin tissue sections wit …
Mass spectrometry imaging (MSI) is emerging as a powerful analytical tool for detection, quantification, and simultaneous spatial mol …
Dual spatial maps of transcript and protein abundance in the mouse brain.
Park CC, Petyuk VA, Qian WJ, Smith RD, Smith DJ. Park CC, et al. Expert Rev Proteomics. 2009 Jun;6(3):243-9. doi: 10.1586/epr.09.46. Expert Rev Proteomics. 2009. PMID: 19489697 Free PMC article. Review.
Integrating quantitative proteomic and transcriptomic datasets promises valuable insights in unraveling the molecular mechanisms of the brain. We concentrate on recent studies using mass spectrometry and microarray data to investigate transcript and protein abundance in no …
Integrating quantitative proteomic and transcriptomic datasets promises valuable insights in unraveling the molecular mechanisms of the b
Spatial and temporal variation of routine parameters: pitfalls in the cerebrospinal fluid analysis in central nervous system infections.
Djukic M, Lange P, Erbguth F, Nau R. Djukic M, et al. J Neuroinflammation. 2022 Jul 6;19(1):174. doi: 10.1186/s12974-022-02538-3. J Neuroinflammation. 2022. PMID: 35794632 Free PMC article. Review.
In this review including reinterpretation of previously published data we illustrate, how anatomical and (patho)physiological conditions can influence routine CSF analysis. Equilibration of the components of the CSF depends on the size of the molecule or particle, e …
In this review including reinterpretation of previously published data we illustrate, how anatomical and (patho)physiological conditions can …
Genome-wide spatial expression profiling in formalin-fixed tissues.
Gracia Villacampa E, Larsson L, Mirzazadeh R, Kvastad L, Andersson A, Mollbrink A, Kokaraki G, Monteil V, Schultz N, Appelberg KS, Montserrat N, Zhang H, Penninger JM, Miesbach W, Mirazimi A, Carlson J, Lundeberg J. Gracia Villacampa E, et al. Cell Genom. 2021 Dec 8;1(3):100065. doi: 10.1016/j.xgen.2021.100065. eCollection 2021 Dec 8. Cell Genom. 2021. PMID: 36776149 Free PMC article.
Formalin-fixed paraffin embedding (FFPE) is the most widespread long-term tissue preservation approach. Here, we report a procedure to perform genome-wide spatial analysis of mRNA in FFPE-fixed tissue sections, using well-established, commercially avai …
Formalin-fixed paraffin embedding (FFPE) is the most widespread long-term tissue preservation approach. Here, we report a procedure t …
Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism.
Yutuc E, Angelini R, Baumert M, Mast N, Pikuleva I, Newton J, Clench MR, Skibinski DOF, Howell OW, Wang Y, Griffiths WJ. Yutuc E, et al. Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):5749-5760. doi: 10.1073/pnas.1917421117. Epub 2020 Mar 4. Proc Natl Acad Sci U S A. 2020. PMID: 32132201 Free PMC article.
To better understand cholesterol metabolism in situ across the complex functional regions of brain, we have developed on-tissue enzyme-assisted derivatization in combination with microliquid extraction for surface analysis and liquid chromatography-mass spect …
To better understand cholesterol metabolism in situ across the complex functional regions of brain, we have developed on-tissue
Spatial visualization of comprehensive brain neurotransmitter systems and neuroactive substances by selective in situ chemical derivatization mass spectrometry imaging.
Shariatgorji R, Nilsson A, Fridjonsdottir E, Strittmatter N, Dannhorn A, Svenningsson P, Goodwin RJA, Odell LR, Andrén PE. Shariatgorji R, et al. Nat Protoc. 2021 Jul;16(7):3298-3321. doi: 10.1038/s41596-021-00538-w. Epub 2021 Jun 2. Nat Protoc. 2021. PMID: 34075230
Molecule-specific techniques such as MALDI and desorption electrospray ionization mass spectrometry imaging enable direct and simultaneous mapping of biomolecules in tissue sections in a single experiment. ...The protocol, using fluoromethylpyridinium and pyrylium r
Molecule-specific techniques such as MALDI and desorption electrospray ionization mass spectrometry imaging enable direct and simulta
254 results