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Preclinical Characterization of Novel Chordoma Cell Systems and Their Targeting by Pharmocological Inhibitors of the CDK4/6 Cell-Cycle Pathway.

von Witzleben A, Goerttler LT, Marienfeld R, Barth H, Lechel A, Mellert K, Böhm M, Kornmann M, Mayer-Steinacker R, von Baer A, Schultheiss M, Flanagan AM, Möller P, Brüderlein S, Barth TF.

Cancer Res. 2015 Sep 15;75(18):3823-31. doi: 10.1158/0008-5472.CAN-14-3270. Epub 2015 Jul 16.


Validation of a Manual Protocol for BRAF V600E Mutation-specific Immunohistochemistry.

Dinges HC, Capper D, Ritz O, Brüderlein S, Marienfeld R, von Deimling A, Möller P, Lennerz JK.

Appl Immunohistochem Mol Morphol. 2015 May-Jun;23(5):382-8. doi: 10.1097/PAI.0000000000000092.


KIT mutations in primary mediastinal B-cell lymphoma.

Nagel PD, Stenzinger A, Feld FM, Herrmann MD, Brüderlein S, Barth TF, Marienfeld R, Endris V, Weichert W, Debatin KM, Westhoff MA, Lessel D, Möller P, Lennerz JK.

Blood Cancer J. 2014 Aug 22;4:e241. doi: 10.1038/bcj.2014.61. No abstract available.


Potential clinical implications of BRAF mutations in histiocytic proliferations.

Bubolz AM, Weissinger SE, Stenzinger A, Arndt A, Steinestel K, Brüderlein S, Cario H, Lubatschofski A, Welke C, Anagnostopoulos I, Barth TF, Beer AJ, Möller P, Gottstein M, Viardot A, Lennerz JK.

Oncotarget. 2014 Jun 30;5(12):4060-70.


Expression and Y435-phosphorylation of Abelson interactor 1 (Abi1) promotes tumour cell adhesion, extracellular matrix degradation and invasion by colorectal carcinoma cells.

Steinestel K, Brüderlein S, Lennerz JK, Steinestel J, Kraft K, Pröpper C, Meineke V, Möller P.

Mol Cancer. 2014 Jun 9;13:145. doi: 10.1186/1476-4598-13-145.


Molecular profiling of chordoma.

Scheil-Bertram S, Kappler R, von Baer A, Hartwig E, Sarkar M, Serra M, Brüderlein S, Westhoff B, Melzner I, Bassaly B, Herms J, Hugo HH, Schulte M, Möller P.

Int J Oncol. 2014 Apr;44(4):1041-55. doi: 10.3892/ijo.2014.2268. Epub 2014 Jan 21.


[Abelson interactor 1 (Abi1) in colorectal cancer. From synaptic plasticity to tumor cell migration].

Steinestel K, Gläsle F, Brüderlein S, Steinestel J, Pröpper C, Möller P.

Pathologe. 2013 Nov;34 Suppl 2:189-94. doi: 10.1007/s00292-013-1810-1. German.


STAT6-mediated BCL6 repression in primary mediastinal B-cell lymphoma (PMBL).

Ritz O, Rommel K, Dorsch K, Kelsch E, Melzner J, Buck M, Leroy K, Papadopoulou V, Wagner S, Marienfeld R, Brüderlein S, Lennerz JK, Möller P.

Oncotarget. 2013 Jul;4(7):1093-102.


CD57(high) neuroblastoma cells have aggressive attributes ex situ and an undifferentiated phenotype in patients.

Schlitter AM, Dorneburg C, Barth TF, Wahl J, Schulte JH, Brüderlein S, Debatin KM, Beltinger C.

PLoS One. 2012;7(8):e42025. doi: 10.1371/journal.pone.0042025. Epub 2012 Aug 10.


Expression of Abelson interactor 1 (Abi1) correlates with inflammation, KRAS mutation and adenomatous change during colonic carcinogenesis.

Steinestel K, Brüderlein S, Steinestel J, Märkl B, Schwerer MJ, Arndt A, Kraft K, Pröpper C, Möller P.

PLoS One. 2012;7(7):e40671. doi: 10.1371/journal.pone.0040671. Epub 2012 Jul 10.


Molecular characterization of putative chordoma cell lines.

Brüderlein S, Sommer JB, Meltzer PS, Li S, Osada T, Ng D, Möller P, Alcorta DA, Kelley MJ.

Sarcoma. 2010;2010:630129. doi: 10.1155/2010/630129. Epub 2010 Dec 30.


Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional-based study.

Presneau N, Shalaby A, Ye H, Pillay N, Halai D, Idowu B, Tirabosco R, Whitwell D, Jacques TS, Kindblom LG, Brüderlein S, Möller P, Leithner A, Liegl B, Amary FM, Athanasou NN, Hogendoorn PC, Mertens F, Szuhai K, Flanagan AM.

J Pathol. 2011 Feb;223(3):327-35. doi: 10.1002/path.2816. Epub 2010 Nov 24.


3D nuclear organization of telomeres in the Hodgkin cell lines U-HO1 and U-HO1-PTPN1: PTPN1 expression prevents the formation of very short telomeres including "t-stumps".

Knecht H, Brüderlein S, Wegener S, Lichtensztejn D, Lichtensztejn Z, Lemieux B, Möller P, Mai S.

BMC Cell Biol. 2010 Dec 14;11:99. doi: 10.1186/1471-2121-11-99.


3D structural and functional characterization of the transition from Hodgkin to Reed-Sternberg cells.

Knecht H, Brüderlein S, Mai S, Möller P, Sawan B.

Ann Anat. 2010 Sep 20;192(5):302-8. doi: 10.1016/j.aanat.2010.07.006. Epub 2010 Aug 6. Review.


Sex-related differences in length and erosion dynamics of human telomeres favor females.

Möller P, Mayer S, Mattfeldt T, Müller K, Wiegand P, Brüderlein S.

Aging (Albany NY). 2009 Jul 14;1(8):733-9.


[U-HO1. A new cell line derived from a primary refractory classical Hodgkin lymphoma].

Möller P, Mader A, Barth TF, Brüderlein S.

Pathologe. 2008 Nov;29 Suppl 2:317-8. doi: 10.1007/s00292-008-1055-6. German.


Lymphocytes of type 2 diabetic women carry a high load of stable chromosomal aberrations: a novel risk factor for disease-related early death.

Boehm BO, Möller P, Högel J, Winkelmann BR, Renner W, Rosinger S, Seelhorst U, Wellnitz B, März W, Melzner J, Brüderlein S.

Diabetes. 2008 Nov;57(11):2950-7. doi: 10.2337/db08-0274. Epub 2008 Jul 23.


Different rates of telomere attrition in peripheral lymphocytes in a pair of dizygotic twins with hematopoietic chimerism.

Brüderlein S, Müller K, Melzner J, Högel J, Wiegand P, Möller P.

Aging Cell. 2008 Oct;7(5):663-6. doi: 10.1111/j.1474-9726.2008.00413.x. Epub 2008 Jul 24. Review.


Hyperinsulinemia induces insulin resistance on glucose and lipid metabolism in a human adipocytic cell line: paracrine interaction with myocytes.

Fernández-Veledo S, Nieto-Vazquez I, de Castro J, Ramos MP, Brüderlein S, Möller P, Lorenzo M.

J Clin Endocrinol Metab. 2008 Jul;93(7):2866-76. doi: 10.1210/jc.2007-2472. Epub 2008 Apr 22.


U-HO1, a new cell line derived from a primary refractory classical Hodgkin lymphoma.

Mader A, Bruderlein S, Wegener S, Melzner I, Popov S, Muller-Hermelink HK, Barth TF, Viardot A, Moller P.

Cytogenet Genome Res. 2007;119(3-4):204-10. doi: 10.1159/000112062. Epub 2008 Feb 1.

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