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Results: 1 to 20 of 62


An Extended Surface Loop on Toxoplasma gondii Apical Membrane Antigen 1 (AMA1) Governs Ligand Binding Selectivity.

Parker ML, Boulanger MJ.

PLoS One. 2015 May 8;10(5):e0126206. doi: 10.1371/journal.pone.0126206. eCollection 2015.


Computational and biophysical approaches to protein-protein interaction inhibition of Plasmodium falciparum AMA1/RON2 complex.

Pihan E, Delgadillo RF, Tonkin ML, Pugnière M, Lebrun M, Boulanger MJ, Douguet D.

J Comput Aided Mol Des. 2015 Mar 31. [Epub ahead of print]


Systems-based analysis of the Sarcocystis neurona genome identifies pathways that contribute to a heteroxenous life cycle.

Blazejewski T, Nursimulu N, Pszenny V, Dangoudoubiyam S, Namasivayam S, Chiasson MA, Chessman K, Tonkin M, Swapna LS, Hung SS, Bridgers J, Ricklefs SM, Boulanger MJ, Dubey JP, Porcella SF, Kissinger JC, Howe DK, Grigg ME, Parkinson J.

MBio. 2015 Feb 10;6(1). pii: e02445-14. doi: 10.1128/mBio.02445-14.


The shear stress of host cell invasion: exploring the role of biomolecular complexes.

Tonkin ML, Boulanger MJ.

PLoS Pathog. 2015 Jan 28;11(1):e1004539. doi: 10.1371/journal.ppat.1004539. eCollection 2015 Jan. No abstract available.


Post-translational modification of LipL32 during Leptospira interrogans infection.

Witchell TD, Eshghi A, Nally JE, Hof R, Boulanger MJ, Wunder EA Jr, Ko AI, Haake DA, Cameron CE.

PLoS Negl Trop Dis. 2014 Oct 30;8(10):e3280. doi: 10.1371/journal.pntd.0003280. eCollection 2014 Oct.


Structural and functional divergence of the aldolase fold in Toxoplasma gondii.

Tonkin ML, Halavaty AS, Ramaswamy R, Ruan J, Igarashi M, Ngô HM, Boulanger MJ.

J Mol Biol. 2015 Feb 27;427(4):840-52. doi: 10.1016/j.jmb.2014.09.019. Epub 2014 Oct 2.


A conserved apicomplexan microneme protein contributes to Toxoplasma gondii invasion and virulence.

Huynh MH, Boulanger MJ, Carruthers VB.

Infect Immun. 2014 Oct;82(10):4358-68. doi: 10.1128/IAI.01877-14. Epub 2014 Aug 4.


Immunization with a functional protein complex required for erythrocyte invasion protects against lethal malaria.

Srinivasan P, Ekanem E, Diouf A, Tonkin ML, Miura K, Boulanger MJ, Long CA, Narum DL, Miller LH.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10311-6. doi: 10.1073/pnas.1409928111. Epub 2014 Jun 23.


Plasticity and redundancy among AMA-RON pairs ensure host cell entry of Toxoplasma parasites.

Lamarque MH, Roques M, Kong-Hap M, Tonkin ML, Rugarabamu G, Marq JB, Penarete-Vargas DM, Boulanger MJ, Soldati-Favre D, Lebrun M.

Nat Commun. 2014 Jun 17;5:4098. doi: 10.1038/ncomms5098.


The inner membrane complex sub-compartment proteins critical for replication of the apicomplexan parasite Toxoplasma gondii adopt a pleckstrin homology fold.

Tonkin ML, Beck JR, Bradley PJ, Boulanger MJ.

J Biol Chem. 2014 May 16;289(20):13962-73. doi: 10.1074/jbc.M114.548891. Epub 2014 Mar 27.


Chromodomain antagonists that target the polycomb-group methyllysine reader protein chromobox homolog 7 (CBX7).

Simhadri C, Daze KD, Douglas SF, Quon TT, Dev A, Gignac MC, Peng F, Heller M, Boulanger MJ, Wulff JE, Hof F.

J Med Chem. 2014 Apr 10;57(7):2874-83. doi: 10.1021/jm401487x. Epub 2014 Mar 26.


The multifunctional role of the pallilysin-associated Treponema pallidum protein, Tp0750, in promoting fibrinolysis and extracellular matrix component degradation.

Houston S, Russell S, Hof R, Roberts AK, Cullen P, Irvine K, Smith DS, Borchers CH, Tonkin ML, Boulanger MJ, Cameron CE.

Mol Microbiol. 2014 Feb;91(3):618-34. doi: 10.1111/mmi.12482. Epub 2014 Jan 7.


Toxoplasma gondii sporozoites invade host cells using two novel paralogues of RON2 and AMA1.

Poukchanski A, Fritz HM, Tonkin ML, Treeck M, Boulanger MJ, Boothroyd JC.

PLoS One. 2013 Aug 5;8(8):e70637. doi: 10.1371/journal.pone.0070637. Print 2013.


Improving biophysical properties of a bispecific antibody scaffold to aid developability: quality by molecular design.

Von Kreudenstein TS, Escobar-Carbrera E, Lario PI, D'Angelo I, Brault K, Kelly J, Durocher Y, Baardsnes J, Woods RJ, Xie MH, Girod PA, Suits MD, Boulanger MJ, Poon DK, Ng GY, Dixit SB.

MAbs. 2013 Sep-Oct;5(5):646-54. doi: 10.4161/mabs.25632. Epub 2013 Jul 8.


Structural and biochemical characterization of Plasmodium falciparum 12 (Pf12) reveals a unique interdomain organization and the potential for an antiparallel arrangement with Pf41.

Tonkin ML, Arredondo SA, Loveless BC, Serpa JJ, Makepeace KA, Sundar N, Petrotchenko EV, Miller LH, Grigg ME, Boulanger MJ.

J Biol Chem. 2013 May 3;288(18):12805-17. doi: 10.1074/jbc.M113.455667. Epub 2013 Mar 19.


Purification, crystallization and X-ray diffraction analysis of Trypanosoma congolense insect-stage surface antigen (TcCISSA).

Tonkin ML, Workman SD, Eyford BA, Loveless BC, Fudge JL, Pearson TW, Boulanger MJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Dec 1;68(Pt 12):1503-6. doi: 10.1107/S1744309112042686. Epub 2012 Nov 14.


Integrated bioinformatic and targeted deletion analyses of the SRS gene superfamily identify SRS29C as a negative regulator of Toxoplasma virulence.

Wasmuth JD, Pszenny V, Haile S, Jansen EM, Gast AT, Sher A, Boyle JP, Boulanger MJ, Parkinson J, Grigg ME.

MBio. 2012 Nov 13;3(6). pii: e00321-12. doi: 10.1128/mBio.00321-12.


Investigating terephthalate biodegradation: structural characterization of a putative decarboxylating cis-dihydrodiol dehydrogenase.

Bains J, Wulff JE, Boulanger MJ.

J Mol Biol. 2012 Oct 26;423(3):284-93. doi: 10.1016/j.jmb.2012.07.022. Epub 2012 Aug 11.


Purification, crystallization and preliminary X-ray diffraction analysis of inner membrane complex (IMC) subcompartment protein 1 (ISP1) from Toxoplasma gondii.

Tonkin ML, Brown S, Beck JR, Bradley PJ, Boulanger MJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jul 1;68(Pt 7):832-4. doi: 10.1107/S174430911202297X. Epub 2012 Jun 28.

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